Willkomm, Janina’s team published research in ACS Catalysis in 2021 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Name: 2,5-Dimethoxytetrahydrofuran

Willkomm, Janina; Bouzidi, Sara; Bertin, Erwan; Birss, Viola I.; Piers, Warren E. published their research in ACS Catalysis in 2021. The article was titled 《Aqueous CO2 Reduction by a Re(bipyridine)-polypyrrole Film Deposited on Colloid-Imprinted Carbon》.Name: 2,5-Dimethoxytetrahydrofuran The article contains the following contents:

Herein, we report a [Re(bipyridine)]-carbon hybrid material for efficient and selective CO2 to CO conversion in water. The Re catalyst was incorporated into a nanoporous colloid-imprinted carbon (CIC) powder by an electrochem. polymerization method. Uniform [Re(bipyridine)]-containing polymer films were formed on the carbon surface, where the catalyst-polymer loading could be controlled by varying the polymerization parameters. Thorough pre- and post-catalysis characterization confirmed the integrity of the [Re(bpy)] CO2 reduction catalyst. CIC|poly[Re] electrodes reduced CO2 to CO in 0.5 M CO2-saturated KHCO3 electrolyte solution at Eappl. = -0.66 V vs. reversible hydrogen electrode (RHE) (η = 550 mV), with initial Faradaic efficiencies for CO formation (FECO) between 88 and 100%. Higher catalyst loadings generally yielded higher FECO and better long-term stability under catalytic conditions, producing CO and maintaining selectivity of above 70% for a period of at least 24 h for the hybrid material with the highest [Re(bipyridine)] polymer loading. While electrochem. analyses suggested some electron and mass transport issues on shorter timescales, these were not confirmed in long-term electrolysis. Our work highlights the great applicability of (electro)polymerization techniques in combination with nanoporous CIC to prepare hybrid materials for energy conversion.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Name: 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Name: 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Tian, Run’s team published research in Results in Chemistry in 2022 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H12O3

Tian, Run; Liang, Zhi-Qun; Wang, Yong; Zeng, Nian-Kai published an article in 2022. The article was titled 《Analysis of aromatic components of two edible mushrooms, Phlebopus portentosus and Cantharellus yunnanensis using HS-SPME/GC-MS》, and you may find the article in Results in Chemistry.COA of Formula: C6H12O3 The information in the text is summarized as follows:

A headspace solid-phase microextraction (HS-SPME) coupled with gas chromatog.-mass spectrometry (GC-MS) was used to evaluate the profile of the volatile components that accounted for the aroma of two edible mushrooms, viz. Phlebopus portentosus and Cantharellus yunnanensis. There were 51 and 69 volatile compounds identified from P. portentosus and C. yunnanensis, resp. These compounds were mainly acids, hydrocarbons, ketones, esters, aldehydes, and alcs., of which acetic acid was most abundant among these volatile components. Onanoic acid, 9-oxo-, Me ester, 2-pentyl-furan, and 5, 6-dihydro-2-pyranone were discovered in the mushrooms for the first time, and the volatile compounds of C. yunnanensis was also investigated for the first time. In addition, the volatile compounds of P. portentosus and C. yunnanensis were analyzed by principal components anal. (PCA). The findings reveal the differences among samples and provide the basic data for the chemotaxonomy in studying P. portentosus and C. yunnanensis. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3COA of Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sun, Qi’s team published research in Chinese Chemical Letters in 2019 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

The author of 《Unexpected activated carbon-catalyzed pyrrolo[1,2-a]quinoxalines synthesis in water》 were Sun, Qi; Liu, Liyan; Yang, Yu; Zha, Zhenggen; Wang, Zhiyong. And the article was published in Chinese Chemical Letters in 2019. Application In Synthesis of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

An interesting and recyclable activated carbon/water catalytic system for efficient synthesis of pyrrolo[1,2-a]quinoxaline derivatives was developed. The intramol. C-N and C-C bond was easily constructed in water under mild condition. This reaction featured a broad substrate scope, a good tolerance to water and air, metal-free, additive-free and redox reagent-free. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application In Synthesis of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sasaki, Ikuo’s team published research in Tetrahedron Letters in 2020 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Electric Literature of C6H12O3

《A synthetic protocol for (-)-ketorolac; development of asymmetric gold(I)-catalyzed cyclization of allyl alcohol with pyrrole ring core》 was written by Sasaki, Ikuo; Yamasaki, Naoto; Kasai, Yusuke; Imagawa, Hiroshi; Yamamoto, Hirofumi. Electric Literature of C6H12O3 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

An asym. synthesis of (-)- and (+)-ketorolac was achieved with 89% ee using a novel Friedel-Crafts (FC) type C-C bond forming cyclization of an allyl alc. containing a pyrrole ring core in the presence of a bimetallic gold(I) salt complex prepared from a 2:2:1 combination of AuCl·SMe2, AgOTf and chiral Quinaphos. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Electric Literature of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Garcia-Marin, Javier’s team published research in ChemMedChem in 2020 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.SDS of cas: 696-59-3

SDS of cas: 696-59-3In 2020 ,《Pyrrolo[1,2-a]quinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B》 appeared in ChemMedChem. The author of the article were Garcia-Marin, Javier; Griera, Mercedes; Sanchez-Alonso, Patricia; Di Geronimo, Bruno; Mendicuti, Francisco; Rodriguez-Puyol, Manuel; Alajarin, Ramon; de Pascual-Teresa, Beatriz; Vaquero, Juan J.; Rodriguez-Puyol, Diego. The article conveys some information:

PTP1B dephosphorylates insulin receptor and substrates to modulate glucose metabolism This enzyme is a validated therapeutic target for type 2 diabetes, but no current drug candidates have completed clin. trials. Pyrrolo[1,2-a]quinoxalines substituted at positions C1-C4 and/or C7-C8 were found to be nontoxic to cells and good inhibitors in the low- to sub-micromolar range, with the 4-benzyl derivative being the most potent inhibitor (0.24 μm). Some analogs bearing chlorine atoms at C7 and/or C8 kept potency and showed good selectivity compared to TCPTP (selectivity index >40). The most potent inhibitors behaved as insulin mimetics by increasing glucose uptake. The 4-benzyl derivative inhibited insulin receptor substrate 1 and AKT phosphorylation. Mol. docking and mol. dynamics simulations supported a putative binding mode for these compounds to the allosteric α3/α6/α7 pocket, but inconsistent results in enzyme inhibition kinetics were obtained due to the high tendency of these inhibitors to form stable aggregates. Computational calculations supported the druggability of inhibitors. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3SDS of cas: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.SDS of cas: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hu,Zhizhi’s team published research in RSC Advances in 2021 | 4415-87-6

RSC Advances published new progress about Absorption. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, COA of Formula: C8H4O6.

Bai, Wu; Hu, Zhizhi; Lu, Yunhua; Xiao, Guoyong; Zhao, Hongbin; Zhu, Jianmin; Liu, Zhaobin published the artcile< Solubility, thermal and photoluminescence properties of triphenyl imidazole-containing polyimides>, COA of Formula: C8H4O6, the main research area is triphenyl imidazole polyimide preparation solubility thermal photoluminescence property.

In this paper, three kinds of tri-Ph imidazole-containing diamines including 2-phenyl-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (PBAI), 2-(4-methylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethyl phenoxy)phenyl)imidazole (MPBAI) and 2-(4-trifluoromethylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (TFPBAI) were synthesized. Then, a series of polyimide (PI) films were prepared by the solution polymerization of the three diamines and various dianhydrides, such as 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA), 1,2,4,5-pyromellitic dianhydride (PMDA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), followed by thermal imidization. The effects of chem. structures on the solubilities and thermal, optical and electrochem. properties of polyimides were explored. All the polyimides exhibited higher glass transition temperatures around 300°C and excellent solubilities in common polar solvents. The polyimide films derived from CBDA or 6FDA showed better optical properties with light color and transparent characteristics. The fluorescence test showed that the photoluminescence color of CBDA-based polyimide films is in the blue range in the CIE 1931 spectrum, while the polyimide film based on PMDA and 6FDA presented black or weak yellow light. However, all these polyimides in solution exhibited similar blue luminescence. Electrochem. tests indicated that the HOMO and LUMO values of these films were around -6.5 and -3.6 eV, and the energy gap difference was about 3.0 eV. Therefore, the tri-Ph imidazole-containing polyimides exhibit comprehensive performance, which will be expected as a new kind of functional material for certain application in the optical and optoelectronics fields.

RSC Advances published new progress about Absorption. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, COA of Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Gupta, Neil’s team published research in The lancet. Gastroenterology & hepatology in 2018-12-11 | 58-97-9

The lancet. Gastroenterology & hepatology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Gupta, Neil; Mbituyumuremyi, Aimable; Kabahizi, Jules; Ntaganda, Fabien; Muvunyi, Claude Mambo; Shumbusho, Fabienne; Musabeyezu, Emmanuel; Mukabatsinda, Constance; Ntirenganya, Cyprien; Van Nuil, Jennifer Ilo; Kateera, Fredrick; Camus, Gregory; Damascene, Makuza Jean; Nsanzimana, Sabin; Mukherjee, Joia; Grant, Philip M published the artcile< Treatment of chronic hepatitis C virus infection in Rwanda with ledipasvir-sofosbuvir (SHARED): a single-arm trial.>, Product Details of C9H13N2O9P, the main research area is .

BACKGROUND: Limited treatment data are available for hepatitis C virus (HCV) in sub-Saharan Africa, especially for genotype 4. Our objective was to establish the safety and efficacy of ledipasvir-sofosbuvir for chronic HCV genotype 1 or 4 infection in adults in Rwanda. METHODS: We did a single-arm trial to evaluate the safety and efficacy of ledipasvir-sofosbuvir in Rwandan adults with chronic HCV infection at a single study site (Rwanda Military Hospital, Kigali, Rwanda). We enrolled individuals aged 18 years or older with HCV genotype 1 or 4 infection and a plasma HCV RNA concentration of more than 1000 IU/mL at screening. All participants were given ledipasvir (90 mg) and sofosbuvir (400 mg) in a single combination tablet once daily for 12 weeks. We established HCV genotype using an Abbott platform, and HCV subtype with PCR amplification. The primary endpoint was the proportion of participants with a sustained virological response 12 weeks after therapy (SVR12). All patients enrolled in the study were included in the primary endpoint analyses. This study is registered with ClinicalTrials.gov, number NCT02964091. FINDINGS: 300 participants were enrolled between Feb 6, 2017, and Sept 18, 2017, and the follow-up period was completed on March 1, 2018. On genotyping, 248 (83%) participants were reported as having genotype 4, four (1%) genotype 1, and 48 (16%) both genotype 1 and genotype 4. Subsequent viral sequencing showed all participants actually had genotype 4 infection with subtype 4k (134 [45%]), subtype 4r (48 [16%]), subtype 4q (42 [14%]), and subtype 4v (24 [8%]) predominating. Overall, 261 (87%, 95% CI 83-91) participants achieved SVR12. In participants with genotype 4r, SVR12 was observed in 27 (56%, 95% CI 41-71) participants versus 234 (93%, 90-96) individuals with other subtypes. There were no drug-related treatment discontinuations due to ledipasvir-sofosbuvir. The most common adverse events were hypertension (97 [32%]), headache (78 [26%]), dizziness (61 [20%]), and fatigue (56 [19%]). There were six serious adverse events; none were assessed to be due to the study drug. 296 participants had data for pill counts at week 4 and 8; 271 (92%) had 100% adherence and only one (<1%) had an adherence of less than 90%. INTERPRETATION: This is the first large-scale prospective study reporting direct-acting antiviral outcomes in sub-Saharan Africa. The high adherence and treatment success without intensive support measures or highly specialised clinical providers, and lack of treatment discontinuations due to adverse events support the feasibility of HCV treatment decentralisation and scale-up in sub-Saharan Africa. Genotype 4r is uniquely expressed in this region and associated with high rates of treatment failure, suggesting a need for rigorous test-of-cure in clinical practice and consideration of the use of newer pangenotypic direct-acting antiviral regimens in this region. FUNDING: Gilead Sciences. The lancet. Gastroenterology & hepatology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yusof, Fitri Adila Amat’s team published research in Chemistry Letters in 2020 | 4415-87-6

Chemistry Letters published new progress about Activation energy (of volume resistivity). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Formula: C8H4O6.

Yusof, Fitri Adila Amat; Noda, Takumi; Takada, Kenji; Kaneko, Tatsuo; Kawai, Mika; Mitsumata, Tetsu published the artcile< Critical Electric Field and Activation Energy for Electric Conductivity for Biopolyimide Using 4,4'-Diamino-α-truxillic Acid and 1,2,3,4-Cyclobutanetetracarboxylic Dianhydride>, Formula: C8H4O6, the main research area is biopolyimide preparation elec property.

Biopolyimides poly(ATA-CBDA) made from of 4,4′-diamino-α-truxillic acid di-Me ester (ATA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA) were synthesized and its elec. volume resistivity measured at various elec. voltages at 10-60°C. The volume resistivity for Kapton and biopolyimide films showed a sudden decrease at a critical elec. field of 2.6 x 107 and 1.0 x 107 V/m, resp. The activation energy at low elec. field for Kapton and biopolyimide was 68 and 90 kJ/mol, resp., meanwhile at high elec. field for Kapton and biopolyimide was 45 and 74 kJ/mol, resp. These results indicate that the carriers for elec. conduction for biopolyimide weakly interact with the polymer chain and the biopolyimide contains many conductive carriers than Kapton.

Chemistry Letters published new progress about Activation energy (of volume resistivity). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ueno, M’s team published research in Tetrahedron Letters in 2001-10-29 | 137105-97-6

Tetrahedron Letters published new progress about Mannich reaction (enantioselective zirconium-catalyzed). 137105-97-6 belongs to class tetrahydrofurans, and the molecular formula is C9H15NO4, HPLC of Formula: 137105-97-6.

Ueno, M.; Kitagawa, H.; Ishitani, H.; Yasuda, S.; Hanada, K.; Kobayashi, S. published the artcile< Catalytic enantioselective synthesis of a novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12)>, HPLC of Formula: 137105-97-6, the main research area is HPA12 hydroxyhydroxymethylphenylpropyldodecanamide catalytic enantioselective synthesis ceramide trafficking inhibitor; enantioselective zirconium catalyzed Mannich reaction HPA12 synthesis.

A novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12, I), has been synthesized using a chiral zirconium-catalyzed asym. Mannich-type reaction as a key-step.

Tetrahedron Letters published new progress about Mannich reaction (enantioselective zirconium-catalyzed). 137105-97-6 belongs to class tetrahydrofurans, and the molecular formula is C9H15NO4, HPLC of Formula: 137105-97-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hirai, Hajime’s team published research in Agricultural and Biological Chemistry in 1976 | 5455-94-7

Agricultural and Biological Chemistry published new progress about Insecticides. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Application of C8H14O2.

Hirai, Hajime; Ueda, Kenzo; Matsui, Masanao published the artcile< Studies on chrysanthemic acid. Part XXV. Alternative synthesis of chrysanthemic acid via tetrahydrofuran derivatives>, Application of C8H14O2, the main research area is chrysanthemic acid insecticide; chloromethylchloroisopropylhexanoic acid ester.

The olefination reaction between 2,2,5,5-tetramethyltetrahydrofuran-3-one and (EtO)2P(:O)CH2CO2Et afforded an isomeric mixture of the normal α,β-unsaturated ester (I) and the endocyclic β,γ-unsaturated ester (II). Catalytic hydrogenation and subsequent hydrolysis of the mixture gave 2,2,5,5-tetramethyltetrahydrofuryl-3-acetic acid III. III was treated with SOCl2 in the presence of ZnCl2 to give Me2CClCH(CH2CO2Et)CH2CClMe2, from which trans-chrysanthemic acid was obtained by a known method. Pyrocin was also obtained in good yield by heating III with BF3-etherate.

Agricultural and Biological Chemistry published new progress about Insecticides. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Application of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem