Heterocyclic Building Blocks-Tetrahydrofuran

Li, Guanya; Xie, Chunyan; Wang, Qinhua; Wan, Dan; Zhang, Yan; Wu, Xin; Yin, Yulong published the artcile< Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is pig epithelial cell uridine monophosphate metabolism.

Taken together, oral administration of UR and UMP could improve the small intestinal morphol., promote epithelial cell apoptosis and renewal of intestinal villus tips, and benefit intestinal development and health thus improving the growth performance and reducing the risk of diarrhea in early-weaned piglets. Moreover, UMP and UR increased the apoptosis ratio of intestinal epithelial cells in in vivo and in vitro experiments Both the UMP and UR decreased the expression of CAD and RRM2 at the jejunal mucosa. UR increased the jejunum villus length/crypt depth ratio, Claudin-3 and E-cadherin expression, and the pyrimidine nucleotide metabolic enzymes including CMPK1, RRM2, UPRT, CTPS1 and CTPS2 in the duodenal mucosa. Results showed that UMP and UR supplements improved the ADG of piglets, and decreased the diarrhea rate. Twenty-one piglets were randomly allotted into three groups, the control group, UMP group and UR group, and orally administered UMP or UR for 10 days. This study aims to investigate the functional effects of UMP and UR on the gut in vitro and in vivo. Uridine monophosphate (UMP) is a major nucleotide analog in mammalian milk and uridine (UR) is its gastro-intestinal metabolite in vivo.

Food & Function published new progress about Apoptosis. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Harper, Kaid C.; Vilardi, Sarah C.; Sigman, Matthew S. published the artcile< Prediction of Catalyst and Substrate Performance in the Enantioselective Propargylation of Aliphatic Ketones by a Multidimensional Model of Steric Effects>, Product Details of C8H14O2, the main research area is catalyst substrate performance enantioselective propargylation aliphatic ketone steric effect.

The effectiveness of a new asym. catalytic methodol. is often weighed by the number of diverse substrates that undergo reaction with high enantioselectivity. Here we report a study that correlates substrate and ligand steric effects to enantioselectivity for the propargylation of aliphatic ketones. The math. model is shown to be highly predictive when applied to substrate/catalyst combinations outside the training set.

Journal of the American Chemical Society published new progress about Aliphatic ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Jun, Minki; Yang, Heesu; Kim, Dongyong; Bang, Gi Joo; Kim, Minah; Jin, Haneul; Kwon, Taehyun; Baik, Hionsuck; Sohn, Jeong-Hun; Jung, Yousung; Kim, Heejin; Lee, Kwangyeol published the artcile< Pd3Pb Nanosponges for Selective Conversion of Furfural to Furfuryl Alcohol under Mild Condition>, Category: tetrahydrofurans, the main research area is furfural furfuryl alc palladium lead nanosponge selective conversion; bimetallic alloys; furfural; hydrogenation; nanoframes; palladium.

Alloy structures with high catalytic surface areas and tunable surface energies can lead to high catalytic selectivity and activities. Herein, the synthesis of sponge-like Pd3Pb multiframes (Pd3Pb MFs) is reported by using the thermodynamically driven phase segregation, which exhibit high selectivity (93%) for the conversion of furfural to furfuryl alc. (FOL) under mild conditions. The excellent catalytic performance of the Pd3Pb MF catalysts is attributed to the high surface area and optimized surface energy of the catalyst, which is associated with the introduction of Pb to Pd. D. functional theory calculations show that the binding energy of FOL to the surface energy-tuned Pd3Pb MF is sufficiently lowered to prevent side reactions such as over-hydrogenation of FOL.

Small Methods published new progress about Acetalization. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ando, Wataru; Kumamoto, Yorio; Tokito, Norihiro published the artcile< Photolysis of a sterically protected bicyclic 1,2,3-selenadiazole>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is selenadiazole sterically protected photolysis olefin; regioselective photochem cyclocondensation selenadiazole olefin; zwitterionic intermediate photolysis selenadiazole.

The photolysis of sterically protected 1,2,3-selenadiazole I in the presence of olefin (e.g. CH2:CHCN, CH2:CHCO2Me, cyclopentadiene) was studied. The regioselective cycloadducts e.g. II (R = CO2Me, cyano) were obtained via the initially formed zwitterionic intermediate.

Tetrahedron Letters published new progress about Photocyclocondensation reaction. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

MacIntosh, Kathryn L.; Beaumont, Simon K. published the artcile< Nickel-Catalyzed Vapour-Phase Hydrogenation of Furfural, Insights into Reactivity and Deactivation>, Quality Control of 97-99-4, the main research area is nickel catalytic vapor phase hydrogenation furfural.

Furfural is a key bioderived platform mol., and its hydrogenation affords access to a number of important chem. intermediates that can act as drop-in replacements to those derived from crude oil or novel alternatives with desirable properties. Here, the vapor phase hydrogenation of furfural to furfuryl alc. at 180° over standard impregnated Ni catalysts is reported and contrasted with the same reaction over Cu chromite. While the selectivity to furfuryl alc. of the unmodified Ni catalysts is much lower than for Cu chromite as expected, the activity of the Ni catalysts in the vapor phase is significantly higher, and the deactivation profile remarkably similar. In the case of the supported Ni catalysts, possible contribution to the deactivation by acidic sites on the catalyst support is discounted based on the similarity of deactivation kinetics on Ni/SiO2 with those seen for less acidic Ni/TiO2 and Ni/CeO2. Powder x-ray diffraction is used to exclude sintering as a primary deactivation pathway. Significant coking of the catalyst (∼ 30% over 16 h) is observed using temperature programmed oxidation This, in combination with the solvent extraction anal. and IR spectroscopy of the coked catalysts points to deactivation by polymeric condensation products of (reactant or) products and hydrocarbon like coke. These findings pave the way for targeted modification of Ni catalysts to use for this important biofeedstock-to-chems. transformation.

Topics in Catalysis published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Quality Control of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yates, Peter; Burke, Patrick Michael published the artcile< Keto ethers. IV. Products formed on reaction of dihydro-2,2,5,5-tetramethyl-3(2H)-furanone with strong acids>, Synthetic Route of 5455-94-7, the main research area is tetramethylfuranone rearrangement acid; furanone tetramethyl rearrangement acid.

Reaction of furanone I with 96 or ca. 100% sulfuric acid or hot polyphosphoric acid followed by aqueous quenching gave the following products: 2-hydroxy-2,5-dimethyl-4-hexen-3-one, 2,4,4-trimethyl-2-cyclopenten-1-one, 3,5,5-trimethyl-2-cyclopenten-1-one, tetrahydro-3,4,5,5-tetramethylfuran-2,3-diol, 2,5-dihydro-3,5,5-trimethyl-2-methylenefuran and its dimer, 2,5-dihydro-2,3,5,5-tetramethyl-2-furanol, 4-hydroxy-2,4-dimethyl-2-pentenoic acid γ-lactone, 2,3,5-trimethyl-2-cyclopenten-1-one (II), and tetramethylfuran (III). In 96% sulfuric acid the products arise by ring opening, ring opening followed by reclosure to carbocyclic products, Me migration from C-2 to C-3 to give rearranged furan derivatives, and oxidation In ca. 100% sulfuric acid or hot polyphosphoric acid further Me migrations can occur to give II and III.

Canadian Journal of Chemistry published new progress about Rearrangement. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Synthetic Route of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Yanling; Liu, Cun; Zhang, Xiongfu published the artcile< One-Step Encapsulation of Bimetallic Pd-Co Nanoparticles Within UiO-66 for Selective Conversion of Furfural to Cyclopentanone>, Synthetic Route of 97-99-4, the main research area is bimetallic palladium cobalt furfural cyclopentanone nanoparticle.

The design of efficient catalysts is of important significance for the transformation of biomass into chems. In this work, bimetallic Pd-Co nanoparticles were encapsulated within UiO-66 to form a core-shell Pd-Co@UiO-66 catalyst via a facile one-step strategy. The as-synthesized Pd-Co@UiO-66 catalysts were characterized and applied to the selective hydrogenation of furfural (FUR) to cyclopentanone (CPO). Compared with the monometallic Pd@UiO-66, the Pd-Co@UiO-66 could demonstrate excellent performance with 96% CPO selectivity and 99% FUR conversion at 120°C under 3 MPa H2 pressure for 12 h. It was found that trace Co had synergetic and promoting effects on the catalytic performance. The core-shell catalysts showed more outstanding recyclability than the supported catalysts, which could maintain high CPO yield after 5th runs.

Catalysis Letters published new progress about Core-shell nanoparticles. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Synthetic Route of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hsu, Shih-Jer; Enkhzaya, Sukhee; Lin, You-Yu; Tseng, Tai-Chung; Khosbayar, Tulgaa; Tsai, Cheng-Hsueh; Wang, Tzu-San; Enkhtuya, Damba; Ivshinkhorol, Dogsom; Naranzul, Nyamsuren; Jargalsaikhan, Badarch; Amarsanaa, Jazag; Baatarkhuu, Oidov; Kao, Jia-Horng published the artcile< Resistance-associated substitution and ledipasvir/sofosbuvir therapy in Mongolian chronic hepatitis C patients>, Synthetic Route of 58-97-9, the main research area is chronic hepatitis C ledipasvir sofosbuvir NS5A Mongolia; Chronic hepatitis C; Ledipasvir; Mongolia; Resistance-associated substitution; Sofosbuvir.

We investigated the effectiveness of ledipasvir/sofosbuvir and the impact of resistance-associated substitutions on the treatment outcome in Mongolian chronic hepatitis C patients. Patients with genotype (GT) 1b HCV infection were prospectively enrolled in Mongolia and treated with LDV/SOF for 12 wk. The proportion of pre-treatment NS5A Y93H RAS in viral quasispecies was measured with next-generation sequencing. The endpoint of LDV/SOF effectiveness was sustained virol. response at post-treatment week 12 (SVR12). A total of 94 CHC patients were evaluated. The baseline Y93H proportion was <1% in 74 patients, 1-15% in 7, 15-50% in 2, and ≥50% in 11. All patients completed 12-wk LDV/SOF treatment and the SVR rate was 90.4%. The rate of failure to achieve SVR12 for patients with Y93H < 1%, 1-15%, and ≥15% were 0%, 14.3%, and 61.5%, resp. (p for trend = 0.001). In univariable anal., older age, baseline alanine transaminase level <40 U/mL, and a higher proportion of Y93H were associated with treatment failure. In multivariable anal., only a higher proportion of Y93H was associated with treatment failure (p = 0.022). LDV/SOF therapy achieves a high SVR rate in Mongolian CHC GT1b patients without baseline Y93H RAS. A higher proportion of Y93H may severely undermine the effectiveness of LDV/SOF. Journal of the Formosan Medical Association published new progress about Aging, animal. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Saimoto, Hiroyuki; Hiyama, Tamejiro; Nozaki, Hitosi published the artcile< Regiocontrolled formation of 4,5-dihydro-3(2H)-furanones from 2-butyne-1,4-diol derivatives. Synthesis of bullatenone and geiparvarin>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is furanone dihydro; butynediol cyclization; bullatenone; geiparvarin.

Two new methods for selective hydration of 1,1,4-trisubstituted 2-butyne-1,4-diols (I) gave 4,5-dihydro-3(2H)-furanones. The first involves selective monoacetylation of the less hindered OH followed by Ag(I)-catalyzed rearrangement and cyclization. to give 3-acetoxy-2,2,5-trisubstituted 2,5-dihydrofurans (II) which on hydrolysis gave 2,2,5-trisubstituted 4,5-dihydro-3(2H)-furanones. Oxidation of II with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone gave 3(2H)-furanones. This method gave naturally occurring 3(2H)-furanones, e.g., bullatenone and geiparvarin. The second approach gave the opposite regioisomer, 2,5,5-trisubstituted 4,5-dihydro-3(2H)-furanones, from diols I by treating the diols with Hg/Nafion-H.

Bulletin of the Chemical Society of Japan published new progress about Cyclization. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brister, Matthew M.; Crespo-Hernandez, Carlos E. published the artcile< Excited-State Dynamics in the RNA Nucleotide Uridine 5'-Monophosphate Investigated Using Femtosecond Broadband Transient Absorption Spectroscopy>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is RNA UMP excited state dynamics electronic relaxation absorption spectroscopy.

Damage to RNA from UV radiation induces chem. modifications to the nucleobases. Unraveling the excited states involved in these reactions is essential; however, investigations aimed at understanding the electronic-energy relaxation pathways of the RNA nucleotide UMP have not received enough attention. In this Letter, the excited-state dynamics of UMP is investigated in aqueous solution Excitation at 267 nm results in a trifurcation event that leads to the simultaneous population of the vibrationally excited ground state, a long-lived 1nπ* state, and a receiver triplet state within 200 fs. The receiver state internally converts to the long-lived 3ππ* state in an ultrafast time scale. The results elucidate the electronic relaxation pathways and clarify earlier transient absorption experiments performed for uracil derivatives in solution This mechanistic information is important because long-lived nπ* and ππ* excited states of both singlet and triplet multiplicities are thought to lead to the formation of harmful photoproducts.

Journal of Physical Chemistry Letters published new progress about Excited singlet state. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem