Category: Tetrahydrofurans

Torres-Pacheco, Luis J. published the artcileSorbitol electro-oxidation reaction on sub<10 nm PtAu bimetallic nanoparticles, Quality Control of 19444-84-9, the publication is Electrochimica Acta (2020), 136593, database is CAplus.

Sorbitol is a highly available and functionalized polyalc., with vast industrial usages and with great potential for fuel cells application. However, few studies were done regarding its electrochem. oxidation Monometallic Au, Pt and PtAu with different compositions from Pt-rich (such as Pt₈₅Au₁₅) to Au-rich (Pt₁₀Au₉₀) nanomaterials were synthesized. Several parameters like sorbitol and KOH concentration, scan rate, charge-transfer resistance, and temperature were tested. According with the physicochem. characterization, average particle sizes from 5.6 to 6.5 nm were found for all electrocatalysts, while Pt at. percentages of 85, 60, 40, and 10% were obtained. XPS revealed shifts in Pt 4f and Au 4f core-levels related to electron d. changes by the interaction between these elements and as a result, the electrocatalytic properties for the sorbitol electrooxidation reaction (SOR) were modified. The PtAu nanomaterials presented an increase of the c.d. with the raise of the KOH and sorbitol concentrations, being Pt₄₀Au₆₀/C the most active electrocatalyst displaying 40 mA mg^-1 at 0.1M sorbitol in 2 M KOH with an onset potential of -0.50 V vs. normal H electrode. This onset potential value was more neg. to that typically reported for other polyols like glycerol and ethylene glycol. The reaction pathway of Pt/C, Au/C and Pt₄₀Au₆₀/C was followed by chromatog. and spectroscopic techniques, finding that the complex surfaces of these electrocatalysts were capable to carry the SOR via several electrons (from 2 to 24 e^–). In this manner, the high electrocatalytic activity of Pt₄₀Au₆₀/C was attributed to the electron d. changes that promote a higher electron transfer forming shorter-chain byproducts.

Electrochimica Acta published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C16H24BF4Ir, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yamaguchi, Sho published the artcileMechanistic Insight into Biomass Conversion to Five-membered Lactone Based on Computational and Experimental Analysis, Computed Properties of 19444-84-9, the publication is ChemistrySelect (2017), 2(2), 591-597, database is CAplus.

We investigated the mechanism of a cascade coupling reaction between 1,3-dihydroxyacetone (DHA) and formaldehyde using d. functional theory (DFT) calculations Based on our exptl. results, and in contrast to the previously proposed reaction pathway, we propose the following pathway: (i) the isomerization and dehydration of DHA to an enolate, (ii) an aldol reaction between the enolate and formaldehyde, (iii) the formation of a five-membered ring, and (iv) a proton transfer to form α-hydroxy-γ-butyrolactone (HBL). Consideration of the thermodn. stability of each substrate enabled us to suggest the most likely pathway, and the construction of a transition state model helped us to clarify the origin of the observed product selectivity.

ChemistrySelect published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C11H15NO2, Computed Properties of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rodriguez-Seoane, Paula published the artcileHydrothermal Extraction of Valuable Components from Leaves and Petioles from Paulownia elongata x fortunei, Quality Control of 19444-84-9, the publication is Waste and Biomass Valorization (2021), 12(8), 4525-4535, database is CAplus.

Abstract: The leaves and petioles of Paulownia elongata x fortunei are residual fractions from the tree plantations com. destined to the production of wood and their valorization could contribute to the rational utilization of this resource. The saccharidic fraction is the most abundant in both parts of the plant and the sugar profile is very similar, but the ethanol extractives are more abundant in leaves. Non isothermal processing was selected since it provided better results than isothermal extraction with shorter times. For this reason, optimization of autohydrolysis under non isothermal operation (140-240°C) was performed for both materials: leaves and petioles. The final autohydrolysis temperature highly influenced the saccharidic, proteic, phenolic and volatile composition of the extracts Operating under selected conditions leaves provided extracts with more antioxidant compounds than petioles. The proposed technol. provides a variety of com. valuable components, which could contribute to the integral use of this energetic crop following a biorefinery approach. Graphic Abstract: [graphic not available: see fulltext].

Waste and Biomass Valorization published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, L. published the artcileAbrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l, Application of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is Leukemia (2013), 27(4), 813-822, database is CAplus and MEDLINE.

The t(10;11)(p12;q23) translocation and the t(10;11)(p12;q14) translocation, which encode the MLL (mixed lineage leukemia)-AF10 and CALM (clathrin assembly lymphoid myeloid leukemia)-AF10 fusion oncoproteins, resp., are two recurrent chromosomal rearrangements observed in patients with acute myeloid leukemia and acute lymphoblastic leukemia. Here, we demonstrate that MLL-AF10 and CALM-AF10-mediated transformation is dependent on the H3K79 methyltransferase Dot1l using genetic and pharmacol. approaches in mouse models. Targeted disruption of Dot1l using a conditional knockout mouse model abolished in vitro transformation of murine bone marrow cells and in vivo initiation and maintenance of MLL-AF10 or CALM-AF10 leukemia. The treatment of MLL-AF10 and CALM-AF10 transformed cells with EPZ004777, a specific small-mol. inhibitor of Dot1l, suppressed expression of leukemogenic genes such as Hoxa cluster genes and Meis1, and selectively impaired proliferation of MLL-AF10 and CALM-AF10 transformed cells. Pretreatment with EPZ004777 profoundly decreased the in vivo spleen-colony-forming ability of MLL-AF10 or CALM-AF10 transformed bone marrow cells. These results show that patients with leukemia-bearing chromosomal translocations that involve the AF10 gene may benefit from small-mol. therapeutics that inhibit H3K79 methylation. Leukemia (2013) 27, 813-822; doi:10.1038/leu.2012.327; published online 4 Dec. 2012.

Leukemia published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Application of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Singh, Sandip K. published the artcileLignin Conversion Using Catalytic Ionic Liquids: Understanding the Role of Cations, Anions, and Hammett Acidity Functions, Product Details of C4H6O3, the publication is Industrial & Engineering Chemistry Research (2019), 58(47), 21273-21284, database is CAplus.

Because it is undisputable that lignin depolymerization is a must to make the biorefinery concept economically feasible, several efforts are put toward it; however, a lot of catalyst designing is required to achieve efficient depolymerization activities. In this work, we show a systematic approach in the synthesis and characterization of ionic liquids (ILs) with varying combinations of cations (imidazole, benzimidazole, phosphonium, and ammonium) and anions (HSO₄, PTS (p-toluenesulfonate), Cl, H₂PO₄, SnCl₃, FeCl₄, and CuCl₃) for the depolymerization of lignin into low-mol. weight aromatic fractions (<220 g/mol) under mild reaction conditions (120 °C, 1 h, ambient pressure). In a methodical approach, effects of various reaction parameters such as temperature (70-170 °C), time (15-360 min), pressure (N₂, 0.5-3 MPa), solvents and substrate, and so forth were studied to achieve best activity. Among all the catalysts, IL with the imidazolium cation and HSO₄ as the anion showed best activity (78% yield). Subsequent to depolymerization, three aromatic monomers (5 wt % pure vanillin) were isolated using flash column chromatog. These aromatic monomers were characterized using gas chromatog. (GC), GC-mass spectrometry, and NMR techniques for their purity. Hammett acidity functions (H₀) of ILs were measured using UV-vis photo-spectroscopy, and values are correlated with lignin depolymerization results. Lignin and tetrahydrofuran-soluble products were thoroughly characterized using assorted physicochem. techniques such as NMR (¹H and ¹³C), gel permittivity chromatog., thermogravimetric anal., and so forth. The catalyst was recycled up to six runs and showed similar results in consecutive reactions.

Industrial & Engineering Chemistry Research published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C17H14O5, Product Details of C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Singh, Sandip K. published the artcileNovel Synthesis of Immobilized Bronsted- Acidic Ionic Liquid: Application in Lignin Depolymerization, COA of Formula: C4H6O3, the publication is ChemistrySelect (2018), 3(19), 5461-5470, database is CAplus.

Designing of efficient catalyst for the valorization of lignin is a topic of long neglect due to intrinsic properties of lignin. We show designing of an efficient, stable and recyclable Immobilized-Bronsted acidic ionic liquid (I-BAIL), which was further used as a solid acid catalyst for the depolymerization of lignin. The synthesized I-BAIL catalyst with sulfonic acid (-SO₃H) groups was found to be stable until 250°C and has 42.2 weight% loading of BAIL anchored on silica framework. The detailed characterization (elemental, Thermogravimetric anal., Fourier transformation-IR, NMR) of catalyst disclosed formation of strong covalent bond between Si and carbon of BAIL, which in turn is responsible for achieving a stable catalyst. The catalyst could successfully depolymerize range of lignin substrates with high mol. weight (60000 Dalton) at 200°C in 1 h to achieve 90% yield of THF soluble products with good mass balance. The formation of products and correlation of products with lignin was achieved with the help of NMR, gel permeation chromatog., gas chromatog., gas chromatog.mass spectrometry, high performance liquid chromatog. etc.

ChemistrySelect published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C5H8N2O, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nielsen, Matthew K. published the artcileDeoxyfluorination with Sulfonyl Fluorides: Navigating Reaction Space with Machine Learning, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Journal of the American Chemical Society (2018), 140(15), 5004-5008, database is CAplus and MEDLINE.

The deoxyfluorination of alcs. with sulfonyl fluorides to give alkyl fluorides is optimized for various types of substrates using different sulfonyl fluorides and bases. The screening data was used to develop a model for predicting optimal reagents and bases for deoxyfluorination reactions of untested substrates using machine learning employing a random forest algorithm.

Journal of the American Chemical Society published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bentley, Mark C. published the artcileComprehensive chemical characterization of the aerosol generated by a heated tobacco product by untargeted screening, Category: tetrahydrofurans, the publication is Analytical and Bioanalytical Chemistry (2020), 412(11), 2675-2685, database is CAplus and MEDLINE.

Abstract: A suite of untargeted methods has been applied for the characterization of aerosol from the Tobacco Heating System 2.2 (THS2.2), a heated tobacco product developed by Philip Morris Products S.A. and commercialized under the brand name IQOS. A total of 529 chem. constituents, excluding water, glycerin, and nicotine, were present in the mainstream aerosol of THS2.2, generated by following the Health Canada intense smoking regimen, at concentrations ≥ 100 ng/item. The majority were present in the particulate phase (n = 402), representing more than 80% of the total mass determined by untargeted screening; a proportion were present in both particulate and gas-vapor phases (39 compounds). The identities for 80% of all chem. constituents (representing > 96% of the total determined mass) were confirmed by the use of authentic anal. reference materials. Despite the uncertainties that are recognized to be associated with aerosol-based untargeted approaches, the reported data remain indicative that the uncharacterized fraction of TPM generated by THS2.2 has been evaluated to the fullest practicable extent. To the best of our knowledge, this work represents the most comprehensive chem. characterization of a heated tobacco aerosol to date.

Analytical and Bioanalytical Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kawashima, Etsuko published the artcileHighly diastereoselective synthesis of (2’S)-[2′-²H]-2′-deoxyribonucleosides from the corresponding ribonucleosides, Application of N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, the publication is Nucleosides & Nucleotides (1995), 14(3-5), 333-6, database is CAplus.

The four (2’S)-[2′-²H]-2′-deoxynucleosides (>90 atom % ²H), were synthesized from the corresponding ribonucleosides involving six steps of reactions, i.e., oxidation of their 2′-hydroxyl group, stereoselective reductive deuteration of the resulting 2′-keto nucleoside intermediates with NaB²H₄ in EtOH-H₂O or EtOH, triflation, bromination with LiBr, highly stereoselective Bu₃SnH-Et₃B reduction of the resulting bromide, and, finally, unmasking.

Nucleosides & Nucleotides published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Application of N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Efimov, V. A. published the artcileMethoxymethyl and (p-nitrobenzyloxy)methyl groups in synthesis of oligoribonucleotides by the phosphotriester method, Product Details of C26H45N5O7Si2, the publication is Russian Journal of Bioorganic Chemistry (2011), 37(2), 254-258, database is CAplus.

An efficient method to synthesize monomer ribonucleotide synthons containing 2′-O-methoxymethyl and 2′-O-(p-nitrobenzyloxy)methyl groups is developed. These synthons are applied to the oligonucleotide phosphotriester method using O-nucleophilic intramol. catalysis at the stage of the internucleotide bond formation. The former synthons may be used for the automatic synthesis of 2′-modified oligonucleotides; the latter synthons made be used for the synthesis of phosphotriester oligoribonucleotides in high yields.

Russian Journal of Bioorganic Chemistry published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Product Details of C26H45N5O7Si2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem