Category: Tetrahydrofurans

Wang, Wenli published the artcileAnalysis of volatile compounds in Chinese dry-cured hams by comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry, COA of Formula: C4H6O3, the publication is Meat Science (2018), 14-25, database is CAplus and MEDLINE.

A microwave assisted extraction method coupled with solvent assisted flavor evaporation (MAE-SAFE) was used to extract the volatiles from three-selected Chinese dry-cured hams (Jinhua ham, Xuanwei ham and Rugao ham). Extracts were analyzed by comprehensive two-dimensional gas chromatog. with high-resolution time-of-flight mass spectrometry (GC × GC/HR-TOFMS), gas chromatog.-mass spectrometry (GC-MS), resp. A total 165 volatile compounds were identified by GC × GC/HR-TOFMS while only 50 compounds were identified by GC-MS. Principal component anal. showed that the specific dominant volatile compounds were [S-(R*,R*)]-2,3-butanediol (26.39%) and 3-methyl-butanoic acid (7.53%) for Jinhua ham, were [R-(R*,R*)]-2,3-butanediol (16.85%) and acetic acid (8.25%) for Rugao ham and were dihydro-4-hydroxy-2(3H)-furanone (11.67%) and hexanoic acid (8.24%) for Xuanwei ham. The results not only provided a fast and mild extraction method to analyze the volatiles in non-volatile food matrixes, but also represented the detailed information of volatile profiles of Chinese dry-cured hams.

Meat Science published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C20H18BrN3, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Makibar, Jon published the artcilePerformance of a conical spouted bed pilot plant for bio-oil production by poplar flash pyrolysis, Product Details of C4H6O3, the publication is Fuel Processing Technology (2015), 283-289, database is CAplus.

Poplar (Populus nigra) flash pyrolysis has been performed at the IK4-Ikerlan 25 kg h^– 1 pilot plant equipped with a conical spouted bed reactor. Gas, bio-oil and char yields and properties have been studied in the 425-525 °C range. This reactor has been proven to be especially suitable for this process as high bio-oil yields have been obtained, with the maximum being 69 weight% at 455 °C. The bio-oil has been collected in two fractions: the lighter one, which accounts for 85 weight% of the bio-oil, has a high water content and is composed mainly of acids and ketones, whereas the heavier fraction has a lower water content and is rich in phenols. These fractions are miscible, obtaining a bio-oil with a water content lower than 25 weight% and a higher heating value in the 16-18 MJ kg^– 1 range.

Fuel Processing Technology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Product Details of C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Semenyuk, Andrey published the artcileSynthesis of RNA Using 2′-O-DTM Protection, HPLC of Formula: 87865-78-9, the publication is Journal of the American Chemical Society (2006), 128(38), 12356-12357, database is CAplus and MEDLINE.

Tert-butyldithiomethyl (DTM), a novel hydroxy protecting group, cleavable under reductive conditions, was developed and applied for the protection of 2′-OH during solid-phase RNA synthesis. This function is compatible with all standard protecting groups used in oligonucleotide synthesis, and allows for fast and high-yield synthesis of RNA. Oligonucleotides containing the 2′-O-DTM groups can be easily deprotected under the mildest possible aqueous and homogeneous conditions. The preserved 5′-O-DMTr function can be used for high-throughput cartridge RNA purification

Journal of the American Chemical Society published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C10H9IO4, HPLC of Formula: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rayne, Sierra published the artcilepH dependent partitioning behaviour of food and beverage aroma compounds between air-aqueous and organic-aqueous matrices, Synthetic Route of 57124-87-5, the publication is Flavour and Fragrance Journal (2016), 31(3), 228-234, database is CAplus.

Aroma compounds in the Flavornet database were screened for ionizable functional groups such as carboxylic acids, aliphatic and aromatic amines, phenols, alcs. and thiols. Of the 738 aroma compounds listed in this database, 101 mols. have ionizable moieties with estimated monomeric aqueous pK_a values ranging between 1.75 and 10.97. pH dependent effective air/water partitioning coefficients (K_aw,eff) and n-octanol/water partitioning coefficients (D_ow) were estimated for all ionizable aroma compounds over the pH range from 0 to 14. The ionizable aroma compounds display a broad range of K_aw,eff (1.8 × 10^-23 to 6.1 atm M^-1) and log D_ow (-6.2 to +7.2 units) values. For many aroma compounds, pH dependent ionization will have a significant effect on K_aw,eff and D_ow, leading to variations in these physico-chem. properties by up to 11 orders of magnitude over the composite pH range of common foods and beverages. Changes in food and beverage pH affect not only the relative contributions of neutral vs. charged forms of ionizable aroma compounds (which directly affects analyte volatility and olfactory reception), but also partitioning between freely dissolved and sorbed forms of the analyte in solution (which indirectly affects analyte volatility). Copyright © 2015 John Wiley & Sons, Ltd.

Flavour and Fragrance Journal published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Synthetic Route of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hua, Geng published the artcileOne-pot inimer promoted ROCP synthesis of branched copolyesters using α-hydroxy-γ-butyrolactone as the branching reagent, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2016), 54(13), 1908-1918, database is CAplus and MEDLINE.

An array of branched poly(ε-caprolactone)s was successfully synthesized using an one-pot inimer promoted ring-opening multibranching copolymerization (ROCP) reaction. The biorenewable, com. available yet unexploited comonomer and initiator 2-hydroxy-γ-butyrolactone was chosen as the inimer to extend the use of 5-membered lactones to branched structures and simultaneously avoiding the typical tedious work involved in the inimer preparation Reactions were carried out both in bulk and in solution using stannous octoate (Sn(Oct)₂) as the catalyst. Polymerizations with inimer equivalent varying from 0.01 to 0.2 were conducted which resulted in polymers with a degree of branching ranging from 0.049 to 0.124. Detailed ROCP kinetics of different inimer systems were compared to illustrate the branch formation mechanism. The resulting polymer structures were confirmed by ¹H, ¹³C, and ₁H-₁₃C HSQC NMR and SEC (RI detector and triple detectors). The thermal properties of polymers with different degree of branching were investigated by DSC, confirming the branch formation. Through this work, we have extended the current use of the non-homopolymerizable γ-butyrolactone to the branched polymers and thoroughly examined its behaviors in ROCP. © 2016 Wiley Periodicals, Inc.J. Polym. Sci., Part A: Polym.Chem. 2016.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sander, Kerstin published the artcileDevelopment of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Journal of Medicinal Chemistry (2015), 58(15), 6058-6080, database is CAplus and MEDLINE.

Increased activity of efflux transporters, e.g., P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), at the blood-brain barrier is a pathol. hallmark of many neurol. diseases, and the resulting multiple drug resistance represents a major clin. challenge. Noninvasive imaging of transporter activity can help to clarify the underlying mechanisms of drug resistance and facilitate diagnosis, patient stratification, and treatment monitoring. We have developed a metabolically activated radiotracer for functional imaging of P-gp/BCRP activity with positron emission tomog. (PET). In preclin. studies, the tracer showed excellent initial brain uptake and clean conversion to the desired metabolite, although at a sluggish rate. Blocking with P-gp/BCRP modulators led to increased levels of brain radioactivity; however, dynamic PET did not show differential clearance rates between treatment and control groups. Our results provide proof-of-concept for development of prodrug tracers for imaging of P-gp/BCRP function in vivo but also highlight some challenges associated with this strategy.

Journal of Medicinal Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liu, Yuping published the artcileSynthesis and odor evaluation of five new sulfur-containing ester flavor compounds from 4-ethyloctanoic acid, Category: tetrahydrofurans, the publication is Molecules (2010), 5104-5111, database is CAplus and MEDLINE.

Five sulfur-containing flavor compounds were designed. and the synthesis of the target compounds was achieved using 4-ethyloctanoyl chloride and thiols and alcs. as starting materials. The products thus obtained [i.e., 4-ethyloctanoic acid 3-(methylthio)propyl ester, 4-ethyloctanethioic acid S-(2-furanylmethyl) ester, 4-ethyloctanethioic acid S-(2-methyl-3-furanyl) ester, 4-ethyloctanoic acid 2-(4-methyl-5-thiazolyl)ethyl ester, 4-ethyloctanethioic acid S-(tetrahydro-2-methyl-3-furanyl) ester] are synthetic sulfur-containing ester flavor compounds which all possess a meaty odor and might be used in foods if approved for this purpose.

Molecules published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liang, Jiajin published the artcileComprehensive insights into xylan structure evolution via multi-perspective analysis during slow pyrolysis process, Synthetic Route of 19444-84-9, the publication is Fuel Processing Technology (2019), 1-7, database is CAplus.

Comprehension in hemicellulose pyrolysis is critical to generate renewable fuel and valuable chem. Herein, a self-designed tubular reactor was applied to observe the appearance alteration and chem. structure evolution during the whole xylan pyrolysis process. Before 200°C, it was free moisture removal stage without significant chem. structure alteration. Xylan began to depolymerize at 200°C corresponding with the appearance change from its original state to dark brown, cleavage of branched-chain and primary product acids & ketones generation. The main chain of xylan was completely broken at 250-350°C via β-1,4-glycosidic bond cleavage, dehydration, decarboxylation, and decarbonylation reaction. Acids were mainly originated from hemicellulose pyrolysis. The typical signals from FTIR, ¹³C CP/MAS NMR were disappeared at 350°C. In the carbonation stage, the C/H and C/O ratio reached 2.01 and 4.54, leading to the aromaticity enhancement of char and formation of carbon-centered radicals.

Fuel Processing Technology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xie, Long-Yong published the artcileVisible-light-promoted direct C-H/S-H cross-coupling of quinoxalin-2(1H)-ones with thiols leading to 3-sulfenylated quinoxalin-2(1H)-ones in air, Category: tetrahydrofurans, the publication is Organic Chemistry Frontiers (2019), 6(24), 3950-3955, database is CAplus.

A new and efficient visible-light-mediated strategy was developed for the synthesis of 3-sulfenylated quinoxalin-2(1H)-ones via direct C-H sulfenylation of quinoxalin-2(1H)-ones with thiols in air at room temperature Through this photochem. reaction, various 3-sulfenylated quinoxalin-2(1H)-ones were be efficiently and conveniently obtained in excellent yields with good functional group tolerance by simple use of rhodamine B as the cheap photocatalyst and air as the green oxidant.

Organic Chemistry Frontiers published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C7H7ClN2S, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhu, Jiayi published the artcileNiSO₄-catalyzed C-H activation/C-S cross-coupling of 1,2,3-triazole N-oxides with thiols, Computed Properties of 57124-87-5, the publication is Organic & Biomolecular Chemistry (2015), 13(12), 3711-3720, database is CAplus and MEDLINE.

An efficient nickel-catalyzed protocol for C-S cross-coupling through the direct functionalization of 2-aryl-1,2,3-triazole N-oxide C-H bonds with aryl or alkyl thiols, or di-Ph disulfide has been developed. The targeted N⁺-O^– bond cleavage can be observed during the reaction, and thus obviates the need to use an addnl. deoxygenation step. This new protocol for the preparation of thiolated 2-aryl-1,2,3-triazoles, e.g., I, appears to offer good yields with high regioselectivity, mild conditions, and a wide substrate scope.

Organic & Biomolecular Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C18H26ClN3O, Computed Properties of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem