Category: Tetrahydrofurans

Takaku, Hiroshi published the artcileSynthesis of oligoribonucleotides by using 2′-O-(1-methyl-1-methoxy)ethyl nucleosides, HPLC of Formula: 87865-78-9, the publication is Chemistry Letters (1987), 1787-90, database is CAplus.

3′,5′-O-Tetraisopropyldisiloxanylnucleosides I (R = benzoyladenine, uridine, R¹ = H) smoothly react with 2-methoxypropene to give I [R¹ = C(OMe)Me₂] in high yields without formation of diastereoisomers. These nucleosides were used as intermediates for oligonucleotide synthesis by the phosphotriester method. The (1-methyl-1-methoxy)ethyl group was removed rapidly from oligonucleotides by acid treatment.

Chemistry Letters published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C12H9N3O4, HPLC of Formula: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hirao, Ichiro published the artcileSynthesis of nonadeca- and octadecaribonucleotides using the solid-phase phosphotriester with tetrahydropyranyl groups as the 2′-hydroxyl-protecting group, Category: tetrahydrofurans, the publication is Bulletin of the Chemical Society of Japan (1989), 62(6), 1995-2001, database is CAplus.

Nonadeca- and octadecaribonucleotides corresponding to the D-loop of tRNA^Phe from yeast and the leader sequence of phage f1 coat protein mRNA were synthesized by the activated phosphotriester method. Coupling yield in the synthesis of oligoribonucleotides depended on the extent of nucleosides loaded on controlled pore glass beads (CPG). N-Acyl-5′-O-dimethoxytrityl-2′-O-tetrahydropyranyl derivatives were used as fully protected ribonucleotide monomer units. The 18mer and 19mer corresponding to the D-loop did not serve as substrates for tRNA (guanosine-2′-)methyltransferase from Thermus thermophilus, but inhibited methylation of the 5′-half fragment of tRNA^Phe. This indicates that both fragments possess some affinity with the enzyme.

Bulletin of the Chemical Society of Japan published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Vichi, Stefania published the artcileDetermination of volatile thiols in roasted coffee by derivatization and liquid chromatography-high resolution mass spectrometric analysis, Related Products of tetrahydrofurans, the publication is Food Research International (2014), 610-617, database is CAplus and MEDLINE.

A fast derivatization/extraction method followed by LC-ESI-HRMS was optimized for the determination of volatile thiols in roasted coffee powder, using ebselen as the derivatization agent. The anal. conditions were optimized on real coffee matrix, which was spiked with representative volatile thiols. The method sensitivity, precision, accuracy and selectivity were evaluated by using representative standard thiols. Estimated LOQs were between 0.02 and 14.8 ng/kg for the thiols evaluated. Recoveries and intra-day and inter-day RSD values obtained in coffee matrix were in general around 40% and between 11 and 30%, resp. The optimized and validated method was applied to real coffee samples. According to the established identification criteria, target thiols were identified and quantified in coffee powder samples. Among them, 4-mercapto-1-butanol and 2-methyl-3-tetrahydrofuranthiol were identified and quantified for the first time in roasted coffee. Moreover, an approach based on the formation of a diagnostic product ion was applied to detect non-target thiols, allowing the detection of nineteen thiol derivatives, fourteen of them were tentatively identified on the basis of their mol. formula. Some of them, such as methanethiol and 3-mercapto-3-methylbutyl acetate were known to be present in coffee volatile fraction, while the rest were not previously described in this product.

Food Research International published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C17H16O2, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Haitao published the artcileFormula structure of liquid beef flavor, COA of Formula: C5H10OS, the publication is Shipin Gongye Keji (2009), 30(12), 326-331, database is CAplus.

The formula structure of flavors is instructive to flavoring. The volatile constituents of 11 liquid beef flavor samples from the market were analyzed by headspace-single drop condensation (HS-SDC) and GC/MS. The framework of liquid beef flavor was summarized by analyzing the type of the detected materials. It was proved that non-meat elements were absolutely necessary in the framework of beef flavor. A good beef flavor should be a great combination of meat flavor material and various types of non-meat elements. One liquid beef flavor was developed based on this research.

Shipin Gongye Keji published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, COA of Formula: C5H10OS.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhi, Xiao-yan published the artcileNatural product-based semisynthesis and biological evaluation of thiol/amino-Michael adducts of xanthatin derived from Xanthium strumarium as potential pesticidal agents, Category: tetrahydrofurans, the publication is Bioorganic Chemistry (2020), 103696, database is CAplus and MEDLINE.

Xanthatin, a natural sesquiterpene lactone, occurs as one of the major constituents of Xanthium plants (Compositae) and exhibits many important biol. properties. To discover natural products-based pesticides, forty-nine Michael-type thiol/amino adducts of xanthatin were synthesized and characterized, while their pesticidal activities were investigated. Among them, compounds 2c, 2h, 2i, and 2t exhibited more potent antifungal activity against Botrytis cinerea (IC₅₀ = 0.96, 0.38, 6.33, and 7.21μg/mL, resp.) than xanthatin and the two com. fungicides. Compounds 2t and 2u displayed broad-spectrum and excellent antifungal effects against all tested phytopathogenic fungi, while their IC₅₀ values ranged from 7.21 to 75.88μg/mL. Compounds 2a, 2f, 2l, 2m, 2v, 7c, 7e, 7h, 7i, and 7j showed moderate larvicidal activity against Plutella xylostella Linnaeus. Furthermore, compounds 2b, 7g, and 7h demonstrated significant ovicidal activity against P. xylostella with the LC₅₀ values of 14.04, 10.00, and 11.95 mg/L, resp. These findings suggest that thiol/amino appended in the C-13 position of xanthatin may improve antifungal and ovicidal activities for the derivatives It was also noticed that the exocyclic double bond of xanthatin is crucial for its larvicidal activity. This work also provides some important hints for further design, synthesis, and structural modification of the xanthanolides sesquiterpene lactones toward development of the new environmentally friendly pesticides for sustainable agricultural production

Bioorganic Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C13H10F2, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Basavapathruni, Aravind published the artcileConformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L, Application In Synthesis of 1338466-77-5, the publication is Chemical Biology & Drug Design (2012), 80(6), 971-980, database is CAplus and MEDLINE.

DOT1L is the human protein methyltransferase responsible for catalyzing the methylation of histone H3 on lysine 79 (H3K79). The ectopic activity of DOT1L, associated with the chromosomal translocation that is a universal hallmark of MLL-rearranged leukemia, is a required driver of leukemogenesis in this malignancy. Here, we present studies on the structure-activity relation of aminonucleoside-based DOT1L inhibitors. Within this series, we find that improvements in target enzyme affinity and selectivity are driven entirely by diminution of the dissociation rate constant for the enzyme-inhibitor complex, leading to long residence times for the binary complex. The biochem. K_i and residence times measured for these inhibitors correlate well with their effects on intracellular H3K79 methylation and MLL-rearranged leukemic cell killing. Crystallog. studies reveal a conformational adaptation mechanism associated with high-affinity inhibitor binding and prolonged residence time; these studies also suggest that conformational adaptation likewise plays a critical role in natural ligand interactions with the enzyme, hence, facilitating enzyme turnover. These results provide critical insights into the role of conformational adaptation in the enzymic mechanism of catalysis and in pharmacol. intervention for DOT1L and other members of this enzyme class.

Chemical Biology & Drug Design published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Application In Synthesis of 1338466-77-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Singh, Sandip K. published the artcileIonic liquids catalyzed lignin liquefaction: mechanistic studies using TPO-MS, FT-IR, RAMAN and 1D, 2D-HSQC/NOSEY NMR, Formula: C4H6O3, the publication is Green Chemistry (2016), 18(14), 4098-4108, database is CAplus.

Valorization of a profusely available alternate resource, biomass and in particular its 3-D intricate component lignin into low mol. weight aromatic products are used as platform chems. and fuel additives, and developing a low temperature catalytic process is imperative in preserving atom efficiency. Ionic liquids, due to their unique properties, offer an advantage to develop such methods under milder conditions. Herein, we show use of -SO₃H functionalized imidazolium based various recyclable Bronsted acidic ionic liquids (BAILs) in catalytic quantity under ambient pressure at 120 °C for depolymerization of lignin (60 000 g mol^-1) into THF soluble products with high efficiency (78% yield, 95% ± 5% mass balance). The decoding of this efficiency by 1D and 2D (HSQC/NOSEY) NMR, FT-IR and RAMAN studies exemplify that the -OH group(s) interact with the electron deficient BAIL cation. The mechanistic insights unraveled in this study open a plethora of opportunities to design catalysts for developing efficient processes.

Green Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C10H11ClO2S, Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Branca, C. published the artcileExperimental analysis about the exploitation of industrial hemp (Cannabis sativa) in pyrolysis, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Fuel Processing Technology (2017), 20-29, database is CAplus.

The pyrolytic conversion of industrial hemp (Cannabis sativa), subjected to various pretreatments, and its parts (woody core and fibers) has been investigated. For the conditions of thermal anal., dominated by primary decomposition, the qual. features of hemp and woody core devolatilization are practically coincident with those of wheat straw and beech wood, resp. Retting and decortication significantly affect the magnitude and position of the peak rate and the char yield. Fiber decomposition, though reflecting the qual. behavior of the majoritarian component cellulose, is deeply affected by hemicellulose/lignin/ash contamination. Packed-bed pyrolysis reproduces the qual. similarities between hemp and wheat straw, on one side, and woody core and beech wood, on the other, mainly in relation to the thermal field (magnitude of reaction-induced overheating) with differences in the yields/composition of the lumped classes of products.

Fuel Processing Technology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sun, Bao-guo published the artcileRelationship of molecular structure of sulfur-containing flavoring compounds to meat flavor, Synthetic Route of 57124-87-5, the publication is Jingxi Huagong (2001), 18(8), 456-460, database is CAplus.

Based on the research on the mol. structure of organic sulfur-containing compounds with meat flavors, we found that the meat flavors are developed by the synergetic effect of a sulfur atom with another sulfur or oxygen atom connected to the adjacent carbon atoms.

Jingxi Huagong published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C15H10O2, Synthetic Route of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quintanilla-Casas, Beatriz published the artcileThiols in brewed coffee: Assessment by fast derivatization and liquid chromatography-high resolution mass spectrometry, Safety of 2-Methyl-3-tetrahydrofuranthiol, the publication is LWT–Food Science and Technology (2015), 64(2), 1085-1090, database is CAplus.

In the present paper, we present a simple, reliable, selective and sensitive method for the identification and quantification of volatile thiols at trace levels in coffee brews. A simultaneous derivatization/extraction procedure followed by liquid chromatog.-electrospray high-resolution mass spectrometry is proposed and adapted to coffee brew matrix, and the performance of the method is evaluated. The linearity, sensitivity, recovery and both the intra-day and inter-day accuracy were all satisfactory. According to established identification criteria, seven target and nine non-target thiols were identified and quantified in coffee brew samples. Several of them are reported here for the first time in coffee brews, and our results are in agreement with previously reported results for coffee powder analyzed using similar anal. approach.

LWT–Food Science and Technology published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Safety of 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem