Category: Tetrahydrofurans

Wojtczak, Blaej published the artcileGeneral method for the synthesis of 2′-O-carboranyl-nucleosides, COA of Formula: C26H45N5O7Si2, the publication is Tetrahedron Letters (2005), 46(23), 3969-3972, database is CAplus.

The carboranyl cage is a new modifying entity for nucleosides, DNA oligonucleotides, and other biomols. Herein, the first reliable method for the synthesis of nucleosides modified with a carborane cluster at the 2′-position is described.

Tetrahedron Letters published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C5H5BrN2, COA of Formula: C26H45N5O7Si2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wu, Haijun published the artcileEthanol-Assisted Hydrothermal Liquefaction of Poplar Using Fe-Co/Al₂O₃ as Catalyst, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Energies (Basel, Switzerland) (2022), 15(9), 3057, database is CAplus.

Although the conversion of lignocellulosic biomass into bio-oil with high yield/quality through hydrothermal liquefaction (HTL) is promising, it still faces many challenges. In this study, a Fex-Co(1-x)/Al₂O₃ catalyst was prepared with the coprecipitation method and low-content ethanol was used as the cosolvent for the HTL of poplar. The results showed that the Fex-Co(1-x)/Al₂O₃ catalyst significantly promoted the yield and energy recovery rate (ERR) of bio-oil compared with the control (10% ethanol content). At 260 °C for 30 min, 60Fe-40Co/Al₂O₃ had the best catalytic effect, achieving the highest bio-oil yield (67.35%) and ERR (93.07%). As a multifunctional bimetallic catalyst, Fex-Co(1-x)/Al₂O₃ could not only increase the degree of hydrogenation deoxidization of the product but also promote the diversity of phenolic compounds gained from lignin. The bio-oil obtained from HTL with Fex-Co(1-x)/Al₂O₃ as catalyst contained lower heterocyclic nitrogen, promoting the transfer of more bio-oil components to substances with lower b.p.

Energies (Basel, Switzerland) published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C22H18O2, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Premkumar, Kavitha published the artcileIdentification of EPZ004777 and FG2216 as inhibitors of TGF-β1 induced Treg cells by screening a library of epigenetic compounds, Computed Properties of 1338466-77-5, the publication is Life Sciences (2022), 120643, database is CAplus and MEDLINE.

Regulatory T cells play an essential role in immune tolerance and homeostasis. Their long-term stability depends on epigenetic modifications and identification of small mol. modulators of Treg differentiation therefore has many applications. In this study, we performed a novel functional screen of an epigenetic compound library to identify compounds that can modulate generation of TGF-β1 induced T regulatory cells. A screening strategy based on IFN-γ ELISA was designed to screen epigenetic compound library. Effect of hit compounds on Treg phenotype and function was assessed by RT-PCR, flow cytometry and suppression assays. TGF-β signalling proteins were assayed by western blotting. Chromatin Immunoprecipitation (ChIP) assay was used to assess epigenetic modifications at Foxp3 gene locus. We screened 160 compounds to identify hits capable of reversing TGF-β induced inhibition of IFN-γ production in activated spleen cells and CD4+ T cells. Two compounds EPZ004777 and FG-2216 consistently reversed TGF-β1 iTregs in terms of (a) differentiation of naive T cells into CD4+CD25+Foxp3+Treg cells, (b) Foxp3 target gene expression and (c) Treg suppressive function without affecting TGF-β downstream signalling. ChIP assay revealed that the compounds were able to reverse – TGF- β mediated decrease in epigenetic marks H3K27me3 and 5-mC and an increase in epigenetic marks H3K4me3 and H3K27Ac in the promoter and conserved non coding sequence (CNS1) regions of the Foxp3 gene. EPZ004777 and FG-2216 have been identified as potent epigenetic modulators that can reverse TGF-β1 induced T regulatory cells and may be used to treat diverse immune disorders.

Life Sciences published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Computed Properties of 1338466-77-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Niu, Ningning published the artcileBromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth, Product Details of C28H41N7O4, the publication is Journal of Biological Chemistry (2016), 291(52), 26647-26657, database is CAplus and MEDLINE.

Small mol. inhibitors for bromodomain and extra-terminal (BET) proteins have recently emerged as potential therapeutic agents in clin. trials for various cancers. However, to date, it is unknown whether these inhibitors have side effects on bone structures. Here, we report that inhibition of BET bromodomain proteins may suppress chondrocyte differentiation and restrain bone growth. We generated a luciferase reporter system using the chondrogenic cell line ATDC5 in which the luciferase gene was driven by the promoter of Col2a1, an elementary collagen of the chondrocyte. The Col2a1-luciferase ATDC5 system was used for rapidly screening both activators and repressors of human collagen Col2a1 gene expression, and we found that BET bromodomain inhibitors reduce the Col2a1-luciferase. Consistent with the luciferase assay, BET inhibitors decrease the expression of Col2a1. Furthermore, we constructed a zebrafish line in which the enhanced green fluorescent protein (EGFP) expression was driven by col2a1 promoter. The transgenic (col2a1-EGFP) zebrafish line demonstrated that BET inhibitors I-BET151 and (+)-JQ1 may affect EGFP expression in zebrafish. Furthermore, we found that I-BET151 and (+)-JQ1 may affect chondrocyte differentiation in vitro and inhibit zebrafish growth in vivo. Mechanistic anal. revealed that BET inhibitors influenced the depletion of RNA polymerase II from the Col2a1 promoter. Collectively, these results suggest that BET bromodomain inhibition may have side effects on skeletal bone structures.

Journal of Biological Chemistry published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Product Details of C28H41N7O4.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chakraborty, Amit published the artcileDisulfide-based protecting groups for the cysteine side chain, Formula: C5H10OS, the publication is Organic Letters (2020), 22(24), 9644-9647, database is CAplus and MEDLINE.

Two new disulfide-based protecting groups (SIT and MOT) (I and II) are proposed for Cys thiol in the substitution of StBu, which is often difficult to remove. Both groups are based on a secondary thiol with a branched point in the β-position for an efficient modulation of its lability and/or stability. This unique structure allows them to be fully compatible with Fmoc/tBu SPPS (Fmoc = 9-fluorenylmethoxycarbonyl). At the end of the synthesis, these groups are removed in a straightforward manner with dithiothreitol with some H₂O.

Organic Letters published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Formula: C5H10OS.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Efimtseva, Ekaterina V. published the artcileSynthesis and properties of O-β-D-ribofuranosyl-(1”→2′)-guanosine-5”-O-phosphate and its derivatives, Related Products of tetrahydrofurans, the publication is Helvetica Chimica Acta (2003), 86(2), 504-514, database is CAplus.

The efficient synthesis of O-β-D-ribofuranosyl-(1” → 2′)-guanosine-5”-O-phosphate and O-β-D-ribofuranosyl-(1”→2′)-adenosine-5”-O-phosphate, minor tRNA components, have been developed, and their conformational properties were examined by NMR spectroscopy.

Helvetica Chimica Acta published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liu, Zhiwei published the artcileA proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies, Formula: C28H41N7O4, the publication is Molecular Cell (2021), 81(19), 4076-4090.e8, database is CAplus and MEDLINE.

KRAS mutant cancer, characterized by the activation of a plethora of phosphorylation signaling pathways, remains a major challenge for cancer therapy. Despite recent advancements, a comprehensive profile of the proteome and phosphoproteome is lacking. This study provides a proteomic and phosphoproteomic landscape of 43 KRAS mutant cancer cell lines across different tissue origins. By integrating transcriptomics, proteomics, and phosphoproteomics, we identify three subsets with distinct biol., clin., and therapeutic characteristics. The integrative anal. of phosphoproteome and drug sensitivity information facilitates the identification of a set of drug combinations with therapeutic potentials. Among them, we demonstrate that the combination of DOT1L and SHP2 inhibitors is an effective treatment specific for subset 2 of KRAS mutant cancers, corresponding to a set of TCGA clin. tumors with the poorest prognosis. Together, this study provides a resource to better understand KRAS mutant cancer heterogeneity and identify new therapeutic possibilities.

Molecular Cell published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Formula: C28H41N7O4.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xuan, Maojie published the artcileC-S coupling with nitro group as leaving group via simple inorganic salt catalysis, Computed Properties of 57124-87-5, the publication is Chinese Chemical Letters (2020), 31(1), 84-90, database is CAplus.

An efficient and practical synthetic protocol to synthesize non-sym. aryl thioethers by nucleophilic aromatic substitution (S_NAr) reaction of nitroarenes by thiols with potassium phosphate as the catalyst is described. Various moderate to strong electron-withdrawing functional groups were tolerated by the system to provided thioethers in a good to excellent yields. The present method allowed access to 3 drug examples in a short reaction time. Finally, mechanistic studies suggested that the reaction may form the classic Meisenheimer complex through a two-step addition-elimination mechanism.

Chinese Chemical Letters published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C37H30ClIrOP2, Computed Properties of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ye, Jiaxin published the artcileTranscriptome analysis identifies key regulators and networks in Acute myeloid leukemia, Related Products of tetrahydrofurans, the publication is Hematology (Abingdon, United Kingdom) (2019), 24(1), 487-491, database is CAplus and MEDLINE.

Acute myeloid leukemia (AML) is a heterogeneous and highly recurrent hematol. malignancy. Studies have shown an association between microRNAs and drive genes in AMLs. However, the regulatory roles of miRNAs in AML and how they act on downstream targets and the signaling pathway has been little studied. As to understand the mechanism of mRNA-miRNA interaction in the blood malignancy from a large scale of transcriptomic sequencing studies, we applied a comprehensive miRNA-mRNA association, co-expression gene network and ingenuity pathway anal. using TCGA AML datasets. Our results showed that his-mir-335 was a critical regulatory of homeobox A gene family. PBX3, KAT6A, MEIS1, and COMMD3-BMI1 were predicted as top transcription regulators in the regulatory network of the HOXA family. The most significantly enriched functions were cell growth, proliferation, and survival in the mRNA-miRNA network. Our work revealed that regulation of the HOXA gene family and its regulation played an important role in the development of AML.

Hematology (Abingdon, United Kingdom) published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C10H16Br3N, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brzezinska, Jolanta published the artcileNon-nucleosidic analogues of polyaminonucleosides and their influence on thermodynamic properties of derived oligonucleotides, Quality Control of 19444-84-9, the publication is Molecules (2015), 20(7), 12652-12669, database is CAplus and MEDLINE.

The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced neg. charge based on internal charge compensation. Due to the ideal distance between cationic groups, polyamines are perfect counterions for oligodeoxyribonucleotides. We have synthesized non-nucleosidic analogs built from units that carry different diol structures instead of sugar residues and functionalized with polyamines. The non-nucleosidic analogs were attached as internal or 5′-terminal modifications in oligodeoxyribonucleotide strands. The thermodn. studies of these polyaminooligonucleotide analogs revealed stabilizing or destabilizing effects that depend on the linker or polyamine used.

Molecules published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem