Category: Tetrahydrofurans

Zavgorodnii, S. published the artcile1-Alkylthioalkylation of nucleoside hydroxyl functions and its synthetic applications: a new versatile method in nucleoside chemistry, Synthetic Route of 87865-78-9, the publication is Tetrahedron Letters (1991), 32(51), 7593-6, database is CAplus.

Treatment of appropriately protected nucleosides I (B = Thy, BzCyt, BzAde, IbGua; R = H) with a mixture of acetic acid, acetic anhydride and dialkyl sulfoxide was shown to give O-(1-alkylthioalkylated) nucleosides I (R = CH₂SMe) that were oxidized to the corresponding sulfoxides and sulfones I [R = CH₂S(O)_nMe, n = 1, 2], or converted via O-halomethyl derivatives I (R = CH₂Br, CH₂Cl) to various O-substituted nucleosides, e.g., II, [B¹ = Thy, Cyt, Ade, Gua; R¹ = CH₂F, CH₂N₃, CH₂CN, CH₂OMe, CH₂P(O)(OH)₂].

Tetrahedron Letters published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C12H9NO, Synthetic Route of 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Khirsariya, Prashant published the artcileSynthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides, Safety of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is Journal of Medicinal Chemistry (2022), 65(7), 5701-5723, database is CAplus and MEDLINE.

Histone methyltransferase DOT1L is an attractive therapeutic target for the treatment of hematol. malignancies. Here, we report the design, synthesis, and profiling of new DOT1L inhibitors based on nonroutine carbocyclic C-nucleoside scaffolds. The exptl. observed SAR was found to be nontrivial as seemingly minor changes of individual substituents resulted in significant changes in the affinity to DOT1L. Mol. modeling suggested that these trends could be related to significant conformational changes of the protein upon interaction with the inhibitors. The compounds 22 and (-)-53 (MU1656), carbocyclic C-nucleoside analogs of the natural nucleoside derivative EPZ004777, and the clin. candidate EPZ5676 (pinometostat) potently and selectively inhibit DOT1L in vitro as well as in the cell. The most potent compound MU1656 was found to be more metabolically stable and significantly less toxic in vivo than pinometostat itself.

Journal of Medicinal Chemistry published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Safety of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Aldakheel, Reem K. published the artcileBactericidal and in vitro cytotoxicity of Moringa oleifera seed extract and its elemental analysis using laser-induced breakdown spectroscopy, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Pharmaceuticals (2020), 13(8), 193, database is CAplus and MEDLINE.

In the current study, we present the correlation between the capability of laser-induced breakdown spectroscopy (LIBS) to monitor the elemental compositions of plants and their biol. effects. The selected plant, Moringa oleifera, is known to harbor various minerals and vitamins useful for human health and is a potential source for pharmaceutical interventions. From this standpoint, we assessed the antibacterial and in vitro cytotoxicity of the bioactive components present in Moringa oleifera seed (MOS) extract Detailed elemental anal. of pellets of MOSs were performed via LIBS. Furthermore, the LIBS outcome was validated using gas chromatog.-mass spectrometry (GC-MS). The LIBS signal was recorded, and the presence of the essential elements (Na, Ca, Se, K, Mg, Zn, P, S, Fe and Mn) in the MOSs were examined The bactericidal efficacy of the alc. MOS extract was examined against Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) by agar well diffusion (AWD) assays and SEM (SEM), which depicted greater inhibition against Gram-pos. bacteria. The validity and DNA nuclear morphol. of human colorectal carcinoma cells (HCT-116) cells were evaluated via an MTT assay and DAPI staining. The MTT assay results manifested a profoundly inhibitory action of MOS extract on HCT116 cell growth. Addnl., MOS extracts produced inhibitory action in colon cancer cells (HCT-116), whereas no inhibitory action was seen using the same concentrations of MOS extract on HEK-293 cells (non-cancerous cells), suggesting that MOS extracts could be non-cytotoxic to normal cells. The antibacterial and anticancer potency of these MOS extracts could be due to the presence of various bioactive chem. complexes, such as Et ester and D-allose and hexadecenoic, oleic and palmitic acids, making them an ideal candidate for pharmaceutical research and applications.

Pharmaceuticals published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Dunkel, Martin published the artcileReplacement of the phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme by an amide bond, SDS of cas: 87865-78-9, the publication is Nucleosides, Nucleotides & Nucleic Acids (2000), 19(4), 749-756, database is CAplus and MEDLINE.

The phosphodiester bond between U4 and G5 in the U-turn of a chem. modified hammerhead ribozyme was substituted by an amide backbone without compromising the ribozyme’s cleavage activity. Furthermore, the modified ribozyme proved to be completely stable against endonucleolytic digestion at this position.

Nucleosides, Nucleotides & Nucleic Acids published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, SDS of cas: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Silva, Ramon published the artcileAdvantages of using ohmic heating in Dulce de Leche manufacturing, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is Innovative Food Science & Emerging Technologies (2020), 102475, database is CAplus.

Ohmic heating (OH, 0, 2, 4, 6, 8, or 10 V cm-1, 72 °C/15 s, 60 Hz) at Dulce de leche processing was investigated. The equipment consisted in an ohmic heating chamber, and rectangular 316 stainless steel electrodes positioned 10 cm apart. OH-treated milk resulted in improvements in the quality parameters of Dulce de leche, with a decrease in energy expenditure (69.85-141.86 vs 1260 kJ) and hydroxymethylfurfural (HMF) levels (7.64-8.54 vs 9.53 μmol L-1), an increase in product homogeneity, and formation of volatile compounds important for the sweetness of Dulce de leche (butanoic acid and 2-furan methanol). In addition, the physicochem. composition, fatty acid profile, and health indexes (atherogenic, thrombogenic, desired fatty acids, and hypercholesterolemic saturated fatty acids) of the products remained without changes. In particular, the use of higher elec. field (> 6 V cm-1) led to a 14-78% decrease in process time, and improved volatiles profile. OH has proven to be a suitable technol. for milk treatment, resulting in improvements in the quality parameters of Dulce de leche with pos. impact at the process time and energy expenditure. The Dulce de Leche processing is characterized by long cooking times to acquire its typical characteristic color and flavor. Normally, it is used pasteurized milk as raw material. Ohmic heating decreased the total time of processing in Dulce de leche manufacturing, providing an economy at the in the energy costs without significant change at the quality parameters of the final product.

Innovative Food Science & Emerging Technologies published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C10H16Br3N, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lackey, Jeremy G. published the artcileToward the discovery of new antifungal agents: the design and validation of a novel 2’P-RNA probe and high throughput screening assay against 2′-phosphotransferase Tpt1p, Category: tetrahydrofurans, the publication is Nucleic Acids Symposium Series (2008), 52(1), 475-476, database is CAplus and MEDLINE.

We report the solid-phase synthesis of novel 2’P-RNA probes for use in fluorescence polarization (FP) ligand binding assays that screens for inhibitors of the yeast 2′-phosphotransferase Tpt1p. The probe was synthesized by utilizing silyl phosphoramidite chem. and a phosphoramidite synthon containing an orthogonal (DMT) protecting group at its 2′-position. Regioselective removal of the 2′-DMT group and phosphitylation of the unmasked 2′-hydroxyl group afforded the desired 2’P-RNA sequence.

Nucleic Acids Symposium Series published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bokov, D. O. published the artcileComparison of the Chemical Compositions of Galanthus woronowii Losinsk. and Galanthus nivalis L. Homeopathic Mother Tinctures by Gas Chromatography with Mass-Selective Detection, Category: tetrahydrofurans, the publication is Pharmaceutical Chemistry Journal (2017), 50(10), 659-667, database is CAplus.

The chem. compositions of homeopathic mother tinctures (HMT) from the two snowdrop species Galanthus woronowii Losinsk. and Galanthus nivalis L. were compared using gas chromatog. with mass-selective detection (GC-MS). A total of 13 compounds were identified in G. woronowii HMT; 42, in G. nivalis HMT. The common constituents of the two tinctures were ethyl-α-D-glucopyranoside, ethyl-α-D-riboside, Et linoleate, and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one. The main marker compounds (galantamine and licorine) were determined Their contents were used to standardize the homeopathic drugs.

Pharmaceutical Chemistry Journal published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Langa-Lomba, Natalia published the artcileActivity of Anthracenediones and Flavoring Phenols in Hydromethanolic Extracts of Rubia tinctorum against Grapevine Phytopathogenic Fungi, Application In Synthesis of 19444-84-9, the publication is Plants (2021), 10(8), 1527, database is CAplus and MEDLINE.

In this work, the chem. composition of Rubia tinctorum root hydromethanolic extract was analyzed by GC-MS, and over 50 constituents were identified. The main phytochems. were alizarin-related anthraquinones and flavoring phenol compounds The antifungal activity of this extract, alone and in combination with chitosan oligomers (COS) or with stevioside, was evaluated against the pathogenic taxa Diplodia seriata, Dothiorella viticola and Neofusicoccum parvum, responsible for the so-called Botryosphaeria dieback of grapevine. In vitro mycelial growth inhibition tests showed remarkable activity for the pure extract, with EC50 and EC90 values as low as 66 and 88 μg·mL-1, resp. Nonetheless, enhanced activity was attained upon the formation of conjugate complexes with COS or with stevioside, with synergy factors of up to 5.4 and 3.3, resp., resulting in EC50 and EC90 values as low as 22 and 56 μg·mL-1, resp. The conjugate with the best performance (COS-R. tinctorum extract) was then assayed ex situ on autoclaved grapevine wood against D. seriata, confirming its antifungal behavior on this plant material. Finally, the same conjugate was evaluated in greenhouse assays on grafted grapevine plants artificially inoculated with the three aforementioned fungal species, resulting in a significant reduction in the infection rate in all cases. This natural antifungal compound represents a promising alternative for developing sustainable control methods against grapevine trunk diseases.

Plants published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Application In Synthesis of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zarini, Daniele published the artcileAre In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes?, Name: 2-Methyl-3-tetrahydrofuranthiol, the publication is Chemical Research in Toxicology (2020), 33(9), 2381-2389, database is CAplus and MEDLINE.

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chems. with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicol. studies, robust data regarding which components in tent. In this study we applied computational methods for studied chems. as a useful tool for predicting the acute toxicity of chems. contained in e-liquids The purpose of t the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approa serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection.

Chemical Research in Toxicology published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H5N3S, Name: 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Deepa, J. published the artcilePreliminary phytochemical screening and GC-MS analysis of methanolic leaf extract of Drypetes sepiaria (Wight & Arn.) Pax. & Hoffim. from Silambur sacred grove, Tamilnadu, Category: tetrahydrofurans, the publication is Journal of Chemical and Pharmaceutical Research (2016), 8(8), 287-291, database is CAplus.

A valuable Indian ethnomedicinal plant, Drypetes sepiaria (Wight & Arn.) Pax. & Hoffim was investigated to determine the phytochem. constituents present in various extracts of the leaves through GC-MS (Gas Chromatog.-Mass Spectrometry) anal. Powd. leaf plant materials were subjected to successive extraction with organic solvents such as methanol by Soxhlet extraction method. In the present study, a total of 23 different compounds identified by GC-MS anal. using methanol extract, all the identified compounds were medicinally valuable for the treatment of various human ailments. In addition, all the phytochem. compounds were needed for further investigations on toxicol. aspects for the development of new lead of therapeutic interest.

Journal of Chemical and Pharmaceutical Research published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem