Category: Tetrahydrofurans

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,124391-75-9

To thoroughly dried ground 4A molecular sieves (5 g) was added ANHYDROUS CH2CI2 (20 ML) and 4-METHYLMORPHOLINE-N-OXIDE MO) (1. 76. G, 15 MMOL). The mixture was stirred at 0 ¡ãC for 15 min, then tetrahydro-3-furanmethanol (0. 96 ML, 10 mmol) and tetrapropylammonium PEIRUTHENATE (TPAP) (0.17 g, 0.5 mmol) were added and the mixture stirred for 90 min. The solvent volume was reduced and the entire reaction content was passed through a short silica gel column with ET20 lutant to yield TETRAHYDRO-FURAN-3-CARBALDEHYDE (approx 50 percent yield, together with A DIMERIC product). Wittig reaction of the crude aldehyde with (cyanomethyl) triphenylphosphonium chloride as DESCIBED for 3-furan-3-yl-propylamine gave 3-(tetrahydro-furan-3-yl)-acrylonitrile (3.3 mmol) as a 2: 1 mixture (1H NMR) of the E/Z isomers after column chromatography (10 percent Et2O/CH2Cl2 elutant). Hydrogenation of 3- (TETRAHYDRO-FURAN-3-YL)-ACRYLONITRILE in the presence of Raney Ni as detailed for 3-furan-3-yl) -propylamine gave the title amine (33 percent yield). ESI-MS (M/Z) 130 [M+H]+.

As the paragraph descriping shows that 124391-75-9 is playing an increasingly important role.

Reference£º
Patent; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2004/63192; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

4100-80-5, 3-Methyldihydrofuran-2,5-dione is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4100-80-5

The starting material is prepared as follows: The mixture of 28.5 g of 2-methylsuccinic anhydride, 23.5 g of 4-aminopyridine and 350 ml of xylene is refluxed on a water separator while stirring for 3.5 hours. The hot solution is decanted from some gummy residue, cooled, filtered, the residue suspended in 100 ml of boiling isopropanol and filtered off again, to yield the 3-methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione melting at 119¡ã-120¡ã. The mixture of 34.6 g thereof, 9 g of 10percent palladium on carbon and 400 ml of glacial acetic acid is hydrogenated at 110¡ã C. and approximately 1.7 atm. until the theoretical amount of hydrogen has been absorbed. The mixture is filtered, evaporated and the residue taken up in water. The pH of the mixture is adjusted to 9-10 with sodium carbonate and the liberated base extracted with methylene chloride. The extract is dried and evaporated, to yield the 3-methyl-1-(4-piperidinyl)-pyrrolidin-2,5-dione, which is used directly without further purification.

4100-80-5 3-Methyldihydrofuran-2,5-dione 20051, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; Ciba-Geigy Corporation; US4255429; (1981); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,17347-61-4

Compound 6 (16 mg, 0.032 mmol), 2,2-dimethylsuccinic anhydride (41 mg, 0.32 mmol), DMAP (8 mg, 0.064 mmol) and pyridine (1.5 mL) were put into a 10 mL glass tube and sealed. The mixture was stirred at 120 C for about 12 h. The reaction mixture was then transferred into a 50 mL flask. Pyridine was removed under reduced pressure. 3N HCl (10 mL) was added, the mixture was extracted three times with EtOAc, and the organic layer washed with 3 N HCl for a second time. Then the organic layer was washed with brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc as eluent) to provide target product 8 (11 mg). White solid, yield 54%. 1H NMR (CDCl3, 400 MHz,ppm) delta: 4.76 (d, 1H, J=12Hz, CH-OCO), in C3), 4.73 (s, 1H, C=CH,in C29), 4.60 (s, 1H, C=CH, in C29), 4.67, 4.51 (2m, 1H, CH-F, in C2), 3.66 (s, 3H, CO2CH3), 2.98 (m, 1H, in C19), 2.76-2.62 (2d, J=16 Hz, CO-CH2-C(CH3)2),1.67 (s, CH3, in C30), 1.32 (s, 6H, 2CH3, CO2H-C(CH3)2-CH2-),0.90, 0.88, 0.86, 0.83, 0.81 (5s, 5 x 3H, 5 x CH3, in C23, C24, C25, C26, C27). MS (ESI-) m/z: 639.45 (M+Na)+, 655.40 (M+K)+ for C37H57FO6.

17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Article; Li, Jizhen; Goto, Masuo; Yang, Xiaoming; Morris-Natschke, Susan L.; Huang, Li; Chen, Chin-Ho; Lee, Kuo-Hsiung; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 68 – 71;,
Tetrahydrofuran – Wikipedia
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88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

88675-24-5, General procedure: A mixture of corresponding 21 (0.48 mmol) and corresponding amine (0.73 mmol) in 2-butyl alcohol (3 mL) was stirred at 125 oC for 12 h. After cooling to room temperature and the solvent was evaporated under reduced pressure. The residue was purification by column chromatography on silica gel to give the derivatives.

The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ji, Dezhong; Zhang, Lingzhi; Zhu, Qihua; Bai, Ying; Wu, Yaoyao; Xu, Yungen; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 334 – 341;,
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453-20-3, 3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,453-20-3

Description 20 : Dihydro-3(2H)-furanone; A mixture of 3-hydroxytetrahydrofuran (3.0 g, 0.034 mol) and pyridinium chlorochromate (14.7 g, 0.068 mol) in DCM (100 ml) was stirred at room temperature overnight. The title product was obtained by pouring the crude product through a silica pad using ethyl acetate as the eluent. The title product was obtained from 2 elutions (2.29 g; 79%). 1H NMR (CDCI3) delta: 2.50 (2H, t), 3.87 (2H, s), 4.26 (2H, t).

453-20-3 3-Hydroxytetrahydrofuran 9960, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/67430; (2006); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- (2-fluorobenzyloxymethyl) isoxazole-3-carboxylic acid (0.7 5 g, 3.0 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (0.62 g, 4.5 mmol), Triethylamine (0.46 g, 4.5 mmol) And 1-hydroxybenzotriazole (0.04 g, 0.3 mmol) Was added to chloroform (amylene addition product) (7.5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.69 g, 3.6 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution, Washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography , The following formula Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (2-fluorobenzyloxymethyl) isoxazole-3-carboxamide (Hereinafter referred to as present amide compound (264)) 0.44 g was obtained., 184950-35-4

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10374-51-3,5-(Hydroxymethyl)dihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.,10374-51-3

A solution of 10 (4.22 g, 36.35 mmol) in DMF (45 mL) was cooled to 0 C (ice bath). Imidazole (3.70 g, 54.35 mmol) was added, followed by TBDPSCl (11.3 mL, 43.46 mmol). After stirring at 0 C for 15 min the ice bath was removed and the mixture was stirred at room temperature for 16 h. After this time, the reaction mixture was partially concentrated at reduced pressure and the resulting residue was partitioned between EtOAc and water. The organic extract was washed with saturated NH4Cl, 5% LiCl, and brine, dried over Na2SO4, filtered and concentrated.The residue was purified by column chromatography (silica, gradient 0-40% EtOAc, hexanes) to provide 11 (10.51 g, 82%): 1H-NMR (500 MHz, CDCl3) delta 7.67-7.64 (m 4H), 7.46-7.38 (m, 6H), 4.60 (ddt, J = 8.1, 5.1, 3.2 Hz, 1H), 3.88 (dd,J = 11.4, 3.4 Hz, 1H), 3.69 (dd, J = 11.4, 3.4 Hz, 1H), 2.67 (ddd, J = 17.6, 10.3, 7.2 Hz, 1H), 2.51 (ddd, J = 17.8, 10.1,6.5 Hz, 1H), 2.33-2.18 (m, 2H), 1.06 (s, 9H). 13C-NMR (125 MHz, CDCl3) delta 177.4, 135.7, 135.5, 133.0, 132.6, 129.9,127.9, 80.0, 65.5, 28.6, 26.8, 23.7, 19.2. Mass spectral data could not be obtained.

As the paragraph descriping shows that 10374-51-3 is playing an increasingly important role.

Reference£º
Article; Pasetto, Paolo; Naginskaya, Jennifer; Tetrahedron Letters; vol. 59; 29; (2018); p. 2797 – 2799;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

165253-31-6, (Tetrahydrofuran-3-yl)methanamine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 90 6-methyl-N-(tetrahydro-3-furanylmethyl)nicotinamide A suspension of 6-methylnicotinic acid (6 mmol) in dry dichloromethane (9 mL) was treated with thionyl chloride (12.4 mmol) at 0 C., stirred for one hour, and concentrated in vacuo. The concentrate was added dropwise to a cold solution of (2RS)-tetrahydro-2-furanylmethylamine (6 mmol) and triethylamine (4.5 mL) in dichloromethane (20 mL). The mixture was stirred for 4 hours and then concentrated in vacuo. The residue was dissolved in dichloromethane, washed sequentially with saturated sodium bicarbonate, water, and brine, dried (MgSO4), filtered, and concentrated in vacuo. The crude product was purified by HPLC on a C-18 column using a solvent system increasing in gradient from 5% to 100% acetonitrile/water containing 0.01% TFA over 50 minutes to provide the desired product as the trifluoroacetate salt. MS m/e 221.1 (M+H)+; 1H NMR (DMSO-d6) delta 1.56-1.65 (m, 1H), 1.91-2.00 (m, 1H), 2.44-2.53 (m, 1H), 2.60 (s, 3H), 3.21-3.33 (m, 2H), 3.48 (q, 1H), 3.59-3.65 (m, 1H), 3.69 (q, 1H), 3.72-3.78 (m, 1H), 7.57 (d, 1H), 8.31 (dd, 1H), 8.79 (t, 1H), 8.96 (d, 11H).

165253-31-6, As the paragraph descriping shows that 165253-31-6 is playing an increasingly important role.

Reference£º
Patent; Haviv, Fortuna; Bradley, Michael F.; Dinges, Jurgen; Sauer, Daryl R.; Henkin, Jack; US2004/67985; (2004); A1;,
Tetrahydrofuran – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.

(1) Under ice water bath conditions, 169 mg (0.93 mM) of (R)-(+)-alpha-amino-gamma-butyrolactone hydrochloride and 0.93 mM of p-bromobenzylsulfonyl chloride were placed in 10 mL of dry CH2Cl2 solution and mixed evenly. Afterwards, add 267 mg (1.5 mM) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and 68 mg (0.6 mM) of 4-dimethylaminopyridine (DMAP). After stirring for 30 min, the ice bath was removed and the reaction was continued for 20 h at room temperature.(2) The solution after the reaction was diluted to CH2Cl2 to a final volume of 100 mL, and the solution was washed three times with an equal volume of 10% (v / v) HCl solution and saturated NaCl solution in a separatory funnel. After the organic phase solution was collected, the residual water in the organic phase was removed by addition of anhydrous MgSO4 and dried at 50 C by rotary evaporator to give the crude product. The crude product was purified by SiO2 column chromatography, TLC, ethyl acetate: petroleum ether = 1.5: 1. The eluate was rotated by rotary evaporator at 50 C and the oil pump was decompressed under reduced pressure to obtain the desired product.

42417-39-0, As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.

Reference£º
Patent; Lanzhou University; Li, Hongyu; Zhao, Yang; Liu, Yingqian; (9 pag.)CN106146432; (2016); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 23 (0334) 5-Phenyloxymethylisoxazole-3-carboxylic acid (0.31 g, 1.4 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.24 g, 1.7 mmol), triethylamine (0.17 g, 1.7 mmol) and 1-hydroxybenzotriazole (0.02 g, 0.17 mmol) were added to chloroform (amylene addition product) (3 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.33 g, 1.7 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.15 g of N-(tetrahydrofuran-3-ylmethyl)-5-phenyloxymethylisoxazole-3 -carboxamide (hereinafter, referred to as Compound of Present Invention (23)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta(ppm)): 1.66-1.69 (1H, m), 2.06-2.14 (1H, m), 2.56-2.60(1H, m), 3.46(2H, t), 3.60(1H, dd), 3.76-3.78(1H, m), 3.85-3.87(1H, m), 3.91-3.93(1H, m), 5.20(2H, s), 6.80(1H, s), 6.94-6.97(3H, m), 7.00-7.05(1H, m), 7.29-7.34(2H, m), 184950-35-4

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem