Category: Tetrahydrofurans

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17347-61-4, Intermediate C: Ethyl 3-(5-methoxy-1H-benzo[d]imidazol-2-yl)-2,2-dimethylpropanoate To a 100 mL round-bottomed flask were added a stir bar, 4-methoxy-o-phenylenediamine bis-hydrochloride salt (2 g, 9.5 mmol), acetonitrile (20 mL), triethylamine (2.6 mL, 19 mmol), and 3,3-dimethyldihydrofuran-2,5-dione (1.2 g, 9.5 mmol). After 1 h, the mixture was concentrated to dryness and ethanol (50 mL) followed by HCl (1 mL, 12 N) was added to the residue. The reaction vessel was heated at 80¡ã Celsius for 12 hours before cooling to RT. The reaction mixture was concentrated to dryness. The residue was diluted with water (50 mL) and neutralized with sat. NaHCO3 until pH was 6.8-7. The aqueous was extracted with diethyl ether (3*100 mL), the combined extracts dried over sodium sulfate, filtered and concentrated to dryness. The residue was subjected to FCC to give the title compound (1.5 g, 57percent). MS (ESI): mass calcd. for C15H20N2O3, 276.15; m/z found, 277.1 [M+H]+. A mixture of two tautomer’s was observed so peaks are listed for identification purposes only. 1H NMR (600 MHz, DMSO-d6) delta 11.99-11.85 (m), 7.39 (d, J=8.7), 7.29 (d, J=8.6), 7.07 (d, J=2.4), 6.92 (d, J=2.4), 6.75 (dd, J=8.6, 2.4), 6.72 (dd, J=8.7, 2.4), 4.13-4.02 (m), 3.78-3.74 (m), 3.00-2.94 (m), 1.24-1.21 (m), 1.13 (t, J=7.1).

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; Chai, Wenying; Dvorak, Curt A.; Eccles, Wendy; Edwards, James P.; Goldberg, Steven D.; Krawczuk, Paul J.; Lebsack, Alec D.; Liu, Jing; Pippel, Daniel J.; Sales, Zachary S.; Tanis, Virginia M.; Tichenor, Mark S.; Wiener, John J. M.; US2014/275029; (2014); A1;,
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10374-51-3, 5-(Hydroxymethyl)dihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1 (S)- gamma -Pivaloyloxymethyl- gamma -butyrolactone (V) To a solution of (S)-gamma-hydroxymethyl-gamma-butyrolactone1 Prepared according to the literature procedure: M. Taninguchi, K. Koga, S. Yamada, Tetrahedron, 30 , 3547 (1974).1(40 g, 0.34M) in pyridine (200 mL) was added pivaloyl chloride (46 g, 0.38M) and the mixture was heated at 50C for 5 h under nitrogen. The reaction was cooled to room temperature and MeOH (50 mL) was added. The mixture was then concentrated in vacuo, taken up in CH2Cl2-water. The CH2Cl2 was washed with water, 30% H3PO4, brine, and dried over MgSO4. After removal of the solvent under reduced pressure, the residual oil was chromatographed on silica gel using CH2Cl2 as eluent to give 2 (48 g, 70%) as a colorless oil: 1H NMR (CDCl3) delta 1.15 (s, 9H), 1.9-2.6 (m, 4H), 4.09 (dd, J=4.8, 12.3 Hz, 1H), 2.29 (dd, J=3.3, 12.3 Hz, 1H), 4.7-4.75 (m, 1H)., 10374-51-3

10374-51-3 5-(Hydroxymethyl)dihydrofuran-2(3H)-one 98431, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; EP501511; (1992); A2;,
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124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 Preparation of (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate To a stirred solution of (tetrahydrofuran-3-yl)methanol (5.0 g, 49.0 mmol) in pyridine (30 mL) was added TsCl (11.2 g, 58.8 mmol) slowly at 0¡ã C. The reaction mixture was stirred at room temperature overnight. The resulting mixture was diluted with EtOAc (150 mL), washed with saturated aqueous citric acid (100 mL*5) and saturated aqueous NaHCO3 (100 mL*3), dried over Na2SO4, filtered and concentrated in vacuo. The resulting product was purified by column chromatography on silica gel (0-15percent EtOAc in petroleum ether) to afford (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (8.7 g, 69percent) as a colorless oil.

124391-75-9, 124391-75-9 (S)-(Tetrahydrofuran-3-yl)methanol 40784875, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Patent GmbH; KARRA, Srinivasa R.; (153 pag.)US2016/168090; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

To a stirred solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy- 5a,5b,8,8,11a-pentamethyl-N-(1-(5-phenyl-1H-imidazol-2-yl)cyclopropyl)-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxamide (Step 2 Example 19, 0.2 g, 0.31 mmol) and 2,2-dimethyl succinicanhydride (0.16 g, 1.2 mmol) in toluene (7 ml), was added DMAP (0.076 g, 0.6 mmol). The reaction mixture was heated at 90 C for 12 h. After completion of the reaction (monitored by TLC), reaction mixture was concentrated under reduced pressure, cooled to 0 C, acidified to pH = 6 with IN HCl and extracted with DCM. The combined organic extracts was washed with water, brine, dried over Na2SO4 then the solvent was evaporated under reduced pressure and to the resulting solid was recrystallized from ACN to give the title compound as a white solid (0.11 g, Yield: 45.83%). 1H NMR (300 MHz, DMSO-d6): delta 12.15 (s, 1H), 11.27 (s, 1H), 8.37 (s, 1H), 7.72-7.70 (m, 2H), 7.39 (s, 1H), 7.31-7.26 (m, 2H), 7.15-7.11 (m, 1H), 4.61 (s, 1H), 4.51 (s, 1H), 4.37-4.32 (m, 1H), 3.00-2.94 (m, 1H), 2.27 (m, 1H), 1.98-1.95 (m, 1H), 1.79-1.73 (m, 1H), 1.62-1.00 (m, 32H), 0.91-0.74 (m, 19H). ESI Mass: 766.56 [M+H]+., 17347-61-4

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; NEELA, Sudhakar; MOGILI, Narsingam; (87 pag.)WO2017/21922; (2017); A1;,
Tetrahydrofuran – Wikipedia
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124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (tetrahydrofuran-3-yl)methanol (1.0 g, 9.8 mmol) inDCM (15 ml) was added N,N-dimethylpyridin-4-amine (122 mg, 1 mmol), TEA (2.0 g, 20mmol) and 4-methylbenzenesulfonyl chloride (1.86 g, 9.8 mmol). The reaction mixture wasstirred at rt for 3 h. The mixture was concentrated and residue was purified by columnchromatography using ethyl acetate in petroleum ether (1/4) to afford tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (900 mg, 36percent yield). LCMS (ESI) m/z: 257.4 (M + 1t

124391-75-9, The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CATALANO, John G.; DICKSON, Hamilton D.; KAZMIERSKI, Wieslaw Mieczyslaw; LEIVERS, Martin R.; WEATHERHEAD, John Gordon; (389 pag.)WO2018/154466; (2018); A1;,
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204512-95-8, (S)-Tetrahydrofuran-3-amine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(3S)-Oxolan-3-amine hydrochloride (83 mg, 0.67 mmol) was added at room temperature to a stirred suspension of 8 -bromo- 1 -(3 ,4-dichlorob enzyl)-3 , 7-dimethyl- 1H- purine-2,6(3H,71])-dione (70 mg, 0.17 mmol) and DIEA (233 pi, 1.34 mmol) in nBuOH (5 ml). The resulting mixture was heated at 120C and stirred for 20h. Further (3S)-oxolan-3- amine hydrochloride (83 mg, 0.67 mmol) and DIEA (233 pi, 1.34 mmol) were added. The temperature was increased to 130C and stirring was continued. After 24h the solvent was removed in vacuo and the residue was purified by prep-HPLC to obtain the title compound. ?HNMR (500 MFIz, DMSO-d6) 7.55 (d, J 8.3 Hz, 1H), 7.51 (d, J 1.9 Hz, 1H), 7.25 (dd, J= 8.3, 2.0 Hz, 1H), 7.12 (d, J= 6.3 Hz, 1H), 4.98 (s, 2H), 4.47 -4.31 (m, 1H), 3.94- 3.84 (m, 2H), 3.72 (td, J= 8.1, 6.0 Hz, 1H), 3.61 (dd, J= 9.0, 4.1 Hz, 1H), 3.58 (s, 3H), 3.35 (s, 3H),2.38-2.07(m, 1H), 1.99- 1.78 (m, 1H).

204512-95-8, As the paragraph descriping shows that 204512-95-8 is playing an increasingly important role.

Reference£º
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; MOYER, Mikel, P.; SAIAH, Eddine; LECCI, Cristina; PACE, Robert, David, Matthew; TYE, Heather; VILE, Julia; (420 pag.)WO2017/106352; (2017); A1;,
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97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of (R)-(tetrahydrofuran-2-yl)methanol (2.0 g, 19.6 mmol) and di-tert-butyl hydrazine-1,2-dicarboxylate (4.5 g, 19.6 mmol) in anhydrous tetrahydrofuran (60 mL) was added triphenylphosphine (7.2 g, 27.4 mmol) followed by di-tert-butyl azodicarboxylate (6.3 g, 27.4 mmol) portionwise. The mixture was stirred for 16 hours, concentrated under reduced pressure and the crude residue purified by flash column chromatography using ethyl acetate, hexane (1:19 to 1:4) as an eluent to obtain the title compound (4.5 g, 72%), as a white solid, mp: 78.8-82.3 C; Rf: 0.19 (1:4 ethyl acetate, hexane); IR (vmax (neat)): 3314, 3254, 2831, 1737, 1661, 1229, 1144 cm-1; 1H NMR (300 MHz, CDCl3): delta 1.45 (18H, s), 1.78-1.99 (4H, m), 3.29-3.66 (2H, m), 3.67-3.91 (2H, m), 4.00-4.16 (1H, m), 6.58 (1H, bs) ppm; 13C NMR (75 MHz, CDCl3): delta 25.6, 28.3, 29.1, 53.3, 68.0, 74.1, 81.1, 155.4 ppm; LRMS (+ESI) m/z: 339.2 ([M+Na]+ 100%)., 97-99-4

The synthetic route of 97-99-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Moir, Michael; Boyd, Rochelle; Gunosewoyo, Hendra; Montgomery, Andrew P.; Connor, Mark; Kassiou, Michael; Tetrahedron Letters; vol. 60; 36; (2019);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

184950-35-4, Tetrahydrofuran-3-ylmethylamine hydrochloride (0.23 g, 1.69 mmol) And triethylamine (0.17 g, 1.69 mmol) Was added to chloroform (amylene added product) (10 mL). To the mixture, 5- (3-phenoxybenzyl) oxymethyl isoxazole-3-carboxylic acid (0.46 g, 1.41 mmol) at room temperature, 1-Hydroxybenzotriazole (0.02 g, 0.14 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.32 g, 1.69 mmol) were added, After stirring overnight, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (3-phenoxybenzyl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (11 4)) 0.54 g was obtained.

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
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88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

DIPEA (1 .93ml, 1 1 .1 mmol) was added to a solution of Tricyclo[3.3.1.13,7]decane-1 – carbonyl chloride (1 ) (2g, 10.1 mmol) and 3-aminotetrahydrofuran; (29)(1 .0ml, 1 1 mmol) in DCM (20ml) and the solution stirred at room temperature for 4 hours. The solution was washed with 0.1 N HCI (30ml), saturated NaHC03 (30ml), dried (Na2S04), filtered and the solvents removed to give crude product which was further purified via crystallization from 15percent EA in hexanes to give as a white solid, 88675-24-5

Big data shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; UNILEVER PLC; UNILEVER N.V.; CONOPCO, INC., D/B/A UNILEVER; HARICHIAN, Bijan; CLOUDSDALE, Ian Stuart; YANG, Lin; DICKSON, JR, John Kenneth; WO2014/139952; (2014); A2;,
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63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection,willBuvacizine Intermediate III(128.1 g, 1 mol) was dissolved in 1 L of dichloromethane,Cooling to 0 ,Was added trimethylsilyl iodide (150mL),The reaction solution was stirred at 20 to 30 C for 2 hours.Followed by the addition of hydrochloric acid solution (1 M, 800 mL) and aqueous sodium thiosulfate solution (10% by mass) as the percentage of sodium thiosulfate and the total mass of sodium thiosulfate aqueous solution, 400 mL. ,The aqueous phase was extracted with 1 L of dichloromethane,The organic phase was washed twice with saturated brine,Dried over anhydrous sodium sulfate,filter,Concentration under reduced pressure gave hexanoic acid derivative IV (254.6 g, 99.5%),Yield 99.5%Purity: 95.6% (GC)., 63095-51-2

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Shanghai Bocimed Pharmaceutical Co., Ltd.; Ying, Shuhuan; Pi, Hongjun; Chen, Jian; Zhou, Wei; Zhang, Jueming; (13 pag.)CN106588740; (2017); A;,
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