Category: Tetrahydrofurans

5061-21-2, 2-Bromo-4-butanolide is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Example 42]; Production of 2-mercapto-4-butyrolactone (using Na2S); 144 g (0.6 mol) of sodium sulfide nonahydrate (manufactured by JUNSEI CHEMICAL Co., Ltd.) were dissolved in a mixed solvent of 34 g of 1, 2-dimethoxyethane (Guaranteed Reagent; manufactured by JUNSEI CHEMICAL Co., Ltd.) and 34 g of purified water (which had been distilled and passed through an ion exchange filter) at room temperature. While theresultant solution was cooled with ice (to 100C or less) and under normal pressure (about 0.10MPa), 79 g of hydrochloric acid (GUARANTEED REAGENT, 35% to 37%; manufactured by JUNSEI CHEMICAL Co., Ltd.) were added with stirring the solution to adjust the pH of the solution to 8.9. While cooling thesolution to maintain the temperature of the solution at 100C or less, 34 g (0.2 mol) of 2-bromo-4-butyrolactone (manufactured by Tokyo Chemical Industry Co. , Ltd. ) were added dropwise into the solution over approximately 20 minutes. The reaction solution after the completion of the dropwise addition was stirred for 2 minutes. The pH of the reaction solution was within the range of 7.5 to 8.9 from when the dropwise addition of 2-bromo-4-butyrolactone was initiated to the stirring after the dropwise addition was completed.Thereafter, while cooling the solution to 100C or less, 24 g of hydrochloric acid were added to the solution over approximately 5 minutes to adjust the pH of the solution to 4.0. An inorganic salt deposited in the solution was removed by suction-filtration, and 20 g of ethyl acetate (Guaranteed Reagent; manufactured by JUNSEI CHEMICAL Co. , Ltd. ) were added to the resultant filtrate to extract the organic phase. The resultant aqueous phase was reextracted with 34 g of ethyl acetate. These extracted organic phases were combined and the resultant organic phase was concentrated and purified by distillation under a reduced pressure to give 17 g of2-mercapto-4-butyrolactone (having a boiling point of 94C/0.3 kPa; with a yield of 72%) .

5061-21-2, As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.

Reference£º
Patent; SHOWA DENKO K.K.; WO2007/139215; (2007); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

19311-37-6, 3-Bromotetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 3-[4-(4-methylpiperazin-1-yl)phenyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,5-dihydro-6H-pyrazolo[4,3-c]pyridin-6-one (15.0 mg, 0.034 mmol, Example 1, Step 3), iodocyclohexane (7.2 mg, 0.034 mmol) and cesium carbonate (33.4 mg, 0.102 mmol) in N,N-dimethylformamide (2.0 mL) was stirred at 80 C. for 18 h. After cooling to room temperature, the mixture was concentrated in vacuo. The crude mixture was then dissolved in DCM (2.0 mL) and TFA (2.0 mL) was added dropwise at room temperature. After stirring for 2 h, the mixture was concentrated in vacuo. The crude mixture was dissolved in MeOH (3.5 mL) and 10% aqueous NH4OH (1.5 mL) was added. The mixture was purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% TFA, at flow rate of 60 mL/min) to give the desired product. LCMS calculated for C23H30N5O (M+H)+: m/z=392.2; Found: 392.3. This compound was prepared according to the procedures described in Example 9, using 3-bromotetrahydrofuran instead of iodocyclohexane as starting material. LCMS calculated for C21H26N5O2 (M+H)+: m/z=380.2; Found: 380.3., 19311-37-6

19311-37-6 3-Bromotetrahydrofuran 12929516, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Incyte Corporation; Ye, Qinda; Liu, Kai; Pan, Jun; Sokolsky, Alexander; Vechorkin, Oleg; Yao, Wenqing; (40 pag.)US2018/72719; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 5; [00113] Preparation of Alfuzosin[00114] To a solution of tetrahydrofuroic acid (5.97 g) in methylene chloride (100 ml) was added thionyl chloride (3.75 ml). After 30 minutes of stirring, N-(4-amino-6,7- dimethoxy-2-quinaaolinyl)-N-methyl-l,3-propanediamine (10.0 g) was added and charged to the reaction mass. To this reaction mass was added triethyl amine, and maintained for about 90 minutes to about 105 minutes. On completion of the reaction as determined by TLC, the reaction mass was filtered to separate the insoluble triethylamine (“TEA”) hydrochloride and the solvent was evaporated at a temperature ranging from about 400C to about 45C under vacuum, to obtain gummy mass. To the gummy mass, isopropyl alcohol (50 ml) was charged and heated to a temperature ranging from about 550C to about 600C and stirred at the same temperature for about 30 to about 35 minutes. The mass was cooled to room temperature. The product was isolated by filtration, washed with isopropyl alcohol (10.0 ml). Wet product was dried at a temperature ranging from about 500C to about 55C to obtained crude alfuzosin (7.8gm). [00115] Purity( by HPLC): Greater than 99.6%, 16874-33-2

The synthetic route of 16874-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLENMARK PHARMACEUTICALS LIMITED; WO2006/90268; (2006); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

57595-23-0, Methyl 4-oxotetrahydrofuran-3-carboxylate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57595-23-0, (b) Tetrahydrofuran-3-one A solution of methyl 3-oxo-tetrahydrofuranyl-4-carboxylate (14.5 g, 0.1 mol) in 10percent H2 SO4 (50 ml) was refluxed for 1 hour. The reaction mixture was cooled and extracted with ether (3*100 ml). The organic layers were combined, dried over MgSO4 and concentrated in vacuo. The pale gold residue was distilled to afford 6.8 g (79percent) of tetrahydrofuran-3-one, B.P. 74¡ã-75¡ã C. at 100 mm Hg.

57595-23-0 Methyl 4-oxotetrahydrofuran-3-carboxylate 14666564, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sterling Winthrop Inc.; US5294612; (1994); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.,184950-35-4

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.22 g, 1.60 mmol) And triethylamine (0.16 g, 1.60 mmol) Was added to chloroform (amylene added product) (8 mL). To the mixture, 5- (5-phenylfurfuryl) oxymethylisoxazole-3-carboxylic acid (0.40 g, 1.34 mmol) at room temperature, 1-Hydroxybenzotriazole (0.02 g, 0.13 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.31 g, 1.60 mmol) were added, After stirring for 3 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equationIndicated by N- (tetrahydrofuran-3-ylmethyl) -5- (5-phenylfurfuryl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (12 4)) 0.35 g was obtained.

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1679-47-6,3-Methyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

To a solution of diisopropylamine (2.3 mL, 16.16 mmol) in tetrahydrofuran (THF) (37 mL),N-Butyllithium (2.5 M in hexanes, 5.92 mL, 14.81 mmol) was added with stirring at -78 C. After stirring for 5 minutes,Alpha-methyl-gamma-butyrolactone(1.416 mL, 14.81 mmol) was added dropwise.After stirring at 0 C for 15 minutes,The reaction mixture is cooled to -75 C.2,6-Dichloropyrazine (2.0059 g, 13.46 mmol) was added dropwise as a solution in THF (7.5 mL). The mixture was stirred overnight while warming to room temperature.Dilute the reaction mixture with saturated aqueous sodium bicarbonate solution,Extracted with dichloromethane (2 ¡Á 10 mL).The combined extracts are dehydrated with anhydrous sodium sulfate,Filter and concentrate under reduced pressure. ProductPurify by silica gel chromatography eluting with 0-40% ethyl acetate / heptane,The desired product (2.5 g, 76% yield) was obtained.

1679-47-6, The synthetic route of 1679-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Abbvie Incorporated; Argiriadi, Maria A.; Breinlinger, Eric C.; Chien, Ellen Yulin Tsai; Cowart, Marlon D.; Frank, Kristine E.; Friedman, Michael M.; Hardy, David J.; Herold, J. Martin; Liu, Huaqing; Chu, Wei; Scanio, Marc J.; Schrimpf, Michael R.; Vargo, Thomas R.; Van Epps, Stacy A.; Webster, Matthew P.; Little, Andrew J.; Dunstan, Teresa A.; Katcher, Matthew H.; Schedler, David A.; (232 pag.)JP6557436; (2019); B1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

16874-33-2, Tetrahydrofuran-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tetrahydro-furan-2-carboxylic acid (2. 42 g, 20. 82 mmol) in anhydrous tetrahydrofuran (120 mL), under an atmosphere of nitrogen at 0 C, was added triethylamine (8. 5 mL, 61. 23 MMOL) and ethyl chloroformate (2. 4 ML, 25. 10 MMOL). White precipitation formed after the addition of ethyl chloroformate and the resulting mixture stirred for 45 minutes at 0 C. Ammonia gas was bubbled into the solution for 2 hours and the gas source removed. The reaction mixture was then allowed to warm to ambient temperature and stirred for 16 hours. The solution was adjusted to pH 1 by addition of 1 N hydrochloric acid, and then extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to give the crude product. The residue was purified by flash column chromatography (hexanes to 10% ethyl acetate/hexanes) to afford the title compound (0. 97 g, 41%) as a white solid. LRMS (MILZ) : 116 (M+H) +. ‘H NMR (CDCI3, 300 MHz) : 4. 35 (1H, dd, J= 8. 5, 5. 8 HZ), 3. 92 (2H, m), 2. 18 (2H, m), 1. 90 (2H, m)., 16874-33-2

As the paragraph descriping shows that 16874-33-2 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; WO2004/92145; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.

The autocatalytic reaction of homoserine lactone hydrochloride was performed using a high pressure reaction system. Specifically, 2 g of HSL.HCl, 45 g of chloroform and 1 g of conc. HCl was added to the reactor and reacted with NO / Air (O2) gas at room temperature (25 ) and high pressure (about 14 atm). After 2 hours of reaction, the product was recovered and the components were analyzed as 92.7% of Cl-GBL, 3.3% of HO-GBL, 3.8% of furanone and 0.2% of other components.

42417-39-0, As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pyridin-4-ylmethyl (3R)-tetrahydrofuran-3-ylcarbamate To a solution of 4-nitrophenyl (pyridin-4-yl)methyl carbonate (Intermediate 1; 274 mg, 1.0 mmol) and DMAP (122 mg, 1.0 mmol) in DMF (5 mL) was added a solution of (R)- tetrahydrofuran-3 -amine toluenesulfonate (259 mg, 1.0 mmol) and DIPEA (174 muL, 1.0 mmol) in DMF (5 mL). The reaction mixture was stirred for 24 hours and then concentrated in vacuo. The residue was purified by normal phase chromatography(gradient eluting with MeOH in DCM from 0% to 2%) and dried in vacuo to give pyridin- 4-ylmethyl (3R)-tetrahydrofuran-3-ylcarbamate (68 mg, 31%) as an off white solid.Analytical HPLC: purity >99% (System A, Rtau = 2.72 min); Analytical LCMS: purity 100% (System C, Rtau = 3.32 min), ES+: 222.8 [MH]+; HRMS calcd for CnHi4N2O3: 222.1004, found 222.1007.

111769-27-8, As the paragraph descriping shows that 111769-27-8 is playing an increasingly important role.

Reference£º
Patent; BIOVITRUM AB (PUBL); WO2009/147216; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.20 g, 1.20 mmol) And triethylamine (0.12 g, 1.20 mmol) Was added to chloroform (amylene added product) (4 mL). To the mixture, Butyl-2H-1,2,3-triazole-4-carboxylic acid (0.17 g, 1.00 mmol) at room temperature, 1-Hydroxybenzotriazole (0.01 g, 0.10 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.23 g, 1.20 mmol) After stirring for 3 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (Tetrahydrofuran-3-ylmethyl) -2-butyl-2H-1,2,3-triazole-4-carboxamide (Hereinafter referred to as the present amide compound (55))0.11 g.

184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem