Category: Tetrahydrofurans

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 7175-81-7, molcular formula is C5H11NO, introducing its new discovery. , 7175-81-7

AMINOMETHYL-SUBSTITUTED THIAZOLOBENZIMIDAZOLE DERIVATIVE

This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives.The novel aminomethyl-substituted thiazolobenzimidazole derivatives which have a metabotropic glutamate receptor action and excellent oral activity are invented and these derivatives are therefore useful as a medicament.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 7175-81-7, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 7175-81-7

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

453-20-3, An article , which mentions 453-20-3, molecular formula is C4H8O2. The compound – 3-Hydroxytetrahydrofuran played an important role in people’s production and life.

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria

PlsY is the essential first step in membrane phospholipid synthesis of Gram-positive pathogens. PlsY catalyzes the transfer of the fatty acid from acyl-phosphate to the 1-position of glycerol-3-phosphate to form the first intermediate in membrane biogenesis. A series of non-metabolizable, acyl-sulfamate analogs of the acyl-phosphate PlsY substrate were prepared and evaluated as inhibitors of Staphylococcus aureus PlsY and for their Gram-positive antibacterial activities. From this series phenyl (8-phenyloctanoyl) sulfamate had the best overall profile, selectively inhibiting S. aureus phospholipid biosynthesis and causing the accumulation of both long-chain fatty acids and acyl-acyl carrier protein intermediates demonstrating that PlsY was the primary cellular target. Bacillus anthracis was unique in being more potently inhibited by long chain acyl-sulfamates than other bacterial species. However, it is shown that Bacillus anthracis PlsY is not more sensitive to the acyl-sulfamates than S. aureus PlsY. Metabolic profiling showed that B. anthracis growth inhibition by the acyl-sulfamates was not specific for lipid synthesis illustrating that the amphipathic acyl-sulfamates can also have off-target effects in Gram-positive bacteria. Nonetheless, this study further advances PlsY as a druggable target for the development of novel antibacterial therapeutics, through the discovery and validation of the probe compound phenyl (8-phenyloctanoyl) sulfamate as a S. aureus PlsY inhibitor.

453-20-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 453-20-3

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Tetrahydrofuran – Wikipedia,
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53558-93-3, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 53558-93-3

Salts of a quinolone-carboxylic acid

The present invention provides novel organic acid addition salts of a quinolone-carboxylic acid of formula (I) STR1 wherein Z is 5-oxotetrahydrofuran-2-carboxylic acid or 2-hydroxyglutaric acid. The salts are highly soluble in water and are thus suitable to prepare a stable injection in storage for a long period of time.

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Tetrahydrofuran – Wikipedia,
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97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

97-99-4, In a round bottom flask was placed (R)-(tetrahydro-furan-2-yl)-methanol (prepared as in PCT WO 2003/095438 A1, Example 3, 4.65 g, 45.5 mmol), methylene chloride (100 mL) and triethylamine (8.4 mL, 60.6 mmol) and it was cooled to 0 C. To this cooled solution was then added a solution of p-toluenesulfonyl chloride (10.4 g, 54.6 mmol) in methylene chloride (30 mL) dropwise. Once the addition was complete the reaction was then warmed to 25 C. and stirred for 16 h. The reaction was then diluted with water (50 mL) and extracted with methylene chloride (3¡Á30 mL). The combined organic extracts were then dried over sodium sulfate, filtered and concentrated in vacuo. Purification on an AnaLogix Intelliflash system (80 g column, 3% ethyl acetate/hexanes to 40% ethyl acetate/hexanes) afforded toluene-4-sulfonic acid tetrahydro-furan-2(R)-ylmethyl ester (8.37 g, 72%) as a clear colorless oil: [alpha]32589=-14.4 (c=0.72, methylene chloride); ES-HRMS m/e calcd for C12H16O4S (M+H)+ 257.0842, observed 257.0841; 1H NMR(300 MHz, CDCl3) delta ppm 1.95-2.08 (m, 1 H, CH of CH2), 2.14-2.40 (m, 3 H, CH2 and CH of CH2), 4.02-4.19 (m, 2 H, OCH2), 4.29-4.49 (m, 3 H, OCH and OCH2), 7.69 (d, J=8.0 Hz, 2 H, Ar), 8.15 (d, J=8.0 Hz, 2 H, Ar).

As the paragraph descriping shows that 97-99-4 is playing an increasingly important role.

Reference£º
Patent; Berthel, Steven Joseph; Kester, Robert Francis; Murphy, Douglas Eric; Prins, Thomas Jay; Ruebsam, Frank; Sarabu, Ramakanth; Tran, Chinh Viet; Vourloumis, Dionisios; US2008/21032; (2008); A1;,
Tetrahydrofuran – Wikipedia
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88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To (2-bromo-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)(4,7,difluoro- 1 H-indol-2-yl)methanone (0.030 g, 0.753 mmol) was added tetrahydrofuran-3-amine (1.0 ml, 5.81 mmol). The mixture was stirred at 80¡ãC for 7 days. The mixture was cooled, then purified directly by basic reverse phase HPLC to give the desired product (0.114 g, 35percent yield)Rt (Method A) 3.15 mins, m/z 405 [M+H]., 88675-24-5

Big data shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; AICURIS GMBH & CO. KG; DONALD, Alastair; URBAN, Andreas; BONSMANN, Susanne; WEGERT, Anita; GREMMEN, Christiaan; SPRINGER, Jasper; (376 pag.)WO2019/86141; (2019); A1;,
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Tetrahydrofuran | (CH2)3CH2O – PubChem

915095-89-5,915095-89-5, (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Take (S)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy) tetrahydrofuran 183kg,400kg anhydrous THF/toluene (1:4) was added to the nitrogen-dried 3000 litre reactor.The liquid nitrogen was cooled to -78, and hexane solution of 1. 6 mol¡¤L-1 n-butyllithium was slowly added dropwise.Stirring was continued at this temperature for 1 h; 600 kg of a 2,3,4,6-tetra-O-trimethylsilyl-D-glucono-lactone (256 kg) in toluene solution cooled to -78C was slowly added dropwise to the above 600 kg. In the reaction solution,-78 reaction for 3 h, after the basic reaction of TLC detection is completed,At this temperature is added 500kg of methanesulfonic acid in methanol solution (methanesulfonic acid 225kg + methanol 275kg);The reaction was stirred at 0 C 4h, and then warmed to 40 C stirred reaction 6h;5 mol?L-1 sodium hydroxide aqueous solution was added to the reaction solution, and the pH was adjusted to 7-8; stirring for 30 min,Extract with ethyl acetate (300kg¡Á2)The organic phase is washed with saturated aqueous sodium chloride solution until neutral, then dried over anhydrous sodium sulfate and filtered.The filtrate was concentrated to dryness to give 208 kg of a light yellow viscous oil with a yield of 87%.

915095-89-5 (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 15941217, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu Engineering Polytechnic College; Feng Chengliang; Yan Bin; (12 pag.)CN107652278; (2018); A;,
Tetrahydrofuran – Wikipedia
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184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 54 (0369) 2-Butyloxazole-5-carboxylic acid (0.10 g, 0.6 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.12 g, 0.9 mmol), triethylamine (0.09 g, 0.9 mmol) and 1-hydroxybenzotriazole (0.01 g, 0.1 mmol) were added to chloroform (amylene addition product) (1.2 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.14 g, 0.7 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight. Then, water was added thereto, and the mixture was extracted three times with ethyl acetate. The organic layer was.washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.13 g of N-(tetrahydrofuran-3-ylmethyl)-2-butyloxazole-5-carboxamide (hereinafter, referred to as Compound of Present Invention (59)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):0.95(3H, t), 1.36-1.45(2H, m), 1.63-1.80(3H, m), 2.03-2.13(1H, m), 2.50-2.63(1H, m), 2.76(2H, t), 3.37-3.50(2H, m), 3.59(1H, dd), 3.73-3.80(1H, m), 3.84-3.94(2H, m), 7.02(1H, brs), 8.08(1H, s), 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

Step G: Intermediate 27-1To a solution of the intermediate 26-1 (26 mg, 0.037 mmol) in anhydrous pyridine (2 mL) were added DMAP (22.42 mg, 0.184 mmol) and 3,3-dimethyldihydro-2,5- furandione (47 mg, 0.367 mmol). After it was stirred at 80 ¡ãC overnight, the reaction mixture was diluted with EtOAc (30 mL). The organic phase was washed with aqueous HC1 (2 N, 10 mL), brine (20 mL), dried over sodium sulfate and evaporated to dryness in vacuo to give a residue, which was purified by column chromatography on silica gel (Hex:EtOAc 4: 1) to afford the intermediate 27-1 (15 mg, 48.9 percent) as a white foam. LC/MS: m/z calculated 835.4, found 858.4 (M + Na)+.

17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE LLC; GAO, Daxin; HAN, Nianhe; JIN, Zhimin; NING, Fangxian; TANG, Jun; WU, Yongyong; YANG, Heping; WO2011/100308; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,42417-39-0

The reactor was charged with 0.5 g of HSL.HCl and 6.5 g of water as a reactant. An Fe (NO3) 3 catalyst was added to the reactor in the ratio shown in Table 5 below to carry out the deamination reaction of HSL ¡¤ HCl. The reaction conditions were 25 C and 1 atm. The product was partially recovered and the components were analyzed. The results are shown in Table 5 below.

As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
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Tetrahydrofuran | (CH2)3CH2O – PubChem

19311-37-6, 3-Bromotetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methyl 6hydroxypyrazoio[1,5-aipyridine-3-carboxy1ate (0.200 g, 1.04 mrnol) was suspended in MeCN (10 rnL), then 3-bromotetrah drofuran (0.131 mL, 1.35 mniol), K2COS (0575 g, 416 mmol) and 1-120 (0.667 rnL) were added. The reaction mixture was stirred under microwave irradiation at 120 C for 30 mm, The reaction mixture wasconcentrated under reduced pressure, the residue dissolved in MeOH (4 rnL)/THF (4 mL), and IM LiOH (4.16 mL, 4.16 mniol) was added. The reaction mixture was stirred under microwave irradiation at 150 C for 15 mm. The reaction mixture was acidified with TFA. filtered, and purified by reverse phase HPLC to afford 6-((tetrahydrofuran-3- y1)oxv)pyrazoIoI.5ajpyridine-3-carboxviic acid (0.155g. 60 %yieid) as an off-whitesolid. MS (ESI) m/-: 249.0 (M-FH)t ?FT NMR (500MHz. DMSO-d6) oe ppm 12.36 (hr s.1H), 8.58 (d. J=i.7 Hz, 1H), 8.30 (s, 1H), 7.96 (d. J=9.6 Hz, IH), 7.34 (dd, J=9.6, 2.2 Hz, IH), 5.12 (ddt, J=6.1, 4.0, 1.7 Hz, IH), 3.93-3.83 (rn. 3H), 377 (td, J=S4, 4.4Hz, 1H), 232 2.20 (n, 1H), 2.09 – 1.98 (m, 11-1).

19311-37-6, The synthetic route of 19311-37-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; SMITH II, Leon M.; LADZIATA, Vladimir; DELUCCA, Indawati; PINTO, Donald, J., P.; ORWAT, Michael J.; DILGER, Andrew K.; PABBISETTY, Kumar Balashanmuga; YANG, Wu; SHAW, Scott A.; GLUNZ, Peter W.; PANDA, Manoranjan; (612 pag.)WO2017/123860; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem