Category: Tetrahydrofurans

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 87392-05-0, molcular formula is C5H8O3, introducing its new discovery. 87392-05-0

CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS

Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 87392-05-0, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 87392-05-0

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 1679-47-6, molcular formula is C5H8O2, introducing its new discovery. , 1679-47-6

DIURETICS

A compound having the structure (I) wherein R is selected from the group consisting of 1) and 2), or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 1679-47-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1679-47-6

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. 15833-61-1. Introducing a new discovery about 15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

Human nonlysosomal glucosylceramidase (GBA2) is one of several enzymes that controls levels of glycolipids and whose activity is linked to several human disease states. There is a major need to design or discover selective GBA2 inhibitors both as chemical tools and as potential therapeutic agents. Here, we describe the development of a fluorescence polarization activity-based protein profiling (FluoPol-ABPP) assay for the rapid identification, from a 350+ library of iminosugars, of GBA2 inhibitors. A focused library is generated based on leads from the FluoPol-ABPP screen and assessed on GBA2 selectivity offset against the other glucosylceramide metabolizing enzymes, glucosylceramide synthase (GCS), lysosomal glucosylceramidase (GBA), and the cytosolic retaining beta-glucosidase, GBA3. Our work, yielding potent and selective GBA2 inhibitors, also provides a roadmap for the development of high-throughput assays for identifying retaining glycosidase inhibitors by FluoPol-ABPP on cell extracts containing recombinant, overexpressed glycosidase as the easily accessible enzyme source.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 15833-61-1, help many people in the next few years.15833-61-1

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

7175-81-7, An article , which mentions 7175-81-7, molecular formula is C5H11NO. The compound – (S)-(Tetrahydrofuran-2-yl)methanamine played an important role in people’s production and life.

Discovery of a novel series of CXCR3 antagonists

The discovery of a novel series of CXCR3 antagonists is described. Starting from an HTS positive, iterative optimization gave potent compounds (IC 50 15 nM in a chemotaxis assay). The strategy employed to improve the metabolic stability of these derivatives is described.

7175-81-7, Interested yet? Read on for other articles about 7175-81-7!

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4344-84-7, name is 5-Oxotetrahydrofuran-2-carboxylic acid, introducing its new discovery. 4344-84-7

A Comprehensive Study on Metal Triflate-Promoted Hydrogenolysis of Lactones to Carboxylic Acids: From Synthetic and Mechanistic Perspectives

Direct hydrogenolysis of lactone to carboxylic acid (i.e., hydrogenolysis of the Calkoxy-O bond with the carbonyl group untouched) is generally difficult, as the current strategies employing Br¡ãnsted acids as the catalyst usually require harsh conditions such as a high temperature and a high H2 pressure. Herein, we report a developed solvent-free catalytic transformation, in which W(OTf)6 is believed to promote the hydrogenolysis process. This strategy could efficiently hydrogenate lactones to carboxylic acids under extra mild conditions (e.g., a reaction temperature of <150 C and 1 atm of H2) and showed a broad substrate scope. In addition, the catalytic protocol can be further applied to the hydrogenolysis of polyhydroxyalkanoate, as a renewable polymer, to the corresponding straight-chain carboxylic acids. An extensive mechanistic study was subsequently performed, and the density functional theory calculations revealed a reaction pattern, including the complete cleavage of the C=O bond with the assistance of the W(OTf)6 catalyst. Moreover, the key intermediate created in the mechanism, as an oxonium with an OTf moiety, was successfully detected by electrospray ionization mass spectra. Through a comparison with the Br¡ãnsted acid-catalyzed system, the study confirmed that the existence of the OTf moiety can significantly lower the barriers associated with the rearrangement and elimination processes. Meanwhile, emphasis was placed on the critical role that the anion plays, as well as the fact that the anion effect is directly related to the chemoselectivity. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.4344-84-7, you can also check out more blogs about4344-84-7

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

52079-23-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 52079-23-9, Name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone, molecular formula is C4H6O3. In a Article, authors is Mori, Kenji£¬once mentioned of 52079-23-9

SYNTHESIS OF THE OPTICALLY ACTIVE FORMS OF 4,10-DIHYDROXY-1,7-DIOXASPIRO<5.5>UNDECANE AND THEIR CONVERSION TO THE ENANTIOMERS OF 1,7-DIOXASPIRO<5.5>UNDECANE, THE OLIVE FLY PHEROMONE

Both the enantiomers of 1,7-dioxaspiro<5.5>undecane, the major component of the pheromone of the olive fly (Dacus oleae), were synthesized from (S)-malic acid.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 52079-23-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 52079-23-9, in my other articles.

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

66838-42-4, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 66838-42-4, name is (R)-Tetrahydrofuran-3-carboxylic acid, introducing its new discovery.

PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR

The present invention is directed to piperidinyl and piperazinyl derivatives of formula (II) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and / or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.66838-42-4, you can also check out more blogs about66838-42-4

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

453-20-3, Name is 3-Hydroxytetrahydrofuran, belongs to Tetrahydrofurans compound, is a common compound. 453-20-3In an article, authors is Akar, once mentioned the new application about 453-20-3.

Total Electron Stopping Powers and CSDA-Ranges from 20 eV to 10 MeV Electron Energies for Components of DNA and RNA

An appropriate formula for the total stopping power of electrons of initial kinetic energy from 20 eV to 10 MeV in some biological materials is presented. The continuous slowing down approximation-range (CSDA-range) from the total stopping power is also made. The collisional stopping power formula is evaluated using Generalized Oscillator Strength (GOS) model and exchange correction on the inelastic differential cross section (IDCS) given by [M. Inokuti, Rev. Mod. Phys. 43 (1971) 297-347] and the radiative stopping power formula is calculated from the bremsstrahlung differential cross section (DCS) given by [H.W. Koch, J.W. Motz, Rev. Mod. Phys. 31 (4) (1959) 920-955]. Calculation of the total stopping powers (SPs) and CSDA-range for biological compounds: C5H5N5 (adenine), C5H5N5O (guanine), C4H5N3O (cytosine), C5H6N2O2 (thymine), C4H4N2O2 (uracil), C4H8O (tetrahydrofuran), C4H8O2 (3-hydroxytetrahydrofuran), C5H10O2 (alpha-tetrahydrofurfuryl alcohol), H3PO4 (phosphoric acid), C19H26N8O13P2 (thymine{single bond}adenine{single bond}DNA) have been introduced for incident electrons in the 20 eV-10 MeV energy range. The calculated results have been compared with experimental data, PENELOPE program results and other theoretical results. The calculated results of total stopping power and CSDA-ranges for electrons in energy range from 20 eV to 10 MeV are found to be in good agreement to within 8% with available data.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 453-20-3

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

104227-71-6, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 104227-71-6

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group 1 in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger’s disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

104227-71-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 104227-71-6!

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Because a catalyst decreases the height of the energy barrier, 15833-61-1, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol, molecular formula is C5H10O2. In a article£¬once mentioned of 15833-61-1

Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor

Through a structure-guided rational drug design approach, we have discovered a highly selective inhibitor compound 40 (JSH-150), which exhibited an IC50 of 1 nM against CDK9 kinase in the biochemical assay and achieved around 300?10000-fold selectivity over other CDK kinase family members. In addition, it also displayed high selectivity over other 468 kinases/mutants (KINOMEscan S score(1) = 0.01). Compound 40 displayed potent antiproliferative effects against melanoma, neuroblastoma, hepatoma, colon cancer, lung cancer as well as leukemia cell lines. It could dose-dependently inhibit the phosphorylation of RNA Pol II, suppress the expression of MCL-1 and c-Myc, arrest the cell cycle and induce the apoptosis in the leukemia cells. In the MV4-11 cell-inoculated xenograft mouse model, 10 mg/kg dosage of 40 could almost completely suppress the tumor progression. The high selectivity and good in vivo PK/PD profile suggested that 40 would be a good pharmacological tool to study CDK9-mediated physiology and pathology as well as a potential drug candidate for leukemia and other cancers.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 15833-61-1, In my other articles, you can also check out more blogs about 15833-61-1

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem