Category: Tetrahydrofurans

87392-05-0, One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Mayer, Sandra F., mentioned the application of 87392-05-0, Name is (R)-(+)-2-Tetrahydrofuroic acid, molecular formula is C5H8O3

Enzyme-triggered enantioconvergent transformation of haloalkyl epoxides

Biocatalytic hydrolysis of 2,3-disubstituted rac-cis- and rac-trans-haloalkyl epoxides 1a-8a using the epoxide hydrolase activity of whole bacterial cells furnished the corresponding vicinal diols 1b-8b as intermediates; these (spontaneously) underwent ring closure to yield cyclic products 1c-6c through an enzyme-triggered cascade reaction. In particular, cis-configured substrates (1a, 3a, 5a, 7a) were transformed in an enantioconvergent fashion, which resulted in the formation of single stereoisomeric products in 100% des and up to 92% ees from the racemates.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 87392-05-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 87392-05-0, in my other articles.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 87219-29-2, In a patent£¬Which mentioned a new discovery about 87219-29-2

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

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Tetrahydrofuran – Wikipedia,
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Let¡¯s face it, organic chemistry can seem difficult to learn. 2144-40-3. Especially from a beginner¡¯s point of view. Like 2144-40-3, Name is (cis-Tetrahydrofuran-2,5-diyl)dimethanol. In a document type is Article, introducing its new discovery.

Kinetics of Catalytic Hydrogenation of 5-Hydroxymethylfurfural to 2,5-bis-Hydroxymethylfuran in Aqueous Solution over Ru/C

5-Hydroxymethylfurfural (5-HMF) is a cellulosic product of the hydrolysis of biomass, and it is widely considered for the production of several interesting chemicals and derivatives. In the present work, catalytic hydrogenation of 5-hydroxymethylfurfural to 2,5-bis-hydroxymethylfuran was investigated using 5% Ru/C in the aqueous phase. Kinetic data were experimentally obtained over a wide range of temperatures (313-343 K), H2 partial pressure (0.69-2.07 MPa), initial HMF concentration (19.8-59.5 mM), and catalyst loading (0.3-0.7 kg/m3) in a three-phase slurry reactor. Disappearance of initial 5-HMF concentrations was modeled using the power law and Langmuir-Hinshelwood-Hougen-Watson models. A model based on the competitive adsorption of molecular H2 and HMF was proposed. It is presumed that surface reaction between nondissociatively chemisorbed H2 and 5-HMF was rate determining. This model provided the best fit for the kinetic data. From the Arrhenius equation, the activation energy for the surface reaction was found to be 104.9 kJ/mol.

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21461-84-7, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 21461-84-7, name is (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid. In an article£¬Which mentioned a new discovery about 21461-84-7

Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: Potent inhibitors of heat shock protein 90

A full account of an asymmetric synthesis of reblastatin (1) and the first total synthesis of autolytimycin (2) and related structural compounds is described. The syntheses expand the utility of a highly regio- and diastereoselective hydrometalation aldehyde addition sequence to assemble the fully functionalized ansa chain of the natural products. Also documented is an intramolecular copper-mediated amidation reaction to close the 19-membered macrolactams. The amidation reaction was also employed for the generation of structural derivatives (6-9) of phenolic ansamycins. Ansamycin natural products and selected structural analogues were evaluated in a competitive binding assay to breast cancer cell lysate and a cytotoxicity assay. Both reblastatin (1) and autolytimycin (2) were shown to bind the heat shock protein 90 with enhanced binding activity (?25 nM) than 17-allylamino-17-demethoxygeldanamycin (17-AAG, 4), a geldanamycin (3) derivative currently under evaluation for treatment of cancer (?100 nM).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 21461-84-7 is helpful to your research. 21461-84-7

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Tetrahydrofuran – Wikipedia,
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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. 89364-31-8. Introducing a new discovery about 89364-31-8, Name is Tetrahydrofuran-3-carboxylic acid

Discovery and hit-to-lead optimization of novel allosteric glucokinase activators

We report on a hit generation and hit-to-lead program of a novel class of glucokinase activators (GKAs). Hit compounds, activators at low glucose concentration only were identified by vHTS. Scaffold modification reliably afforded activators also at high substrate level. Potency was increased by introduction of a hydrogen bond acceptor as proposed by molecular docking. Replacement of the initial alkylene linkers with a rigid 1,2-phenylene motif followed by further studies eventually furnished a series of potent lead compounds exhibiting steep SAR.

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4971-56-6, An article , which mentions 4971-56-6, molecular formula is C4H4O3. The compound – Furan-2,4(3H,5H)-dione played an important role in people’s production and life.

Organic reaction in water: A highly efficient and environmentally friendly synthesis of spiro compounds catalyzed by L -proline

We have developed a clean, simple and efficient method for the synthesis of spiro compounds by three-component reaction of isatins (=1H-indole-2,3-diones) or acenaphthylene-1,2-dione, 1,3-diphenyl-1H-pyrazoles-5-amines, and tetronic acid (=furan-2,4-(3H,5H)-dione or 2-hydroxy-1,4-naphthoquinone in the presence of a catalytic amount of L-proline in aqueous media. The advantages of this procedure are mild reaction conditions, high yields of products, operational simplicity, and easy workup procedures employed. Copyright

4971-56-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4971-56-6

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Tetrahydrofuran – Wikipedia,
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An article , which mentions 105-21-5, molecular formula is C7H12O2. The compound – Gamma-heptalactone played an important role in people’s production and life., 105-21-5

Lactonization of Unsaturated Alcohols Catalyzed by Palladium Complexes under Neutral Conditions

Secondary and tertiary allylic alcohols react with carbon monoxide in the presence of catalytic quantities of bis(dibenzylideneacetone)palladium (0) and 1,4-bis(diphenylphosphino)butane affording lactones in 45-92percent isolated yields. alpha,beta-Unsaturated acids are formed by isomerization and carbonylation of primary allylic alcohols. 2-(5H)-Furanones were isolated in yields of 60-80percent when alkynols were employed as substrates for the cyclocarbonylation process.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

An article , which mentions 87392-05-0, molecular formula is C5H8O3. The compound – (R)-(+)-2-Tetrahydrofuroic acid played an important role in people’s production and life., 87392-05-0

A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters

(Chemical Equation Presented) A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

16874-34-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.16874-34-3, Name is Ethyl tetrahydrofuran-2-carboxylate, molecular formula is C7H12O3. In a Article, authors is Shirai, Kimihiro£¬once mentioned of 16874-34-3

Effects of trifluoroethanol as a co-solvent on the electrochemical oxidation of hardly oxidizable organic compounds

2,2,2-Trifluoroethanol was found to be a suitable co-solvent for the electrochemical oxidation of organic compounds such as cyclic ethers, gamma-butyrolactone derivatives, primary alcohols, and toluenes substituted with electron-withdrawing groups, all of which were resistant toward oxidation in methanol. The oxidation products could be utilized as worthwhile synthetic intermediates.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.16874-34-3. In my other articles, you can also check out more blogs about 16874-34-3

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. 87219-29-2. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.87219-29-2, Name is (S)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate, molecular formula is C12H13NO4, introducing its new discovery.

beta-Pseudopeptide foldamers. the homo-oligomers of (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid (D-Oxac)

A total synthesis in solution and a conformational analysis of the homo-oligomers of (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid (D-Oxac) to the tetramer level are described. As the D-Oxac building block contains both an oxazolidin-2-one and a beta-amino acid group, it may represent a new type of conformationally constrained tool for the construction of beta-pseudopeptide foldamers. A conformational investigation using NMR and an extensive, unconstrained analysis with a Monte Carlo search to the octamer level, both in water and in chloroform, showed that these homo-oligomers tend to fold in a regular helical structure in a competitive solvent, such as water. Since aqueous solutions are of major relevance for biological systems, these molecules are good candidates for application to these environments.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem