Category: Tetrahydrofurans

453-20-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 453-20-3, C4H8O2. A document type is Review, introducing its new discovery.

Synthetic strategy and SAR studies of C-glucoside heteroaryls as SGLT2 inhibitor: A review

Gliflozins constitute an important class of compounds useful as sodium glucose co-transporter (SGLT2) inhibitors to treat type-II diabetes. They act by blocking sodium-glucose transport protein 2 which is responsible for re-absorption of glucose in the proximal convoluted tubule (PCT) of kidney and thus its inhibition reduces blood glucose level. There are a number of gliflozins which have been approved by drug regulatory bodies like FDA, EMA and PMDA whereas some others are in pipeline in their late developmental phases. The present review article offers a detailed account of synthetic strategies employed for the synthesis, alternate synthetic routes along with Structure Activity Relationship (SAR) studies of well-established as well as newly developed SGLT2 inhibitors.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

453-20-3, One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Maljkovi, Jelena, mentioned the application of 453-20-3, Name is 3-Hydroxytetrahydrofuran, molecular formula is C4H8O2

Absolute differential cross sections for elastic electron scattering from small biomolecules

The results of an experimental investigation of electrons colliding with a set of biomolecules that are assumed to be analogues of the building blocks of DNA (furan, 3- hydroxytetrahydrofuran and pyrimidine) and proteins (formamide, N-methylformamide) are presented. Absolute differential cross sections at medium incident electron energies 40 eV- 300 eV are presented and compared for these different targets. The experimental results are also compared with available calculations, based on the corrected form of independent atom model and show good agreement over the energy range studied.

453-20-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 453-20-3

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

22929-52-8, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 22929-52-8

CYCLIC ETHER DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYAMIDE

The invention relates to Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide of general formula (I) which are inhibitors of phosphodiesterase 2, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 89364-31-8, molcular formula is C5H8O3, introducing its new discovery. 89364-31-8

SUBSTITUTED IMIDAZOTRIAZINES

The invention relates to novel substituted imidazotriazines, to methods for the production thereof, and to their use for producing medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative diseases, particularly Parkinson’s disease and schizophrenia.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 89364-31-8, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 89364-31-8

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

13031-04-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 13031-04-4, name is 4,4-Dimethyldihydrofuran-2,3-dione. In an article£¬Which mentioned a new discovery about 13031-04-4

Creating diverse target-binding surfaces on FKBP12: Synthesis and evaluation of a rapamycin analogue library

FK506 and rapamycin are immunosuppressive drugs with a unique mode of action. Prior to binding to their protein targets, these drugs form a complex with an endogenous chaperone FK506-binding protein 12 (FKBP12). The resulting composite FK506-FKBP and rapamycin-FKBP binding surfaces recognize the relatively flat target surfaces of calcineurin and mTOR, respectively, with high affinity and specificity. To test whether this mode of action may be generalized to inhibit other protein targets, especially those that are challenging to inhibit by conventional small molecules, we have developed a parallel synthesis method to generate a 200-member library of bifunctional cyclic peptides as FK506 and rapamycin analogues, which were referred to as “rapalogs”. Each rapalog consists of a common FKBP-binding moiety and a variable effector domain. The rapalogs were tested for binding to FKBP12 by a fluorescence polarization competition assay. Our results show that FKBP12 binds to most of the rapalogs with high affinity (KI values in the nanomolar to low micromolar range), creating a large repertoire of composite surfaces for potential recognition of macromolecular targets such as proteins.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 13031-04-4 is helpful to your research. 13031-04-4

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

4971-56-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 4971-56-6, Name is Furan-2,4(3H,5H)-dione,introducing its new discovery.

Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells

Podophyllotoxin (PT) and its clinically used analogues are known to be powerful antitumour agents. These compounds contain a trans fused strained gamma-lactone system, a feature that correlates to the process of epimerisation, whereby the trans gamma-lactone system of ring D opens and converts to the more thermodynamically stable cis epimer. Since these cis epimers are known to be either less active or lacking antitumour activity, epimerisation is an undesirable feature from a chemotherapeutic point of view. To circumvent this problem, considerable efforts have been reported, amongst which is the synthesis of azapodophyllotoxins where the stereocentres at C2 and C3 are removed in order to preclude epimerisation. Herein we report the identification of a novel C3 hydroxy, cis-selective gamma-lactone configuration of ring C in the azapodophyllotoxin scaffold, through an efficient stereoselective multicomponent reaction (MCR) involving fluorinated and non-fluorinated aldehydes. This configuration releases the highly strained trans gamma-lactone system in podophyllotoxin analogues into the more thermodynamically stable cis gamma-lactone motif and yet retains significantly potent activity. These compounds were evaluated against the human cancer lines MCF-7 and 22Rv1 in vitro. Fourteen out of the seventeen tested compounds exhibited sub-micromolar activity with IC50 values in the range of 0.11-0.91 muM, which is comparable and in some cases better than the activity profile of etoposide in this assay. Interestingly, we obtained strong evidence from spectroscopic and X-ray data analyses that the previously reported structure of similar analogues is not accurate. Molecular modelling performed using the podophyllotoxin binding site on beta tubulin revealed a novel binding mode of these analogues. Furthermore, sub-cellular study of our compounds using immunolabelling and confocal microscopy analyses showed strong microtubule disruptive activity, particularly in dividing cells.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

453-20-3, In an article, published in an article,authors is Che, Penghua, once mentioned the application of 453-20-3, Name is 3-Hydroxytetrahydrofuran,molecular formula is C4H8O2, is a conventional compound. this article was the specific content is as follows.

A strategy of ketalization for the catalytic selective dehydration of biomass-based polyols over H-beta zeolite

Biomass contains plentiful hydroxyl groups that lead to an oxygen-rich structure compared to petroleum-based chemicals. Dehydration is the most energy-efficient technique to remove oxygen; however, multiple similar vicinal hydroxyl groups in sugar alcohols impose significant challenges for their selective dehydration. Here, we present a novel strategy to control the etherification site in sugar alcohols by the ketalization of the vicinal-diol group for the highly selective formation of tetrahydrofuran derivatives. A ketone firstly reacts with terminal vicinal hydroxyl groups to form the 1,3-dioxolane structure. This structure of the constrained 1,3-dioxolane ring would improve the accessibility of reactive groups to facilitate intramolecular etherification. As a better leaving group than water, the ketone can also promote intramolecular etherification. Consequently, a range of tetrahydrofuran derivatives are produced in excellent yields with the H-beta zeolite catalyst under mild reaction conditions. This strategy opens up new opportunities for the efficient upgrading of biomass via the modification or protection of hydroxyl groups.

453-20-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 453-20-3

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

66838-42-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 66838-42-4, molcular formula is C5H8O3, introducing its new discovery.

INHIBITORS OF BRUTON’S TYROSINE KINASE AND METHODS OF THEIR USE

Compounds of formula (I’) and methods of their use and preparation, as well as compositions comprising compounds of formula (I’).

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 66838-42-4, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 66838-42-4

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, belongs to Tetrahydrofurans compound, is a common compound. 4100-80-5In an article, authors is Alsbou, Eid, once mentioned the new application about 4100-80-5.

Whole sample analysis of bio-oils and thermal cracking fractions by Py-GC/MS and TLC-FID

A combination of pyrolysis-GC/MS and TLC-FID techniques were used for whole sample analysis of bio-oil samples obtained from different liginocellulosic biomasses, (i.e., birch wood, pine wood, barley straw and forest residue and thermal-cracking fractions). Both techniques showed the ability to analyze the whole sample without cleanup or fractionation and to distinguish among the bio-oils based on their feedstock sources. The TLC-FID is a chromatographic method whereby the oil solution is spotted on a TLC rod, developed by a two solvent system and the chromatographic bands measured by flame ionization detection (FID). The Py-GC/MS instrument uses a sample cup and a vertical microfurnace to analysis bio-oils. The non-volatiles fraction remaining in the cup were weighed after thermal evaporation-GC/MS. The hardwood birch bio-oil was shown to have syringol and its derivatives compared to pine wood and barley straw bio-oils that were shown to have methoxyphenolic and non-methoxy-phenolic compounds, respectively. TLC-FID shows clear differences in the peak areas and shapes for the bio-oils fractions by solvent development on chromarods and are in agreement with the results obtained by Py-GC/MS. Furthermore, forest residue bio-oil and its thermal cracking fractions could be effectively characterized by TLC-FID (and Py-GC/MS) whereby the light fraction was composed of a wide range of lower polarity compounds while middle and heavy fraction had higher polarity compounds.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 15833-61-1, molecular formula is C5H10O2, introducing its new discovery. 15833-61-1

LINOLEIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION OR FOOD COMPOSITION COMPRISING SAID LINOLEIC ACID DERIVATIVES, AND THEIR USES

This invention relates to linoleic acid derivative of Formula (I) below comprising a hydrophobic part C17H31 linked to a polar head part “A”: wherein said polar head part A is selected from A1 to A4 below: wherein R1 and R2 are independently selected from the group composed of H or a saturated or unsaturated, straight or branched alkyl group containing 1 to 8 carbon atoms, or R1 and R2 are linked together to form a divalent radical of formula -R1-R2-, wherein -R1-R2- is preferably -CH2-CH2- or-(CH2)3-; R3 is independently selected from the group composed of:

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem