Category: Tetrahydrofurans

Sasidharan, Sreeja; Pochinda, Simon; Elgaard-Joergensen, Paninnguaq Naja; Rajamani, Sudha; Khandelia, Himanshu; Raghunathan, V. A. published the artcile< Interaction of the mononucleotide UMP with a fluid phospholipid bilayer>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is mononucleotide uridine monophosphate phospholipid cryogenic SEM.

Interaction between mononucleotides and lipid membranes is believed to have played an important role in the origin of life on Earth. Studies on mononucleotide-lipid systems hitherto have focused on the influence of the lipid environment on the organization of the mononucleotide mols., and the effect of the latter on the confining medium has not been investigated in detail. We have probed the interaction of the mononucleotide, UMP (UMP), and its disodium salt (UMPDSS) with fluid dimyristoylphosphatidylcholine (DMPC) membranes, using small-angle X-ray scattering (SAXS), cryogenic SEM (cryo-SEM) and computer simulations. UMP adsorbs and charges the lipid membrane, resulting in the formation of unilamellar vesicles in dilute solutions Adsorption of UMP reduces the bilayer thickness of DMPC. UMPDSS has a much weaker effect on interbilayer interactions. These observations are in very good agreement with the results of an all-atom mol. dynamics simulation of these systems. In the presence of counterions, such as Na+, UMP forms small aggregates in water, which bind to the bilayer without significantly perturbing it. The phosphate moiety in the lipid headgroup is found to bind to the hydrogens from the sugar ring of UMP, while the choline group tends to bind to the two oxygens from the nucleotide base. These studies provide important insights into lipid-nucleotide interactions and the effect of the nucleotide on lipid membranes.

Soft Matter published new progress about Boltzmann constant. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ruan, Luna; Zhang, Huan; Zhou, Man; Zhu, Lihua; Pei, An; Wang, Jiexiang; Yang, Kai; Zhang, Chuanqun; Xiao, Suqun; Chen, Bing Hui published the artcile< A highly selective and efficient Pd/Ni/Ni(OH)2/C catalyst for furfural hydrogenation at low temperatures>, Quality Control of 97-99-4, the main research area is furfural hydrogenation nickel palladium carbon nanocatalyst furfuryl alc.

Hydrogenation of furfural (FF) produces a train of products such as furfuryl alc. (FFA), tetrahydrofurfuryl alc. (THFFA) and 2-methylfuran (2-MF). The Pd/Ni/Ni(OH)2/C nanocatalyst was successfully prepared under mild conditions by hydrazine hydrate reduction and galvanic replacement methods. Pd/Ni/Ni(OH)2/C had much higher conversion of furfural and selectivity toward furfuryl alc. for the selective hydrogenation of furfural than the monometallic catalysts (eg. Pd/C or Ni/C) due to its unique nanostructure of palladium island-on-Ni/Ni(OH)2 nanoparticles and thus the synergy effect between Pd, Ni and Ni(OH)2 related species. The proposed mechanism of the synergistic effect was also provided. Pd/Ni/Ni(OH)2/C showed high selectivity (90.0% or 92.4%) to furfuryl alc. at quite low reaction temperatures (5°C or 10°C), and had good stability. We used various characterization techniques (XRD, HRTEM, STEM-EDS elemental mapping and line-scanning, XPS, HS-LEIS) to compare the nanostructural differences between the monometallic and bimetallic catalysts as well as to explain the possible reasons for the superior performance of Pd/Ni/Ni(OH)2/C to corresponding monometallic catalysts.

Molecular Catalysis published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Quality Control of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Weerachawanasak, Patcharaporn; Krawmanee, Pacharaporn; Inkamhaeng, Weerachat; Cadete Santos Aires, Francisco J.; Sooknoi, Tawan; Panpranot, Joongjai published the artcile< Development of bimetallic Ni-Cu/SiO2 catalysts for liquid phase selective hydrogenation of furfural to furfuryl alcohol>, Application of C5H10O2, the main research area is development bimetallic nickel copper SiO2 catalyst liquid hydrogenation furfural.

Bimetallic Ni-Cu/SiO2 catalysts with different Cu loading (2-5 wt%) were developed for liquid phase selective hydrogenation of furfural to furfuryl alc. Among these, bimetallic 2%Ni-X%Cu/SiO2 (X = 2, 5) catalysts exhibited better catalytic performances than monometallic 2%Ni/SiO2 and 2%Cu/SiO2. Moreover, the bimetallic 2%Ni-5%Cu/SiO2 catalyst showed the best catalytic performance with 94% of furfural conversion and 64% of furfuryl alc. selectivity. The synergetic effect of NiCu alloy particles that are present on bimetallic Ni-Cu/SiO2 catalysts change the adsorption configuration of furfural on the catalyst surface resulting in high catalytic performance in liquid phase selective hydrogenation of furfural to furfuryl alc.

Catalysis Communications published new progress about Hydrogenation catalysts. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wappes, Ethan A.; Vanitcha, Avassaya; Nagib, David A. published the artcile< β C-H di-halogenation via iterative hydrogen atom transfer>, SDS of cas: 5455-94-7, the main research area is geminal dihalide regioselective preparation; imidate preparation photochem tandem dihalogenation hydrogen transfer.

A radical relay strategy for mono- and di-halogenation (iodination, bromination, and chlorination) of sp3 C-H bonds was developed. This is the first example of β C-H di-halogenation is achieved through sequential C-H abstraction by iterative, hydrogen atom transfer (HAT). A double C-H functionalization was enabled by in-situ generated imidate radicals, which facilitate selective N to C radical translocation and tunable C-X termination. The versatile, geminal di-iodide products were further elaborated to β ketones and vinyl iodides. Mechanistic experiments explained the unique di-functionalization selectivity of this iterative HAT pathway, wherein the second C-H iodination is twice as fast as the first.

Chemical Science published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, SDS of cas: 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Dwivedi, Sumant; Nag, Aniruddha; Sakamoto, Shigeki; Funahashi, Yasuyoshi; Harimoto, Toyohiro; Takada, Kenji; Kaneko, Tatsuo published the artcile< High-temperature resistant water-soluble polymers derived from exotic amino acids>, HPLC of Formula: 4415-87-6, the main research area is temperature resistant water soluble polyimide preparation.

High-performance water-soluble polymers have a wide range of applications from engineering materials to biomedical plastics. However, existing materials are either natural polymers that lack high thermostability or rigid synthetic polymers. Therefore, we design an amino acid-derived building block, 4,4′-diamino-α-truxillate dianion (4ATA2-), that induces water solubility in high-performance polymers. Polyimides containing 4ATA2- units are intrinsically water-soluble and are processed into films cast from an aqueous solution The resulting polyimide films exhibit exceptional transparency and extremely high thermal stability. In addition, the films can be made insoluble in water by simple post-treatment using weak acid or multivalent metal ions such as calcium. The synthesized polyimide’s derived from bio-based resources are useful for yielding waterborne polymeric high-performance applications.

RSC Advancespublished new progress about Elongation at break. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, HPLC of Formula: 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brandao, Tiago A. S.; Richard, John P. published the artcile< Orotidine 5'-monophosphate decarboxylase: The operation of active site chains within and across protein subunits>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is orotidine monophosphate decarboxylase Saccharomyces active site subunit substrate.

The D37 and T100′ side chains of orotidine 5′-monophosphate decarboxylase (OMPDC) interact with the C-3′ and C-2′ ribosyl hydroxyl groups, resp., of the bound substrate. We compare the intra-subunit interactions of D37 with the inter-subunit interactions of T100′ by determining the effects of the D37G, D37A, T100’G, and T100’A substitutions on the following: (a) kcat and kcat/Km values for the OMPDC-catalyzed decarboxylations of OMP and 5-fluoroorotidine 5′-monophosphate (FOMP) and (b) the stability of dimeric OMPDC relative to the monomer. The D37G and T100’A substitutions resulted in 2 kcal mol-1 increases in ΔG† for kcat/Km for the decarboxylation of OMP, while the D37A and T100’G substitutions resulted in larger 4 and 5 kcal mol-1 increases, resp., in ΔG†. The D37G and T100’A substitutions both resulted in smaller 2 kcal mol-1 decreases in ΔG† for the decarboxylation of FOMP compared to that of OMP. These results show that the D37G and T100’A substitutions affect the barrier to the chem. decarboxylation step while the D37A and T100’G substitutions also affect the barrier to a slow, ligand-driven enzyme conformational change. Substrate binding induces the movement of an α-helix (G’98-S’106) toward the substrate C-2′ ribosyl hydroxy bound at the main subunit. The T100’G substitution destabilizes the enzyme dimer by 3.5 kcal mol-1 compared to the monomer, which is consistent with the known destabilization of α-helixes by the internal Gly side chains [Serrano, L., et al. (1992) Nature, 356, 453-455]. We propose that the T100’G substitution weakens the α-helical contacts at the dimer interface, which results in a decrease in the dimer stability and an increase in the barrier to the ligand-driven conformational change.

Biochemistrypublished new progress about Conformational transition. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sornkamnerd, Saranyoo; Sasaki, Shuhei; Mitsumata, Tetsu; Takada, Kenji; Okada, Tomohiro; Ando, Shinji; Kaneko, Tatsuo published the artcile< Orientation Analysis of Polymer Chains in Optically Transparent Biopolyimides Having Rigid and Bending Backbones>, Quality Control of 4415-87-6, the main research area is optically transparent biopolyimide polymer chain orientation.

Optically transparent and heat-resistant polymer films are useful in the field of organic glasses usable for elec. insulators for panels, windows, optical devices, etc. A series of biopolyimides having non-π-conjugated backbones prepared using a renewable diamine, 4,4′-diaminotruxillic acid di-Me esters, and various dianhydride monomers were prepared and cast onto substrates to form transparent films with high heat resistances and good elec. resistance. The second order orientation coefficients (P200) of the biopolyimide films were evaluated by polarized attenuated total reflection Fourier-transform IR spectroscopy, and the P200 values for the C-N stretching vibrations at a wavenumber of 1365 cm-1 displayed a good correlation with that for the aromatic C-C stretching at 1510 cm-1, regardless of the dianhydride structure. The in-plane/out-of-plane birefringence and coefficients of linear thermal expansion exhibited strong correlations with P200 except for those of a few samples. Most of the biopolyimide films exhibited good transparencies with low birefringence and high elec. resistance, which are applicable to flexible substrates with a low coefficient of thermal expansion for panel displays.

ChemistrySelectpublished new progress about Birefringence. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Quality Control of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xie, Chun-yan; Wang, Qinhua; Li, Guanya; Fan, Zhiyong; Wang, Hong; Wu, Xin published the artcile< Dietary supplement with nucleotides in the form of uridine monophosphate or uridine stimulate intestinal development and promote nucleotide transport in weaned piglets>, Quality Control of 58-97-9, the main research area is piglet UMP uridine dietary supplement intestine development nucleotide transport; intestinal development; uridine; uridine monophosphate; weaned piglets.

BACKGROUND : Nucleotides are key constituents of milk, where they are utilized in cell replication, although there are limited studies for weaned piglets. This study evaluated the effects of uridine monophosphate (UMP) with uridine (UR) feed supplementation on the intestinal development and nucleotide transport in weaned piglets. RESULTS : Supplementation with UMP significantly increased (P ≤ 0.05) plasma glucose, and UR supplementation significantly reduced (0.05 ≤ P ≤ 0.10) the plasma total cholesterol (TC) of piglets when compared with that of the control group, although non-significant difference (P ≥ 0.05) in growth performance was observed among three groups. Piglets fed supplementary UR exhibited greater (P ≤ 0.05) crypt depth in the duodenum and ileum when compared with those in the supplementary UMP and control groups. Real-time quant. polymerase chain reaction (RT-qPCR) results revealed that UR supplementation increased (P ≤ 0.05) the relative mRNA levels of genes encoding the transmembrane proteins ZO-1 and occludin in the duodenum mucosa, and ZO-1 in the jejunum mucosa (P ≤ 0.05). Similarly, UR supplementation increased (P ≤ 0.05) expression of solute carriers SLC28A1 and SLC29A1 in the duodenum mucosa. Conversely, claudin-1 expression in the duodenum mucosa was inhibited (P ≤ 0.05) by dietary supplementation with UMP or UR. CONCLUSION : Collectively, our data indicated that dietary supplementation with UMP or UR was conducive to stimulating intestinal development and promoting nucleotide transport in weaned piglets.

Journal of the Science of Food and Agriculturepublished new progress about Body weight. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Quality Control of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chung, Sang J.; Chung, Suhman; Lee, Hyun Soo; Kim, Eun-Jung; Oh, Kyung Seok; Choi, Hyuk Soon; Kim, Kwang S.; Kim, Yeoun Jin; Hahn, Jong Hoon; Kim, Dong H. published the artcile< Mechanistic Insight into the Inactivation of Carboxypeptidase A by α-Benzyl-2-oxo-1,3-oxazolidine-4-acetic Acid, a Novel Type of Irreversible Inhibitor for Carboxypeptidase A with No Stereospecificity>, Product Details of C9H15NO4, the main research area is carboxypeptidase A inactivation oxazolidine derivative.

On the basis of the active site topol. and enzymic catalytic mechanism of carboxypeptidase A (CPA), a prototypical zinc-containing proteolytic enzyme, α-benzyl-2-oxo-1,3-oxazolidine-4-acetic acid (1), was designed as a novel type of mechanism-based inactivator of the enzyme. All four possible stereoisomers of the inhibitor were synthesized in an enantiomerically pure form starting with optically active aspartic acid, and their CPA inhibitory activities were evaluated to find that surprisingly all of the four stereoisomers inhibit CPA in a time dependent manner. The inhibited enzyme did not regain its enzymic activity upon dialysis. The inactivations were prevented by 2-benzylsuccinic acid, a competitive inhibitor that is known to bind the active site of the enzyme. These kinetic results strongly support that the inactivators attach covalently to the enzyme at the active site. The anal. of ESI mass spectral data of the inactivated CPA ascertained the conclusion from the kinetic results. The values of second-order inhibitory rate constants (kobs/[I]o) fall in the range of 1.7-3.6 M-1 min-1. The lack of stereospecificity shown in the inactivation led us to propose that the ring cleavage occurs by the nucleophilic attack at the 2-position rather than at the 5-position and the ring opening takes place in an addition-elimination mechanism. The tetrahedral transition state that would be generated in this pathway is thought to be stabilized by the active site zinc ion, which was supported by the PM3 semiempirical calculations In addition, α-benzyl-2-oxo-1,3-oxazolidine-5-acetic acid (18), a structural isomer of 1 was also found to inactivate CPA in an irreversible manner, reinforcing the nucleophilic addition-elimination mechanism. The present study demonstrates that the transition state for the inactivation pathway plays a critical role in determining stereochem. of the inactivation.

Journal of Organic Chemistrypublished new progress about Enzyme inhibition kinetics. 137105-97-6 belongs to class tetrahydrofurans, and the molecular formula is C9H15NO4, Product Details of C9H15NO4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Vlasova, Nataliya; Markitan, Olga published the artcile< Phosphate-nucleotide-nucleic acid: Adsorption onto nanocrystalline ceria surface>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is cerium dioxide deoxyribonucleic acid phosphate nucleotide.

The adsorption of DNA (DNA) and its constituents – phosphate and nucleotides on the surface of nanocrystalline cerium dioxide (pHpzc = 6.3) in NaCl solutions was investigated using multi batch adsorption experiments over a wide range pH. The adsorption data of inorganic phosphate, and nucleotides were interpreted as a formation of outer and inner sphere surface complexes in term of the Basic Stern surface complexation model. The comparison of adsorptions of DNA, phosphate and nucleotides has revealed that double-stranded DNA is mainly adsorbed with the participation of phosphate backbone of its mol. The approach of DNA to the oxide surface due to the electrostatic attraction promotes other types of interaction, e.g. dispersion interaction and hydrogen bonding.

Colloids and Surfaces, A: Physicochemical and Engineering Aspectspublished new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem