Category: Tetrahydrofurans

Harrison, Carrie-Ann; Jackson, P. Mark; Moody, Christopher J.; Williams, Jonathan M. J. published the artcile< Cyclopenta[b]indoles. Part 2. Model studies towards the tremorgenic mycotoxins>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is cyclopentaindole; tremorgenic mycotoxin cyclopentindole.

The 7-bromocyclopenta[b]indole I has been converted into the hydroxybutenyl derivatives and a tetrahydrofuranylidene derivative in model studies towards the elaboration of paspalitrem and lolitrem type side chains. In a parallel approach, the cyclopentapyrrole II was converted into the fused α-pyrone III which acted as a pyrrole-2,3-quinodimethane, and underwent Diels-Alder reaction to give, after loss of carbon dioxide, the cyclopentaindoles, e.g. IV.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Indole alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Verevkin, Sergey P.; Siewert, Riko; Pimerzin, Andrey A. published the artcile< Furfuryl alcohol as a potential liquid organic hydrogen carrier (LOHC): Thermochemical and computational study>, HPLC of Formula: 97-99-4, the main research area is furfuryl alc liquid organic hydrogen carrier thermochem hydrogenation dehydrogenation.

The liquid organic H carriers (LOHCs) are considered as a promising materials for H storage. The liquid phase standard molar enthalpies of formation of furfuryl alc. and tetrahydrofurfuryl alc. were obtained from high-precision combustion calorimetry. Their standard molar enthalpies of vaporization were derived from the vapor pressure temperature dependences measured by the transpiration method. Gas phase molar enthalpies of formation of furfuryl alc. and tetrahydrofurfuryl alc. calculated by the high-level quantum-chem. method G4, were in an excellent agreement with the exptl. results. Reaction enthalpies and equilibrium temperature of the hydrogenation/dehydrogenation reactions of furfuryl alc. were calculated and compared with the data for furan and other potential liquid organic H carriers.

Fuel published new progress about Alcohols Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, HPLC of Formula: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nardelli, Silvia; Riggio, Oliviero; Rosati, Davide; Gioia, Stefania; Farcomeni, Alessio; Ridola, Lorenzo published the artcile< Hepatitis C virus eradication with directly acting antivirals improves health-related quality of life and psychological symptoms.>, Synthetic Route of 58-97-9, the main research area is Alexithymia; Depression; Directly acting antivirals; Health related quality of life; Hepatitis C virus; State and trait anxiety.

BACKGROUND: Alterations in health-related quality of life (HRQoL) and neuropsychological disorders were described in the hepatitis C virus (HCV) patients. Although several studies investigated the modifications of HRQoL after HCV eradication, no data exists on the modifications of neuropsychological symptoms. AIM: To investigate the effect of directly acting antivirals (DAAs) treatment on HRQoL and neuropsychological symptoms. METHODS: Thirty nine patients with HCV infection underwent a neuropsychological assessment, including Zung-Self Depression-Rating-Scale, Spielberg State-Trait Anxiety Inventory Y1-Y2 and the Toronto-Alexithymia Scale-20 items before and after DAAs treatment. HRQoL was detected by Short-Form-36 (SF-36). RESULTS: All HRQoL domains, but role limitation physical and bodily pain, significantly improved after treatment. Interestingly, after DAAs treatment, all domains of HRQoL returned similar to those of controls. Each neuropsychological test significantly improved after HCV eradication. A significant correlation was observed among each psychological test and the summary components of SF-36. At multiple linear regression analysis including each psychological test as possible covariates, Zung-Self Depression Rating Scale (Zung-SDS) score was independently and significantly related to summary components of the SF-36 in the basal state and the difference between Zung-SDS score before and after treatment was the only variable significantly and independently related to the modification of HRQoL induced by the treatment. CONCLUSION: Neuropsychological symptoms strongly influenced HRQoL in HCV patients and there was a significant improvement of neuropsychological tests and HRQoL after DAAs treatment.

World journal of gastroenterology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Garavagno, Maria de los A.; Hernandez, Federico J.; Jara-Toro, Rafael A.; Mahecha, Genesys; Barrera, Javier A.; Taccone, Raul A.; Pino, Gustavo A. published the artcile< Rate coefficient and mechanism of the OH-initiated degradation of cyclobutanol: A combined experimental and theoretical study>, Application of C5H10O2, the main research area is cyclobutanol OH initiated degradation rate coefficient exptl theor study.

The degradation process of cyclobutanol (cButOH) by hydroxyl radical (OH), under atm. conditions, (750 ± 10) Torr of air and (296 ± 2) K, has been studied. The rate coefficient for the title reaction (k296K = (7.3 ± 0.6) x 10-12 cm3 mol.-1 s-1) was determined at 296 K by the conventional relative-rate method. Electronic structure calculations with uCCSD(T)/uBHandHLYP/aug-cc-PVDZ were conducted to study the reaction mechanism. The global rate coefficient was also calculated using the transition state theory with tunneling corrections, obtaining a value of 5.4 x 10-12 cm3 mol.-1 s-1 in agreement with the exptl. determination Addnl., reaction products identification in clean and NOx-contaminated atmospheres was performed for the first time. The identified reaction products and their corresponding yields (YP) depend on the environment composition in which the reaction is studied. In the absence of NOx, cyclobutanone (cButanone) was the only identified product, with YcButanone = (0.66 ± 0.08). In NOx-contaminated atmospheres, in addition to cButanone, THF (THF), 2-nitro-1-butanol (2N1B), 3-nitro-2-butanol (3N2B) and 2-methyl-2-nitro-1-propanol (2M2N1P), were also identified as primary reaction products. Under this condition, we were able to determine only the yields of cButanone and THF (YcButanone = 0.38 ± 0.05 and YTHF = 0.28 ± 0.02). A likely reaction mechanism for the observed products is proposed and the atm. implications are discussed.

Atmospheric Environment published new progress about Alcohols, nitro Role: POL (Pollutant), OCCU (Occurrence). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Meng, Xiaoyu; Wang, Lei; Chen, Lifang; Xu, Ming; Liu, Ning; Zhang, Junbo; Yang, Yusen; Wei, Min published the artcile< Charge-separated metal-couple-site in NiZn alloy catalysts towards furfural hydrodeoxygenation reaction>, Reference of 97-99-4, the main research area is nickel zinc alloy catalyst furfural hydrodeoxygenation reaction.

Catalytic conversion of biomass furfural (FAL) to high value-added products (e.g., 2-methylfuran, MF) has attracted considerable attention, in which control over catalytic selectivity plays a crucial issue. Herein, a series of heterogonous NiZn alloy supported on the mixed metal oxides (MMO) were synthesized derived from layered double hydroxides (LDHs) with various Ni/Zn ratio (3/1, 1/1 or 1/3). XRD, HRTEM and XAFS measurements confirm that with the increase of Zn content, the corresponding NiZn alloy transforms from α-NiZn to β-NiZn. Dramatically, the selectivity of MF displays an improvement from 12% to 95% along with this phase transformation process; and the MF yield reaches to 95% over Ni1Zn3-MMO sample. A combination study including XPS, CO-DRIFTS, in situ FT-IR and DFT calculation verifies that metallic Ni serves as active site, resulting in an effective suppression of side reactions. Moreover, a charge-separated metal-couple-site (Niδ–Znδ+) is on the surface of Ni1Zn3-MMO originating from electron transfer between Ni and Zn. This active structure stabilizes a η2(C, O) adsorption configuration of intermediate, in which C atom is bonded to the Niδ- site and O atom is attached to the Znδ+ site. This work provides an efficient and cost-effective catalyst that can simultaneously inhibit C=C hydrogenation and promote C-O cleavage, which would be potentially used in catalytic conversion of biomass-derived platform mols.

Journal of Catalysis published new progress about Adsorption energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

El-Baraky, Iman A.; Abbassi, Maggie M.; Ebeid, Fatma S.; Hassany, Mohamed; Sabry, Nirmeen A.; El-Sayed, Manal H. published the artcile< Beta-thalassemia major alters sofosbuvir/ledipasvir exposure in Hepatitis C virus infected adolescent patients>, Formula: C9H13N2O9P, the main research area is beta thalassemia major sofosbuvir ledipasvir Hepatitis C virus; Hepatitis C virus; Ledipasvir; Pharmacokinetics; Sofosbuvir; Thalassemia.

Hepatitis C virus (HCV) infected adolescents with beta-thalassemia major (BTM) are considered a potential population for HCV micro-elimination model development where BTM may neg. impact the pharmacokinetic exposure parameters of sofosbuvir/ledipasvir (SOF/LED).The study aimed at studying the effect of BTM on SOF/LED and SOF metabolite (GS-331007) pharmacokinetics.A prospective, controlled study recruiting BTM and control HCV infected adolescents (Clinicaltrials.gov identifier-NCT04353986). Pharmacokinetic exposure to GS-331007 and LED was the primary pharmacokinetic outcome. No-effect boundaries were set to 90confidence interval (CI) of exposure geometric mean ratio (GMR) within 70-143. Dose suitability was based on the 90CI of exposure GMR within 50-200compared to adults. The percentage of patients achieving sustained virol. response 12 wk post-treatment (SVR12) was the primary efficacy endpoint.Thirteen patients were enrolled per study group. All patients were included in the pharmacokinetic anal. (n=26). BTM patients showed lower GS-331007 and LED exposure that could, resp., be as low as 45.4and 36.1compared to their control group. GS-331007 exposure in BTM patients was nearly half (56.8, 90CI 45.3-71.2) that observed in adults. Despite that low drug exposure in 46.2of BTM patients may alert dose unsuitability, they achieved SVR12. Moreover, patients with total bilirubin ≥1.93 mg/dL were predicted to have low GS-331007 exposure (0.913 receiver operating characteristic area under the curve with sensitivity and specificity >80).The identified systematically lower drug exposure in BTM patients might partially explain relapses or treatment failures among BTM patients reported in other studies. BTM may be a hurdle towards implementing HCV micro-elimination model that may necessitate dose-adjustment.

Clinics and Research in Hepatology and Gastroenterology published new progress about Geometric phase. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Formula: C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Mironenko, R. M.; Belskaya, O. B.; Likholobov, V. A. published the artcile< Solvent effect on the rate and direction of furfural transformations during hydrogenation over the Pd/C catalyst>, Category: tetrahydrofurans, the main research area is furfural palladium catalyst hydrogenation kinetics solvent effect.

The rate and directions of transformations during the liquid-phase hydrogenation of furfural with mol. hydrogen in the presence of the 5%Pd/C catalyst (at 423 K, 3 MPa) depend substantially on the chem. nature of the solvent. The main products of the catalytic transformations in alcs. are alkyl furyl ethers. Hydrogenation in solvent environment of aromatic hydrocarbons and 1,4-dioxane (nonpolar solvents), as well as in Et acetate and DMF (polar aprotic solvents) leads to the predominant formation of furfuryl alc., and its highest selectivity (up to 92%) is achieved with the use of DMF.

Russian Chemical Bulletin published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Zhi-Xin; Wei, Xian-Yong; Yang, Zheng; Li, Jun; Yan, Wei-Wei; Bie, Lei-Lei; Zhang, Yang-Yang; Li, Sheng; Zong, Zhi-Min published the artcile< Selective hydrogenation of bio-based furfural over Co-based catalysts derived from zeolitic imidazolate frame materials>, Name: (Tetrahydrofuran-2-yl)methanol, the main research area is hydrogenation bio furfural cobalt catalyst zeolitic imidazolate frame.

Co-Zn/NC was prepared by a sacrificial template self-reduction method with zeolitic imidazolate frame-8 (ZIF-8) impregnating the Co2+ as the precursor. At 125°C for 2.5 h, furfural was completely converted to furan-2-ylmethanol (FM) over Co17Zn/NC600, while FM selectivity over Co/NC600 is only 70.6%. According to multiple characterizations, Co17Zn/NC600 (Co loading 17%, calcined at 600°C) consists of flower-like spherical Co3ZnC nanoparticles (NPsCo3ZnC) uniformly distributed on its surface. The NPsCo3ZnC are the main active ingredients for highly selective furfural hydrogenation to FM, which is confirmed by furfural hydrogenation over Co-Zn/NC prepared with different Co loadings and different calcination temperatures The excellent activity and stability of Co17Zn/NC600 were confirmed by recycling experiment and furfural conversion is still above 90% after repeated use of Co17Zn/NC600 for 8 cycles.

Molecular Catalysis published new progress about Binding energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Date, Nandan S.; Hengne, Amol M.; Huang, K.-W.; Chikate, Rajeev C.; Rode, Chandrashekhar V. published the artcile< One pot hydrogenation of furfural to 2-methyl tetrahydrofuran over supported mono- and bi-metallic catalysts>, Computed Properties of 97-99-4, the main research area is iron nickel metallic hydrogenation catalyst furfural methyl THF.

2-Methyltetrahydrofuran is a valuable com. product that can be obtained by direct hydrogenation of furfural. In the present study, among several carbon supported bimetallic Ir-Ni catalysts with different loadings screened, 4% Ir-4% Ni/C catalyst showed excellent activity in terms of direct conversion (99%) to 2-MeTHF with a maximum selectivity of ∼74% at 220°C and 750 psig, suppressing the formation of side chain as well as ring opening products. The catalytic activity was found to be mainly affected by catalyst preparation methods, metal loadings, surface composition, temperature, pressure and catalyst loading. HR-TEM and STEM revealed well dispersed Ir-Ni NPs having the particle sizes in the range of 2 to 5 nm. Different phases of Ir i. e. Ir° and IrO2 as well as oxygen vacancies were found to be responsible for hydrogenation of furfural to 2-Me furan while, Ni° and NiO were responsible for further hydrogenation to 2-MeTHF. The synergic effect between Ir and Ni was established through XPS, H2-TPR anal. With the help of some control experiments, the plausible reaction pathway was also proposed. The catalyst prepared by co-impregnation method found more effective than prepared by sequential addition method. At lower Ni loadings of 1% and 2%, low temperature of 160°C as well as at low H2 pressure of 250 psig, mixture of furfuryl alc. and 2-Me furan were formed selectively. Catalyst could be successfully reused up to 3 times without leaching of metals.

ChemistrySelect published new progress about Charcoal Role: CAT (Catalyst Use), PRP (Properties), USES (Uses). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Computed Properties of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Behairy, Behairy E.; El-Araby, Hanaa A.; El-Guindi, Mohamed A.; Basiouny, Hosam-Eldin M.; Fouad, Ola A.; Ayoub, Bassam A.; Marei, Ayman M.; Sira, Mostafa M. published the artcile< Safety and Efficacy of 8 Weeks Ledipasvir/Sofosbuvir for Chronic Hepatitis C Genotype 4 in Children Aged 4-10 Years>, Computed Properties of 58-97-9, the main research area is ledipasvir sofosbuvir antiviral agent hepatitis C virus infection; children; direct-acting antiviral drugs; efficacy; hepatitis C virus; ledipasvir; safety; sofosbuvir.

To evaluate the safety and efficacy of shortened 8-wk regimen of ledipasvir/sofosbuvir (LED/SOF) combination therapy in treatment-naive children without cirrhosis aged 4-10 years of age with chronic hepatitis C virus (HCV) infection. This observational single arm prospective study included 30 treatment-naive children (20 males) with proved chronic HCV fulfilling inclusion criteria. Their body weights ranged from 17 to 26 kg. All the included children received a single oral dose of LED/SOF 45/200 mg for 8 wk. Body weight, HCV-RNA, complete blood count, and liver function tests were monitored at 0, 2, 4, and 8 wk and sustained virol. response was evaluated after 12 wk after treatment (SVR12). The emergence of any side effects was also monitored. The most common risk factor (53.3%) was an parent or sibling with HCV infection. Twenty-nine patients (96.7%) were neg. for HCV-RNA by week 2 of treatment and 1 patient became neg. by week 4. The end of treatment response and SVR12 were 100%. Transaminases levels declined and returned to normal levels by week 2. Major side effects were fatigue in 90% (27/30) and headache in 76.7% (23/30). Side effects were minimal, tolerable, and did not interfere with daily activity or necessitate treatment discontinuation. A shortened 8-wk regimen of LED/SOF (45/200 mg) is safe and effective with 100% SVR12 in treatment-naive children with cirrhosis aged 4-10 years with chronic HCV infection genotype 4.

Journal of Pediatrics (New York, NY, United States) published new progress about Antiviral agents. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Computed Properties of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem