Category: Tetrahydrofurans

Falcao, Fatima; Lopes, Carla; Viegas, Erica; Perez, Rita; Aldir, Isabel; Farinha, Helena; Carvalho, Antonio; Mirco, Ana; Marques, Susana; Costa, Tiago Bana E.; Miranda, Ana Claudia; Lebre, Luis; Peixe, Paula; Chagas, Cristina; Mansinho, Kamal; Correia, Jose Manuel published the artcile< Experience of a Portuguese center: effectiveness of direct-acting antiviral therapy for hepatitis C>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is Antiviral Agents/therapeutic use; Hepacivirus/drug effects; Hepatitis C/drug therapy; Portugal.

Introduction: In late 2014, Portugal implemented a national program for the treatment of patients with chronic hepatitis C with directacting antiviral agents. This program has made Portugal one of the first European countries to implement a structured measure of treatment to eliminate this serious public health problem. The aim of this study was to assess the effectiveness of direct-acting antiviral therapy in the treatment of patients with chronic hepatitis C virus infection. Material and Methods: A retrospective observational study was conducted at Centro Hospitalar de Lisboa Ocidental on the national online platform from Dec. 2014 until Feb. 2017 and included patients with hepatitis C virus infection who underwent treatment. The primary endpoint was sustained virol. response at least 12 wk post treatment. Data was analyzed with the SPSS 17.0 program. Results: During the study period, 820 patients completed therapy and achieved sufficient follow-up time to assess sustained virol. response with an overall response rate of 97.2% (n = 797) and a response rate of 98.0%, 99.5%, 90.9%, 95.1% and 94.2% for genotypes 1a, 1b, 2, 3 and 4, resp. Data suggested that advanced fibrosis (F3/F4), human immunodeficiency virus co-infection and treatment failure with interferon and ribavirin were not neg. related with sustained virol. response in our population. Most patients (80.1%) completed treatment with ledipasvir/sofosbuvir ± ribavirin. The most common adverse events were fatigue and insomnia followed by headache and weight loss. Discussion: Patients predominantly had genotype 1 infection which correlates with HCV distribution in Europe, but we found a major proportion in genotype 4 which can be explained by immigration from African countries. Our patients’ ages ranging from 22 to 90 years, reflected a new approach with no upper age limit. Direct-acting antivirals regimens resulted in remarkably high SVR rates compared to interferon-based regimens, which were consistent with clin. trials data. Conclusion: Our data showed that direct-acting antiviral-based regimens are safe and have a high success rate in the treatment of patients with hepatitis C virus infection in a real-world setting.

Acta Medica Portuguesa published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ryu, Incheol; Kim, Yoon Ki published the artcile< AU-rich element-mediated mRNA decay via the butyrate response factor 1 controls cellular levels of polyadenylated replication-dependent histone mRNAs>, Formula: C9H13N2O9P, the main research area is mRNA decay AU rich element BRF1 polyadenylated replication histone; ARE-mediated mRNA decay; ELAV like RNA binding protein 1 (ELAVL1); Hu antigen R (HuR); RNA; RNA degradation; RNA metabolism; RNA turnover; RNA-protein interaction; ZFP36 ring finger protein like 1 (ZFP36L1); butyrate response factor 1 (BRF1); histone mRNA biogenesis; mRNA stability; polyadenylation; posttranscriptional regulation; replication-dependent histone mRNA.

Replication-dependent histone (RDH) mRNAs have a nonpolyadenylated 3′-UTR that ends in a highly conserved stem-loop structure. Nonetheless, a subset of RDH mRNAs has a poly(A) tail under physiol. conditions. The biol. meaning of poly(A)-containing (+) RDH mRNAs and details of their biosynthesis remain elusive. Here, using HeLa cells and Western blotting, qRT-PCR, and biotinylated RNA pulldown assays, we show that poly(A)+ RDH mRNAs are post-transcriptionally regulated via adenylate- and uridylate-rich element-mediated mRNA decay (AMD). We observed that the rapid degradation of poly(A)+ RDH mRNA is driven by butyrate response factor 1 (BRF1; also known as ZFP36 ring finger protein-like 1) under normal conditions. Conversely, cellular stresses such as UV C irradiation promoted BRF1 degradation, increased the association of Hu antigen R (HuR; also known as ELAV-like RNA-binding protein 1) with the 3′-UTR of poly(A)+ RDH mRNAs, and eventually stabilized the poly(A)+ RDH mRNAs. Collectively, our results provide evidence that AMD surveils poly(A)+ RDH mRNAs via BRF1-mediated degradation under physiol. conditions.

Journal of Biological Chemistry published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Formula: C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Harrison, Carrie-Ann; Jackson, P. Mark; Moody, Christopher J.; Williams, Jonathan M. J. published the artcile< Cyclopenta[b]indoles. Part 2. Model studies towards the tremorgenic mycotoxins>, Reference of 5455-94-7, the main research area is cyclopentaindole; tremorgenic mycotoxin cyclopentindole.

The 7-bromocyclopenta[b]indole I has been converted into the hydroxybutenyl derivatives and a tetrahydrofuranylidene derivative in model studies towards the elaboration of paspalitrem and lolitrem type side chains. In a parallel approach, the cyclopentapyrrole II was converted into the fused α-pyrone III which acted as a pyrrole-2,3-quinodimethane, and underwent Diels-Alder reaction to give, after loss of carbon dioxide, the cyclopentaindoles, e.g. IV.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Indole alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Reference of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Verevkin, Sergey P.; Siewert, Riko; Pimerzin, Andrey A. published the artcile< Furfuryl alcohol as a potential liquid organic hydrogen carrier (LOHC): Thermochemical and computational study>, HPLC of Formula: 97-99-4, the main research area is furfuryl alc liquid organic hydrogen carrier thermochem hydrogenation dehydrogenation.

The liquid organic H carriers (LOHCs) are considered as a promising materials for H storage. The liquid phase standard molar enthalpies of formation of furfuryl alc. and tetrahydrofurfuryl alc. were obtained from high-precision combustion calorimetry. Their standard molar enthalpies of vaporization were derived from the vapor pressure temperature dependences measured by the transpiration method. Gas phase molar enthalpies of formation of furfuryl alc. and tetrahydrofurfuryl alc. calculated by the high-level quantum-chem. method G4, were in an excellent agreement with the exptl. results. Reaction enthalpies and equilibrium temperature of the hydrogenation/dehydrogenation reactions of furfuryl alc. were calculated and compared with the data for furan and other potential liquid organic H carriers.

Fuel published new progress about Alcohols Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, HPLC of Formula: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nardelli, Silvia; Riggio, Oliviero; Rosati, Davide; Gioia, Stefania; Farcomeni, Alessio; Ridola, Lorenzo published the artcile< Hepatitis C virus eradication with directly acting antivirals improves health-related quality of life and psychological symptoms.>, Computed Properties of 58-97-9, the main research area is Alexithymia; Depression; Directly acting antivirals; Health related quality of life; Hepatitis C virus; State and trait anxiety.

BACKGROUND: Alterations in health-related quality of life (HRQoL) and neuropsychological disorders were described in the hepatitis C virus (HCV) patients. Although several studies investigated the modifications of HRQoL after HCV eradication, no data exists on the modifications of neuropsychological symptoms. AIM: To investigate the effect of directly acting antivirals (DAAs) treatment on HRQoL and neuropsychological symptoms. METHODS: Thirty nine patients with HCV infection underwent a neuropsychological assessment, including Zung-Self Depression-Rating-Scale, Spielberg State-Trait Anxiety Inventory Y1-Y2 and the Toronto-Alexithymia Scale-20 items before and after DAAs treatment. HRQoL was detected by Short-Form-36 (SF-36). RESULTS: All HRQoL domains, but role limitation physical and bodily pain, significantly improved after treatment. Interestingly, after DAAs treatment, all domains of HRQoL returned similar to those of controls. Each neuropsychological test significantly improved after HCV eradication. A significant correlation was observed among each psychological test and the summary components of SF-36. At multiple linear regression analysis including each psychological test as possible covariates, Zung-Self Depression Rating Scale (Zung-SDS) score was independently and significantly related to summary components of the SF-36 in the basal state and the difference between Zung-SDS score before and after treatment was the only variable significantly and independently related to the modification of HRQoL induced by the treatment. CONCLUSION: Neuropsychological symptoms strongly influenced HRQoL in HCV patients and there was a significant improvement of neuropsychological tests and HRQoL after DAAs treatment.

World journal of gastroenterology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Computed Properties of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Garavagno, Maria de los A.; Hernandez, Federico J.; Jara-Toro, Rafael A.; Mahecha, Genesys; Barrera, Javier A.; Taccone, Raul A.; Pino, Gustavo A. published the artcile< Rate coefficient and mechanism of the OH-initiated degradation of cyclobutanol: A combined experimental and theoretical study>, Related Products of 97-99-4, the main research area is cyclobutanol OH initiated degradation rate coefficient exptl theor study.

The degradation process of cyclobutanol (cButOH) by hydroxyl radical (OH), under atm. conditions, (750 ± 10) Torr of air and (296 ± 2) K, has been studied. The rate coefficient for the title reaction (k296K = (7.3 ± 0.6) x 10-12 cm3 mol.-1 s-1) was determined at 296 K by the conventional relative-rate method. Electronic structure calculations with uCCSD(T)/uBHandHLYP/aug-cc-PVDZ were conducted to study the reaction mechanism. The global rate coefficient was also calculated using the transition state theory with tunneling corrections, obtaining a value of 5.4 x 10-12 cm3 mol.-1 s-1 in agreement with the exptl. determination Addnl., reaction products identification in clean and NOx-contaminated atmospheres was performed for the first time. The identified reaction products and their corresponding yields (YP) depend on the environment composition in which the reaction is studied. In the absence of NOx, cyclobutanone (cButanone) was the only identified product, with YcButanone = (0.66 ± 0.08). In NOx-contaminated atmospheres, in addition to cButanone, THF (THF), 2-nitro-1-butanol (2N1B), 3-nitro-2-butanol (3N2B) and 2-methyl-2-nitro-1-propanol (2M2N1P), were also identified as primary reaction products. Under this condition, we were able to determine only the yields of cButanone and THF (YcButanone = 0.38 ± 0.05 and YTHF = 0.28 ± 0.02). A likely reaction mechanism for the observed products is proposed and the atm. implications are discussed.

Atmospheric Environment published new progress about Alcohols, nitro Role: POL (Pollutant), OCCU (Occurrence). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Herrera, C.; Fuentealba, D.; Ghampson, I. T.; Sepulveda, C.; Garcia-Fierro, J. L.; Canales, Roberto I.; Escalona, N. published the artcile< Selective conversion of biomass-derived furfural to cyclopentanone over carbon nanotube-supported Ni catalyst in Pickering emulsions>, Related Products of 97-99-4, the main research area is furfural hydrogenation cyclopentanone carbon nanotube nickel catalyst Pickering emulsion.

A well-characterized carbon nanotube-supported nickel catalyst (Ni/CNTox) was assembled at the liquid-liquid interface and evaluated for the conversion of furfural. The nanoparticles were found to be mainly distributed on the interface of the emulsion droplets, forming stable Pickering emulsion. Catalytic activity was studied under different reaction conditions to determine an optimal condition for the rearrangement of furfural to cyclopentanone, an important precursor to valuable chems. It was found that the highest furfural conversion (35%) and cyclopentanone yield (25%) was obtained at 200 oC, 2 MPa of H2 pressure, and with the same dodecane/water ratio after 1 h of reaction.

Catalysis Communications published new progress about Carbon nanotubes (catalyst support). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Meng, Xiaoyu; Wang, Lei; Chen, Lifang; Xu, Ming; Liu, Ning; Zhang, Junbo; Yang, Yusen; Wei, Min published the artcile< Charge-separated metal-couple-site in NiZn alloy catalysts towards furfural hydrodeoxygenation reaction>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is nickel zinc alloy catalyst furfural hydrodeoxygenation reaction.

Catalytic conversion of biomass furfural (FAL) to high value-added products (e.g., 2-methylfuran, MF) has attracted considerable attention, in which control over catalytic selectivity plays a crucial issue. Herein, a series of heterogonous NiZn alloy supported on the mixed metal oxides (MMO) were synthesized derived from layered double hydroxides (LDHs) with various Ni/Zn ratio (3/1, 1/1 or 1/3). XRD, HRTEM and XAFS measurements confirm that with the increase of Zn content, the corresponding NiZn alloy transforms from α-NiZn to β-NiZn. Dramatically, the selectivity of MF displays an improvement from 12% to 95% along with this phase transformation process; and the MF yield reaches to 95% over Ni1Zn3-MMO sample. A combination study including XPS, CO-DRIFTS, in situ FT-IR and DFT calculation verifies that metallic Ni serves as active site, resulting in an effective suppression of side reactions. Moreover, a charge-separated metal-couple-site (Niδ–Znδ+) is on the surface of Ni1Zn3-MMO originating from electron transfer between Ni and Zn. This active structure stabilizes a η2(C, O) adsorption configuration of intermediate, in which C atom is bonded to the Niδ- site and O atom is attached to the Znδ+ site. This work provides an efficient and cost-effective catalyst that can simultaneously inhibit C=C hydrogenation and promote C-O cleavage, which would be potentially used in catalytic conversion of biomass-derived platform mols.

Journal of Catalysis published new progress about Adsorption energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

El-Baraky, Iman A.; Abbassi, Maggie M.; Ebeid, Fatma S.; Hassany, Mohamed; Sabry, Nirmeen A.; El-Sayed, Manal H. published the artcile< Beta-thalassemia major alters sofosbuvir/ledipasvir exposure in Hepatitis C virus infected adolescent patients>, Electric Literature of 58-97-9, the main research area is beta thalassemia major sofosbuvir ledipasvir Hepatitis C virus; Hepatitis C virus; Ledipasvir; Pharmacokinetics; Sofosbuvir; Thalassemia.

Hepatitis C virus (HCV) infected adolescents with beta-thalassemia major (BTM) are considered a potential population for HCV micro-elimination model development where BTM may neg. impact the pharmacokinetic exposure parameters of sofosbuvir/ledipasvir (SOF/LED).The study aimed at studying the effect of BTM on SOF/LED and SOF metabolite (GS-331007) pharmacokinetics.A prospective, controlled study recruiting BTM and control HCV infected adolescents (Clinicaltrials.gov identifier-NCT04353986). Pharmacokinetic exposure to GS-331007 and LED was the primary pharmacokinetic outcome. No-effect boundaries were set to 90confidence interval (CI) of exposure geometric mean ratio (GMR) within 70-143. Dose suitability was based on the 90CI of exposure GMR within 50-200compared to adults. The percentage of patients achieving sustained virol. response 12 wk post-treatment (SVR12) was the primary efficacy endpoint.Thirteen patients were enrolled per study group. All patients were included in the pharmacokinetic anal. (n=26). BTM patients showed lower GS-331007 and LED exposure that could, resp., be as low as 45.4and 36.1compared to their control group. GS-331007 exposure in BTM patients was nearly half (56.8, 90CI 45.3-71.2) that observed in adults. Despite that low drug exposure in 46.2of BTM patients may alert dose unsuitability, they achieved SVR12. Moreover, patients with total bilirubin ≥1.93 mg/dL were predicted to have low GS-331007 exposure (0.913 receiver operating characteristic area under the curve with sensitivity and specificity >80).The identified systematically lower drug exposure in BTM patients might partially explain relapses or treatment failures among BTM patients reported in other studies. BTM may be a hurdle towards implementing HCV micro-elimination model that may necessitate dose-adjustment.

Clinics and Research in Hepatology and Gastroenterology published new progress about Geometric phase. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Electric Literature of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Mironenko, R. M.; Belskaya, O. B.; Likholobov, V. A. published the artcile< Solvent effect on the rate and direction of furfural transformations during hydrogenation over the Pd/C catalyst>, Electric Literature of 97-99-4, the main research area is furfural palladium catalyst hydrogenation kinetics solvent effect.

The rate and directions of transformations during the liquid-phase hydrogenation of furfural with mol. hydrogen in the presence of the 5%Pd/C catalyst (at 423 K, 3 MPa) depend substantially on the chem. nature of the solvent. The main products of the catalytic transformations in alcs. are alkyl furyl ethers. Hydrogenation in solvent environment of aromatic hydrocarbons and 1,4-dioxane (nonpolar solvents), as well as in Et acetate and DMF (polar aprotic solvents) leads to the predominant formation of furfuryl alc., and its highest selectivity (up to 92%) is achieved with the use of DMF.

Russian Chemical Bulletin published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem