Category: Tetrahydrofurans

de Castro, Sonia; Ferrer-Orta, Cristina; Mills, Alberto; Fernandez-Cureses, Gloria; Gago, Federico; Verdaguer, Nuria; Camarasa, Maria-Jose published the artcile< (F)uridylylated peptides linked to VPg1 of foot-and-mouth disease virus (FMDV): design, synthesis and X-ray crystallography of the complexes with FMDV RNA-dependent RNA polymerase>, Category: tetrahydrofurans, the main research area is furidylylated peptide complex VPg FMDV RNA Xray crystallog; 5-fluorouracil; RNA-dependent RNA polymerase; VPg; foot-and-mouth disease virus; uridylylation inhibition.

Foot-and-mouth disease virus (FMDV) is an RNA virus belonging to the Picornaviridae family that contains three small viral proteins (VPgs), named VPg1, VPg2 and VPg3, linked to the 5′-end of the viral genome. These VPg proteins act as primers for RNA replication, which is initiated by the consecutive binding of two UMP mols. to the hydroxyl group of Tyr3 in VPg. This process, termed uridylylation, is catalyzed by the viral RNA-dependent RNA polymerase named 3Dpol. 5-Fluorouridine triphosphate (FUTP) is a potent competitive inhibitor of VPg uridylylation. Peptide anal. showed FUMP covalently linked to the Tyr3 of VPg. This fluorouridylylation prevents further incorporation of the second UMP residue. The mol. basis of how the incorporated FUMP blocks the incorporation of the second UMP is still unknown. To investigate the mechanism of inhibition of VPg uridylylation by FUMP, we have prepared a simplified 15-mer model of VPg1 containing FUMP and studied its x-ray crystal structure in complex with 3Dpol. Unfortunately, the fluorouridylylated VPg1 was disordered and not visible in the electron d. maps; however, the structure of 3Dpol in the presence of VPg1-FUMP showed an 8 Å movement of the β9-α11 loop of the polymerase towards the active site cavity relative to the complex of 3Dpol with VPg1-UMP. The conformational rearrangement of this loop preceding the 3Dpol B motif seems to block the access of the template nucleotide to the catalytic cavity. This result may be useful in the design of new antivirals against not only FMDV but also other picornaviruses, since all members of this family require the uridylylation of their VPg proteins to initiate the viral RNA synthesis.

Molecules published new progress about Antiviral agents. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Walter, Patrick; Mechaly, Ariel; Bous, Julien; Haouz, Ahmed; England, Patrick; Lai-Kee-Him, Josephine; Ancelin, Aurelie; Hoos, Sylviane; Baron, Bruno; Trapani, Stefano; Bron, Patrick; Labesse, Gilles; Munier-Lehmann, Helene published the artcile< Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is allostery; cryo-EM single particle analysis; crystal structure; enzyme regulation; nucleotide metabolism.

Tuberculosis claims significantly more than one million lives each year. A feasible way to face the issue of drug resistance is the development of new antibiotics. Bacterial UMP (UMP) kinase is a promising target for novel antibiotic discovery as it is essential for bacterial survival and has no counterpart in human cells. The UMP kinase from M. tuberculosis is also a model of particular interest for allosteric regulation with two effectors, GTP (pos.) and UTP (neg.). In this study, using X-ray crystallog. and cryo-electron microscopy, we report for the first time a detailed description of the neg. effector UTP-binding site of a typical Gram-pos. behaving UMP kinase. Comparison between this snapshot of low affinity for Mg-ATP with our previous 3D-structure of the GTP-bound complex of high affinity for Mg-ATP led to a better understanding of the cooperative mechanism and the allosteric regulation of UMP kinase. Thermal shift assay and CD experiments corroborate our model of an inhibition by UTP linked to higher flexibility of the Mg-ATP-binding domain. These new structural insights provide valuable knowledge for future drug discovery strategies targeting bacterial UMP kinases.

FEBS Journal published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bergman, Ylva; Ciampini, Marisa; Jalal, Sania; Lagiakos, Helen Rachel; Aguilar, Marie-Isabel; Perlmutter, Patrick published the artcile< The synthesis of Fmoc-O-allyl β-serine>, Related Products of 137105-97-6, the main research area is serine beta allyl Fmoc protected synthesis diazomethane safety; allyl serine Boc protected Arndt Eistert homologation Seebach safety; aspartic acid tertbutoxycarbonyl protected allylation.

Two concise routes for the synthesis of the title amino acid have been developed. The first route employs Seebach’s general approach with Arndt Eistert homologation of Boc-O-allyl α-serine (Boc = tert-butoxycarbonyl) as the key process. The second route employs an approach using Boc-α-aspartic acid as a starting material with a selective palladium-catalyzed O-allylation as key processes. These two routes are evaluated for their relative efficiency and safety.

Tetrahedron: Asymmetry published new progress about Allylation. 137105-97-6 belongs to class tetrahydrofurans, and the molecular formula is C9H15NO4, Related Products of 137105-97-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ruan, Luna; Pei, An; Liao, Jianhua; Zeng, Li; Guo, Guangrong; Yang, Kai; Zhou, Qin; Zhao, Ning; Zhu, Lihua; Chen, Bing Hui published the artcile< Nitrogen-doped carbon nanotubes-supported PdNiCo nanoparticles as a highly efficient catalyst for selective hydrogenation of furfural>, Synthetic Route of 97-99-4, the main research area is furfural selective hydrogenation catalyst.

Nitrogen-doped carbon nanotubes (N-CNTs) was synthesized via covalent functionalization, and the monometallic (Pd/CNTs, Pd/N-CNTs), bimetallic (NiCo/CNTs, NiCo/N-CNTs, PdNi/CNTs, PdCo/CNTs, PdNi/N-CNTs, PdCo/N-CNTs) and trimetallic (PdNiCo/CNTs, PdNiCo/N-CNTs) catalysts were prepared by simple liquid chem. reduction The catalytic performance of as-obtained catalysts was evaluated by furfural hydrogenation. The properties of electron and surface active sites and nanostructures of as-prepared catalysts were characterized. And the relationship between the above-mentioned characteristic textures and catalytic performance of as-synthesized catalysts was further discussed and established. 97.1% Selectivity to tetrahydrofurfuryl alc. could be obtained over PdNiCo/N-CNTs (furfural conversion-100%), but tetrahydrofurfuryl alc. selectivity was only 41.8% when using PdNiCo/CNTs. This investigation confirmed that the catalytic performance of PdNiCo/N-CNTs was much more excellent than other catalysts mainly due to its own PdNiCo alloy nanostructure and the electronic synergy effect between PdNiCo metallic nanoparticles and N-CNTs. Furthermore, there were much weaker basic sites in PdNiCo/N-CNTs, which greatly increased its catalytic properties.

Fuel published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Synthetic Route of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bakharev, Vladimir V.; Gidaspov, Alexander A.; Zalomlenkov, Vladimir A.; Parfenov, Victor E.; Golovina, Olga V.; Slepukhin, Pavel A. published the artcile< Opening of the 1,3,5-triazine ring in 3-methyl-5-(trinitromethyl)tetrazolo[1,5-a][1,3,5]triazin-7-one by the action of alcohols>, Product Details of C5H10O2, the main research area is tetrazolotriazinone ring opening alc.

It was shown for the first time that in the reaction of 3-methyl-5-(trinitromethyl)tetrazolo[1,5-a][1,3,5]triazin-7-one with alcs. in the presence of bases, along with the expected substitution of the trinitromethyl group, opening of the 1,3,5-triazine ring with the addition of an alc. at the site of the C-N bond cleavage takes place. It was found that in the absence of bases only opening of the 1,3,5-triazine ring occurs with the formation of alkyl esters of {1-[(1-methyl-1H-tetrazol-5-yl)imino]-2,2,2-trinitroethyl}carbamic acid, and the trinitromethyl group retains high reactivity and can be substituted by the action of alcs. in the presence of a base.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Due, Ong The; Chaikledkaew, Usa; Genuino, Anne Julienne M.; Sobhonslidsuk, Abhasnee; Thakkinstian, Ammarin published the artcile< Systematic Review with meta-analysis: efficacy and safety of direct-acting antivirals for chronic hepatitis C genotypes 5 and 6>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is chronic hepatitis C genotype direct acting antiviral metaanalysis.

Direct-acting antivirals (DAAs) are modern treatments for chronic hepatitis C infection, but majority of available evidence on its treatment effect covers genotypes 1 to 4. Therefore, the efficacy and safety of DAAs for genotypes 5 and 6 need to be analyzed. Studies were identified from Medline, Scopus, and CENTRAL and a Chinese database CNKI, from inception until Dec 4, 2018. Clin. trials were included if they enrolled patients with genotypes 5 and/or 6 infection, any type of second-generation DAAs was studied, and sustained virol. response was assessed at the 12th week after treatment (SVR12) as outcome measure. Metaanal. using metaprop statistical program was applied for pooling proportions if data were sufficient (i.e., at least 2 studies). Thirteen studies were included in the anal. Four studies assessed the efficacy of four DAA regimens in genotype 5 patients, which were mainly sofosbuvir (SOF) plus pegylated-interferon/ribavirin (PR) or other DAAs, with SVR12 ranging from 94.4% to 100%. Twelve studies assessed the efficacy of seven DAA regimens among genotype 6 patients, but only two DAA regimens (i.e., SOF + PR and SOF/ledipasvir) had sufficient data for pooling. The pooled SVR12 rates (95% CI) were 99.6% (92.2 to 100) for SOF + PR and 99.2% (96.5 to 100) for SOF/ledipasvir. No treatment-related serious adverse event was reported, while the nonserious adverse events were comparable to other genotypes. In conclusion, DAAs are effective and may be safe for the treatment of chronic hepatitis C genotypes 5 and 6. However, our evidence is based on noncomparative studies; hence, further larger-scale randomized controlled trials in these genotypes are still required.

BioMed Research International published new progress about Antiviral agents. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wu, Qi; Ma, Xiaoru; Zheng, Feng; Lu, Xuemin; Lu, Qinghua published the artcile< Synthesis of highly transparent and heat-resistant polyimides containing bulky pendant moieties>, Application In Synthesis of 4415-87-6, the main research area is transparent heat polyimide bulky pendant moiety.

A new diamine with bulky pendant biphenyl and ortho-position di-Me structures, 4,4′-((1,1′-biphenyl)-4-ylmethylene)bis(2,6-dimethylaniline), was synthesized via a one-pot reaction of 4-biphenyl carboxaldehyde and 2,6-dimethylaniline. The diamine was employed to polymerize with several dianhydrides via one-step condensation under high-temperature conditions. The light yellow or colorless polyimide (PI) films obtained were found to have cut-off wavelengths in the range 286-358 nm and transmittance over 80% in the visible region (400-780 nm). Meanwhile, these PIs possessed excellent solubility in common organic solvents, even in low-boiling-point solvents such as chloroform (CHCl3), dichloromethane (CH2Cl2) and THF. The glass transition temperatures (Tg) of the PIs were determined to exceed 343 °C, even to 456 °C. All PI films were flexible with a tensile strength of 78-119 MPa, a Young’s modulus of 2.0-2.5 GPa and elongation at break of 4.0%-8.2%. Therefore, these colorless PIs can be used as candidate materials for flexible display substrates. © 2019 Society of Chem. Industry.

Polymer International published new progress about Boiling point. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Application In Synthesis of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fovanna, Thibault; Campisi, Sebastiano; Villa, Alberto; Kambolis, Anastasios; Peng, Gael; Rentsch, Daniel; Krocher, Oliver; Nachtegaal, Maarten; Ferri, Davide published the artcile< Ruthenium on phosphorous-modified alumina as an effective and stable catalyst for catalytic transfer hydrogenation of furfural>, Electric Literature of 97-99-4, the main research area is ruthenium phosphorus modified alumina catalyst preparation furfural hydrogenation.

Supported ruthenium was used in the liquid phase catalytic transfer hydrogenation of furfural. To improve the stability of Ru against leaching, phosphorus was introduced on a Ru/Al2O3 based catalyst upon impregnation with ammonium hypophosphite followed by either reduction or calcination to study the effect of phosphorus on the physico-chem. properties of the active phase. Characterization using X-ray diffraction, solid state 31P NMR spectroscopy, X-ray absorption spectroscopy, temperature programmed reduction with H2, IR spectroscopy of pyridine adsorption from the liquid phase and transmission electron microscopy indicated that phosphorus induces a high dispersion of Ru, promotes Ru reducibility and is responsible for the formation of acid species of bronsted character. As a result, the phosphorus-based catalyst obtained after reduction was more active for catalytic transfer hydrogenation of furfural and more stable against Ru leaching under these conditions than a benchmark Ru catalyst supported on activated carbon.

RSC Advances published new progress about Calcination. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Netto-Ferreira, J. C.; Wintgens, V.; Scaiano, J. C. published the artcile< Lifetimes of biradicals produced in the Norrish Type I reaction of methyl-substituted 2-tetralones>, Application of C8H14O2, the main research area is Norrish photolysis biradical lifetime tetralone.

The Norrish Type I biradicals derived from 2-tetralones decay by a competition of recyclization to the starting material, intramol. disproportionation to yield aldehydes and decarbonylation. The last path is only favored in the case of 3,3-dimethylated derivatives while, in the other extreme, the parent 2-tetralone is essentially photostable. The biradical lifetimes are around 140 ns in benzene and 40 ns or less in nonaromatic solvents; they show little sensitivity to the solvent polarity and hydrogen bonding ability. The remarkable stabilization of the biradical in benzene is probably due to specific interactions between the acyl center in the biradical and benzene, since similar effects have not been observed in other biradicals.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Biradicals Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Application of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yuan, Bingbing; Li, Pengfei; Wang, Peng; Yang, Hao; Sun, Honghong; Li, Peng; Sun, Haixiang; Niu, Q. Jason published the artcile< Novel aliphatic polyamide membrane with high mono-/divalent ion selectivity, excellent Ca2+, Mg2+ rejection, and improved antifouling properties>, SDS of cas: 4415-87-6, the main research area is aliphatic polyamide nanofiltration membrane preparation water desalination ion rejection.

Monomer design and reconstruction is typically a preferred route to tune the inner structure and screen the performance of polyamide nanofilms for their efficiency and ease of scaling up in industrial production Herein, two kinds of novel acyl chloride monomers, 1,2,3,4-cyclobutane tetracarboxylic acid chloride (BTC) and 1,2,4,5-cyclohexanetetracarboxylic acid chloride (HTeC), have been designed and synthesized. The BTC and HTeC monomers can rapidly react with amine mol. at interface to form an aliphatic polyamide nanofilm that is denser than that of TMC based polyamide membrane. The resulting mean effective pore size of the BTC and HTeC polyamide nanofilms is 0.184 nm and 0.197 nm, which is lower than that of the TMC nanofilm at 0.238 nm. Desalination experiments revealed that the aliphatic polyamide membrane shows more than a 98% rejection rate for CaCl2, MgCl2, and MgSO4 and a water flux of 84.4 kg m-2 h-1 MPa-1 (for 2000 ppm MgSO4). Moreover, the ion selectivity of Na+/Mg2+ and Na+/Ca2+ of the BTC membrane is as high as 126 and 31.5, resp. These are much higher than those of the related TMC and com. nanofiltration membranes. Fouling experiments indicate that the flux decline rate (FDR) of the aliphatic polyamide membrane is only 38%, whereas the FDR of the full-aromatic polyamide membrane is 60%. Further investigations confirmed that surface roughness is the main factor affecting the fouling behaviors of polyamide membranes. Our results demonstrate that BTC and HTeC monomers are unique potential materials in the fabrication of nanofiltration membranes used for water treatment such as water softening and ion sieving.

Separation and Purification Technology published new progress about Anions (mono and divalent). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, SDS of cas: 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem