Category: Tetrahydrofurans

Taylor, Martin J.; Beaumont, Simon K.; Islam, Mohammed J.; Tsatsos, Sotirios; Parlett, Christopher A. M.; Issacs, Mark A.; Kyriakou, Georgios published the artcile< Atom efficient PtCu bimetallic catalysts and ultra dilute alloys for the selective hydrogenation of furfural>, Reference of 97-99-4, the main research area is atom PtCu bimetallic catalyst dilute alloy hydrogenation furfural.

A range of Pt:Cu bimetallic nanoparticles were investigated for the liquid-phase selective hydrogenation of furfural, an important platform biomass feedstock. Alloying of the two metals had a profound effect on the overall catalytic activity, providing superior rates of reaction and achieving the needed high selectivity towards furfuryl alc. Furthermore, we investigated the catalytic activity of an Ultra Dilute Alloy (UDA) formed via the galvanic replacement of Cu atoms by Pt atoms on dispersed host Cu nanoparticles (at. ratio Pt:Cu 1:20). This UDA, after overcoming an induction period, exhibits exceptionally high initial rates of hydrogenation under modest hydrogen pressures of 10 and 20 bar, rivalling the catalytic turnover for the monometallic Pt (containing 12 times more Pt), and outdoing the pure Cu or other compositions of bimetallic nanoparticle alloy catalysts. These atom efficient catalysts are ideal candidates for the valorization of furfural due to their activity and vastly greater economic viability.

Applied Catalysis, B: Environmental published new progress about Hydrogenation catalysts. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pan, Calvin Q.; Tiongson, Benjamin C.; Hu, Ke-Qin; Han, Steven-Huy B.; Tong, Myron; Chu, Danny; Park, James; Lee, Tai Ping; Bhamidimarri, Kalyan Ram; Ma, Xiaoli; Xiao, Pei Ying; Mohanty, Smruti R.; Wang, Dan published the artcile< Real-World Study on Sofosbuvir-based Therapies in Asian Americans With Chronic Hepatitis C>, Product Details of C9H13N2O9P, the main research area is sofosbuvir chronic hepatitis C treatment.

Limited data exist with regard to treatment outcomes in Asian Americans with chronic hepatitis C (CHC). We evaluated sofosbuvir (SOF)-based regimens in a national cohort of Asian Americans. Eligible Asian Americans patients with CHC who had posttreatment follow-up of 24 wk for SOF -based therapies from Dec. 2013 to June 2017 were enrolled from 11 sites across the United States. The primary endpoint was sustained virol. response (SVR) rates at posttreatment weeks 12 and 24. Secondary endpoints were to evaluate safety by tolerability and adverse events (AEs). Among 231 patients screened, 186 were enrolled. At baseline, 31% (57/186) patients were cirrhotic, 34% (63/186) were treatment experienced. Most of the subjects (42%, 79/186) received ledispavir/SOF therapy. The overall SVR%, ran12 was 95ging from 86% in genotype (GT) 1b on SOF+ribavirin to 100% in GT 1b patients on ledipasvir/SOF at subgroup analyses. SVR12 was significantly lower in cirrhotic than in noncirrhotic patients [88% (50/57) vs. 98% (126/129), P<0.01]. Stratified by GT, SVR12 were: 96% (43/45) in GT 1a; 93% (67/72) in GT 1b; 100% (23/23) in GT 2; 90% (19/21) in GT 3; 100% (1/1) in GT 4; 83% (5/6) in GT 5; and 100% (16/16) in GT 6. Cirrhotic patients with treatment failure were primarily GT 1, (GT 1a, n = 2; GT 1b, n = 4) with 1 GT 5 (n = 1). Patients tolerated the treatment without serious AEs. Late relapse occurred in 1 patient after achieving SVR12. In Asian Americans with CHC, SOF-based regimens were well tolerated without serious AEs and could achieve high SVR12 regardless of hepatitis C viral infection GT. Journal of Clinical Gastroenterology published new progress about Chronic hepatitis C. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Gupta, Mrityunjay; Levine, Samantha R.; Spitale, Robert C. published the artcile< Probing Nascent RNA with Metabolic Incorporation of Modified Nucleosides>, HPLC of Formula: 58-97-9, the main research area is .

Conspectus: The discovery of previously unknown functional roles of RNA in biol. systems has led to increased interest in revealing novel RNA mols. as therapeutic targets and the development of tools to better understand the role of RNA in cells. RNA metabolic labeling broadens the scope of studying RNA by incorporating of unnatural nucleobases and nucleosides with bioorthogonal handles that can be utilized for chem. modification of newly synthesized cellular RNA. Such labeling of RNA provides access to applications including measurement of the rates of synthesis and decay of RNA, cellular imaging for RNA localization, and selective enrichment of nascent RNA from the total RNA pool. Several unnatural nucleosides and nucleobases have been shown to be incorporated into RNA by endogenous RNA synthesis machinery of the cells. RNA metabolic labeling can also be performed in a cell-specific manner, where only cells expressing an essential enzyme incorporate the unnatural nucleobase into their RNA. Although several discoveries have been enabled by the current RNA metabolic labeling methods, some key challenges still exist: (i) toxicity of unnatural analogs, (ii) lack of RNA-compatible conjugation chemistries, and (iii) background incorporation of modified analogs in cell-specific RNA metabolic labeling. In this Account, we showcase work done in our laboratory to overcome these challenges faced by RNA metabolic labeling. To begin, we discuss the cellular pathways that have been utilized to perform RNA metabolic labeling and study the interaction between nucleosides and nucleoside kinases. Then we discuss the use of vinyl nucleosides for metabolic labeling and demonstrate the low toxicity of 5-vinyluridine (5-VUrd) compared to other widely used nucleosides. Next, we discuss cell-specific RNA metabolic labeling with unnatural nucleobases, which requires the expression of a specific phosphoribosyl transferase (PRT) enzyme for incorporation of the nucleobase into RNA. In the course of this work, we discovered the enzyme uridine monophosphate synthase (UMPS), which is responsible for nonspecific labeling with modified uracil nucleobases. We were able to overcome this background labeling by discovering a mutant uracil PRT (UPRT) that demonstrates highly specific RNA metabolic labeling with 5-vinyluracil (5-VU). Furthermore, we discuss the optimization of inverse-electron-demand Diels-Alder (IEDDA) reactions for performing chem. modification of vinyl nucleosides to achieve covalent conjugation of RNA without transcript degradation Finally, we highlight our latest endeavor: the development of mutually orthogonal chem. reactions for selective labeling of 5-VUrd and 2-vinyladenosine (2-VAdo), which allows for potential use of multiple vinyl nucleosides for simultaneous investigation of multiple cellular processes involving RNA. We hope that our methods and discoveries encourage scientists studying biol. systems to include RNA metabolic labeling in their toolkit for studying RNA and its role in biol. systems.

Accounts of Chemical Research published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, HPLC of Formula: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Byun, Mi Yeon; Lee, Man Sig published the artcile< Pt supported on hierarchical porous carbon for furfural hydrogenation>, HPLC of Formula: 97-99-4, the main research area is furfural hydrogenation hierarchical porous carbon platinum catalyst.

Hierarchical porous carbon (HPC) was prepared using colloidal silica of different sizes as a template, and used as a support for Pt nanoparticles. The Pt dispersion varied with the pore size and structure of the HPC supports. However, the measured Pt dispersions (70%-76%) suggested that this characteristic was not affected by the pore size distribution above a certain size. The activities of the prepared Pt/HPC catalysts for furfural hydrogenation were then investigated. The HPC supports with large pores allowed for greater contact between the Pt nanoparticles and reactants due to the high mass transfer rate, resulting in the highest furfural conversion and 1-pentanol selectivity. In contrast, the HPC supports with small pores exhibited higher furfuryl alc. selectivities. The effect of the solvent on furfural hydrogenation was also investigated, and it was found that the solubility of H2 in the solvent affected the furfural conversion and product selectivity.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Catalyst supports. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, HPLC of Formula: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Popov, Yu. V.; Mokhov, V. M.; Nebykov, D. N.; Shirkhanyan, P. M.; Gendler, T. A.; Shemet, V. V. published the artcile< Colloidal and Nanosized Catalysts in Organic Synthesis: XXIV. Study of Hydrogenation of Furan and Its Derivatives in the Presence of MgO-Supported Nickel and Cobalt Nanoparticles>, Category: tetrahydrofurans, the main research area is furan hydrogenation nickel nanocatalyst plug flow reactor.

The processes of hydrogenation of furan and its derivatives (2-methylfuran, furfuryl alc., and furfural) in plug-flow type reactor under atm. hydrogen pressure at 20-220°C in the presence of supported nickel nanoparticles prepared via chem. reduction have been investigated. It has been found that nickel nanoparticles supported on magnesium oxide surface are the most reactive and stable under the considered conditions. This catalyst allows the corresponding hydrogenation products with 100% yield and complete conversion of the substrate.

Russian Journal of General Chemistry published new progress about Furans Role: RCT (Reactant), RACT (Reactant or Reagent). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Morgado-Carrasco, Daniel; Combalia, Andrea; Fustà-Novell, Xavier; Mascaró, José Manuel Jr; Iranzo, Pilar published the artcile< Aggressive erosive lichen planus associated with hepatitis C responding to sofosbuvir/ledipasvir treatment.>, Synthetic Route of 58-97-9, the main research area is .

There is no abstract available for this document.

Indian journal of dermatology, venereology and leprology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Phanthuwongpakdee, Jakkapon; Harimoto, Toyohiro; Babel, Sandhya; Dwivedi, Sumant; Takada, Kenji; Kaneko, Tatsuo published the artcile< Flame retardant transparent films of thermostable biopolyimide metal hybrids>, Electric Literature of 4415-87-6, the main research area is flame retardant transparent film thermostable bio polyimide metal hybrid.

The development of flame retardant transparent films is important for elec. devices and building materials it but it is still a challenge. Herein, flame retardant films having high optical transparency were developed from the amino acid-based biopolyimide (BPI) salt with aluminum (BPI-COOAl) and copper ions (BPI-COOCu). The microscale combustion calorimetry anal. revealed that for BPI-COOAl, the total heat released (THR) and peak heat released rate were 4.5 W/g and 18.9 kJ/g, resp. These values were lower than those of its precursors and BPI-COOCu. BPI-COOAl was rated V-0 for the Underwriters Laboratories vertical burning standard test. The polymer also retained a high transparency of more than 80% transmittance at a wavelength of 450 nm. The tensile strength was also preserved at 63.7 MPa. For BPI-COOCu, 14.6 kJ/g THR and 47.1 MPa tensile strength were observed When a colorful ion such as Cu was used, BPI-COOCu became a flame retardant film that was a green filter. The char formation of Al2O3 and Cu2O in their resp. polymer complexes was deduced as the main flame suppression mechanism. The present films of biopolyimide salts are advantageous in showcasing the balance of different essential material properties such as flame retardancy, thermo-mech. stability, and transparency.

Polymer Degradation and Stability published new progress about Cation exchange. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Electric Literature of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Mineguchi, Yuri; Goto, Kyosuke; Sudo, Yuna; Hirayama, Kentaro; Kashiwagi, Hirotoshi; Sasagase, Izumi; Kitazawa, Haruki; Asakuma, Sadaki; Fukuda, Kenji; Urashima, Tadasu published the artcile< Characterisation of sugar nucleotides in colostrum of dairy domestic farms animals>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is colostrum sugar nucleotide UMP UDP.

The biol. significance and heterogeneity of bovine, caprine and ovine colostrum sugar nucleotides is unclear. Colostrum sugar nucleotides and sugar monophosphates were purified and characterised with 1H-NMR spectroscopy. UDP-galactose (UDP-Gal) and UDP-glucose (UDP-Glc) were identified in colostrum of Holstein and Brown Swiss cows; UDP-Gal, UDP-Glc, UDP-N-acetylgalactosamine (UDP-GalNAc) and UDP-N-acetylglucosamine (UDP-GlcNAc) were found in Japanese Saanen goat colostrum. UDP-Gal, UDP-Glc, UDP-GalNAc and UDP-GlcNAc were found in Corriedale sheep but not in the Suffolk and Fraise Land breeds. The presence/absence of these sugar nucleotides in colostrum is heterogeneous among dairy domestic farm animals and the three sheep breeds. In addition, a nucleotide, uridine-ribose diphosphate (UDP) was identified in the colostra of Japanese Saanen goat, and Suffolk and Fraiseland sheep, while uridine-ribose monophosphate (UMP) was detected in the colostrum of Brown Swiss cow and the three breed sheep. N-acetylglucosamine-1-phosphate (GlcNAc-1-P) was also identified in the colostrum of the goat and two cow breeds.

International Dairy Journal published new progress about Bos taurus. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nazarski, Ryszard; Skolimowski, Janusz; Skowronski, Romuald published the artcile< Sterically crowded five-membered heterocyclic systems. Part I. Synthesis of acetylene derivatives of azolidyne and oxolane>, Product Details of C8H14O2, the main research area is ethynylation Favorskii pyrrolidinone tetramethyl; alkynylation tetrahydrofuranone tetramethyl; alkynylpyrrolidinol tetramethyl; alkynylfuranol tetrahydrotetramethyl.

Alkynyl 5-membered heterocyclic compounds I (R = H, Ph; X = O, NH) were prepared by alkynylation of the heterocyclic ketones II by the Favorskii alkynylation (KOH, alkyne, THF) or Grignard-Iotsitch method (EtMgBr, alkyne). Favorskii ethynylation of II (X = NH) gave 44% I (R = H; X = NH), whereas Favorskii ethynylation of II (X = O) gave no ethynylation product which indicated that the amino group in II (X = NH) acts as a catalyst in the ethynylation.

Polish Journal of Chemistry published new progress about 5455-94-7. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Salnikova, Ksenia E.; Larichev, Yurii V.; Sulman, Esther M.; Bykov, Alexey V.; Sidorov, Alexander I.; Demidenko, Galina N.; Sulman, Mikhail G.; Bronstein, Lyudmila M.; Matveeva, Valentina G. published the artcile< Selective Hydrogenation of Biomass-Derived Furfural: Enhanced Catalytic Performance of Pd-Cu Alloy Nanoparticles in Porous Polymer>, Application of C5H10O2, the main research area is biomass derived furfural hydrogenation palladium copper nanoparticle polymer catalyst; Pd−Cu alloys; furfural; hydrogenation; hypercrosslinked polystyrene; nanostructures.

Here, the development of a new catalyst is reported for the selective furfural (FF) hydrogenation to furfuryl alc. (FA) based on about 7 nm sized Pd-Cu alloy nanoparticles (NPs) formed in inexpensive, com. available micro/mesoporous hypercrosslinked polystyrene (HPS). A comparison of the catalytic properties of as-synthesized and reduced (denoted “”r””) catalysts as well as Pd-Cu alloy and monometallic palladium NPs showed a considerable enhancement of the catalytic performance of Pd-Cu/HPS-r compared to other catalysts studied, resulting in about 100% FF conversion, 95.2% selectivity for FA and a TOF of 1209 h-1. This was attributed to the enrichment of the NP surface with copper atoms, disrupting the furan ring adsorption, and to the presence of both zerovalent and cationic palladium and copper species, resulting in optimal hydrogen and FF adsorption. These factors along with exceptional stability of the catalyst in ten consecutive catalytic cycles make it highly promising in practical applications.

ChemPlusChem published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem