Category: Tetrahydrofurans

Buvelot, He Lene’s team published research in Frontiers in Immunology in 2021 | 58-97-9

Frontiers in Immunology published new progress about Homo sapiens. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Reference of 58-97-9.

Buvelot, He Lene; Roth, Myriam; Jaquet, Vincent; Lozkhin, Andrey; Renzoni, Adriana; Bonetti, Eve-Julie; Gaia, Nadia; Laumay, Floriane; Mollin, Michele; Stasia, Marie-Jose; Schrenzel, Jacques; Franc ois, Patrice; Krause, Karl-Heinz published the artcile< Hydrogen peroxide affects growth of S. aureus through downregulation of genes involved in pyrimidine biosynthesis>, Reference of 58-97-9, the main research area is hydrogen peroxide carA pyrimidine Staphylococcus; S. aureus; carA; hydrogen peroxide; neutrophils; pyrimidine metabolism.

Reactive oxygen species (ROS) play a crucial role in the cellular defense against S. aureus, as evidenced by the importance of this pathogen in patients lacking the ROS-generating phagocyte NADPH oxidase NOX2. ROS concentrations required to kill S. aureusin vitro are much higher than those found in the phagosome. We therefore hypothesized that sublethal ROS concentrations may play a role in S. aureus gene dysregulation and investigated the in vitro transcriptomic response of S. aureus to sublethal concentrations of hydrogen peroxide (H2O2). A striking observation of these experiments was a coordinated and massive downregulation of genes involved in pyrimidine metabolism Using transposon insertion mutants, we demonstrated that deletion of carA, a gene involved in pyrimidine synthesis, led to a significant growth defect and to an increased sensitivity of S. aureus to added H2O2. The phenotype of the carA mutant could be reversed through supplementation with the pyrimidine precursor uracil, or with a multicopy vector encoding carA. As opposed to the impact of ROS on extracellular survival, carA deletion did not affect the intracellular survival in neutrophils. Our results raise the possibility that ROS-dependent downregulation of pyrimidine metabolism might be a survival strategy of S. aureus, allowing colonization through intracellular survival, while decreasing the risk of killing the host through dampened extracellular growth.

Frontiers in Immunology published new progress about Homo sapiens. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Reference of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhu, Yanru’s team published research in ACS Catalysis in 2020-08-07 | 97-99-4

ACS Catalysis published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Zhu, Yanru; Zhao, Wenfang; Zhang, Jian; An, Zhe; Ma, Xiaodan; Zhang, Zhijun; Jiang, Yitao; Zheng, Lirong; Shu, Xin; Song, Hongyan; Xiang, Xu; He, Jing published the artcile< Selective activation of C-OH, C-O-C, or C=C in furfuryl alcohol by engineered Pt Sites supported on layered double oxides>, Product Details of C5H10O2, the main research area is selective activation carbon OH oxygen furfuryl alc engineered.

The selective activation of targeted bonds in biomass-derived furfural or furfuryl alc. with complex chem. linkages (C-C/C-H/C-O, C=C/C=O, or C-O-H/C-O-C) is of great challenge for biomass upgrading, expecting well-defined catalyst and definite catalytically active sites. This work demonstrates an efficient targeted activation to C-OH, C-O-C, or C=C by engineering the structure of catalytic Pt sites, affording 2-methylfuran (2-MF), tetrahydrofurfuryl alc. (THFA), or 1,2-pentanediol (1,2-PeD) as product in the hydroconversion of furfuryl alc. The catalytic Pt sites have been engineered as at. Pt, coordination unsaturated Pt-Pt in atom-thick dispersion, or coordination unsaturated 3D Pt-Pt by tailoring the Pt dispersion (single atom, 2D cluster, or 3D cluster) on Mg and Al-containing layered double oxide (Mg(Al)O) support. The selective activation of C-OH, C-O-C, or C=C has been traced with the FT-IR spectra recorded surface reaction. On at. Pt, C-O-H is easily activated, with the assistance of Mg(Al)O support, with O-terminal adsorption without affecting furan C-O and C=C. However, C=C in the furan ring is easier to be activated on coordination-unsaturated Pt-Pt in atom-thick dispersion, resulting in a step-by-step hydrogenation to generate THFA. On coordination-unsaturated 3D Pt-Pt, the hydrogenolysis of furan ring is favored, resulting in the cleavage of furan C-O to produce 1,2-PeD. Also, the Mg(Al)O supports derived from Mg and Al layered double hydroxides (LDHs) here also play a key role in promoting the selectivity to 1,2-PeD by providing basic sites.

ACS Catalysis published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sunyol, C’s team published research in Applied Catalysis, A: General in 2021-02-05 | 97-99-4

Applied Catalysis, A: General published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Sunyol, C.; English Owen, R.; Gonzalez, M. D.; Salagre, P.; Cesteros, Y. published the artcile< Catalytic hydrogenation of furfural to tetrahydrofurfuryl alcohol using competitive nickel catalysts supported on mesoporous clays>, Name: (Tetrahydrofuran-2-yl)methanol, the main research area is catalyst hydrogenation furfural tetrahydrofurfuryl alc nickel supported mesoporous clay.

Nickel catalysts supported on mesoporous clays with different acid properties, such as montmorillonite MK-10, Al-pillared montmorillonite, mesoporous Na-saponite and mesoporous H-saponite, were prepared, characterized and tested for the hydrogenation of furfural to tetrahydrofurfuryl alc. (THFA). Clays were also modified introducing basicity through magnesium oxide in different amounts Catalysts with higher acidity or low amounts of metallic centers favored deactivation and/or selectivity to the non-desired products. Interestingly, the addition of MgO both neutralized the acidity of the montmorillonite supports and improved the hydrogenation of the furanic ring, resulting in higher selectivity to THFA. The best catalyst was the one prepared with montmorillonite MK-10 covered by 30 wt% of magnesium oxide and with 8.8% of the Ni metal phase achieving total conversion and total selectivity to THFA. The activity of this catalyst was maintained after several reuses.

Applied Catalysis, A: General published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Vieux, Karl-Frederic’s team published research in Nucleic Acids Research in 2021 | 58-97-9

Nucleic Acids Research published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (GLD2). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Vieux, Karl-Frederic; Prothro, Katherine P.; Kelley, Leanne H.; Palmer, Cameron; Maine, Eleanor M.; Veksler-Lublinsky, Isana; McJunkin, Katherine published the artcile< Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans>, Application of C9H13N2O9P, the main research area is microRNA TUT4 TUT7 CDE1 Candida.

MicroRNAs are frequently modified by addition of untemplated nucleotides to the 3′ end, but the role of this tailing is often unclear. Here we characterize the prevalence and functional consequences of microRNA tailing in vivo, using Caenorhabditis elegans. MicroRNA tailing in C. elegans consists mostly of mono-uridylation of mature microRNA species, with rarer mono-adenylation which is likely added to microRNA precursors. Through a targeted RNAi screen, we discover that the TUT4/TUT7 gene family member CID-1/CDE-1/PUP-1 is required for uridylation, whereas the GLD2 gene family member F31C3.2-here named GLD-2-related 2 (GLDR-2)-is required for adenylation. Thus, the TUT4/TUT7 and GLD2 gene families have broadly conserved roles in miRNA modification. We specifically examine the role of tailing in microRNA turnover. We determine half-lives of microRNAs after acute inactivation of microRNA biogenesis, revealing that half-lives are generally long (median = 20.7 h), as observed in other systems. Although we observe that the proportion of tailed species increases over time after biogenesis, disrupting tailing does not alter microRNA decay. Thus, tailing is not a global regulator of decay in C. elegans. Nonetheless, by identifying the responsible enzymes, this study lays the groundwork to explore whether tailing plays more specialized context- or miRNA-specific regulatory roles.

Nucleic Acids Research published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (GLD2). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Saksena, Anil K.’s team published research in Tetrahedron Letters in 1995 | CAS: 160709-02-4

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 160709-02-4

Recommanded Product: 160709-02-4On March 13, 1995, Saksena, Anil K.; Girijavallabhan, Viyyoor M.; Lovey, Raymond G.; Pike, Russell E.; Wang, Haiyan; Ganguly, Ashit K.; Morgan, Brian; Zaks, Alesey; Puar, Mohinder S. published an article in Tetrahedron Letters. The article was 《Highly stereoselective access to novel 2,2,4-trisubstituted tetrahydrofurans by halocyclization: practical chemoenzymic synthesis of SCH 51048, a broad-spectrum orally active antifungal agent》. The article mentions the following:

A convenient synthesis of (-)-(2R)-cis-tosylate I is reported via stereoselective 5-exo-iodocyclization of the optically active 2,2-disubstituted olefin II. Enzymic desymmetrization of the homoallylic diol III with Novo SP435 allowed optimal pro(S) selectivity to provide the desired (-)-monoacetate II. Under the irreversible reaction conditions, the presence of a bulky aryl substituent on the 2,2-disubstituted olefin seems to determine stereochem. outcome of these halocyclizations. The experimental part of the paper was very detailed, including the reaction process of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Recommanded Product: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Green, Keith D.’s team published research in ACS Infectious Diseases in 2022 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H12O3

COA of Formula: C6H12O3In 2022 ,《Discovery and Optimization of 6-(1-Substituted pyrrole-2-yl)-s-triazine Containing Compounds as Antibacterial Agents》 appeared in ACS Infectious Diseases. The author of the article were Green, Keith D.; Pang, Allan H.; Thamban Chandrika, Nishad; Garzan, Atefeh; Baughn, Anthony D.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie. The article conveys some information:

Antimicrobial drug resistance is a major health issue plaguing healthcare worldwide and leading to hundreds of thousands of deaths globally each year. Tackling this problem requires discovery and development of new antibacterial agents. In this study, we discovered novel 6-(1-substituted pyrrole-2-yl)-s-triazine containing compounds that potently inhibited the growth of Staphylococcus aureus regardless of its methicillin-resistant status, displaying min. inhibitory concentration (MIC) values as low as 1μM. The presence of a single imidazole substituent was critical to the antibacterial activity of these compounds Some of the compounds also inhibited several nontubercular mycobacteria. We have shown that these mols. are potent bacteriostatic agents and that they are nontoxic to mammalian cells at relevant concentrations Further development of these compounds as novel antimicrobial agents will be aimed at expanding our armamentarium of antibiotics. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3COA of Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ozaki, Tomoya’s team published research in Chemistry – A European Journal in 2021 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Product Details of 696-59-3In 2021 ,《Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N-Ts Bond in a Different Light》 was published in Chemistry – A European Journal. The article was written by Ozaki, Tomoya; Yorimitsu, Hideki; Perry, Gregory J. P.. The article contains the following contents:

Easy-to-access arylsulfonyl pyrroles I (R = 4-MeC6H4, 4-FC6H4, etc.) as synthetic linchpins for sulfonamides RC6H4S(O)2R1 (R1 = CH3, F, 5-(trifluoromethyl)pyridin-2-yl, etc.) functionalization have been described. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chem., electrochem. and photochem. pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ma, Kaiqing’s team published research in Bioorganic & Medicinal Chemistry in 2021 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 696-59-3

Ma, Kaiqing; Zhang, Mengchen; Wu, Xingkang; Yang, Peng; Yin, Caixia published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Discovery of a potent β-catenin destabilizer for overcoming the resistance of 5-fluorouracil in colorectal cancer》.Application of 696-59-3 The article contains the following contents:

Wnt/β-catenin signalling is frequently activated in colorectal cancer, in which nuclear β-catenin accumulation contributes to tumor initiation and progression. However, therapeutic agents in clin. use targeting this pathway are lacking. In this report, we describe the synthesis of novel stemona alkaloid analogs and their biol. evaluation, among which compound 3 was identified to efficiently inhibit various CRC cells, including 5-fluorouracil-resistant CRC cells. Mechanistically, this study revealed that compound 3 reduced the protein level of β-catenin without affecting its mRNA level, which suggests an alternative mechanism for β-catenin degradation The expression of downstream proteins, including c-myc, survivin, and cyclin D1, was also significantly inhibited, even in Wnt-activated CRC cells. Briefly, our data highlight the potential of compound 3 as a destabilizer of β-catenin for the treatment of CRC patients. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Roman, Gheorghe’s team published research in Turkish Journal of Chemistry in 2019 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2,5-Dimethoxytetrahydrofuran

The author of 《Design, synthesis, and evaluation of the antimycobacterial activity of 3-mercapto-1,2,4-triazole-pyrrole hybrids》 were Roman, Gheorghe; Bostanaru, Andra-Cristina; Nastasa, Valentin; Mares, Mihai. And the article was published in Turkish Journal of Chemistry in 2019. Quality Control of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

A series of 3-mercapto-1,2,4-triazole-pyrrole hybrids was designed as antimycobacterial agents by employing 5-(4-(1H-pyrrol-1-yl)phenyl)-4H-1,2,4-triazole-3-thiol as the scaffold onto which several types of moieties were introduced in the triazole ring at N-4 and N-2 and as substituents of the mercapto function. The aforementioned moieties are an allyl or a Ph moiety at N-4; an aminomethyl group at N-2; or Me, substituted benzyl, ethoxycarbonylmethyl, or substituted phenacyl at sulfur. Investigation of the compounds in the resulting library as growth inhibitors of Mycobacterium smegmatis showed that their min. inhibitory concentration was higher than 64 mg/L. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ravindran, Darvin R.’s team published research in Journal of Chemistry in 2020 | CAS: 19444-84-9

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.HPLC of Formula: 19444-84-9

《Chemical composition and larvicidal activity of flower extracts from Clitoria ternatea against Aedes (diptera: culicidae)》 was written by Ravindran, Darvin R.; Bharathithasan, Madhuri; Ramaiah, Patmani; Rasat, Mohd Sukhairi Mat; Rajendran, Dinesh; Srikumar, Shakila; Ishak, Intan H.; Said, Abd Rahman; Ravi, Rajiv; Amin, Mohamad Faiz Mohd. HPLC of Formula: 19444-84-9 And the article was included in Journal of Chemistry in 2020. The article conveys some information:

Mosquitoes have always been a human health threat; the major global health problems caused by them are malaria, dengue fever, yellow fever, and Zika as well as several other vector-borne outbreaks. The major problems in controlling these vectors borne diseases are related to resistance to eradication measures. Different classes of insecticides used for controlling public health have raised the concern of resistant problems with mosquitoes and environmental pollution caused by the control measures. Thus, a search for alternative natural compounds is necessary for solving the insecticidal resistance problem using pesticides in the larval stage of vector development as well as creating a chem.-free environment for a healthy society. Hence, the major focus of this study is to identify the larvicidal mechanisms, metabolite, antioxidants, and chem. compounds and elucidate their structures from C. ternatea flower and to test their efficacies against early 4th instar larvae of Aedes aegypti and Aedes albopictus. Clitoria ternatea flowers were collected from the garden of the Faculty of Medicine in International Quest University, Ipoh, Perak, and thence used for crude extraction Further on, the metabolite test, antioxidant test, and chromatog. techniques were conducted to identify the chem. composition of extracts and their chem. structures were identified using GCMS-QP2010 Ultra (Shimadzu). Next, the extracts were evaluated against the early 4th instar larvae of Aedes mosquito vectors following the WHO procedures for larval bioassays. The larvicidal activity of Clitoria ternatea flower extracts evidently affected the early 4th instar larvae of Aedes mosquito vectors. The highest larvicidal activity was observed against the early 4th instar larvae of Aedes aegypti with the LC50 and LC95 values of 1056 and 2491 mg/L, resp. Meanwhile, the larvae bioassay test for Aedes albopictus recorded the LC50 and LC95 values of 1425 and 2753 mg/L. Moreover, the results for nontarget organism test on guppy fish, Poecilia reticulata, showed no mortalities with flower extracts at 2500 mg/L, hence posing no toxic effects on fish. In this study, we have found a total of 16 chem. compounds and 6 chem. compounds have been reported to possess direct insecticidal, larvicidal, and pupicidal effects. Six chems. with insecticidal properties were found to be glycerin, 2-hydroxy-gamma-butyrolactone, neophytadiene, n-hexadecanoic acid, cis-vaccenic acid, and octadecanoic acid with a total of 28.7% efficacy. Clitoria ternatea flower extracts also showed different types of phenols such as anthocyanins, flavonoids, and tannins. Our findings showed that the crude extract of Clitoria ternatea flower bioactive mols. is effective and may be developed as biolarvicide for Aedes mosquito vector control. Furthermore, this study also provided a baseline understanding for future research work in the field of applications of Clitoria ternatea flower extracts for their long-term effects on human health such as a food additive, antioxidant, and cosmetic. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9HPLC of Formula: 19444-84-9) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.HPLC of Formula: 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem