Category: Tetrahydrofurans

Product Details of 696-59-3In 2019 ,《Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives》 appeared in Molecular Diversity. The author of the article were Zhang, Shu-Guang; Liang, Chao-Gen; Sun, Yue-Qing; Teng, Peng; Wang, Jia-Qun; Zhang, Wei-Hua. The article conveys some information:

A series of novel pyrrole- and pyrazole-substituted coumarins, compounds I [R1 = H, Me, F, etc.; R2 = Me, CH2Cl, CF3, R3 = H, Me, etc.] and II [R4 = H, Me, Et, etc.; R5 = H, Me, etc.] and evaluated their antifungal activity against six phytopathogenic fungi in-vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds I [R1 = H, R2 = CH2Cl, R3 = Me] and II [R4 = H, Me, Et, R5 = Me; R4 = H’ R5 = CF3 R4R5 = (CH2)4]exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Furthermore, compound I [R1 = H, R2 = CH2Cl, R3 = Me] displayed stronger antifungal activity against Rhizoctorzia solani (EC50 = 15.4 μg/mL) than pos. control Osthole (EC50 = 67.2 μg/mL). The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,ChemCatChem included an article by Jensen, Pernille Rose; Taarning, Esben; Meier, Sebastian. Quality Control of 3-Hydroxydihydrofuran-2(3H)-one. The article was titled 《Probing the Lewis Acid Catalyzed Acyclic Pathway of Carbohydrate Conversion in Methanol by In Situ NMR》. The information in the text is summarized as follows:

Future bioindustries will rely on the formation of diverse chems. at high yield through various reaction pathways. These pathways include reactions to a series of alpha-hydroxy esters and acids that can be formed from the conversion of C3-C6 carbohydrates by Lewis acidic catalysts in alcs. and water. Definitive kinetic and mechanistic insights to support the development of carbohydrate conversion processes are arguably less developed than for analogous biocatalytic processes. Here, we visualize acyclic pathways of carbohydrate dehydration, using the acyclic C4 carbohydrate erythrulose as a probe mol. for the conversion by homogeneous SnCl4 in methanol. In situ studies allow the detection of previously postulated intermediates, identify the branch point to competing products and provide energetic and mechanistic insight by kinetic anal. Reversibility of reactions, stereoselectivity and differential propensity for deuterium incorporation in competing pathways can be tracked by the formation of compounds with asym. mass distribution. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Quality Control of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Quality Control of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Bioresource Technology included an article by Zhou, Haoqin; Brown, Robert C.; Wen, Zhiyou. Reference of 2,5-Dimethoxytetrahydrofuran. The article was titled 《Anaerobic digestion of aqueous phase from pyrolysis of biomass: Reducing toxicity and improving microbial tolerance》. The information in the text is summarized as follows:

Among the products of pyrolysis is an aqueous phase (AP), which contains a significant fraction of carbon but is too dilute to make recovery of this organic content cost-effectively. This study was to explore the use of AP for anaerobic digestion. Different treatment methods including overliming, Fenton’s reagent oxidation, bleaching and activated carbon adsorption were investigated to reduce toxicity of AP. Overliming treatment increased biogas production up to 32-fold compared to non-treated AP. Enhancing the tolerance of the bacterial and archaeal community to the AP toxicity was also attempted with a directed evolution method, resulting the microbes’ tolerance to AP from 5% to 14%. Directed evolution resulted a major bacterial taxa as Cloacimonetes, Firmicutes, and Chloroflexi, while shifted the predominant archaea shifted from acetoclastic to hydrogenotrophic methanogens. Collectively, the results demonstrated that combining feedstock treatment and directed evolution of the microbial community is an effective way for AP anaerobic digestion. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Thaltiri, Vikranth; Shanmugapriya, V.; Panda, Pradeepta K. published an article in 2021. The article was titled 《Efficient and Gram-Scale Synthesis of 1-Methyl-2,3,4-Trinitropyrrole: A Promising Precursor for Insensitive High Energy Melt-Castable Materials》, and you may find the article in ChemistrySelect.Computed Properties of C6H12O3 The information in the text is summarized as follows:

1-Methyl-2,3,4,5-tetranitropyrrole (NMTNP) was recently found to be a promising insensitive high energy melt-castable material. To prove its potentials further, herewith, 1-methyl-2,3,4-trinitropyrrole was established as a potent precursor for NMTNP, by developing a method for its efficient synthesis with excellent overall yield. This method involves mild nitrating conditions, easier purification (minimal chromatog.) and readily available reagents and hence can be scaled up easily. In addition, the facile synthesis of 2,3,4-trinitropyrrole during this process can lead to new class of pyrrole based high energy d. materials. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Computed Properties of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ren, Fei; Li, Zeshun; Li, Kai; Zheng, Xiaoyan; Shi, Jianbing; Zhang, Chen; Guo, Heng; Tong, Bin; Xi, Lei; Cai, Zhengxu; Dong, Yuping published an article in 2021. The article was titled 《Donor strategy for promoting nonradiative decay to achieve an efficient photothermal therapy for treating cancer》, and you may find the article in Science China: Chemistry.Quality Control of 2,5-Dimethoxytetrahydrofuran The information in the text is summarized as follows:

Photothermal therapy (PTT) is emerging as an effective treatment for superficial carcinoma. A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency. Aiming to address this challenge, we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore PTT photosens/itizers of high efficiency. Among these multi-arylpyrrole derivatives, MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency (up to 72%) when it is encapsulated by an amphiphilic polymer. As a result, the MAP4-FE nanoparticles have shown satisfactory PTT effects on in vivo tumor eradication under the guidance of photoacoustic signals. The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,ChemistrySelect included an article by Brites, Nathan P.; Dilelio, Marina C.; Martins, Guilherme M.; Carmo, Gabriele do; Morel, Ademir F.; Kaufman, Teodoro S.; Silveira, Claudio C.. Computed Properties of C6H12O3. The article was titled 《Synthesis and Antifungal Activity of 4- and 6-(1H-Pyrrol-1-yl) Coumarins, and their Thiocyanato Derivatives》. The information in the text is summarized as follows:

Facile and efficient syntheses of 4-(1H-pyrrol-1-yl)-coumarins and 6-(1H-pyrrol-1-yl)-coumarins from the corresponding aminocoumarins are reported. The transformations were optimized and their corresponding scope and limitations were assessed. Selected (1H-pyrrol-1-yl)-coumarins were further subjected to a mild thiocyanation, underwent selective functionalization on the pyrrole nucleus. A set of 10 differently substituted compounds was submitted to activity testing against various fungal strains. It was found that the introduction of a SCN moiety increased the antifungal activity, turning some compounds into fungicidal agents, to the point that one of the thiocyanato derivatives displayed an antifungal profile comparable to those of fluconazole and nystatin. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Computed Properties of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem