Category: Tetrahydrofurans

Nakagawara, Kosuke; Takeuchi, Chieri; Ishige, Kazuya published the artcile< 5 ′-CMP and 5 ′-UMP promote myogenic differentiation and mitochondrial biogenesis by activating myogenin and PGC-1α in a mouse myoblast C2C12 cell line>, Product Details of C9H13N2O9P, the main research area is cytidinemonophosphate uridinemonophosphate myogenin PGCalpha myoblast myogenic differentiation mitochondrial biogenesis; 5′-CMP, Cytidine-5′-monophosphate; 5′-UMP, Uridine-5′-monophosphate; BS, Bovine serum; Cytidine-5′-monophosphate; Endurance; FBS, Fetal bovine serum; MRF, Myogenic regulatory factor; Mitochondria; MyHC, Myosin heavy chanin; Myogenic differentiation; Nutrition; Uridine-5′-monophosphate.

Ribonucleotides are basic monomeric building blocks for RNA considered as conditionally essential nutrients. They are normally produced in sufficient quantity, but can become insufficient upon stressful challenges. The administration of pyrimidine nucleotides, such as cytidine-5′-monophosphate (5′-CMP) and uridine-5′-monophosphate (5′-UMP), enables rats to endure prolonged exercise. However, the underlying mechanisms have remained elusive. To investigate these mechanisms, we studied the effect of 5′-CMP and 5′-UMP on muscular differentiation and mitochondrial biogenesis in myoblast C2C12 cells. A 5′-CMP and 5′-UMP were found to increase the mRNA levels of myogenin, which is a myogenic regulatory protein expressed during the final differentiation step and fusion of myoblasts into myotubes. The 5′-CMP and 5′-UMP also promoted myoblast differentiation into myotube cells. The 5′-CMP and 5′-UMP further increased the mRNA levels of PGC-1α which regulates mitochondrial biogenesis and skeletal muscle fiber type. In addition, 5′-CMP and 5′-UMP increased mitochondrial DNA copy number and enhanced mRNA levels of slow-muscle myosin heavy chains. Moreover, cytidine and uridine, nucleosides corresponding to 5′-CMP and 5′-UMP, markedly promoted myotube formation in C2C12 cells. Considering the metabolism and absorption of nucleotides, the active bodies underlying the effects observed with 5′-CMP and 5′-UMP could be cytidine and uridine. In conclusion, our results indicate that 5′-CMP and 5′-UMP can promote myogenic differentiation and mitochondrial biogenesis, as well as increase slow-twitch fiber via the activation of myogenin and PGC-1α. In addition, 5′-CMP and 5′-UMP may be considered as safe and effective agents to enhance muscle growth and improve the endurance in skeletal muscles.

Biochemistry and Biophysics Reports published new progress about Absorption. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Stucchi, Marta; Alijani, Sharam; Manzoli, Maela; Villa, Alberto; Lahti, Riikka; Galloni, M. G.; Lassi, Ulla; Prati, Laura published the artcile< A Pt-Mo hybrid catalyst for furfural transformation>, Product Details of C5H10O2, the main research area is platinum molybdenum catalyst furfural hydrogenation.

Furfural is a high-value chem., being the precursor of compounds such as furfuryl alc. and tetrahydrofurfuryl alc. Pt is known as active for furfural hydrogenation, but the high price limits its exploitation and imposes the search for alternatives. Here we presented a Pt/Mo bimetallic system with enhanced catalytic activity for furfural hydrogenation. For comparison, monometallic Mo- and Pt-supported on activated carbon have been prepared by impregnation and sol-immobilization. The bimetallic Pt/Mo was prepared impregnating the Mo-AC catalyst with Pt, using Na2PtCl4 as a precursor, PVA, and NaBH4 as reducing agent. HR-TEM analyses on Pt/Mo catalyst showed Mo-containing agglomerates embedded in the carbon matrix, displaying diffraction fringes with spacing typical of Mo4O11 in the orthorhombic phase, as well as Pt nanoparticles more evenly dispersed in the Mo-AC system compared to bare AC. The Pt/Mo catalyst showed higher activity than both monometallic ones, and it converted 92% of furfural to furfuryl alc. and Et furfuryl ether with 20% and 80% selectivity, resp. However, despite a lower initial activity, the monometallic Mo/AC catalyst showed a complete selectivity to the ether.

Catalysis Today published new progress about Binding energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Mikolas, Lena A; Jacques, Kimberly; Huq, Mostaqul; Krasner, Charles; Mambourg, Scott E published the artcile< Utilizing Clinical Pharmacist Specialist to Manage Hepatitis C Virus Patients on Direct-Acting Antiviral Therapy.>, HPLC of Formula: 58-97-9, the main research area is direct-acting antivirals; hepatitis C virus infection; liver disease; sustained virologic response.

OBJECTIVES: To evaluate outcomes of a clinical pharmacist specialist (CPS)-managed hepatitis C virus (HCV) treatment clinic (HCVTC) in treating HCV-infected veterans with direct-acting antivirals (DAAs). METHODS: We established a CPS-managed HCVTC under a collaborative practice agreement with our infectious disease physician (IDP). A total of 132 veterans were treated between November 1, 2014, and November 30, 2015. The CPS engaged in pretreatment screening, drug selection, patient education, medication counseling, drug therapy monitoring, drug utilization review, addressing issues on drug adherence, and routine and posttreatment follow-up of patients to assess sustained virologic response (SVR) after 12 weeks of treatment. RESULTS: Of 132 patients managed by the CPS, 87 (66%) were treated with ledipasvir/sofosbuvir (LDV/SOF), 29 (22%) with paritaprevir/ritonavir/ombitasvir + dasabuvir (PrOD), and 16 (12%) with sofosbuvir (SOF)-based regimen. The corresponding regimens demonstrated a SVR rate of 92% (n = 80), 100% (n = 29), and 93.8% (n = 15), respectively. We achieved an SVR rate of 94% against HCV genotype 1 (GT-1) and 100% against GT-2 to GT-4. The overall SVR rate was 94% across regimens, showing 93% in treatment-naive patients and 96% in treatment-experienced patients, and 93% in noncirrhotic and 94% in compensated cirrhotic patients. The results were comparable to SVR data reported in pivotal trials for DAAs. CONCLUSION: The results suggest that CPS could be effectively utilized in drug therapy management of HCV-infected patients treated with DAAs.

Journal of pharmacy practice published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, HPLC of Formula: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pirmoradi, Maryam; Gulotty, Robert J.; Kastner, James R. published the artcile< Continuous hydroxyketone production from furfural using Pd-TiO2 supported on activated carbon>, Product Details of C5H10O2, the main research area is hydroxyketone furfural palladium titania activated carbon catalyst.

Pd-TiO2, Pd-Cu and Pd-Fe activated carbon (AC) supported catalysts were employed for continuous selective hydrogenation of furfural. The effect of reaction parameters on product selectivity and space time yield (STY) was determined Weak acid sites, generated by the Pd-TiO2 catalyst opened the furan ring and resulted in a STY of 134 g Lcat-1 h-1 (610 g kgcat-1 h-1) and 39% selectivity to 5-hydroxy-2-pentanone (5H2P), a hydrogenation product of furan ring opening, in a short residence time (7.6 min) at 180°C and 300 psig. The Pd-Cu and Pd-Fe catalysts were selective towards tetrahydrofurfuryl alc. and furfuryl alc. A STY of 259 g Lcat-1 h-1 (1182 g kgcat-1 h-1) and 42% selectivity to furfuryl alc. was achieved in the presence of the Pd-Cu catalyst at 180°C and 300 psig (3.8 min). The Pd/TiO2/AC catalyst shows promise for continuous production of 5H2P, a building block for many drugs and a precursor to 1,4-pentanediol.

Catalysis Science & Technology published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hu, Kaitai; Ye, Qingqing; Fan, Yingtao; Nan, Junyi; Chen, Fangyuan; Gao, Yang; Shen, Yingzhong published the artcile< Preparation and characterization of organic soluble polyimides with low dielectric constant containing trifluoromethyl for optoelectronic application>, Related Products of 4415-87-6, the main research area is organic polyimide dielec trifluoromethyl optoelectronic.

Polyimide (PI) films have excellent comprehensive properties and bright prospects in the next generation of optoelectronic and microelectronic applications. PIs were synthesized by aromatic diamines and alicyclic dianhydrides considered to be the most effective method for preparing polyimides with high light transmittance and low dielec. constant In order to improve the overall performance of polyimide, the introduction of a large trifluoromethyl group into the main chain is also considered a powerful strategy. In this article a novel diamine containing 6 trifluoromethyl groups has been designed and synthesized by Suzuki reaction. Afterwards, PIs were synthesized with fluorinated aromatic dianhydride and alicyclic dianhydride through a two-step method. The two PIs have excellent solubility: PI-a and PI-b exhibited excellent solubility in common polar solvents. Such as DMF, DMAc, NMP and DMSO at room temperature, and PI-a was soluble in low-boiling solvents such as Et acetate, CH2Cl2 and CHCl3 at room temperature PI-b was soluble in low-boiling solvents acetone and CHCl3 at room temperature, which was rarely seen in other aromatic polyimides. Soluble in common organic solvents, especially low b.p. solvents, made these polymers easy to process and suitable for processing technol. in solution This was an important modification for PIs. They also showed good high temperature resistance: the decomposition temperature (T5%) of two PIs were 520°C and 475°C. In addition, the residual rate at 790°C was 50% and 49% resp. Two PI films had a very low dielec. constant 2.26 and 2.24, resp., which was attributed to the hyperbranched structure and strong electron-withdrawing fluorine-containing groups. PI-a and PI-b also had low water absorption of 0.66% and 0.72%, resp. The transmittance of PI-a and PI-b high transparent films at 450 nm were 74% and 82%, resp. The significant optical modification was mainly due to the weak electron-accepting alicyclic unit and the large trifluoromethyl electron withdrawing group. This work mainly provided an effective strategy for synthesizing comprehensive excellent performance PIs with high transmittance, excellent solubility, low water absorption, high heat resistance and low dielec. constant

European Polymer Journal published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Related Products of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ueno, Masaharu; Huang, Yi-Yong; Yamano, Akihito; Kobayashi, Shu published the artcile< Revised Stereochemistry of Ceramide-Trafficking Inhibitor HPA-12 by X-ray Crystallography Analysis>, COA of Formula: C9H15NO4, the main research area is crystal mol structure ceramide trafficking inhibitor HPA; ceramide trafficking inhibitor preparation MSBAR.

In response to Berkes’s report revising the stereochem. of HPA-12, an important ceramide-trafficking inhibitor that was discovered and synthesized and its stereochem. determined in 2001, the synthesis and the stereochem. were reinvestigated. A large-scale synthetic method for HPA-12 based on a Zn-catalyzed asym. Mannich-type reaction in water was developed. Single crystals of HPA-12 for X-ray crystallog. anal. were obtained from Et propionate/n-hexane, and the stereochem. was definitely determined to be 1R,3S, consistent with Berkes’s revised structure.

Organic Letters published new progress about Conformation. 137105-97-6 belongs to class tetrahydrofurans, and the molecular formula is C9H15NO4, COA of Formula: C9H15NO4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lu, Yunhua; Zhang, Jianhua; Xiao, Guoyong; Li, Lin; Hou, Mengjie; Hu, Junyi; Wang, Tonghua published the artcile< Synthesis and gas permeation properties of thermally rearranged poly(ether-benzoxazole)s with low rearrangement temperatures>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is polyetherbenzoxazole synthesis thermal rearrangement gas permeation property.

The diamine monomer, 9,9-bis[4-(4-amino-3-hydroxylphenoxy)phenyl] fluorene (bis-AHPPF) was successfully synthesized according to our modified method. A series of hydroxyl-containing poly(ether-imide)s (HPEIs) were prepared by polycondensation of the bis-AHPPF diamine with six kinds of dianhydrides, including 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), pyromellitic dianhydride (PMDA), 3,3′,4,4′-biphenyl tetracarboxylic diandhydride (BPDA), 3,3′,4,4′-oxydiphthalic anhydride (ODPA), 3,3′,4,4′-benzophenonetetracarboxylic dianhydride (BTDA) and 4,4′-(hexafluoroisopropylidine)diphthalic anhydride (6FDA) followed by thermal imidization. The corresponding thermally rearranged (TR) membranes were obtained by solid state thermal treatment at high temperature under a nitrogen atm. The chem. structure, and phys., thermal and mech. properties of the HPEI precursors were characterized. The effects of heat treatment temperature and dianhydrides on the gas transport properties of the poly(ether-benzoxazole) (PEBO) membranes were also investigated. It was found that these HPEIs showed excellent thermal and mech. properties. All the HPEI precursors underwent thermal conversion in a N2 atmosphere with low rearrangement temperatures The gas permeabilities of the PEBO membranes increased with the increase of thermal treatment temperature When HPEI-6FDA was treated at 450°C for 1 h, the H2, CO2, O2 and N2 permeabilities of the membrane reached 239.6, 196.04, 46.41 and 9.25 Barrers coupled with a O2/N2 selectivity of 5.02 and a CO2/N2 selectivity of 21.19. In six TR-PEBOs, PEBO-6FDA exhibited the lowest rearrangement temperature and largest gas permeabilities. Therefore, thermally rearranged membranes from bis-AHPPF-based HPEIs are expected to be promising materials for gas separation

RSC Advances published new progress about Complex modulus, tan δ. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ren, Dezhang; Wang, Jingyi; Jiang, Xuelei; Song, Zhiyuan; Norinaga, Koyo; Huo, Zhibao published the artcile< A Supported Ni Catalyst Produced from Ni-Al Hydrotalcite-Like Precursor for Reduction of Furfuryl Alcohol to Tetrahydrofurfuryl Alcohol by NaBH4 in Water>, Synthetic Route of 97-99-4, the main research area is furfuryl alc reduction nickel catalyst preparation property.

Tetrahydrofurfuryl alc. (THFA) is a kind of high value-added compound in industry, which can be obtained from biomass chem. engineering. However, Synthesis of THFA under mild condition with green hydrogen donors remains a big challenge. In this article, a supported Ni catalyst derived from Ni-Al hydrotalcite-like compounds (HTs) as precursors for the reduction of furfuryl alc. (FA) into THFA with NaBH4 as reducing agent in water was first reported. As a result, Ni/Al2O3-HT exhibited high catalytic activity for the transformation, and THFA was achieved in 100% yield at 60°C for 60 min. Moreover, Ni/Al2O3-HT could be recycled at least seven times without the loss of its activity. Under optimized conditions, the reduction reaction of several furan and ketone compounds was investigated. A possible mechanism for the reduction of FA to afford THFA was also proposed.

ChemistrySelect published new progress about Pore size (volume). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Synthetic Route of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wasacz, J. P.; Badding, V. G. published the artcile< A hydration of an alkyne illustrating steam and vacuum distillation>, HPLC of Formula: 5455-94-7, the main research area is laboratory experiment alkyne hydration; steam distillation laboratory experiment.

An experiment involving the conversion of 2,5-dimethyl-3-hexyne-2,5-diol to 2,2,5,5-tetramethyltetrahydrofuran-3-one, suitable for an early organic chem. laboratory course and using aqueous mercuric sulfate without the use of acid, is described. The experiment demonstrated several principles and techniques: hydration of an alkyne; steam distillation; vacuum distillation (optimal); drying of an organic liquid; stereochem.; synthesis of a ketone; keto-enol tautomerism; synthesis of a cyclic ether; and salting out techniques (optional).

Journal of Chemical Education published new progress about Alkynes Role: MSC (Miscellaneous). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, HPLC of Formula: 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brister, Matthew M.; Crespo-Hernandez, Carlos E. published the artcile< Excited-State Dynamics in the RNA Nucleotide Uridine 5'-Monophosphate Investigated Using Femtosecond Broadband Transient Absorption Spectroscopy>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is RNA UMP excited state dynamics electronic relaxation absorption spectroscopy.

Damage to RNA from UV radiation induces chem. modifications to the nucleobases. Unraveling the excited states involved in these reactions is essential; however, investigations aimed at understanding the electronic-energy relaxation pathways of the RNA nucleotide UMP have not received enough attention. In this Letter, the excited-state dynamics of UMP is investigated in aqueous solution Excitation at 267 nm results in a trifurcation event that leads to the simultaneous population of the vibrationally excited ground state, a long-lived 1nπ* state, and a receiver triplet state within 200 fs. The receiver state internally converts to the long-lived 3ππ* state in an ultrafast time scale. The results elucidate the electronic relaxation pathways and clarify earlier transient absorption experiments performed for uracil derivatives in solution This mechanistic information is important because long-lived nπ* and ππ* excited states of both singlet and triplet multiplicities are thought to lead to the formation of harmful photoproducts.

Journal of Physical Chemistry Letters published new progress about Excited singlet state. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem