Category: Tetrahydrofurans

Patent: WO2021207711 A2 | Chadwick, Alexandra et al. published a patent in 2021| cas: 550-33-4

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Product Details of 550-33-4

Chemically modified guide RNAs for genome editing with Cas9 was written by Chadwick, Alexandra; Rajeev, Kallanthottathil G.; Rohde, Ellen; Cheng, Christopher; Reiss, Caroline. And the patent was published on October 14,2021.Product Details of 550-33-4 The following contents are mentioned in the patent:

Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing PCSK9 and ANGPTL3 gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Product Details of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Product Details of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Patent: WO2010011895 A1 | Maier, Martin et al. published a patent in 2010| cas: 550-33-4

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 550-33-4

Enhancement of siRNA silencing activity using universal bases or mismatches in the sense strand was written by Maier, Martin; Addepalli, Haripriya; Manoharan, Muthiah. And the patent was published on January 28,2010.HPLC of Formula: 550-33-4 The following contents are mentioned in the patent:

Double-stranded nucleic acids useful as an siRNAs are provided that have a sense strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified or non-natural nucleobases, or one or more mismatch base pairings with the antisense strand. A method of gene silencing comprises administering to a mammal in need thereof a therapeutically effective amount of a double-stranded oligonucleotides containing a sense strand and an antisense strand, where the sense strand contains one or more modified nucleobases or one or more mismatch base pairings with the antisense strand. The effect of mismatch base pairing and modified nucleobases on siRNA potency is dependent on the mismatched base pair and its position on the sense strand. Apparently, local destabilization in the central region of the sense strand via mismatched base pairs (position 9-12) are more effective in enhancing potency than those outside of this region. The effect of modified nucleobases (e.g., 2,4-difluorotoluyl-ribonucleotide and -deoxyribonucleotide, 5-nitroindole deoxyribonucleotide and ribonucleotide, deoxyribo- and ribonebularine,, deoxy- and riboinosine, and ribo- or deoxyribo-2-aminopurine) to enhance potency over the parent compound is particularly significant in position 10. While there is no significant correlation between activity and thermal stability at positions 9, 11, and 12, the potency of the siRNAs appears to increase with decreased thermal stability due to modifications in position 10. Further, abasic modifications in position 10 and 12 particularly enhance potency over the parent compound This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4HPLC of Formula: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Patent: US20100009927 A1 | Alberte, Randall S. et al. published a patent in 2010| cas: 550-33-4

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C10H12N4O4  

Anti-inflammatory and anti-allergy extracts from nettle was written by Alberte, Randall S.; Roschek, William P., Jr.; Li, Dan. And the patent was published on January 14,2010.Electric Literature of C10H12N4O4   The following contents are mentioned in the patent:

The present invention relates in part to nettle extracts comprising at least one compound useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions. The nettle extracts showed inhibitory activities against COX-1, COX-2, 5-lipoxygenase, and tryptase, as well as H1 antagonistic activity. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Electric Literature of C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Patent: WO2018046752 A1 | Gloekler, Joern et al. published a patent in 2018| cas: 550-33-4

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Related Products of 550-33-4

Convertible nucleic acid adapters was written by Gloekler, Joern; Frohme, Marcus. And the patent was published on March 15,2018.Related Products of 550-33-4 The following contents are mentioned in the patent:

The invention relates to a method and a kit comprising single or at least partially double-stranded adapters comprising sequences with base modifications that are ligated to nucleic acid fragments and converted to generate asym. ends for specific recognition. The method is based on two main sequence conversion mechanisms, a direct conversion of specific bases and an indirect conversion by copying, wherein both mechanisms may be combined. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Related Products of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Related Products of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Faraj, Osama Abdulrahman’s team published research in JPMA. The Journal of the Pakistan Medical Association in 2021 | 58-97-9

JPMA. The Journal of the Pakistan Medical Association published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Faraj, Osama Abdulrahman; AlBayati, Sabeha Moosa published the artcile< Assessment of outcome for sample of Iraqi patients with chronic hepatitis C virus infection treated by Ledipasvir/sofosbuvir drug.>, Application of C9H13N2O9P, the main research area is Hepatitis C virus, Ledipasvir/sofosbuvir, Iraq..

OBJECTIVE: To evaluate the response to treatment by the new directly acting antivirals drugs Sofosbuvir and Ledipasvir (Harvoni), on Iraqi patients diagnosed with hepatitis C infection genotype1 and genotype 4. METHODS: This prospective study was conducted in the Gastroenterology unit of Al- Yarmouk Teaching Hospital, Baghdad, Iraq, from February 2019 to February 2020. Included were one hundred patients diagnosed with hepatitis C by antibody test and viral load. All non-cirrhotic participants received a drug containing 400 mg sofosbuvir /90 mg ledipasvir once daily for 12 weeks, whereas the cirrhotics had to take it for 24 weeks. Laboratory Investigations and viral load were assessed at baseline, and twelve weeks after end of treatment. RESULTS: The predominant genotype was 1 with 58 (58 %) patients whereas genotype 4 had 42 (42%) patients. Liver cirrhosis was present in 9(9%) patients and severe renal impairment in 27(27%) patients. Undetectable viral load at the end of treatment (week 12) was observed in 96 (96%) patients whereas 4 (4%) patients were reported as non-responders. CONCLUSIONS: Excellent therapeutic results were achieved with generic combination of sofosbuvir/ledipasvir. The regimen is highly effective and tolerable with the highest viral response observed in HCV patients with genotype 1and 4, inclusive of patients with chronic renal failure or cirrhosis.

JPMA. The Journal of the Pakistan Medical Association published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Qingfei’s team published research in Nano Research in 2021-03-31 | 4415-87-6

Nano Research published new progress about Antitumor agents. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, HPLC of Formula: 4415-87-6.

Zhang, Qingfei; Kuang, Gaizhen; He, Shasha; Liu, Sha; Lu, Hongtong; Li, Xiaoyuan; Zhou, Dongfang; Huang, Yubin published the artcile< Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy>, HPLC of Formula: 4415-87-6, the main research area is platinum polymeric nanoplatform CRISPR gene editing synergistic cancer therapy.

CRISPR/Cas9 system has become a promising gene editing tool for cancer treatment. However, development of a simple and effective nanocarrier to incorporate CRISPR/Cas9 system and chemotherapeutic drugs to concurrently tackle the biol. safety and packaging capacity of viral vectors and combine gene editing-chemo for cancer therapy still remains challenges. Herein, a chain-shattering Pt(IV)-backboned polymeric nanoplatform is developed for the delivery of EZH2-targeted CRISPR/Cas9 system (NPCSPt/pEZH2) and synergistic treatment of prostate cancer. The pEZH2/Pt(II) could be effectively triggered to unpack/release from NPCSPt/pEZH2 in a chain-shattering manner in cancer cells. The EZH2 gene disruption efficiency could be achieved up to 32.2% of PC-3 cells in vitro and 21.3% of tumor tissues in vivo, leading to effective suppression of EZH2 protein expression. Moreover, significant H3K27me3 downregulation could occur after EZH2 suppression, resulting in a more permissive chromatin structure that increases the accessibility of released Pt(II) to nuclear DNA for enhanced apoptosis. Taken together, substantial proliferation inhibition of prostate cancer cells and further 85.4% growth repression against s.c. xenograft tumor could be achieved. This chain-shattering Pt(IV)-backboned polymeric nanoplatform system not only provides a prospective nanocarrier for CRISPR/Cas9 system delivery, but also broadens the potential of combining gene editing-chemo synergistic cancer therapy.

Nano Research published new progress about Antitumor agents. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, HPLC of Formula: 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Serranti, Daniele’s team published research in Journal of pediatric gastroenterology and nutrition in 2019 | 58-97-9

Journal of pediatric gastroenterology and nutrition published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Serranti, Daniele; Dodi, Icilio; Nicastro, Emanuele; Cangelosi, Antonina M; Riva, Silvia; Ricci, Silvia; Bartolini, Elisa; Trapani, Sandra; Mastrangelo, Greta; Vajro, Pietro; D’Antiga, Lorenzo; Resti, Massimo; Indolfi, Giuseppe published the artcile< Shortened 8-Week Course of Sofosbuvir/Ledipasvir Therapy in Adolescents With Chronic Hepatitis C Infection.>, Application of C9H13N2O9P, the main research area is .

Treatment-naïve, noncirrhotic adults with chronic hepatitis C virus genotype 1 infection and with viremia levels <6 million IU/mL could be effectively treated with sofosbuvir/ledipasvir for 8 weeks. The aim of this pilot, prospective, open-label, multicenter study was to evaluate the efficacy and safety of this shortened treatment course in adolescents (≥12 years). The efficacy endpoint was sustained virological response 12 weeks after the end of treatment. Safety was assessed by adverse events and clinical/laboratory data. Fourteen consecutive adolescents (median age 16.5 years, Q1 14.1-Q3 17.4; female 57.1%), vertically infected, were enrolled and treated (June 2018-January 2019). Overall, the end of treatment response and sustained virological response 12 weeks after the end of treatment were 100%. No grade 3 to 4 adverse event or a serious adverse event was observed. Further studies are needed to confirm the optimal efficacy of the shortened 8-week treatment with sofosbuvir/ledipasvir for treatment-naïve, noncirrhotic adolescents with chronic hepatitis C virus genotype 1 infection and pretreatment viremia level < 6 million IU/mL. Journal of pediatric gastroenterology and nutrition published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xu, Wenhua’s team published research in Journal of Applied Polymer Science in 2020 | 4415-87-6

Journal of Applied Polymer Science published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Xu, Wenhua; Ma, Xiaoru; Su, Yuanhai; Song, Yang; Shang, Minjing; Lu, Xuemin; Lu, Qinghua published the artcile< Synthesis of highly transparent and thermally stable copolyimide with fluorine-containing dianhydride and alicyclic dianhydride>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is transparent polyimide film material preparation alicyclic dianhydride diamine.

The development of optical films is highly desirable for applications in flexible displayers. In this work, a copolyimide (co-PI) film with high thermal stability and high transparency was prepared by the copolymerization of 2,2′-bis(trifluoromethyl)-4,4′-diaminodiphenyl ether, cyclobutanetetracarboxylic dianhydride, and 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA). The effects of aliphatic dianhydride and fluorine dianhydride monomers on the optical, thermal, and mech. properties of the co-PIs were discussed in detail based on the exptl. results and theor. simulations. We found that the preparation of polyimide (PI) based on the combination of two dianhydrides could obtain the PI film with excellent comprehensive performance due to nonconjugated structure and strong electron-withdrawing effect. Through the structure and composition optimization, a PI film of PI-6FDA-70 with Tg of 300°C, Td10% more than 500°C, the average transparency of 90% and the elongation at the breakage more than 8% was prepared Such mol. design provides a practical approach to develop high-performance colorless PI films.

Journal of Applied Polymer Science published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Campisi, Sebastiano’s team published research in ACS Catalysis in 2020-05-15 | 97-99-4

ACS Catalysis published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application of C5H10O2.

Campisi, Sebastiano; Chan-Thaw, Carine E.; Chinchilla, Lidia E.; Chutia, Arunabhiram; Botton, Gianluigi A.; Mohammed, Khaled M. H.; Dimitratos, Nikolaos; Wells, Peter P.; Villa, Alberto published the artcile< Dual-Site-Mediated Hydrogenation Catalysis on Pd/NiO: Selective Biomass Transformation and Maintenance of Catalytic Activity at Low Pd Loading>, Application of C5H10O2, the main research area is hydrogenation catalysis palladium NiO biomass transformation.

Creating a new chem. ecosystem based on platform chems. derived from waste biomass has significant challenges; catalysts need to be able to convert these highly functionalized mols. to specific target chems., economical – not relying on large quantities of precious metals – and maintain activity over many cycles. Herein, we demonstrate how Pd/NiO is able to direct the selectivity of furfural hydrogenation and maintain performance at low Pd loading by a unique dual-site mechanism. Sol-immobilization was used to prepare 1 wt% Pd nanoparticles supported on NiO and TiO2, with the Pd/NiO catalyst showing enhanced activity with a significantly different selectivity profile; Pd/NiO favors tetrahydrofurfuryl alc. (72%), whereas Pd/TiO2 produces furfuryl alc. as the major product (68%). D. functional theory studies evidenced significant differences on the adsorption of furfural on both NiO and Pd surfaces. Based on this observation we hypothesized that the role of Pd was to dissociate hydrogen, with the NiO surface adsorbing furfural. This dual-site hydrogenation mechanism was supported by comparing the performance of 0.1 wt% Pd/NiO and 0.1 wt% Pd/TiO2. In this study, the 0.1 and 1 wt% Pd/NiO catalysts had a comparable activity, whereas there was a 10 fold reduction in performance for 0.1 weight% Pd/TiO2. When using TiO2 as the support the Pd nanoparticles are responsible for both hydrogen dissociation and furfural adsorption, and the activity is strongly correlated with the effective metal surface area. This work has significant implications for the upgrading of bio-derived feedstocks, suggesting alternative ways for promoting selective transformations and reducing the reliance on precious metals.

ACS Catalysis published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Arumugam, Selvamani’s team published research in ChemistrySelect in 2020-07-27 | 97-99-4

ChemistrySelect published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Arumugam, Selvamani; Kuppan, Jayaprakash; Devaraj, Murugan; Arumugam, Sivasamy published the artcile< Fe-Pd-immobilized Al-pillared laponite clay as efficient catalyst for conversion of furfural into tetrahydrofurfuryl alcohol>, Name: (Tetrahydrofuran-2-yl)methanol, the main research area is iron palladium immobilized laponite hydrogenation catalyst furfural tetrahydrofurfuryl alc.

Furfural has been widely reported as a new-generation renewable source for the production of chems. and fuels. In this study, Fe-Pd immobilized Al-pillared laponite clay material with suitable catalytic properties was explored as an efficient catalyst for the direct conversion of furfural (FAL) into tetrahydrofurfuryl alc. (THFOL) under the mild reaction conditions (H2 pressure- 10 bar, temperature- 60°C and time- 4 h). The synthesized samples were characterized by several physico-chem. techniques. XRD, FT-IR, H2-TPR and ICP-OES results revealed the successful loading of those bi-metals into the Al-pillared laponite structure. Acidity of the sample has been thoroughly investigated by NH3-TPD and FT-IR techniques. The catalytic activity of synthesized samples was thoroughly evaluated for the total hydrogenation of FAL for the production of THFOL. It was observed that pure Fe-Pd catalyst showed very low FAL conversion (∼53%) and THFOL selectivity (∼38%), whereas the Al-pillared laponite clay supported Fe-Pd catalyst showed an increase in the FAL conversion and THFOL selectivity up to 95% and 98%, resp. The high performance of Fe-Pd/Al-pillared laponite catalyst towards the formation of THFOL is not only ascribed to the fine dispersion of Fe and Pd species and their synergistic effect but also due to the high surface area, mesoporosity and suitable acidity of Al-pillared laponite. The recyclability of the catalyst was also explored thoroughly which confirmed their stability. Sustainability of this process lies in the utilization of low-value bio-derived FAL for the production of industrially important THFOL chem.

ChemistrySelect published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem