Category: Tetrahydrofurans

An inhibitor of mannosylation of retinyl-phosphate was written by Datema, Roelf; Schwarz, Ralph T.. And the article was included in Bioscience Reports on March 31,1984.COA of Formula: C15H23FN2O16P2  The following contents are mentioned in the article:

The guanosine disphosphate and uridine diphosphate esters of the antiviral sugar analog 2-deoxy-2-fluoro-D-glucose (GDP-FGlc [67341-45-1] and UDP-FGlc [67341-43-9]) were synthesized and tested as inhibitors of formation of lipid-linked sugars in cell-free extracts Formation of dolichol phosphate mannose  [55598-56-6] and of dolichol diphosphate di-N-acetylchitobiose were not inhibited by either sugar nucleotide. Formation of dolichol phosphate glucose  [55607-88-0] was inhibited by UDP-FGlc, but not by GDP-FGlc. Although GDP-FGlc did not inhibit formation of dolichol phosphate mannose, it did inhibit formation of retinyl phosphate mannose  [55722-25-3] from retinyl phosphate  [53859-19-1] and GDP-mannose. This inhibition was not reversed by exogenous retinyl phosphate, nor was FGlc from GDP-Glc incorporated into retinyl phosphate-linked derivatives As FGlc inhibits formation of dolichol phosphate mannose in intact cells, but does not decrease pool sizes of GDP-mannose and dolichol-phosphate (Datema, R., et al., 1980), that inhibition of formation of retinyl-phosphate mannose by one of the metabolites of FGlc, namely GDP-FGlc, may lead to decreased synthesis of dolichol phosphate mannose in FGlc-treated cells. This implies a role for vitamin A  [68-26-8] in the dolichol cycle of protein glycosylation. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9COA of Formula: C15H23FN2O16P2 ).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.COA of Formula: C15H23FN2O16P2 

67341-43-9;Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester;The future of 67341-43-9;New trend of C15H23FN2O16P2 ;function of 67341-43-9

Molecular mechanism of ATP versus GTP selectivity of adenylate kinase was written by Rogne, Per; Rosselin, Marie; Grundstroem, Christin; Hedberg, Christian; Sauer, Uwe H.; Wolf-Watz, Magnus. And the article was included in Proceedings of the National Academy of Sciences of the United States of America on March 20,2018.Recommanded Product: (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the article:

Enzymic substrate selectivity is critical for the precise control of metabolic pathways. In cases where chem. related substrates are present inside cells, robust mechanisms of substrate selectivity are required. Here, we report the mechanism utilized for catalytic ATP vs. GTP selectivity during adenylate kinase (Adk)-mediated phosphorylation of AMP. Using NMR spectroscopy we found that while Adk adopts a catalytically competent and closed structural state in complex with ATP, the enzyme is arrested in a catalytically inhibited and open state in complex with GTP. X-ray crystallog. experiments revealed that the interaction interfaces supporting ATP and GTP recognition, in part, are mediated by coinciding residues. The mechanism provides an at. view on how the cellular GTP pool is protected from Adk turnover, which is important because GTP has many specialized cellular functions. In further support of this mechanism, a structure-function anal. enabled by synthesis of ATP analogs suggests that a hydrogen bond between the adenine moiety and the backbone of the enzyme is vital for ATP selectivity. The importance of the hydrogen bond for substrate selectivity is likely general given the conservation of its location and orientation across the family of eukaryotic protein kinases. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Recommanded Product: (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Recommanded Product: (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4  ;function of 550-33-4

Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification was written by Offen, Wendy; Martinez-Fleites, Carlos; Yang, Min; Eng, Kiat-Lim; Davis, Benjamin G.; Tarling, Chris A.; Ford, Christopher M.; Bowles, Dianna J.; Davies, Gideon J.. And the article was included in EMBO Journal on March 22,2006.HPLC of Formula: 67341-43-9 The following contents are mentioned in the article:

Glycosylation is a key mechanism for orchestrating the bioactivity, metabolism and location of small mols. in living cells. In plants, a large multigene family of glycosyltransferases is involved in these processes, conjugating hormones, secondary metabolites, biotic and abiotic environmental toxins, to impact directly on cellular homeostasis. The red grape enzyme UDP-glucose:flavonoid 3-O-glycosyltransferase (VvGT1) is responsible for the formation of anthocyanins, the health-promoting compounds which, in planta, function as colorants determining flower and fruit color and are precursors for the formation of pigmented polymers in red wine. We show that VvGT1 is active, in vitro, on a range of flavonoids. VvGT1 is somewhat promiscuous with respect to donor sugar specificity as dissected through full kinetics on a panel of nine sugar donors. The three-dimensional structure of VvGT1 has also been determined, both in its Michaelis complex with a UDP-glucose-derived donor and the acceptor kaempferol and in complex with UDP and quercetin. These structures, in tandem with kinetic dissection of activity, provide the foundation for understanding the mechanism of these enzymes in small mol. homeostasis. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9HPLC of Formula: 67341-43-9).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 67341-43-9

67341-43-9;Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester;The future of 67341-43-9;New trend of C15H23FN2O16P2 ;function of 67341-43-9

The terpene limonene induced the green mold of citrus fruit through regulation of reactive oxygen species (ROS) homeostasis in Penicillium digitatum spores was written by Tao, Nengguo; Chen, Yue; Wu, Yalan; Wang, Xiao; Li, Lu; Zhu, Andan. And the article was included in Food Chemistry on March 30,2019.Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the article:

Herein, the dosage effect of limonene on the P. digitatum spore germination and its regulatory mechanisms were investigated. Results showed that limonene only at low concentrations displayed a stimulatory role, with the optimal concentration being 0.25 μL/mL. GC-MS and GC anal. revealed that limonene contents remained relative stable and no evidence of transformation was observed at stimulatory concentrations Metabolomics anal. showed that 61 metabolites including organic acids, amino acids, sugars, nucleosides, fatty acids, and their derivatives, were significantly changed (P < 0.05), suggesting the transitions between soluble sugars and energy-related metabolisms Proteomic anal. demonstrated that proteins in energy-related pathways and ROS homeostasis were also influenced. These were further confirmed by the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST), the contents of reactive oxygen species (ROS), hydrogen peroxide (H2O2), and glutathione (GSH). Our present research indicates that ROS homeostasis is involved in the limonene induced spore germination of P. digitatum. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4  ;function of 550-33-4

The Reopening Rate of the Fingers Domain Is a Determinant of Base Selectivity for RB69 DNA Polymerase was written by Lee, Harold R.; Wang, Mina; Konigsberg, William. And the article was included in Biochemistry on March 17,2009.Application In Synthesis of Thymidine 5′-(tetrahydrogen triphosphate) xsodium salt The following contents are mentioned in the article:

Two divalent metal ions are required for nucleotide incorporation by DNA polymerases. Here we use the bacteriophage RB69 DNA polymerase (RB69 pol) and the metal ion exchange-inert nucleotide analog rhodium(III) deoxythymidine triphosphate (Rh·dTTP) to investigate the requirements of metal binding to the A site and to the B site, independently. We show that while binding of a metal ion to the A site is required for the nucleotidyl transfer reaction to occur, this metal binding is insufficient to initiate the prechem. enzyme isomerization that has been observed with this polymerase. Moreover, we show that binding of a deoxynucleoside triphosphate (dNTP), in the absence of a catalytic metal ion, is sufficient to induce this conformational change. In this report, we also present several lines of evidence (from pulse-chase, rapid chem. quench-flow, and stopped-flow fluorescence experiments) for the reverse rate of the enzyme isomerization, closed to open, of a DNA polymerase complex. The implications of these data for the fidelity of DNA polymerization by RB69 pol are discussed. This study involved multiple reactions and reactants, such as Thymidine 5′-(tetrahydrogen triphosphate) xsodium salt (cas: 18423-43-3Application In Synthesis of Thymidine 5′-(tetrahydrogen triphosphate) xsodium salt).

Thymidine 5′-(tetrahydrogen triphosphate) xsodium salt (cas: 18423-43-3) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Application In Synthesis of Thymidine 5′-(tetrahydrogen triphosphate) xsodium salt

18423-43-3;Thymidine 5′-(tetrahydrogen triphosphate) xsodium salt;The future of 18423-43-3;New trend of C10H14N2Na3O14P3;function of 18423-43-3

Biocatalytic synthesis of seleno-, thio- and chloro-nucleobase modified nucleosides by thermostable nucleoside phosphorylases was written by Zhou, Xinrui; Yan, Weizhu; Zhang, Chong; Yang, Zhaoyi; Neubauer, Peter; Mikhailopulo, Igor A.; Huang, Zhen. And the article was included in Catalysis Communications on March 5,2019.Formula: C10H12N4O4   The following contents are mentioned in the article:

Selenium-containing nucleosides are the building blocks of the Se-nucleic acids useful for structure-and-function study, drug discovery and for targeting nucleic acids and their protein complexes. However, chem. synthesis of these Se-containing nucleosides is labor-intensive and provides low overall yields. Thus, we decided to explore biocatalytic synthesis of the modified nucleosides (such as Se-nucleosides) by employing thermostable nucleoside phosphorylases from thermophilic microorganisms. We were surprised to discover that these enzymes can still recognize the nucleobases containing rather larger atoms, Se vs. O atom. These enzymes also showed excellent adaptability to some modified purines with high substrate conversion (up to 97%). This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Formula: C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Formula: C10H12N4O4  

550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4  ;function of 550-33-4

Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N-(Acyloxy)phthalimides was written by Sherwood, Trevor C.; Li, Ning; Yazdani, Aliza N.; Dhar, T. G. Murali. And the article was included in Journal of Organic Chemistry on March 2,2018.Recommanded Product: 550-33-4 The following contents are mentioned in the article:

An improved, one-pot Minisci reaction has been developed using visible light, an organic photocatalyst, and carboxylic acids as radical precursors via the intermediacy of in situ-generated N-(acyloxy)phthalimides. The conditions employed are mild, demonstrate a high degree of functional group tolerance, and do not require a large excess of the carboxylic acid reactant. As a result, this reaction can be applied to drug-like scaffolds and mols. with sensitive functional groups, enabling late-stage functionalization, which is of high interest to medicinal chem. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Recommanded Product: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Recommanded Product: 550-33-4

550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4  ;function of 550-33-4

Synthesis of 2′,3′-dideoxypurinenucleosides via the palladium catalyzed reduction of 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)purine derivatives was written by Shiragami, Hiroshi; Amino, Yusuke; Honda, Yutaka; Arai, Masayuki; Tanaka, Yasuhiro; Iwagami, Hisao; Yukawa, Toshihide; Izawa, Kunisuke. And the article was included in Nucleosides & Nucleotides on March 31,1996.Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

Practical method to produce 2′,3′-dideoxypurinenucleosides from 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)purines (I; R1 = NH2, OH, R2 = H; R1 = OH, R2 = NHAc) was developed. High ratio of 2′,3′-dideoxynucleoside to 3′-deoxyribonucleoside was obtained by selecting the reaction conditions (solvent, pH and/or base), or changing 2′-acyloxy leaving group. The reaction mechanism was studied by deuteration experiments of I (R1 = NH2, R2 = H) and 1-(3,5-di-O-acetyl-2-bromo-2-deoxy-β-D-ribofuranosyl)thymine (II). This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Megaspinoxide A: New Norterpene Cyclic Peroxide from the Sponge Diacarnus megaspinorhabdosa was written by Ibrahim, Sabrin R. M.; Al Haidari, Rwaida A.; Mohamed, Gamal A.. And the article was included in Natural Products Journal on March 31,2014.HPLC of Formula: 550-33-4 The following contents are mentioned in the article:

Re-investigation of the methanolic extract of the sponge Diacarnus megaspinorhabdosa afforded 1 new norsesterpene cyclic peroxide megaspinoxide A (I), together with 2 known compounds sigmosceptrellin B and nebularine. The structures of the isolated compounds were established on the basis of 1- and 2-dimensional NMR spectroscopic studies (1H, 13C, DEPT, COSY, HMQC, HMBC, and ROESY) as well as, mass spectral anal. The isolated compounds were evaluated for their cytotoxic and antimicrobial activities. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4HPLC of Formula: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.HPLC of Formula: 550-33-4

550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4  ;function of 550-33-4

Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists was written by Bruns, Robert F.. And the article was included in Canadian Journal of Physiology and Pharmacology on June 30,1980.HPLC of Formula: 13146-72-0 The following contents are mentioned in the article:

Adenosine [58-61-7] (ED50 15 μM) causes a 50-fold increase in intracellular cyclic AMP in the VA13 human fibroblast line. A total of 128 nucleosides was tested as agonists and antagonists. Eight classes of compounds were found: full agonists (14 compounds), weak agonists (20), high-efficacy partial agonists (16), low-efficacy partial agonists (7), competitive inhibitors (11), noncompetitive inhibitors (3), partial agonist – noncompetitive inhibitors (3), and inactive compounds (54). The noncompetitive inhibitors antagonized the responses to adenosine, isoproterenol, and prostaglandin E1 and thus may have been adenylate cyclase inhibitors. The most potent noncompetitive inhibitor, 2′,5′-dideoxyadenosine [6698-26-6] was a partial inhibitor, reducing the response to isoproterenol by only 77% even at very high concentrations The most potent agonists, partial agonists, and pure antagonists had apparent affinities of about 5 μM. Although all positions were important for affinity at the adenosine receptor, only the 3′- and 5′-positions and to a much lesser extent the 6- and 8-positions had an effect on efficacy. The receptor tolerated bulky groups at the 6-position of adenosine, had an Et-sized pocket near the 5′-position, and had little bulk tolerance towards modifications at other positions. Among the full agonists, only one 5′-derivative and one 2-position derivative had higher apparent affinity than adenosine. Studies with conformationally restricted agonists and antagonists showed that adenosine must be in the anti conformation in order to bind to the receptor. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0HPLC of Formula: 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.HPLC of Formula: 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0