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Compounds of formula (I): wherein R1, R2, R3, B, W, Z, m and n are as defined in the description The compounds of the present invention have pro-apoptotic and/ or anti-proliferative properties making it possible to use them in pathologies involving a defect in apoptosis, such as, for example, in the treatment of cancer and of immune and auto-immune diseases.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

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Persulfate is used as an oxidizing breaker in hydraulic fracturing fluids to breakdown gelling agents and clean out wellbores. Persulfate may be activated using conditions like those encountered in the wellbore, producing strong oxidizing radicals that degrade organic compounds. Thus, this study examined persulfate activated transformation of organic additives in a simulated hydraulic fracturing brine by investigating the transformation of furfural. Pseudo-first-order reactions kinetics of furfural degradation in conditions that mimic a fracture, including high temperature, acidified pH, ferric sulfate, and a laboratory simulated hydraulic fracturing brine, were established. The activation energies for furfural removal in acidic (pH 2.54) hydraulic fracturing brine was 105.6 kJ mol?1 without ferric sulfate and 105.1 kJ mol?1 with 23.3 mg L?1 ferric sulfate. A high-pressure reactor was used to simulate the effects of pressure on persulfate activation. Increasing pressure was shown to increase activation of persulfate at 55 C. Applying 3000 psi to the reactor nearly halved the apparent furfural activation energy compared to experiments at atmospheric pressure. Finally, reaction byproducts were presented with the findings showing that halogenated organic byproducts form in hydraulic fracturing brine during persulfate use.

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Tetrahydrofuran – Wikipedia,
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Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R1-R3 R6c and X1 are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV-1) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treating diseases mediated by the CCR5 receptor.

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Tetrahydrofuran – Wikipedia,
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The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.

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Tetrahydrofuran – Wikipedia,
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A little inspiration: The systematic preparation of sixteen natural product-inspired polyhydroylated pyrrolidine-based isomeric scaffolds is described. Each scaffold possesses four stereogenic centers and one exo-aminomethyl moiety, which allows for rapid substituent diversity. To exemplify biological applications, these new privileged scaffolds were used to discover new human Golgi alpha-mannosidase II inhibitors. The most potent inhibitor shows competitive behavior with a Ki value of 24 nM. Copyright

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The present invention relates to a class of novel heterocyclic compounds, to pharmaceutical compositions comprising the compounds and their use in the treatment of kinetoplastid infections.

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The invention discloses a compound, pharmaceutical composition and its use. The compounds of this invention have the formula (I) structure: Wherein all substituents are as defined herein. The invention pharmaceutical composition comprises a therapeutically effective amount of formula (I) compound and a pharmaceutically acceptable of the first layer, the medical composition of the present invention can be used for treating individual used in the manufacture of the proprotein convertase subtilisin kexin 9-related diseases. (by machine translation)

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Tetrahydrofuran – Wikipedia,
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Fluorine-substituted indazole compounds, pharmaceutical compositions containing these compounds and uses thereof. The compounds and pharmaceutical compositions can be used as soluble guanylate cyclase simulators.

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Tetrahydrofuran – Wikipedia,
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This invention concerns the use of 2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)­pyrrolidin-3-yl]-piperazin- l -yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)-methanone and its derivatives having neurokinin antagonistic activity, in particular a combined NK1/NK2/NK3 antagonistic activity and to modulate the activity of dopaminergic pathways in the brain, as a medicine for the prophylactic and/or therapeutic treatment of schizophrenia. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, theN-oxide form thereof and prodrugs thereof.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem