Category: 696-59-3

In 2022,EL-Mahdy, Ahmed F. M.; Bakhite, Etify A.; Abdel-Hafez, Shams H.; Ibrahim, Omaima F.; Abdu-Allah, Hajjaj H. M.; Marae, Islam S. published an article in Journal of Heterocyclic Chemistry. The title of the article was 《Synthesis, characterization, and photophysical properties of some new thieno[2,3-b]pyridines bearing phenylethenyl moiety》.Reference of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

The 5-acetyl-3-cyano-6-methyl-4-(2-phenylethenyl)pyridine-2(1H)-thione was synthesized by interaction of cinnamylidene-2-cyanothioacetamide and acetylacetone or via one-pot reaction of E-cinnamaldehyde, 2-cyanothioacetamide, and acetylacetone. Reaction of 5-acetyl-3-cyano-6-methyl-4-(2-phenylethenyl)pyridine-2(1H)-thione with Et iodide or N-chloroacetyl derivative of aromatic amines RC6H4NHC(O)CH2Cl (R = Me, OMe, acetyl, Cl) in boiling ethanol containing sodium ethoxide gave the 5-acetyl-3-cyano-2-ethylsulfanyl-6-methyl-4-(2-phenylethenyl)pyridine and 5-acetyl-3-amino-2-(N-arylcarbamoyl)-6-methyl-4-(2-phenylethenyl)thieno[2,3-b]pyridines I, resp. Compound I (R = Cl) was reacted with 2,5-dimethoxytetrahydrofuran or tri-Et orthoformate to furnish 5-acetyl-2-[N-(4-chlorophenyl)carbamoyl]-6-methyl-4-(2-phenylethenyl)-3-(1H-pyrrol-1-yl)- thieno[2,3-b]pyridine or 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one, resp. The photophys. properties of I (Me, OMe, Cl), and 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one were fully studied and the obtained results included herein. The fluorescence data confirmed that compounds I (Me, OMe, Cl), and 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one exhibit aggregation-induced emission behavior with high absolute quantum yields. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Formal enantioselective total synthesis of bisdehydroneostemoninine》 was published in Journal of Asian Natural Products Research in 2020. These research results belong to Ma, Kai-Qing; Ren, Hu-Bin; Chao, Jian-Bin; Qin, Xue-Mei. Quality Control of 2,5-Dimethoxytetrahydrofuran The article mentions the following:

A formal enantioselective total synthesis of bisdehydroneostemoninine I employing L-glutamic acid as the chiral pool is described. The key features of the synthesis include regioselective and enantioselective opening of the chiral epoxide, (2R)-2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]oxirane with dimethylsulfonium methylide and tandem Friedel-Crafts cyclization followed by lactonization to form a 5-7-5 tricyclic core of the target stemona alkaloids I. The synthetic route provides opportunities to explore the biol. behavior of enantiopure compound I.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of 2,5-DimethoxytetrahydrofuranIn 2020 ,《Towards the template synthesis of conjugated pyrrole based oligo-heteroaryls》 was published in Journal of the Indian Chemical Society. The article was written by Panda, Biswajit. The article contains the following contents:

Synthesis of polymers and Oligomers with various interesting phys. properties is a rewarding task for the chemist. oligoheteroaryls are a significant class of organic compounds due to their wide applicability in various fields. Here, in this article, the synthetic studies directed for the preparation of conjugated pyrrole based oligo-heteroaryls was reported. The successful synthesis of double stranded polymeric ladderphane using ring opening metathesis polymerizations (ROMP) and palladium catalyzed Suzuki coupling were the key feature of this work. Hydrolysis of the double stranded polymer was unsuccessful due to its insoluble nature. The effort to increase the solubility of the double stranded polymers by the incorporation of long-chain aliphatic counterpart is underway in our laboratory In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Li, Guangchen; Xing, Yangyang; Zhao, Hui; Zhang, Jin; Hong, Xin; Szostak, Michal published an article in Angewandte Chemie, International Edition. The title of the article was 《Chemoselective Transamidation of Thioamides by Transition-Metal-Free N-C(S) Transacylation》.Name: 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

The first general, mild and highly chemoselective method for transamidation of thio-amides by NC(S) transacylation using non-nucleophilic anilines was reported. The method was broadly compatible with N-Ar tertiary thioamides and N-thioacyl-azoles as selective N-thioacyl transfer reagents. DFT studies that provided insight into the chemoselectivity of this new transamidation method and provided guidelines for the development of future transamidation methods of the thioamide bond.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Name: 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Name: 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 696-59-3In 2019 ,《Direct Synthesis of Multi-functional Pyrimidine, Pyrazine, and Pyridine Scaffolds via Inter-molecular and Intramolecular Annulations of 3-Amino-thieno[2,3-b]pyridine-2-carboxylate》 was published in Journal of Heterocyclic Chemistry. The article was written by El-Sayed, Hassan A.; Said, Said A.. The article contains the following contents:

A direct and facile synthesis of a new series of tricyclic and tetracyclic pyrimidine, pyrazine, and pyridine derivatives fused to thieno[2,3-b]pyridine was performed from Et carboxylate I as a synthon. The antibacterial results illustrated no significant results for the investigated compounds except compound II, which has moderate activity against Gram-pos. bacteria. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Recommanded Product: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Recommanded Product: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of 2,5-DimethoxytetrahydrofuranIn 2022 ,《Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir》 appeared in Organic Process Research & Development. The author of the article were Roy, Sarabindu; Yadaw, Ajay; Roy, Subho; Sirasani, Gopal; Gangu, Aravind; Brown, Jack D.; Armstrong, Joseph D. III; Stringham, Rodger W.; Gupton, B. Frank; Senanayake, Chris H.; Snead, David R.. The article conveys some information:

Pyrrolo[2,1-f][1,2,4]triazine (I) is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound I was produced through a newly developed synthetic methodol. utilizing simple building blocks such as pyrrole, chloramine, and formamidine acetate by examining the mechanistic pathway for the process optimization exercise. Triazine I was obtained in 55% overall yield in a two-vessel-operated process. This work describes the safety of the process, impurity profiles and control, and efforts toward the scale-up of triazine for the preparation of kilogram quantity. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 696-59-3In 2021 ,《Mo-Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties》 appeared in Chemistry – A European Journal. The author of the article were Hernandez-Ruiz, Raquel; Rubio-Presa, Ruben; Suarez-Pantiga, Samuel; Pedrosa, Maria R.; Fernandez-Rodriguez, Manuel A.; Tapia, M. Jose; Sanz, Roberto. The article conveys some information:

A catalytic domino reduction-imine formation-intramol. cyclization-oxidation for the general synthesis of a wide variety of biol. relevant N-polyheterocycles, such as quinoxaline- and quinoline-fused derivatives, and phenanthridines, is reported. A simple, easily available, and environmentally friendly dioxomolybdenum(VI) complex has proven to be a highly efficient and versatile catalyst for transforming a broad range of starting nitroarenes involving several redox processes. Not only is this a sustainable, step-economical as well as air- and moisture-tolerant method, but also it is worth highlighting that the waste byproduct generated in the first step of the sequence is recycled and incorporated in the final target mol., improving the overall synthetic efficiency. Moreover, selected indoloquinoxalines have been photophys. characterized in cyclohexane and toluene with exceptional fluorescence quantum yields above 0.7 for the alkyl derivatives The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《IRMOF-3 biological activity enhancement by post-synthetic modification》 was written by Abdelhameed, Reda M.; Darwesh, Osama M.; Rocha, Joao; Silva, Artur M. S.. Synthetic Route of C6H12O3This research focused onzinc metal organic framework IRMOF3 derivative nanoparticle antimicrobial. The article conveys some information:

The growing resistance of pathogens to conventional antibiotics has become a public health problem requiring novel effective solutions In this context, metal-organic frameworks (MOFs) are attracting attention because they can act as reservoirs releasing metal ions with antibacterial properties. This action is reminiscent of that proposed for metal- and metal oxide-nanoparticles but different from the action of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications. Here, IRMOF-3 was modified with 2,5-dimethoxytetrahydrofuran, N,N’-disuccinimidyl carbonate, acryloyl chloride, and phthalaldehyde to produce, resp., IRMOF-3-FU, IRMOF-3-SU, IRMOF-3-AC, IRMOF-3-DL in 38 to 90% yields. Remarkably, the biol. activity of these compounds evaluated against various bacterial and fungal strains is higher than the activity of com. antibiotics. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of 2,5-DimethoxytetrahydrofuranIn 2022 ,《Lactam Strategy Using Amide-Selective Nucleophilic Addition for Quick Access to Complex Amines: Unified Total Synthesis of Stemoamide-Type Alkaloids》 was published in Bulletin of the Chemical Society of Japan. The article was written by Sugiyama, Yasukazu; Soda, Yasuki; Yoritate, Makoto; Tajima, Hayato; Takahashi, Yoshito; Shibuya, Kana; Ogihara, Chisato; Yokoyama, Takashi; Oishi, Takeshi; Sato, Takaaki; Chida, Noritaka. The article contains the following contents:

In this article, the authors report full details of the unified total synthesis of stemoamide-type alkaloids by chemoselective assembly of five-membered rings based on the lactam strategy. First, the concise and gram-scale synthesis of tricyclic stemoamide was achieved by vinylogous Michael addition-reduction sequence of an unsaturated γ-lactam with an unsaturated γ-lactone, followed by N-alkylation to form the seven-membered ring. From stemoamide as a common intermediate, chemoselective nucleophilic addition of unsaturated lactone derivatives provided tetracyclic natural products. While stemonine was obtained by an Ir-catalyzed lactam-selective reductive Mannich reaction, saxorumamide and isosaxorumamide were produced through the lactone-selective nucleophilic addition of the lithiated 2-silyl furan. The developed conditions for the lactam-selective nucleophilic reactions were highly general, and were found to be applicable to the total synthesis of pentacyclic stemocochinin and isostemocochinin. The strategy enabled the concise and unified total synthesis of tricyclic, tetracyclic and pentacyclic stemoamide-type alkaloids within 12 steps from a com. available compound The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Safety of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Safety of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of 2,5-DimethoxytetrahydrofuranIn 2020 ,《Synthesis and characterization of some new pyridines, thieno[2,3-b] pyridines and pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-ones bearing styryl moiety》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Al-Waleedy, Safiyyah A. H.; Bakhite, Etify A.; Abbady, Mohamed S.; Abdu-Allah, Hajjaj H. M.. The article conveys some information:

Reaction of compound 3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridine-2(1H)-thione with some N-aryl-2-chloroacetamides, in the presence of sodium acetate, gave the corresponding 2-(N-arylcarbamoylmethylsulfanyl)-3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridines I [R1 = H, Me, NO2, etc.]. Reaction of compound 3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridine-2(1H)-thione with some N-aryl-2-chloroacetamides, in the presence of sodium acetate, gave the corresponding 2-(N-arylcarbamoylmethylsulfanyl)-3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridines I [R1 = H, Me, NO2, etc.]. When compounds I were subjected to Thorpe-Ziegler reaction conditions, they converted into the corresponding 3-amino-5-ethoxycarbonyl-2-(N-arylcarbamoyl)-6-methyl-4-styrylthieno[2,3-b]pyridines II [R2 = NH2]. Compounds II [R1 = H, Cl, NO2, R2 = NH2] were reacted, in turn, with 2,5-dimethoxytetrahydrofuran to furnish the corresponding 3-(pyrrol-1-yl)thieno-pyridines II [R2 = 1-pyrrolyl]. Reactions of II [R2 = NH2] with tri-Et orthoformate were also carried out to form 3-aryl-8-acetyl-7-methyl-9-styrylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-ones III [X = C]. Reactions of compounds II [R1 = OMe, Cl, R2 = NH2] with nitrous acid were also carried out to form 3-aryl-8-acetyl-7-methyl-9-styrylpyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]triazine-4(3H)-ones III [X = N]. Structural formulas of all synthesized compounds I, II and III were characterized and confirmed on the basis of their elemental and spectral analyzes. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Safety of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Safety of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem