Category: 696-59-3

The author of 《Nucleophilic Substitution of Hydrogen Atom in Initially Inactivated Pyrrole Ring》 were Pozharskii, Alexander F.; Ozeryanskii, Valery A.; Dyablo, Olga V.; Pogosova, Olga G.; Borodkin, Gennady S.; Filarowski, Aleksander. And the article was published in Organic Letters in 2019. Formula: C6H12O3 The author mentioned the following in the article:

It has been found that 1-dialkylamino-8-(pyrrolyl-1)naphthalenes I[R = Me, Me; (CH2)4], upon treatment with an equimolar amount of HBF4 under ambient conditions, produce 1-dialkylammonium salts which are transformed into 7,7-dialkyl-7H-pyrrolo[1,2-a]perimidine-7-ium tetrafluoroborates II [R = Me, Me; (CH2)4, X =BF4], resp. The reaction proceeds in a highly selective manner and represents the first case of nucleophilic substitution of hydrogen in the initially inactivated pyrrole ring. The scope and limitations of the transformation, apparently operating due to the joint action of the “”proximity effect”” and proton catalysis, are outlined. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Advanced Synthesis & Catalysis included an article by Wei, Zhao; Zhang, Jinlong; Yang, Huameng; Jiang, Gaoxi. Reference of 2,5-Dimethoxytetrahydrofuran. The article was titled 《Bronsted Acid-Catalyzed Asymmetric Ring-Closing Alkylation of Inert N-substituted Pyrroles with α, β-Unsaturated Ketones》. The information in the text is summarized as follows:

A chiral Bronsted acid catalyzed asym. intramol. ring-closing alkylation of inert pyrroles with α, β-unsaturated ketones has been developed. This approach gave a wide range of 4-phenyl-4,5-dihydro-6H-benzo[f]pyrrolo[1,2-a]azepin-6-ones in high yields with good enantioselectivities under mild reaction conditions. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Chemistry – An Asian Journal included an article by Ni, Jixiang; Jiang, Yong; Qi, Zhenjie; Yan, Rulong. Category: tetrahydrofurans. The article was titled 《TFAA-Catalyzed Annulation Synthesis of Spiro Pyrrolo[1,2-a]quinoxaline Derivatives from 1-(2-Aminophenyl)pyrroles and Benzoquinones/Ketones》. The information in the text is summarized as follows:

A metal-free trifluorosulfonate anhydride (TFAA)-catalyzed strategy for the synthesis of spiro pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and benzoquinones/ketones was developed. With this general method, spiro pyrrolo[1,2-a]quinoxalines were accessed via nucleophilic addition and cyclization. This reaction exhibited good functional group tolerance and a wide range of products were obtained in moderate to good yields. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Category: tetrahydrofurans)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

HPLC of Formula: 696-59-3In 2020 ,《A pro-gastrin-releasing peptide imprinted photoelectrochemical sensor based on the in situ growth of gold nanoparticles on a MoS2 nanosheet surface》 appeared in Analyst (Cambridge, United Kingdom). The author of the article were Wang, Xing; Deng, Hongping; Wang, Chen; Wei, Qiuxi; Wang, Yanying; Xiong, Xiaoxing; Li, Chunya; Li, Wenwen. The article conveys some information:

Lamellar MoS2 nanosheets were successfully prepared by hydrothermal synthesis using 1-(3-mercaptopropyl)-3-methyl-imidazolium bromine (MIMBr) ionic liquid as a sulfur source and a morphol. control agent, and sodium molybdate as a molybdenum source. Gold nanoparticles were assembled on the surface of MoS2 nanosheets by the in situ reduction of chloroauric acid at low temperatures to successfully fabricate AuNP/2D-MoS2 nanocomposites, thus improving photoelectrochem. response. AuNP/2D-MoS2 nanocomposites were used as photoelec. active materials modified onto a glassy carbon electrode surface to construct a photoelectrochem. (PEC) sensor. Then, using 1-(N-pyrrolpropyl)-3-methyl-imidazolium bromine (PMIMBr) ionic liquid as a functional monomer and pro-gastrin-releasing peptide (Pro-GRP) as a template, a molecularly imprinted polymerized ionic liquid film was electrochem. deposited on an AuNP/2D-MoS2/GCE surface. Upon removing the templates, a molecularly imprinted photoelectrochem. sensor was constructed for the sensing of a tumor marker, pro-gastrin-releasing peptide. Exptl. conditions including ascorbic acid concentration, polymerization conditions, incubation time, and pH value of the incubation solution have been optimized. Under the optimized conditions, the molecularly imprinted photoelectrochem. sensor can specifically detect the target protein Pro-GRP in the range of 0.02 ng mL-1-5 ng mL-1 with a detection limit of 0.0032 ng mL-1 (S/N = 3). The practicability of this photoelectrochem. sensor was demonstrated by accurately determining Pro-GRP in human serum samples. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3HPLC of Formula: 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.HPLC of Formula: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ibrahim, Dhuaou; Boulet, Pascal; Gros, Philippe C.; Pierrat, Philippe published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Efficient Access to Arylated Aza-ullazines by Regioselective Functionalization of their Pyridine Ring by H-Li Exchange and Electrophilic Substitution》.Application of 696-59-3 The article contains the following contents:

The regioselective functionalization of aza-ullazines had been successfully realized for the first time by either metalation using BuLi-containing aggregates (BuLi-LiDMAE) or electrophilic substitution. Mono and di-bromo-derivatives were obtained in good to excellent yields and further successfully converted into aryl-azaullazines I [R = H, Ph; Ar = Ph, 4-CHOC6H4, 6-chloro-3-pyridyl, 5-formyl-2-thienyl] and alkynyl-azaullazines II [R1 = H, CCPh; Ar1 = Ph, 4-Bu2NC6H4] by Suzuki and Sonogashira cross-coupling reactions. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Neutral Pyrrole Nitrogen Atom as a π- and Mixed n,π-Donor in Hydrogen Bonding》 were Pozharskii, Alexander F.; Ozeryanskii, Valery A.; Filatova, Ekaterina A.; Dyablo, Olga V.; Pogosova, Olga G.; Borodkin, Gennady S.; Filarowski, Aleksander; Steglenko, Dmitriy V.. And the article was published in Journal of Organic Chemistry in 2019. Category: tetrahydrofurans The author mentioned the following in the article:

9-Dimethylaminobenzo[g]indoles I [R1, R2 given:H,H (3);4-MeC6H4,Me(4);4-O2NC6H4,Me(5);H, CF3(6)] and 1-dimethylamino-8-(pyrrolyl-1)naphthalene 7 were examined as possible models for establishing the ability of the pyrrole nitrogen atom to participate in [NHN]+ hydrogen bonding as a proton acceptor. Indoles 3-5 (to a lesser extent 6) form rather stable tetrafluoroborates, with the proton mostly located on the NMe2 group but simultaneously engaged in the formation of a charged intramol. [NHN]+ hydrogen bond (IHB) with the pyrrole N atom. The theor. estimated energies of IHB in salts 3H+BF4–6H+BF4- vary between 7.0-10.7 and 6.2-7.0 kcal mol-1 in vapor and MeCN, resp. The pyrrole N atom undergoes a perceptible pyramidalization but still remains involved in the 6π-electron aromatic system, suggesting that the hydrogen bonding in salts 3H+BF4–6H+BF4- represents a previously unknown mixed NH···N(n,π) interaction. Despite the favorable orientation of the N-H bond and the pyrrole ring in salt 7H+BF4-, no signs of NH···N(n) bonding in it were noticed, and the existing interaction was classified as pure NH···N(π). The results obtained may be useful in studies of secondary protein structures, especially those α-helix sections which contain tryptophan residues. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Category: tetrahydrofurans)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Design, synthesis and photophysical properties of novel star-shaped truxene-based heterocycles utilizing ring-closing metathesis, Clauson-Kaas, Van Leusen and Ullmann-type reactions as key tools》 was written by Alvi, Shakeel; Ali, Rashid. Electric Literature of C6H12O3This research focused ontruxene preparation; Clauson–Kaas reaction; Ullmann-type coupling; Van Leusen reaction; heterocycles; ring-closing metathesis; truxene. The article conveys some information:

Herein, three novel distinctly different routes for the generation of C3-sym. pyrrole-based truxene architectures I [R = NH2, 4-CHOC6H4, pyrrol-1-yl, etc.] by means of cyclotrimerization, ring-closing metathesis (RCM), Clauson-Kaas and Ullmann-type coupling reactions as key steps was revealed. Moreover, some other interesting heterocyclic systems possessing oxazole, imidazole, benzimidazole and benzoxazole in the framework of truxene were also assembled. Addnl., the preliminary photophys. properties (absorption and emission) for these versatile systems was revealed. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Electric Literature of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of C6H12O3In 2020 ,《Singlet Fission in a Pyrrole-Fused Cross-Conjugated Skeleton with Adaptive Aromaticity》 was published in Journal of the American Chemical Society. The article was written by Wang, Long; Lin, Lu; Yang, Jingjing; Wu, Yishi; Wang, Hua; Zhu, Jun; Yao, Jiannian; Fu, Hongbing. The article contains the following contents:

Singlet fission (SF) materials hold the potential to increase the power conversion efficiency of solar cells by reducing the thermalization of high-energy excited states. The major hurdle in realizing this potential is the limited scope of SF-active materials with high fission efficiency, suitable energy levels, and sufficient chem. stability. Herein, using theor. calculation and time-resolved spectroscopy, a highly stable SF material is developed on dipyrrolonaphthyridinedione (DPND), a pyrrole-fused cross-conjugated skeleton with a distinctive adaptive aromaticity (dual aromaticity) character. The embedded pyrrole ring with 4n + 2 π-electron features aromaticity in the ground state, while the dipole resonance of the amide bonds promotes a 4n π-electron Baird’s aromaticity in the triplet state. Such an adaptive aromaticity renders the mol. efficient for the SF process [E(S1) ≥ 2E(T1)] without compromising its stability. Up to 173% triplet yield, strong blue-green light absorption, and suitable triplet energy of 1.2 eV, as well as excellent stability, make DPND a promising SF sensitizer toward practical applications.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Electric Literature of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Zeng, Zhenya; Zhang, Jiangbo; Jia, Miao; Wu, Bo; Cai, Xunzhi; Zhang, Xingsong; Feng, Yixiao; Ma, Youhong; Gao, Qingfu; Fei, Zonglei published an article in Organic Process Research & Development. The title of the article was 《Development of a Scalable Route with Efficient Stereoisomer Control to YZJ-1139, an Orexin Receptor Antagonist》.COA of Formula: C6H12O3 The author mentioned the following in the article:

An effort toward the synthesis and process development of the orexin receptor antagonist YZJ-1139 I was described in this article. I contains the azabicyclic nortropane structure with three chiral centers. By the original process, highly pure intermediates or API could be obtained by chromatog. with a relatively low yield. To remove the undesirable stereoisomers as early as possible, an N-(R)-α-phenethyl was synthesized by the Robinson-Schopf reaction and easily purified as its hydrochloride. The single crystal X-ray study was used to confirm the stereo configuration of I. The protecting group could be easily removed by transfer hydrogenation, resulting in an enantiomerically pure intermediate as its D-tartrate. The overall yield for preparing I was significantly increased, and this cost-efficient process might be promising in future com. productions. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3COA of Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.COA of Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Muley, Arabinda; Karumban, Kalai Selvan; Gupta, Parth; Kumbhakar, Sadananda; Giri, Bishnubasu; Raut, Rajnikant; Misra, Ashish; Maji, Somnath published their research in Journal of Organometallic Chemistry in 2021. The article was titled 《Synthesis, structure, spectral, redox properties and anti-cancer activity of Ruthenium(II) Arene complexes with substituted Triazole Ligands》.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran The article contains the following contents:

Three versatile half-sandwich ruthenium(II) p-cymene complexes bearing substituted triazole ligands exhibit promising cancer cell growth inhibition activity towards A549 lung adenocarcinoma and MDA-MB-231 breast adenocarcinoma cells. In this context, the triazole based phthalimide protected new ligand (2-(3, 5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione) (L1) was prepared Three ruthenium(II) p-cymene complexes [Ru(η6-p-cymene)(L1)Cl]Cl: [1]Cl, L1: (2-(3,5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione), [Ru(η6-p-cymene)(L2)Cl]Cl: [2]Cl and [Ru(η6-p-cymene)(L2)Cl](PF6): [2](PF6), L2 (2,2′-(4-(1H-pyrrol-1-yl)-4H-1,2,4-triazole-3,5-diyl)dipyridine) have been successfully synthesized and characterized by different spectral and anal. tools. Pyrrole protected substituted ruthenium complexes [2]Cl and [2](PF6) have been successfully identified structurally by single-crystal x-ray diffraction studies and confirmed the successful anion exchange. The redox properties of the ligands and the targeted metal complexes have been carefully examined Cellular staining, live-cell imaging and MTT assay have been performed for all the complexes. Authors have demonstrated that their synthesized ruthenium(II) p-cymene complexes are capable of inducing significant cytotoxicity in A549 lung cancer cell lines, with an IC50 values of 6.56 ± 0.31μM, 4.74 ± 0.2μM and 13.67 ± 0.64μM and in MDA-MB-231 breast cancer cell lines with an IC50 values of 1.13 ± 0.046μM, 0.36 ± 0.016μM and 11.32 ± 0.49μM for [1]Cl, [2]Cl and [2](PF6) resp. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application In Synthesis of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem