Category: 696-59-3

Application of 696-59-3In 2019 ,《Effects of fused rings linked to the 2,5-position of pyrrole derivatives with near-infrared emission on their aggregation-enhanced emission properties》 appeared in Materials Chemistry Frontiers. The author of the article were Ren, Fei; Shi, Jianbing; Tong, Bin; Cai, Zhengxu; Dong, Yuping. The article conveys some information:

Fluorescent materials with near-IR (NIR) emission are important kinds of functional dyes for bioimaging and medical diagnosis. In this work, a type of pyrrole derivative with NIR emission was designed and synthesized through the introduction of different fused rings at the 2,5-position of pyrrole (MAP) and a furanylidene (FE) group at the 3-position of pyrrole (MAP-FE), which constructed a typical donor-π bridge-acceptor (D-π-A) structure. All MAP-FEs have shown aggregation-enhanced emission (AEE) properties. Different fused rings or different positions of substitution on the same fused ring had significant effects on the NIR photoluminescence (PL) properties. In addition, by comparison with the change in the radiative and nonradiative rates of the precursor MAPs and MAP-FEs in solution and the solid state, it can be concluded that the rings fused to the 2,5-position of pyrrole have a two-sided effect on the PL properties of organic dyes: one effect is an improvement in the quantum yield, and the other effect causes a π-π stacking interaction that is unfavorable for emission. The introduction of FE groups as acceptors in MAP-FEs not only red shifted emission wavelengths but also effectively avoided π-π stacking in the aggregated state, which are beneficial for PL properties. These results could provide general guidance for designing NIR dyes with AEE characteristics when using fused rings to improve their PL properties. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Synthesis and Investigation of Thermal, Optical and Electrochemical Properties of 2,4,6-Trisubstituted Pyrimidines》 was written by Slobodinyuk, Daria G.; Slobodinyuk, Alexey I.; Shklyaeva, Elena V.; Abashev, Georgii G.. Related Products of 696-59-3This research focused ontrisubstituted pyrimidine preparation UV vis spectra fluorescence redox potential. The article conveys some information:

A number of novel fluorophores have been synthesized containing an electron-withdrawing pyrimidine core and electron donating N,N-dimethylaminophenyl, 4-(9H-carbazol-9-yl)phenyl, Ph and pyrrol-1-yl fragments at positions 2, 4 and 6 of the pyrimidine ring. Thermal, optical and electrochem. properties of these substances have been studied. The structure-property dependences of substituted pyrimidines have been established. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Related Products of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Afsina, C. M. A.; Rohit, K. R.; Anilkumar, G. published an article in Results in Chemistry. The title of the article was 《A green protocol for the synthesis of N-aryl pyrroles: A modified Clauson-Kaas approach using zinc catalyst》.Synthetic Route of C6H12O3 The author mentioned the following in the article:

The first zinc-catalyzed simple and convenient protocol for the synthesis of N-substituted pyrroles I (R = H, Me, Cl, etc.; R1 = H, Me, OMe, NO2; R2 = H, OH, I, etc.; R3 = H, Me) through a modified Clauson-Kaas reaction without co-catalyst, ligand, base and solvent has been described. N-substituted pyrroles I were prepared from various aniline derivatives 2-R-3-R1-4-R2-5-R3-C6HNH2 and 2,5-dimethoxytetrahydrofuran under green condition by utilizing low cost, eco-friendly, non-toxic and easily accessible Zn(OTf)2 as catalyst. A wide variety of N-substituted pyrroles I was afforded in moderate to excellent yields from easily available starting materials at 70°C. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2》 was written by Jing, Changcheng; Mallah, Shahida; Kriemen, Ella; Bennett, Steven H.; Fasano, Valerio; Lennox, Alastair J. J.; Hers, Ingeborg; Aggarwal, Varinder K.. Reference of 2,5-DimethoxytetrahydrofuranThis research focused onthromboxane A2 fluorinated preparation platelet aggregation induction; hydrolysis kinetics fluorinated thromboxane A2. The article conveys some information:

Platelet activation results in the generation of thromboxane A2 (TxA2), which promotes thrombus formation by further amplifying platelet function, as well as causing vasoconstriction. Due to its role in thrombus formation and cardiovascular disease, its production is the target of antiplatelet drugs such as aspirin. However, the study of TxA2-stimulated cellular function has been limited by its instability (t1/2 = 32 s, pH = 7.4). Although more stable analogs such as U46619 and difluorinated 10,10-F2-TxA2 have been prepared, we targeted a closer mimic to TxA2 itself, monofluorinated 10-F-TxA2, since the number of fluorine atoms can affect function. Key steps in the synthesis of F-TxA2 included α-fluorination of a lactone bearing a β-alkoxy group, and a novel synthesis of the strained acetal. F-TxA2 was found to be 105 more stable than TxA2, and surprisingly was only slightly less stable than F2-TxA2. Preliminary biol. studies showed that F-TxA2 has similar potency as TxA2 toward inducing platelet aggregation but was superior to F2-TxA2 in activating integrin αIIbβ3. The synthesis is described of 10-F-thromboxane A2 I, a stable mimic of TxA2 (105 x more stable) with similar potency as TxA2 toward inducing platelet aggregation. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 696-59-3In 2019 ,《Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives》 appeared in Molecular Diversity. The author of the article were Zhang, Shu-Guang; Liang, Chao-Gen; Sun, Yue-Qing; Teng, Peng; Wang, Jia-Qun; Zhang, Wei-Hua. The article conveys some information:

A series of novel pyrrole- and pyrazole-substituted coumarins, compounds I [R1 = H, Me, F, etc.; R2 = Me, CH2Cl, CF3, R3 = H, Me, etc.] and II [R4 = H, Me, Et, etc.; R5 = H, Me, etc.] and evaluated their antifungal activity against six phytopathogenic fungi in-vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds I [R1 = H, R2 = CH2Cl, R3 = Me] and II [R4 = H, Me, Et, R5 = Me; R4 = H’ R5 = CF3 R4R5 = (CH2)4]exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Furthermore, compound I [R1 = H, R2 = CH2Cl, R3 = Me] displayed stronger antifungal activity against Rhizoctorzia solani (EC50 = 15.4 μg/mL) than pos. control Osthole (EC50 = 67.2 μg/mL). The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Bioresource Technology included an article by Zhou, Haoqin; Brown, Robert C.; Wen, Zhiyou. Reference of 2,5-Dimethoxytetrahydrofuran. The article was titled 《Anaerobic digestion of aqueous phase from pyrolysis of biomass: Reducing toxicity and improving microbial tolerance》. The information in the text is summarized as follows:

Among the products of pyrolysis is an aqueous phase (AP), which contains a significant fraction of carbon but is too dilute to make recovery of this organic content cost-effectively. This study was to explore the use of AP for anaerobic digestion. Different treatment methods including overliming, Fenton’s reagent oxidation, bleaching and activated carbon adsorption were investigated to reduce toxicity of AP. Overliming treatment increased biogas production up to 32-fold compared to non-treated AP. Enhancing the tolerance of the bacterial and archaeal community to the AP toxicity was also attempted with a directed evolution method, resulting the microbes’ tolerance to AP from 5% to 14%. Directed evolution resulted a major bacterial taxa as Cloacimonetes, Firmicutes, and Chloroflexi, while shifted the predominant archaea shifted from acetoclastic to hydrogenotrophic methanogens. Collectively, the results demonstrated that combining feedstock treatment and directed evolution of the microbial community is an effective way for AP anaerobic digestion. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Thaltiri, Vikranth; Shanmugapriya, V.; Panda, Pradeepta K. published an article in 2021. The article was titled 《Efficient and Gram-Scale Synthesis of 1-Methyl-2,3,4-Trinitropyrrole: A Promising Precursor for Insensitive High Energy Melt-Castable Materials》, and you may find the article in ChemistrySelect.Computed Properties of C6H12O3 The information in the text is summarized as follows:

1-Methyl-2,3,4,5-tetranitropyrrole (NMTNP) was recently found to be a promising insensitive high energy melt-castable material. To prove its potentials further, herewith, 1-methyl-2,3,4-trinitropyrrole was established as a potent precursor for NMTNP, by developing a method for its efficient synthesis with excellent overall yield. This method involves mild nitrating conditions, easier purification (minimal chromatog.) and readily available reagents and hence can be scaled up easily. In addition, the facile synthesis of 2,3,4-trinitropyrrole during this process can lead to new class of pyrrole based high energy d. materials. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Computed Properties of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ren, Fei; Li, Zeshun; Li, Kai; Zheng, Xiaoyan; Shi, Jianbing; Zhang, Chen; Guo, Heng; Tong, Bin; Xi, Lei; Cai, Zhengxu; Dong, Yuping published an article in 2021. The article was titled 《Donor strategy for promoting nonradiative decay to achieve an efficient photothermal therapy for treating cancer》, and you may find the article in Science China: Chemistry.Quality Control of 2,5-Dimethoxytetrahydrofuran The information in the text is summarized as follows:

Photothermal therapy (PTT) is emerging as an effective treatment for superficial carcinoma. A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency. Aiming to address this challenge, we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore PTT photosens/itizers of high efficiency. Among these multi-arylpyrrole derivatives, MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency (up to 72%) when it is encapsulated by an amphiphilic polymer. As a result, the MAP4-FE nanoparticles have shown satisfactory PTT effects on in vivo tumor eradication under the guidance of photoacoustic signals. The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,ChemistrySelect included an article by Brites, Nathan P.; Dilelio, Marina C.; Martins, Guilherme M.; Carmo, Gabriele do; Morel, Ademir F.; Kaufman, Teodoro S.; Silveira, Claudio C.. Computed Properties of C6H12O3. The article was titled 《Synthesis and Antifungal Activity of 4- and 6-(1H-Pyrrol-1-yl) Coumarins, and their Thiocyanato Derivatives》. The information in the text is summarized as follows:

Facile and efficient syntheses of 4-(1H-pyrrol-1-yl)-coumarins and 6-(1H-pyrrol-1-yl)-coumarins from the corresponding aminocoumarins are reported. The transformations were optimized and their corresponding scope and limitations were assessed. Selected (1H-pyrrol-1-yl)-coumarins were further subjected to a mild thiocyanation, underwent selective functionalization on the pyrrole nucleus. A set of 10 differently substituted compounds was submitted to activity testing against various fungal strains. It was found that the introduction of a SCN moiety increased the antifungal activity, turning some compounds into fungicidal agents, to the point that one of the thiocyanato derivatives displayed an antifungal profile comparable to those of fluconazole and nystatin. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Computed Properties of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

COA of Formula: C6H12O3In 2022 ,《Discovery and Optimization of 6-(1-Substituted pyrrole-2-yl)-s-triazine Containing Compounds as Antibacterial Agents》 appeared in ACS Infectious Diseases. The author of the article were Green, Keith D.; Pang, Allan H.; Thamban Chandrika, Nishad; Garzan, Atefeh; Baughn, Anthony D.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie. The article conveys some information:

Antimicrobial drug resistance is a major health issue plaguing healthcare worldwide and leading to hundreds of thousands of deaths globally each year. Tackling this problem requires discovery and development of new antibacterial agents. In this study, we discovered novel 6-(1-substituted pyrrole-2-yl)-s-triazine containing compounds that potently inhibited the growth of Staphylococcus aureus regardless of its methicillin-resistant status, displaying min. inhibitory concentration (MIC) values as low as 1μM. The presence of a single imidazole substituent was critical to the antibacterial activity of these compounds Some of the compounds also inhibited several nontubercular mycobacteria. We have shown that these mols. are potent bacteriostatic agents and that they are nontoxic to mammalian cells at relevant concentrations Further development of these compounds as novel antimicrobial agents will be aimed at expanding our armamentarium of antibiotics. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3COA of Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem