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The present study was carried out to evaluate phytochemical composition and pharmacological activities of leaf extract of Lusia zeylanica by using different solvents. The solvents like n-hexane, ethyl acetate and methanolic were used to extract dried leaf material of L. zeylanica. These extracts were analyzed for phytochemical constituents with GC-MS analysis and antimicrobial activity tested against four bacterial strains and three fungal strains by using the agar diffusion method. In-vitro anticancer activity was done against two cancer cell lines (MCF-7 and HeLa cell line) by using MTT assay. Phytochemical analysis revealed the presence of coumarins, flavonoids, glycosides, phenols, saponins, tannins, and terpenoids. GC-MS analysis determines the presence of 11 compounds in ethyl acetate, 7 compounds in methanolic extracts and a total of 7 unknown compounds respectively. A significant cancer cell growth inhibition was observed for two extracts with IC50 values ranging between 18.36 mug/ml to 67.914 mug/ml. Our result shows this plant is a promising source of phytocompounds with potential antimicrobial and anticancer activity.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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[reaction: see text] An approach to the macrocyclic core of apicularen A is described. Thus, cross-coupling of the aryl triflate 7 with the vinylstannane 19 provided the styrene 20. Deprotection led to the dihydroxy acid 22. Through a size-selective macrolactonization, the 12-membered macrolactone 23 was obtained. Treatment of 24 with N-phenyl selenophthalimide gave the desired trans-pyran 24. This approach might parallel the biosynthetic pathway.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Rapid removal of recalcitrant organic contaminants from coking wastewater remains a challenge. Powder coke is a burden to coke plant and environment, has the potential as a cost-effective absorbent material. But its absorption capacity is limited by the dense crystalline carbon structure and low surface activity. This study proposes a facile method to fabricate powder coke-derived adsorbent by tuning the surface functional groups. Results revealed that the obtained powder coke-derived adsorbent presented a relatively smooth surface, worm-like pore structure and discernible graphitization degree. The O1S and N1S functional groups were increased from 27.7% to 52.2%. The adsorption of recalcitrant organic contaminants from coking wastewater was increased by 70%, implying significantly by the reduced UV254. The increased N and O-contained functional groups on the surface could introduce hydrophobic force and pi-pi EDA interactions, which are responsible to the enhanced interactions between powder coke-derived adsorbent and recalcitrant organic contaminants (PAHs and BAD, etc). The engineering aspect of the powder coke-derived adsorbent was discussed in the perspective of recent advances and challenges. This study provides scientific basis for its effective use of powder coke as an adsorbent for tertiary treatment of coke wastewater, so as to achieve the dual purposes of clean production and environmental protection.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The present invention provides compounds, compositions thereof, and methods of using the same.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The study aimed to evaluate extraction efficiency, detection and quantification of phytochemicals, minerals and antioxidative capacity of different parts of Salacia chinensis L. Continuous shaking extraction, steam bath assisted extraction, ultrasonic extraction and microwave assisted extraction with varied time intervals were employed for extraction of phenolics, flavonoids, and antioxidants. Preliminary screening revealed the presence of wide array of metabolites along with carbohydrates and starch. Steam bath assisted extraction for 10 min exposure was found most suitable for extraction phenolics (46.02 ¡À 2.30 mg of gallic acid equivalent per gram of dry weight and 48.57 ¡À 2.42 mg of tannic acid equivalent per gram of dry weight) and flavonoids (35.26 ¡À 1.61 mg of quercetin equivalent per gram of dry weight and 51.60 ¡À 2.58 mg of ellagic acid equivalent per gram of dry weight). In support, reverse phase-high performance liquid chromatography- diode array detector confirmed the presence of seven pharmaceutically important phenolic acids. Antioxidant capacity was measured by 1, 1- diphenyl-1-picryl hydrazyl (DPPH), ferric reducing antioxidant power (FRAP), 2, 2?-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) scavenging (ABTS) and N, N-dimethyl-p-phenylenediamine (DMPD) assays and represented as trolox equivalent antioxidant capacity (TEAC) and ascorbic acid equivalent antioxidant capacity (AEAC). Antioxidant capacity ranged from 121.02 ¡À 6.05 to 1567.28 ¡À 78.36 muM trolox equivalent antioxidant capacity and 56.62 ¡À 2.83 to 972.48 ¡À 48.62 muM ascorbic acid equivalent antioxidant capacity. Roots showed higher yields of illustrated biochemical parameters, however fresh fruit pulp was found a chief source of minerals. Gas chromatography-mass spectroscopic analysis revealed the presence of a vast array of phytoconstituents associated with different plant parts. The present study revealed the amounts of minerals and diverse phytoconstituents in various parts of S. chinensis and confirmed its medicinal and nutritional implications.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

More research is needed about (R)-(-)-5-Oxotetrahydrofuran-2-carboxylicacid

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Anodic Fragmentation of O-Acylated alpha-Hydroxy Carboxylic Acids

Depending on the degree of substitution at the alpha-carbon atom, the electrolyses of O-acylated alpha-hydroxy carboxylic acids 1 yield products of fragmentation (aldehydes or ketones 5) and products derived from acylium ions 4 in concurrence with simple anodic substitution products (acylales, amides, and imides, respectively).Dioxiranyl cations 2 are involved as intermediates.The fragmentation of the dioxiranyl cation 2 is investigated by semiempirical MINDO/3 calculations (Scheme 1).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Zidovudine derivatives having antibacterial activity and its preparation method and application (by machine translation)

The invention discloses a Combivir derivative and its preparation method and application, which belongs to the antibacterial activity of the medicament with the synthesis technology field. The technical scheme of the present invention is to point: zidovudine derivatives having antibacterial activity, structural formula is:, wherein R is C1 – 4 Alkyl or a halogen atom. The invention also discloses the zidovudine derivatives having antibacterial activity of specific synthetic process and its application in preparing antibacterial drug. The invention according to zidovudine containing azido group in the molecule, by reacting it with click with different substituents of the aniline base alkyne apperception compound reaction to get zidovudine derivatives, and selecting the Staphylococcus aureus – gram positive bacteria, gram-negative bacteria and fungi – Escherichia coli – Candida albicans to the synthesized Combivir derivative of the in vitro antibacterial activity determination, the results show that the compounds demonstrate better antibacterial activity. (by machine translation)

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Catalytic Organic Reactions in Water toward Sustainable Society

Traditional organic synthesis relies heavily on organic solvents for a multitude of tasks, including dissolving the components and facilitating chemical reactions, because many reagents and reactive species are incompatible or immiscible with water. Given that they are used in vast quantities as compared to reactants, solvents have been the focus of environmental concerns. Along with reducing the environmental impact of organic synthesis, the use of water as a reaction medium also benefits chemical processes by simplifying operations, allowing mild reaction conditions, and sometimes delivering unforeseen reactivities and selectivities. After the “watershed” in organic synthesis revealed the importance of water, the development of water-compatible catalysts has flourished, triggering a quantum leap in water-centered organic synthesis. Given that organic compounds are typically practically insoluble in water, simple extractive workup can readily separate a water-soluble homogeneous catalyst as an aqueous solution from a product that is soluble in organic solvents. In contrast, the use of heterogeneous catalysts facilitates catalyst recycling by allowing simple centrifugation and filtration methods to be used. This Review addresses advances over the past decade in catalytic reactions using water as a reaction medium.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Peptides

A novel peptide of the formula: STR1 wherein A is hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl or alkoxy; R is STR2 X is –S– or –(CH2)n — where n is 1 or 2 has a weaker TRH releasing activity than TRH and a stronger anaesthesia-antagonistic activity, spontaneous movement-stimulant activity or dopamine-potentiating activity than TRH.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Antibiotic 2-(3-oxo-2-isoxazolidinyl)-5-oxo-2-tetrahydrofuran-carboxylates

The compound represented by the formula: STR1 where R1 stands for amino or an organic residue bonded through nitrogen; R2 stands for carboxyl or a group derivable therefrom; R3, R4, R5, R6, R7 and R8 independently stand for hydrogen or an organic residue, including the case where R5 or R6 forms a chemical bond or a ring with R7 or R8 ; X stands for hydrogen, methoxy or formylamino; or a salt thereof, produceable by the present method, exhibits excellent antimicrobial activity, and is utilized as antimicrobial agents.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem