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52079-23-9, Name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone, belongs to Tetrahydrofurans compound, is a common compound. COA of Formula: C4H6O3In an article, once mentioned the new application about 52079-23-9.

Synthesis and Nuclear Magnetic Resonance Studies of Some N-Acylated Methyl 4-Amino-4,6-dideoxy-alpha-D-mannopyranosides

The methyl alpha-glycosides of 4-amino-4,6-dideoxy-D-mannopyranose (perosamine), N-acylated with either formic, acetic, or (S)-2,4-dihydroxybutanoic acid, have been synthesized.The (1)H and (13)C n.m.r. spectra of these substances and the parent, non-N-acylated glycoside, demonstrated how the chemical shifts are influenced by the N-acylation.The N-formyl derivative occured in two conformations, s-cis and s-trans, and the free-energy barrier between these, 86.9 kJ mol-1, was defined by dynamic n.m.r. spectroscopy.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS FOR LOCAL DRUG DELIVERY

The present invention relates to a compound according to formula (I) wherein R1 is selected from the group consisting of 5- and 6- membered heteroaryl, (C1- C6)alkyl, (C3-C6)cycloalkyl, (4-6)-membered heterocycloalkyl and phenyl; R2 is selected from (C1-C3)alkyl and halo(C1-C3)alkyl; R3 is selected from phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R4 is selected from hydrogen, halogen, (C1- C4)alkyl and halo(C1-C4)alkyl; X1 is selected from CH, C(Rb) and N, X2 is selected from CH and N; Y is selected from -NH- and -O-; m is 0 or 1; n is 0 or 1; L represents a bond, -O-, -NH- or -N(RC)-; or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Related Products of 52079-23-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 52079-23-9, molcular formula is C4H6O3, introducing its new discovery.

Enantioselective synthesis of alpha-hydroxy gamma-butyrolactones from an ephedrine-derived morpholine-dione

An ephedrine-derived morpholine dione is employed in the enantioselective synthesis of (S)-alpha-hydroxy gamma,gamma-dimethyl-gamma-butyrolactone and (S)-alpha-hydroxy gamma-butyrolactone. A one-pot alkylation/allylation protocol for the stereoselective conversion of the dione to 2-alkyl-2-allyl morpholinones, key intermediates for alpha-alkyl-alpha-hydroxy-gamma-butyrolactones, is described.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Application of 52079-23-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.52079-23-9, Name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone, molecular formula is C4H6O3. In a article£¬once mentioned of 52079-23-9

Stereoselective 1,4-phenyl migration from silicon to carbon in alpha-siloxy cyclic acetal systems: A concise synthesis of 1,2-cis-phenyl C-glycoside and enantioenriched silanol

The treatment of O-glycoside with alcohol in the presence of montmorillonite K10 clay and 4-A MS yields the 1,4-aryl migration product with a 1,2-cis-phenyl C-glycoside scaffold and a chiral silyl moiety with high stereoselectivity.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Synthesis of some analogs of the methyl alpha-glycoside of the presumed antigenic determinant of the O-specific polysaccharide of Vibrio cholerae O:1, serotype ogawa

The following analogs of the title determinant, methyl 4,6-dideoxy-4-(3-deoxy-L-glycero-tetronamido)-2-O-methyl-alpha-D- mannopyranoside, have been prepared: methyl 3,4,6-trideoxy-4-(3-deoxy-L-glycero-tet ronamido)-2-O-methyl-alpha-D-mannopy ranoside, methyl 4,6-dideoxy -4-(4-hy droxybuty ramido)-2-O-methyl-alpha-D-mannopy ranoside, methyl 4,6-dideoxy -4-(3,4-dideoxy-L-glycero-tetronamido)-2-O-methyl-alpha-D-mannopyranoside, methyl 4,6-dideoxy -4-(3-deoxy -D-glycero-tetronamido)-2-O-methyl-alpha-D-mannopyranoside, methyl 4,6-dideoxy-4-(2-deoxy-L-glycero-tetronamido)-2-O-methyl-alpha-D- mannopyranoside, methyl 4-acetamido-4,6-dideoxy-2-O-methyl-alpha-D-mannopyranoside, methyl 4,6-dideoxy-4-(3-deoxy-L-glycero-tetronamido)-2-O-ethyl-alpha-D- mannopyranoside, and methyl 4,6-dideoxy-4-(3-deoxy-L-glycero-tetronamido)-2-O-propyl-alpha-D- mannopyranoside.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Easy access to the epothilone family – Synthesis of epothilone B

An easy access to four out of five naturally occurring epothilones (A- E, 1-5) is reported. Key steps are an enantioselective Mukaiyama type aldol reaction, (E)- and (Z)-selective olefinations, and a sulfone alkylation.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Epothilone B and its derivatives as novel antitumor drugs: Total and partial synthesis and biological evaluation

Microtubule stabilizing natural products, as exemplified by paclitaxel (taxolR), are being considered as novel drugs against malignant therapy resistent solid tumors. Among these compounds, epothilone B and some of its derivatives have emerged as particularly promising candidates for industrial development. The total and partial syntheses of these compounds are described in detail, and some of the most important recent results on their biological activity are discussed.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C4H6O3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52079-23-9, name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone. In an article£¬Which mentioned a new discovery about 52079-23-9

Synthesis of the 2-deoxy analogue of the methyl alpha-glycoside of the monosaccharide repeating unit of the O-polysaccharide of Vibrio cholerae O:1

Keywodrs: Polysaccharide; Vibrio cholerae O:1; Glycoside; Synthesis

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C4H6O3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52079-23-9, name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone. In an article£¬Which mentioned a new discovery about 52079-23-9

4,6-HEXADECADIENE-2,4-DICARBOXYLIC ACID DERIVATIVE

A 4,6-hexadecadiene-2,4-dicarboxylic acid derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, each of which has an anti-tumor activity, and the like, are provided. [wherein, R1 represents hydroxy, ?OR3 (wherein R3 represents optionally substituted lower alkyl or an optionally substituted aliphatic heterocyclic group), or ?NR4R5 (wherein R4 and R5 may be the same or different, and each represents a hydrogen atom or optionally substituted lower alkyl) and R2 represents hydroxy or ?OR6 (wherein R6 represents optionally substituted lower alkyl or optionally substituted aralkyl)]

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Synthesis of 1alpha,25-dihydroxy-24R-fluorocholecalciferol and 1alpha,25-dihydroxy-24S-fluorocholecalciferol

1alpha,25-Dihydroxy-24R-fluorocholecalciferol and 1alpha,25-dihydroxy-24S-fluorocholecalciferol, analogs of 1alpha,25-dihydroxy-cholecalciferol which is physiologically the most active metabolite of vitamin D3, are synthesized in a multistep process from the known substance 1alpha,3beta-dihydroxyandrost-5-en-17-one. The new analogs are characterized by the ability to increase intestinal calcium transport, increase serum calcium and phosphate concentrations and to increase the deposition of these minerals in bones. These compounds will find a ready application as substitutes for natural 1alpha,25-dihydroxycholecalciferol in the treatment of disease states characterized by metabolic calcium and phosphate deficiencies. Exemplary of such disease states are the following: osteosclerosis, anticonvulsant treatment, osteopenia, fibrogenesis-imperfecta ossium, secondary hyperparathyrodism, hypoparathyroidism, hyperparathyroidism, cirrhosis, obstructive jaundice, drug induced metabolism, medullary carcinoma, chronic renal disease, hypophosphatemic VDRR, vitamin D-dependent rickets, sarcoidosis, glucocorticoid antagonism, malabsorption syndrome, steatorrhea, tropical sprue, idiopathic hypercalcemia and milk fever.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem