Category: 51856-79-2

Electric Literature of C8H11NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about A practical method for the synthesis of indolylaryl- and bisindolylmaleimides. Author is Roy, Sudipta; Roy, Sujata; Gribble, Gordon W..

Indolyl(aryl)- and indolyl(heteroaryl)maleimides, including bisindolylmaleimides, were prepared via the reaction of N-methylindole-3-glyoxylamide with Me arylacetates in the presence of potassium tert-butoxide. The desired products were isolated after recrystallization in good yields.

Although many compounds look similar to this compound(51856-79-2)Electric Literature of C8H11NO2, numerous studies have shown that this compound(SMILES:O=C(OC)CC1=CC=CN1C), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate(SMILESS: O=C(OC)CC1=CC=CN1C,cas:51856-79-2) is researched.Formula: C13H20N4O2. The article 《Water-compatible cycloadditions of oligonucleotide-conjugated strained allenes for DNA-encoded library synthesis》 in relation to this compound, is published in ChemRxiv. Let’s take a look at the latest research on this compound (cas:51856-79-2).

DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features-related to elements found to be powerful in phenotypic screening.

Although many compounds look similar to this compound(51856-79-2)Reference of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, numerous studies have shown that this compound(SMILES:O=C(OC)CC1=CC=CN1C), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 51856-79-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Mild Aminoacylation of Indoles and Pyrroles through a Three-Component Reaction with Ynol Ethers and Sulfonyl Azides. Author is Alford, Joshua S.; Davies, Huw M. L..

An effective method for aminoacylation of indoles and pyrroles has been achieved. The transformation involves a multicomponent one-pot cascade reaction between indoles or pyrroles, ynol ethers, and sulfonyl azides, creating four different bonds regioselectively through N-sulfonyltriazole intermediates. E.g., in presence of copper(I) thiophene-2-carboxylate in 1,2-DCE, multicomponent reaction of PhOCCH, MsN3, and 1-methylindole, followed by addition of Amberlyst 15, gave 87% acylated indole derivative I. The oxo-tryptamines and oxo-pyrroloethanamines are generated in moderate to high yields under mild reaction conditions.

Compounds in my other articles are similar to this one(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Related Products of 51856-79-2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 51856-79-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Synthesis and antifungal activity of some new 1,2,4-triazole and furan containing compounds. Author is Shehata, Ihsan A..

Several new 1,2,4-triazole analogs attached to substituted Ph, pyrrole or furan 5-membered heterocycles were synthesized and screened for their antimicrobial activity. Bromination of Me 2-methylfuran-3-carboxylate, followed by ring closure with aniline, gave 5,6-dihydro-4-oxo-5-phenyl-4H-furo[2,3-c]pyrrole (I) in 55% yield (two steps). Compounds I and 3-(1-methyl-2-pyrrolylmethyl)-4-phenyl-5-(4-chlorophenylcarbamoylmethylthio)-1,2,4-triazole showed a prominent activity against C. albicans and S. cerevisiae.

Compounds in my other articles are similar to this one(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Product Details of 51856-79-2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis, antimicrobial, and anti-inflammatory activities of acetamido pyrrolyl azoles》. Authors are Sowmya, Donthamsetty V.; Basha, Shaik Sharafuddin; Devi, Palampalli Uma Maheswari; Lavanyalatha, Yerraguravagari; Padmaja, Adivireddy; Padmavathi, Venkatapuram.The article about the compound:Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetatecas:51856-79-2,SMILESS:O=C(OC)CC1=CC=CN1C).Computed Properties of C8H11NO2. Through the article, more information about this compound (cas:51856-79-2) is conveyed.

Series of 2-(pyrrol-2-yl)-N-(oxazol-2-yl)acetamides I [R = H, Me, MeO, Cl, Br, NO2; X = O], 2-(pyrrol-2-yl)-N-(thiazol-2-yl)acetamides I [X = S] and 2-(pyrrol-2-yl)-N-(imidazol-2-yl)acetamides I [X = NH] were prepared via reaction of (5-benzoyl-1-methyl-1H-pyrrol-2-yl)acetic acid with 4-aryloxazol-2-amines/4-arylthiazol-2-amines/4-aryl-1H-imidazol-2-amines resp. All the synthesized compounds I were screened for their antibacterial, antifungal and anti-inflammatory activities. Among the tested compounds, 2-(pyrrol-2-yl)-N-(thiazol-2-yl)acetamides I [R = NO2; X = S] and 2-(pyrrol-2-yl)-N-(imidazol-2-yl)acetamides I [R = NO2; X = N] exhibited promising antibacterial activity against K. pneumoniae. The 2-(pyrrol-2-yl)-N-(imidazol-2-yl)acetamides I [R = NO2; X = N] showed good antifungal activity against P. chrysogenum and 2-(pyrrol-2-yl)-N-(oxazol-2-yl)acetamidesI [R = MeO; X = O] displayed potential anti-inflammatory activity.

When you point to this article, it is believed that you are also very interested in this compound(51856-79-2)Computed Properties of C8H11NO2 and due to space limitations, I can only present the most important information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 51856-79-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about An Electrophilic Approach to the Palladium-Catalyzed Carbonylative C-H Functionalization of Heterocycles.

A palladium-catalyzed approach to intermol. carbonylative C-H functionalization is described. This transformation is mediated by PtBu3-coordinated palladium catalyst and allows the derivatization of a diverse range of heterocycles, including pyrroles, indoles, imidazoles, benzoxazoles, and furans. Preliminary studies suggest that this reaction may proceed via the catalytic formation of highly electrophilic intermediates. Overall, this provides with an atom-economical and general synthetic route to generate aryl-(hetero)aryl ketones I (Y = O, NBn, NMe, NEt, etc.; Z = CH, N; R = H, 4-F, 3-Br, 2-Cl, 4-CO2Et, 4- CN, etc.) using stable reagents (aryl iodides and CO) and without the typical need to exploit pre-metalated heterocycles in carbonylative coupling chem.

When you point to this article, it is believed that you are also very interested in this compound(51856-79-2)Product Details of 51856-79-2 and due to space limitations, I can only present the most important information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 51856-79-2, is researched, SMILESS is O=C(OC)CC1=CC=CN1C, Molecular C8H11NO2Journal, Applied Catalysis, A: General called Hydrogenation of pyrrole derivatives. Part III. Hydrogenation of methyl 1-methyl-2-pyrroleacetate, Author is Hegedus, Laszlo; Mathe, Tibor; Tungler, Antal, the main research direction is hydrogenation pyrroleacetate; pyrrolidineacetate preparation.Electric Literature of C8H11NO2.

A new hydrogenation method for the saturation of the pyrrole ring has been applied in the hydrogenation of Me 1-methyl-2-pyrroleacetate in nonacidic medium. Various catalytic metals and solvents have been screened. High conversion and selectivity were achieved with rhodium and ruthenium catalysts. In palladium catalyzed hydrogenations the selectivity was improved by appropriate solvents.

When you point to this article, it is believed that you are also very interested in this compound(51856-79-2)Electric Literature of C8H11NO2 and due to space limitations, I can only present the most important information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate(SMILESS: O=C(OC)CC1=CC=CN1C,cas:51856-79-2) is researched.COA of Formula: C14H24O4. The article 《Synthesis and evaluation of CE-0266: a new human neutrophil elastase inhibitor》 in relation to this compound, is published in Bioorganic Chemistry. Let’s take a look at the latest research on this compound (cas:51856-79-2).

The synthesis and evaluation of 4-(methylsulfinyl)phenyl 2-(1-methyl-2-pyrrolyl)butyrate (CE-0266) (I) and the related sulfide and sulfone derivatives, CE-0265 and CE-0267, resp., are described. The potency of the inhibitors toward human neutrophil elastase increases across the series of CE-0265, I, CE-0267. I, with a ϰ3Ki*/ϰ2 value of 36 nM, exhibited high selectivity for elastase and was chosen for addnl. in vitro studies.

As far as I know, this compound(51856-79-2)Recommanded Product: 51856-79-2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of C8H11NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Water-compatible cycloadditions of oligonucleotide-conjugated strained allenes for DNA-encoded library synthesis. Author is Westphal, Matthias V.; Hudson, Liam; Mason, Jeremy W.; Pradeilles, Johan A.; Zecri, Frederic J.; Briner, Karin; Schreiber, Stuart L..

DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles, and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features, related to elements found to be powerful in phenotypic screening. DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features-related to elements found to be powerful in phenotypic screening.

This literature about this compound(51856-79-2)Synthetic Route of C8H11NO2has given us a lot of inspiration, and I hope that the research on this compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of C8H11NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Transition-Metal-Free Electrophilic Fluoroalkanesulfinylation of Electron-Rich (Het)Arenes with Fluoroalkyl Heteroaryl Sulfones via C(Het)-S and S=O Bond Cleavage. Author is Wei, Jun; Bao, Kun; Qi, Chengcheng; Liu, Yao; Ni, Chuanfa; Sheng, Rong; Hu, Jinbo.

A novel Ph2P(O)Cl-mediated direct fluoroalkanesulfinylation of electron-rich (het)arenes such as indole, 1-methyl-1H-pyrrole, 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline, etc. using fluoroalkyl heteroaryl sulfones I as the RnSO source (Rn = CF3, CF3(CF2)3, CF2Cl, CF2Br, CF2COOCH2CH3) was developed. This is the first example where 2-HetSO2Rf performs as the RfSO synthon in organic synthesis via both C(Het)-S and S = O bond cleavage.

In addition to the literature in the link below, there is a lot of literature about this compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Synthetic Route of C8H11NO2, illustrating the importance and wide applicability of this compound(51856-79-2).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem