Category: 4971-56-6

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Furan-2,4(3H,5H)-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3

A simple and efficient one-pot approach for assembling novel spiro[indolepyranopyrrole] derivatives was developed and used to prepare a series of biologically important compounds. The reaction was easily performed with high efficiency under very simple and mild conditions without any catalysts and it gave good yields, avoiding time-consuming costly synthesis and laborious workup and purification of products. The cytotoxic activities of these new spiro[indolepyranopyrrole] derivatives were evaluated in vitro. Most of the tested compounds exhibited significant cytotoxicities to Raji cell lines. Georg Thieme Verlag Stuttgart New York.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of 4971-56-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a article，once mentioned of 4971-56-6

Structural simplification of an antimitotic natural product podophyllotoxin with mimetic heterocyclic scaffolds constructed using multicomponent reactions led to the identification of compounds exhibiting low nanomolar antiproliferative and apoptosis-inducing properties. The most potent compounds were found in the dihydropyridopyrazole, dihydropyridonaphthalene, dihydropyridoindole, and dihydropyridopyrimidine scaffold series. Biochemical mechanistic studies performed with dihydropyridopyrazole compounds showed that these heterocycles inhibit in vitro tubulin polymerization and disrupt the formation of mitotic spindles in dividing cells at low nanomolar concentrations, in a manner similar to podophyllotoxin itself. Separation of a racemic dihydropyridonaphthalene into individual enantiomers demonstrated that only the optical antipode matching the absolute configuration of podophyllotoxin possessed potent anticancer activity. Computer modeling, performed using the podophyllotoxin binding site on beta-tubulin, provided a theoretical understanding of these successful experimental findings.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 4971-56-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Article，once mentioned of 4971-56-6

The one-step three-component microwave assisted synthesis between aromatic aldehydes with tetronic acid or indan-1,3-dione readily formed the Knoevenagel adducts that underwent addition of 3-methylisoxazol-5-amine 1 to form the isoxazolo[5,4-b]pyridine products 8[a,b,d,e,g] in 67?90% yield. The multicomponent reaction using dimedone formed the respective addition products 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones 8[c,f,h] (36?79%). In contrast, the sonication of an aryl aldehyde and dimedone with an equivalent amount of 2-hydroxyammonium formate exclusively generated the Knoevenagel adduct 4c via hydro-4c. When microwaved either with 3-amino-5-methylisoxazole 1 or 3,4,5-trimethoxyaniline 14 in ethanoic acid?ethylacetate (1:1), tetrahydroacridones 15[a,b] formed in high yields (88?92%). Importantly, this two-step reaction sequence generates highly reproducible and pure products.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. name: Furan-2,4(3H,5H)-dione, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 4971-56-6

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 4971-56-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Article，once mentioned of 4971-56-6

New derivatives of benzo[f]furo[3,4-b]quinoline, spiro[benzo[f]quinoline-2, 3’furan], and benzo[f]-quinoline-2-carboxylic acid were synthesized with high selectivity by three-component condensation of tetronic acid with naphthalen-2-amine and formaldehyde.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 4971-56-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 4971-56-6, Name is Furan-2,4(3H,5H)-dione,introducing its new discovery.

New antibiotics are desperately needed to combat the increasing number of antibiotic resistant strains of pathogenic microorganisms. Natural products remain the most propitious source of novel antibiotics. It is widely accepted that actinobacteria are prolific producers of natural bioactive compounds. We argue that the likelihood of discovering a new compound having a novel chemical structure can be increased with intensive efforts in isolating and screening rare genera of microorganisms. Screening rare actinomycetes and their previously underrepresented genera from unexplored environments in natural product screening collections is one way of achieving this. Rare actinomycetes are usually regarded as the actinomycete strains whose isolation frequency is much lower than that of the streptomycete strains isolated by conventional methods. The relevance of the rare actinomycetes in this regard can also be demonstrated by the fact that many of the successful antimicrobial agents currently available in the market are produced by them. This chapter focuses on the bioactive secondary metabolites from rare actinomycetes with emphasis on their structures, relevant biological activities, source organisms, covering over 150 structures of different bioactive compounds produced by them with 84 citations. Its aim is to give the reader a brief view of the bioactive compounds from the rare actinomycetes and we wish to update our understanding of the potential of the rare actinomycetes by focusing on their biodiscovery potential. The emphasis is placed on new compounds discovered from these microorganims with bioactive potential. Copyright

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 4971-56-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Patent，once mentioned of 4971-56-6

The present invention relates to a process for the preparation of enaminocarbonyl compounds of the formula (I) where compounds of the formula (II) are reacted in the presence of a Br°nsted acid to give compounds of the formula (I), and A, R1 and Z are as defined in the description, and also corresponding starting compounds which are used in the process according to the invention.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 4971-56-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a article，once mentioned of 4971-56-6

As one of the most widely investigated compound skeleton, quinolines possess important medicinal and biological activities. As such, a great number of literatures, including reviews, have reported various methodologies to construct quinolines. Recently, organocatalyzed reactions have attracted the attention of organic chemists due to its being ?green? because the reactions avoid the use of toxic metals. In this review, various distinctive contributions are surveyed with specific emphasis on organocatalyzed reactions for quinoline core constructions.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of 4971-56-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4971-56-6, molcular formula is C4H4O3, introducing its new discovery.

Although 3-bromo-2,5-dihydrofuran-2-one and 4-bromo-2,5-dihydrofuran-2-one were first reported in 1894, considerable ambiguity still exists about the correct structure assignment of the two compounds. The present article gives a brief overview on the varying assignments of constitution and describes a novel method for the formation of 3-bromo-2,5-dihydrofuran-2-one. A comparison is made of the experimental 13C NMR chemical shifts with values predicted by increment calculations and experimental 1/C-C coupling constants are given for both compounds. Secure structural assignments are now available for both isomers.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4971-56-6 is helpful to your research. Synthetic Route of 4971-56-6

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 4971-56-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Patent，once mentioned of 4971-56-6

The invention discloses a method for preparing swiss that Wei intermediates of the method, the method condensable acetyl acetic acid ethyl ester as the raw material, after 4 step reaction to obtain the key swiss that Wei middle style I compound. The method has reasonable process, the operation is simple, low cost, high yield, through this method can better realize the industrialization, the production efficiency is improved. (by machine translation)

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem