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Reference of 4971-56-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Article,once mentioned of 4971-56-6

A facile and efficient multicomponent ultrasound-assisted ?on water? synthesis of benzodiazepine ring

Abstract: A facile and efficient multicomponent synthesis of benzodiazepine ring in water under ultrasound irradiation is reported first time.The current procedure escapes traditional chromatography and purification process and provided the product in excellent yields of 95% as compared to conventional methods. The approach was also validated on gram-scale synthesis. Graphic abstract: [Figure not available: see fulltext.].

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Reference of 4971-56-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4971-56-6, molcular formula is C4H4O3, introducing its new discovery.

Pesticides in honey: A review on chromatographic analytical methods

Honey is a product of high consumption due to its nutritional and antimicrobial properties. However, residues of pesticides, used in plagues’ treatment in the hive or in crop fields in the neighborhoods, can compromise its quality. Therefore, determination of these contaminants in honey is essential, since the use of pesticides has increased significantly in recent decades because of the growing demand for food production. Furthermore, pesticides in honey can be an indicator of environmental contamination. As the concentration of these compounds in honey is usually at trace levels and several pesticides can be found simultaneously, the use of highly sensitive and selective techniques is required. In this context, miniaturized sample preparation approaches and liquid or gas chromatography coupled to mass spectrometry became the most important analytical techniques. In this review we present and discuss recent studies dealing with pesticide determination in honey, focusing on sample preparation and separation/detection methods as well as application of the developed methods worldwide. Furthermore, trends and future perspectives are presented. & 2015 Elsevier B.V. All rights reserved.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome Chemistry Experiments For Furan-2,4(3H,5H)-dione

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4971-56-6, Name is Furan-2,4(3H,5H)-dione, belongs to tetrahydrofurans compound, is a common compound. Formula: C4H4O3In an article, once mentioned the new application about 4971-56-6.

CHAPTER 12: Calicheamicins as Antibody-Drug Conjugate (ADC) Payloads

The calicheamicins are one of the most intriguing and well-studied classes of antibody-drug conjugate (ADC) payloads. It took over three decades of dedicated research effort to reach approval by the European and American regulatory authorities of the ADCs Mylotarg (gemtuzumab ozogamicin, 1)1 and Besponsa (inotuzumab ozogamicin, 2),2 both of which bear the same semi-synthetic calicheamicin payload derived from the naturally occurring calicheamicin complex (Figure 12.1).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The important role of Furan-2,4(3H,5H)-dione

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Synthetic Route of 4971-56-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a article,once mentioned of 4971-56-6

Recent developments in tubulin polymerization inhibitors: An overview

Microtubules are protein biopolymers formed through polymerization of heterodimers of I±-and I2-tubulins. Disruption of microtubules can induce cell cycle arrest in G2-M phase and formation of abnormal mitotic spindles. Their importance in mitosis and cell division makes microtubules an attractive target for anticancer drug discovery. A number of naturally occurring compounds such as paclitaxel, epothilones, vinblastine, combretastatin, and colchicines exert their effect by changing dynamics of tubulin such as polymerization and depolymerization. During past few years, rapid development of the novel tubulin polymerization inhibitors has been witnessed. Diverse classes of chemical compounds from the natural as well as from the synthetic origin have been extensively studied. This review highlights the various classes of synthetically derived chemical compounds those have been reported in last few years as potential tubulin polymerization inhibitors. A brief synthetic methodology to access these compounds has been highlighted along with the brief SAR studies. We strongly believe that this review will provide a platform to the synthetic chemists and biologists to design and synthesize new and potent compounds to inhibit the tubulin polymerization.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Can You Really Do Chemisty Experiments About Furan-2,4(3H,5H)-dione

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C4H4O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3

Sulfur(IV)-mediated transformations: From ylide transfer to metal-free arylation of carbonyl compounds

The development of a direct ylide transfer to carbonyl derivatives and of a sulfoxide-mediated arylation is presented from a unified perspective. Mechanistic studies (including density functional calculations) support a common reaction pathway and showcase how subtle changes in reactant properties can lead to disparate and seemingly unrelated reaction outcomes.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

New explortion of Furan-2,4(3H,5H)-dione

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Related Products of 4971-56-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a article£¬once mentioned of 4971-56-6

Dual complex of amylose with iodine and magnetite nano-crystallites: Enhanced superparamagnetic and catalytic performance for synthesis of spiro-oxindoles

Mass magnetization of magnetite nanoparticles was enhanced by disassembling and encapsulating their building nano-crystallites with water-soluble starch. Incorporation of iodine into the as-prepared nano-conglomerate led to formation of a ternary nano-complex and further enhancement of its superparamagnetic susceptibility. As an additional evidence for the anomalously heightened superparamagnetic property, the ternary nano-complex showed lower magnetic remanence and coercivity than the pristine magnetite it was made from. These findings were ascribed to significant changes in, at least, size of the magnetite nano-crystallites during formation of the nano-composite. A significant enhancement was also observed in the catalytic efficiency of the nano-composite, as was successfully exemplified in the synthesis of some novel spiro[oxindole-dihydropyridine]s via a three-component reaction between isatins, furan-2,4(3H,5H)-dione and aminouracils ?on water?.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Recent advances in synthesis and medicinal chemistry of benzodiazepines

Benzodiazepines (BZDs) represent a diverse class of bicyclic heterocyclic molecules. In the last few years, benzodiazepines have emerged as potential therapeutic agents. As a result, several mild, efficient and high yielding protocols have been developed that offer access to various functionalized benzodiazepines (BZDs). They are known to possess a wide array of biological activities such as anxiolytic, anticancer, anticonvulsant, antipsychotics, muscle relaxant, anti-tuberculosis, and antimicrobial activities. The fascinating spectrum of biological activities exhibited by BZDs in various fields has prompted the medicinal chemist to design and discover novel benzodiazepine-based analogs as potential therapeutic candidates with the desired biological profile. In this review, an attempt has been made by to summarize (1) Recent advances in the synthetic chemistry of benzodiazepines which enable their synthesis with desired substitution pattern; (2) Medicinal chemistry of BZDs as therapeutic candidates with promising biological profile including insight of mechanistic studies; (3) The correlation of biological data with the structure i.e. structure-activity relationship studies were also included to provide an insight into the rational design of more active agents.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of Furan-2,4(3H,5H)-dione

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Application of 4971-56-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Article£¬once mentioned of 4971-56-6

A practical green approach to diversified spirochromene/spiropyran scaffolds via a glucose-water synergy driven organocatalytic system

The development of a versatile, new biomimetic glucose-water organocatalytic system promoted, one-pot green and practical method for the synthesis of diversified spirochromenes/spiropyrans is reported. To the best of our knowledge this is the first report on the use of a glucose-water system as a catalyst in organic synthesis. Superior green credentials, operational simplicity, easy scale up and recyclability of the catalyst are the key strengths of this method, which combined with attributes like broad substrate scope, mild reaction conditions, short reaction times, cost effectiveness, high atom economy and good to excellent yields make the present method a distinct improvement over existing methods.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about Furan-2,4(3H,5H)-dione

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Synthetic Route of 4971-56-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Article£¬once mentioned of 4971-56-6

Multicomponent synthesis of a new series of 4H-furo[3,4-b]pyrans, with iron(III) triflate as catalyst

We report the first efficient multicomponent reaction, catalyzed by iron(III) triflate, for synthesis of a new series of functionalized 4H-furo[3,4-b]pyran derivatives.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extracurricular laboratory:new discovery of Furan-2,4(3H,5H)-dione

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Metabolic mechanisms of resistance to spirodiclofen and spiromesifen in Iranian populations of Panonychus ulmi

The European red mite, Panonychus ulmi (Koch), is one of the major pests of apple trees worldwide. Cyclic keto-enol compounds such as spirodiclofen and spiromesifen are frequently used to control phytophagous spider mites in agricultural crops, including P. ulmi on apple trees. Spider mites, however, can rapidly develop resistance against acaricides and, in this study, multiple P. ulmi populations from apple orchards in Iran were monitored for spirodiclofen and spiromesifen resistance. The Urmia and Shahin Dej population showed the highest spirodiclofen resistance ratio (more than 150-fold) compared to the susceptible Ahar population. Toxicity bioassays also revealed the presence of moderate cross-resistance between spiromesifen and spirodiclofen, but not towards the chitin synthase inhibitor etoxazole. As a first step towards elucidating spirodiclofen resistance mechanisms, the role of detoxification enzymes (cytochrome P450 monooxygenases, carboxyl/choline esterases and glutathione S-transferases) was investigated by in vivo synergism and in vitro enzyme assays. PBO pretreatment synergized spirodiclofen toxicity in the populations of Urmia and Shahin Dej to a higher extent than in the susceptible Ahar population. Furthermore, enzyme activity measurements showed relatively higher activity of detoxifying enzymes in the resistant populations. In conclusion, increased detoxification is most likely underlying spirodiclofen resistance and results in limited cross-resistance to spiromesifen.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem