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An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to beta-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharmacokinetic and pharmacodynamics properties. CSL have been classified according to their chemical structures and the chemical structures of the pyridine and azine containing antimitotic compounds are described. The designed principles behind the structural modifications and the achieved effect on the biological activity upon inclusion of these heterocycles are also discussed. Lessons from the achievements and failures have been extracted and future perspectives delineated.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Nowadays, “green” is a hot topic almost everywhere, from retailers to universities to industries; and achieving a green status has become a universal aim. However, polymers are commonly considered not to be “green”, being associated with massive energy consumption and severe pollution problems (for example, the “Plastic Soup”) as a public stereotype. To achieve green polymers, three elements should be entailed: (1) green raw materials, catalysts and solvents; (2) eco-friendly synthesis processes; and (3) sustainable polymers with a low carbon footprint, for example, (bio)degradable polymers or polymers which can be recycled or disposed with a gentle environmental impact. By utilizing biobased monomers in enzymatic polymerizations, many advantageous green aspects can be fulfilled. For example, biobased monomers and enzyme catalysts are renewable materials that are derived from biomass feedstocks; enzymatic polymerizations are clean and energy saving processes; and no toxic residuals contaminate the final products. Therefore, synthesis of renewable polymers via enzymatic polymerizations of biobased monomers provides an opportunity for achieving green polymers and a future sustainable polymer industry, which will eventually play an essential role for realizing and maintaining a biobased and sustainable society.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Top Picks: new discover of Furan-2,4(3H,5H)-dione

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New cycloaddition has been established for the synthesis of indoline-spiro benzofurodiazepine derivatives. Those reactions were conducted by reacting readily available and inexpensive starting materials, such as benzene- 1,2-diamines, tetronic acid and indoline-2,3-diones, in aqueous solution under microwave irradiation. When mono-substituted benzene-1,2-diamines as an amine component was employed, the reaction regioselectively resulted in the poly-functionalized indoline-spiro benzofurodiazepine with good yields. The present green synthesis shows attractive characteristics such as the use of water as reaction media, concise one-pot conditions, short reaction periods, easy work-up/purification and reduced waste production without the use of any strong acids or metal promoters.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Discovery of Furan-2,4(3H,5H)-dione

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Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of Furan-2,4(3H,5H)-dione, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 4971-56-6

Treatment of phenyl isothiocyanate with heterocyclic beta-dicarbonyl compounds gave novel aminoketene S,N-acetals, whose alkylation using haloalkanes has been studied.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Sesterterpenes form a small group of terpenoids that are mainly present in the marine world although they are also produced by terrestrial organisms such as fungi, and in minor extent higher plants, lichens and insects. Sesterterpenes are diverse and these compounds display significant biological activities such as anti-inflammatory, cytotoxic, anticancer, antimicrobial, antitubercular, and anti-biofilm. This review presents the sesterterpenoid compounds identified from marine sources between 2013 and 2017. Structures are grouped as scalaranes, linear sesterterpenes and other sesterterpenes. Natural sources and reported biological activities are summarized in a table format.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The root exudate composition reflects the contradictory-concomitantly attractive and repulsive-behaviour of plants towards soil microorganisms. Plants produce antimicrobial, insecticide and nematicide compounds to repel pathogens and invaders. They also produce border cells that detach from roots and play an important role as biological and physical barrier against aggressors. Plants produce also metabolites used as carbon source resulting in the attraction of phytobeneficial soil microorganisms that help plants in controlling diseases directly via the production of antimicrobial compounds or indirectly via the induction of plant systemic resistance. The root exudates may have a direct impact on carbon and nitrogen cycling, as they exhibit a rhizosphere priming effect towards soil organic matter degraders, and may inhibit nitrification process by soil nitrifying microorganisms. They also contain signalling molecules required for the establishment of ‘plant-microorganisms’ interactions. The composition of root exudates is therefore broad ranging, consisting of feeding, antimicrobial and signalling molecules. We thus focused this review on current research concerning the role of the root exudate composition in ‘plant-microorganisms’ interactions and functioning of the rhizosphere.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The present invention provides 4-Aza-2,3-didehydropodophyllotoxin compound of general formula A (4a-4z and 4aa-4ae) as useful potential antitumour agents against human cancer cell lines. The present invention further provides a process for the synthesis of 4-Aza-2,3-didehydropodophyllotoxin compounds (4a-4z and 4aa-4ae).

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam 3, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Two-spotted spider mite, Teranychus urticae (Acari: Tetranychide), is one of the most important agricultural pests throughout the world. The high reproductive potential, short life cycle, combined with frequent acaricide applications has resulted in resistance development to a wide range of acaricides. Resistance to acaricides has an important role in inefficiency of chemical control of this pest. In the present study, the susceptibility of two populations of two-spotted spider mite collected from Karaj (KrS) and Mahallat (MhR) to spirodiclofen was investigated. The bioassay was conducted using a leaf-dip method on same-age protonymphs. Bioassay results showed that there was a significant difference between LC50 values of KrS and MhR populations. The resistance ratio was obtained as 22.19. The synergistic effects of triphenyl phosphate (TPP), piperonyl butoxide (PBO) and diethyl maleate (DEM) were assessed using residual contact vial (RCV) bioassay method. Results of the synergistic studies showed significant differences between LC50 values of spirodiclofen with spirodiclofen + PBO and spirodiclofen + TPP in MhR population. The most synergistic effect in MhR population was related to PBO. The results of enzyme assays revealed that the most ratio activity in MhR population to KrS population was related to cytochrome P450 monoxygenase (3.02) and the lowest ratio activity was related to glutathione S-transferase (GST) (1.40). These results confirmed that esterase and cytochrome P450 monoxygenase are probably involved in resistance of T. urticae to s irodiclofen

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem