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Compartment-specific degradation half-lives are essential pieces of information in the regulatory risk assessment of synthetic chemicals. However, their measurement according to regulatory testing guidelines is laborious and costly. Despite the obvious ecological and economic benefits of knowing environmental degradability as early as possible, its consideration in the early phases of rational chemical design is therefore challenging. Here, we explore the possibility to use half-lives determined in highly time- and work-efficient biotransformation experiments with activated sludge and mixtures of chemicals to predict soil half-lives from regulatory simulation studies. We experimentally determined half-lives for 52 structurally diverse agrochemical active ingredients in batch reactors with three concentrations of the same activated sludge. We then developed bi- and multivariate models for predicting half-lives in soil by regressing the experimentally determined half-lives in activated sludge against average soil half-lives of the same chemicals extracted from regulatory data. The models differed in how we accounted for sorption-related bioavailability differences in soil and activated sludge. The best-performing models exhibited good coefficients of determination (R2 of around 0.8) and low average errors (COA of Formula: C4H4O3

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Tetrahydrofuran – Wikipedia,
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A new series of 10-phenyl-7,9-dihydro-3 H-furo[3,4-b]pyrazolo[4,3-f] quinolin-9-one derivatives has been synthesized through an efficient multicomponent reaction of tetronic acid, 5-aminoindazole and various aromatic aldehydes catalyzed by copper(II) triflate under ultrasonic irradiation.

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Tetrahydrofuran – Wikipedia,
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The vibrational assignment of tetronic acid has been extended by analysis of polarized IR spectral data on single crystals. Many of the molecular vibrations that were difficult to assign from unpolarized IR and Faman spectra1, 2 could be resolved and assigned from the polarized IR spectra. The optical crystallographic properties of tetronic acid are also reported.

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Tetrahydrofuran – Wikipedia,
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A catalytic one-pot microwave assisted synthesis of 4-azapodophyllotoxin has been described. Rational design of experiment has been used to obtain the reaction yield.

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Tetrahydrofuran – Wikipedia,
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Cyclobutanes derived from [2+2] photocycloaddition reactions of tetronic acid esters were subjected to free-radical fragmentation reactions. The product formation was strongly dependent on the relative stabilities of the intermediate radicals, thus leading to either an oxepane or a methylenetetrahydrofuran in good yields. Georg Thieme Verlag Stuttgart.

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The Brazilian marine biodiversity represents a unique, yet underexplored resource of biologically active compounds. This review provides an analysis of the development of marine natural products chemistry in Brazil within the period comprised between 2004 and 2017. Emphasis is directed towards marine invertebrate and marine microorganisms metabolites, including isolation, structure analysis, biosynthesis, bioactivities and total synthesis. An overview of the research on marine natural products by Brazilian researchers is also discussed, as well as perspectives for the development of the chemistry of marine natural products in Brazil.

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The phytophagous mite is highly polyphagous and widespread in warmer regions and greenhouses around the world, and so the focus of novel acaricides is shifting towards more effective, ecofriendly new chemical entity with unique modes of action. In this study, eighteen spirobutyrolactones derived from natural tetronic acid have been synthesized and their acaricidal activities against Tetranychus cinnabarinus were investigated by slide-dip method. The results of preliminary bioassay indicate that some of these compounds exhibited promising acaricidal activities, especially, compounds 6 and 18 show significant activities against T. cinnabarinus than the commercial spirodiclofen 1 (27.37% mortality), and which present 58.55% and 82.24% mortality at tested dose, respectively. The relationship between structure and acaricidal activity was also discussed based on the experimental data, and which indicate that the compounds (16, 17 and 18) with non-substituted phenyl ring (R1 = H) show obviously better activities. Especially, we also can find that substituted benzoyl unit will help to increase the activity than substituted phenylacetyl group.

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Inorganic salts and tween 80 are known to induce the lignin degrading peroxidase expression of Phanerochaete chrysosporium in submerged culture. In this study, the wheat straw pretreatment supplemented with inorganic salts (salts group), tween 80 (plus) and no supplementation to the biomass (minus) were examined. Among the solid state fermentation groups, salts group resulted in a substantial degradation of wheat straw within one week, along with the highest lignin loss (25%) and ?250% higher efficiency for the total sugar release through enzymatic hydrolysis. The results were correlated with pyrolysis GC-MS (Py-GC-MS), thermogravimetric (TG)/differential thermogravimetric (DTG) and X-ray diffraction (XRD). The results suggested that the supplementation of inorganic salts in the solid state fermentation of wheat straw significantly enhances the degradation rate of the biomass by P. chrysosporium which can be exploited as an alternative means to existing pretreatment technologies.

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A facile and efficient procedure has been reported for the synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-diones by the condensation reaction of benzaldehydes, 1,3-cyclohexanediones and anilinolactones in the presence of CuFe2O4 as a reusable nanocatalyst with high catalytic activity in water. The notable advantages of this method are excellent isolated yields, short reaction times, simple workup procedure and little environmental impact. Graphical Abstract: [Figure not available: see fulltext.].

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Tetrahydrofuran – Wikipedia,
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The production of energy from wood biomass is as old as humanity itself. There has been enormous progress in research of sustainable pyrolysis processes for optimal energy conversion in the past 30 years. Pyrolisis?gas chromatography?mass spectrometry (PY-GC-MS) was used to examine the components of bark and wood of Toona sinensis for expanding high value utilization different parts of trees. In the study, 174 chemical constituents were identified in the bark; 169 chemical constituents were identified in the wood, respectively. The chemical composition of bark is different from that of wood. The change in thermal cracking 30 min ago is not very large. In the retention time is more than 30 min, they are very different. Because the ash content of bark had much large corresponding wood. Mainly the phenols and their derivatives formed after the pyrolysis of lignin and extractives. The chemical composition of T. sinensis provides a scientific basis for the development and utilization of the plant. The richer chemical constituents of T. sinensis are found, which will provide new scientific evidence for further development and utilization of bark and wood of T. sinensis.

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Tetrahydrofuran – Wikipedia,
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