Extended knowledge of 3-Hydroxytetrahydrofuran

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Electron and positron scattering from biomolecules

We review recent results from experimental studies of electron and positron collisions with the important biomolecules 3-hydroxy-tetrahydrofuran, formic acid and methanol and ethanol. Where possible, comparison to corresponding results from theoretical calculations is made. Finally, some possible future directions for this research area will be explored.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about 453-20-3

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DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins

The huge resources that had gone into Human Immunodeficiency virus (HIV) research led to the development of potent antivirals able to suppress viral load in the majority of treated patients, thus dramatically increasing the life expectancy of people living with HIV. However, life-long treatments could result in the emergence of drug-resistant viruses that can progressively reduce the number of therapeutic options, facilitating the progression of the disease. In this scenario, we previously demonstrated that inhibitors of the human DDX3X helicase can represent an innovative approach for the simultaneous treatment of HIV and other viral infections such as Hepatitis c virus (HCV). We reported herein 6b, a novel DDX3X inhibitor that thanks to its distinct target of action is effective against HIV-1 strains resistant to currently approved drugs. Its improved in vitro ADME properties allowed us to perform preliminary in vivo studies in mice, which highlighted optimal biocompatibility and an improved bioavailability. These results represent a significant advancement in the development of DDX3X inhibitors as a novel class of broad spectrum and safe anti-HIV-1 drugs.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about 453-20-3

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453-20-3, Name is 3-Hydroxytetrahydrofuran, belongs to Tetrahydrofurans compound, is a common compound. Quality Control of 3-HydroxytetrahydrofuranIn an article, once mentioned the new application about 453-20-3.

DITHIOPHOSPHATO-PLATINUM-COMPLEXES FOR THE TREATMENT OF CANCERS

Complex of formulas: (I), (II) or (III): which are suitable for the treatment of tumors.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Archives for Chemistry Experiments of 3-Hydroxytetrahydrofuran

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Electron interaction with deoxyribose analogue molecules in gaseous phase

We present recent results on elastic and inelastic low/medium energy electron interaction with tetrahydrofuran, C4H8O, tetrahydrofurfuryl alcohol, C5H10O2 and 3-hydroxytetrahydrofuran, C4H8O2 molecules in gaseous phase. A comparative study of both absolute differential cross sections for elastic electron scattering and electron energy loss spectra, in a wide incident electron energy range from 50 to 300 eV, has been given. The measurements of the cross sections were performed both as a function of scattering angle and incident electron energy and normalized to the absolute scale according to relative flow measurements and reliable calculations. The experimental elastic DCSs are compared with the most recent theoretical results. Both for elastic and inelastic scattering a special attention has been paid to investigate potential differences in electron scattering processes upon substitution of one of the H-atom in tetrahydrofuran by the OH group (in 3-hydroxytetrahydrofuran) or CH2OH group (in tetrahydrofurfuryl alcohol).

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extracurricular laboratory:new discovery of 453-20-3

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 453-20-3, and how the biochemistry of the body works.Electric Literature of 453-20-3

Electric Literature of 453-20-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.453-20-3, Name is 3-Hydroxytetrahydrofuran, molecular formula is C4H8O2. In a Patent£¬once mentioned of 453-20-3

THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS

The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Top Picks: new discover of 3-Hydroxytetrahydrofuran

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Nickel nanoparticles inlaid in lignin-derived carbon as high effective catalyst for lignin depolymerization

Ni nanoparticles inlaid in lignin-derived carbon constructing the ?inlaid type? Ni/C-I was reported to improve stability and adjust metal-support interaction of lignin hydrogenolysis catalyst. The Ni/C-I was further heat treated in air to prepare Ni/C-R so as to re-expose the blocked active sites by carbon species. A lot of characterization techniques were carried out to confirm the ?inlaid structure? of the catalysts. The lignin depolymerization results demonstrated that the Ni/C-R had better catalytic performance than traditional ?supported type? Ni/C, 23.3% aromatic monomer yield and 82.4% bio-oil yield were achieved. Moreover, the mechanism studies with lignin model compound revealed that Ni/C-R had better bond breaking ability than Ni/C, even C[sbnd]C bond could be cleaved. The electron effect could be responsible for that, since the electrons could transfer from Ni0 to carbon support for Ni/C-R, which could improve the bond breaking ability.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some scientific research about 3-Hydroxytetrahydrofuran

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Elastic scattering of electrons from alanine

Differential cross sections (DCSs) for elastic scattering of electrons from alanine, have been measured using a crossed beam system for incident energies between 20 and 80 eV and scattering angles from 10 to 150. The experimental data were placed upon an absolute scale by normalisation to calculated absolute integral cross sections obtained using the corrected independent-atom method incorporating an improved quasifree absorption model. The calculated data-set includes DCSs and integral elastic and inelastic cross sections in the incident energy range between 1 and 10,000 eV. These theoretical results are found to agree very well with the experimental data both in the shape and magnitude of DCSs except at the smallest scattering angles.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome Chemistry Experiments For 3-Hydroxytetrahydrofuran

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Direct Calpha-heteroarylation of structurally diverse ethers: Via a mild N -hydroxysuccinimide mediated cross-dehydrogenative coupling reaction

An important challenge in the Calpha-heteroarylation of ethers is the requirement of a large excess amount of ethers (that are used as solvents in many cases) to achieve effective transformations. This drawback has significantly restricted the Calpha-heteroarylation of ethers to the use of simple and easily accessible ether substrates. To overcome this limitation, a new, efficient, N-hydroxysuccinimide (NHS) mediated, mild and metal-free CDC strategy for the direct Calpha-heteroarylation of diverse ethers has been developed. Different to our previous benzaldehyde mediated photoredox Calpha-heteroarylation, we have identified NHS as a new and efficient mediator without using light. A distinct non-photoredox engaged hydrogen-atom-transfer (HAT) mechanism that used a nitrogen-centered radical cation produced from NHS is initially revealed. Notably, only 5-10 equivalents of ethers as coupling partners are used, which allows for structurally diverse and complex ethers to engage in this process, to create highly medicinally relevant Calpha-heteroarylated ethers. Furthermore, more structurally diverse heterocyclics can serve as reactants for this process.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Carbon dioxide assisted thermal decomposition of cattle excreta

To develop the environmentally benign thermo-chemical process, this study placed great emphasis on the influence of CO2 on pyrolysis of cattle excreta for energy recovery. To this end, this study evaluates the possible enhanced energy recovery from cattle excreta using CO2 as reaction medium/feedstock in the thermal degradation of cattle excreta. The enhanced generation of CO in the presence of CO2 reached up to 15.15 mol% (reference value: 0.369 mol%) at 690 C, which was equivalent to ~ 4000 times more generation of CO. In addition to the enhanced generation of CO, the enhanced generation of H2 and CH4 in the thermal degradation of cattle excreta in CO2. Thus, the findings of this study revealed two genuine roles of CO2: 1) enhanced thermal cracking of volatile organic carbons (VOCs) evolved from the thermal degradation of cattle excreta and 2) direct reaction between VOCs and CO2 via gas phase reaction.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and irradiation. They have been implicated in the pathology of a variety of different diseases with an inflammatory component including asthma, stroke, Alzheimer’s disease, and type 2 diabetes mellitus. In this work, high-throughput screening identified a JNK inhibitor with an excellent kinase selectivity profile. Using X-ray crystallography and biochemical screening to guide our lead optimization, we prepared compounds with inhibitory potencies in the low-double-digit nanomolar range, activity in whole cells, and pharmacokinetics suitable for in vivo use. The new compounds were over 1000-fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38alpha, and p38delta and showed little inhibitory activity against a panel of 74 kinases.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem