Some scientific research about 3-Hydroxytetrahydrofuran

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Electron-stimulated desorption of H- from condensed-phase deoxyribose analogues: Dissociative electron attachment versus resonance decay into Dipolar dissociation

We report the 5-40 eV electron-stimulated desorption (ESD) yields of H- from thin films of the DNA backbone sugarlike analogues tetrahydrofuran (I), 3-hydroxytetrahydrofuran (II), and alpha-tetrahydrofurfuryl alcohol (III), as well as ESD yields from submonolayer amounts of these compounds condensed on multilayer Ar films. For the pure disordered solid films, our results corroborate the previous observation of a peak in the H- yield function at an incident electron energy, Ei, of ?10 eV attributed to dissociative electron attachment (DEA) along the CH bonds via the formation of a core-excited resonance. For II and III, a second low-energy peak is also observed in the H- ESD yield function. This peak appears near an Ei of 7.3 eV as a weak shoulder superimposed on the low-energy side of the 10 eV structure; it is associated with a core-excited Feshbach resonance leading to H- production via DEA to the OH substituent. For each of the three molecules, we observe near 23 eV a third broad peak in the H- ESD yield functions. Measurements of the H- yields, as a function of the coverage of thin Ar spacer films by I, II, and III, suggest that the 23-eV peak is not due to multiple electron scattering, but results from direct transient anion formation above the dipolar dissociation threshold. These results, combined with those recorded at higher Ar spacer thickness, indicate that the 23-eV peak arises principally from decay of a transient anion (or anions) into an electronic excited state (or states), which dissociates into H- and the corresponding positive ion radical.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS

Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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AMINO PYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, B, R1, R2, R3, R4a, R5, and Z are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Functionalization of C(sp2)?H bonds of arenes and heteroarenes assisted by photoredox catalysts for the C?C bond formation

The formation of C?C bonds from arenes and heteroarenes through transition metal-catalyzed C?H bond functionalizations is one of the major achievements of these last decades. It is now possible to perform such transformations under mild reaction conditions with the help of visible light photocatalysis leading to eco-friendly and safer process to build organic molecules or materials. This chapter will focus on photoredox catalysis which involves a C(sp2)?H bond functionalization step for the formation of C(sp2)?C bonds [i.e., direct arylations and (perfluoro)alkylations] and will show how this hot topic contributes to the development of green chemistry.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Preparation and Antitumor Activity of New Mitomycin A Analogues

A series of 26 mitomycin A analogues including 23 new ones was prepared by a variety of methods.The most useful methods were alkoxide exchange on mitomycin A and treatment of 7-hydroxymitosane with 3-substituted 1-phenyltriazenes.Many of the new analogues were superior to mitomycin C in the P388 leukemia assay and the more stringent subcutaneous B16 melanoma assay both in mice.Four of them gave long-term survivors in the latter assay.Quantitative correlations between log P and antitumor activity were not possible, but some guidelines for future analogue development are proposed.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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8-AMINOISOQUINOLINE CompoundS AND USES THEREOF

3-Carbonylamino-8-aminoisoquinoline Compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The Compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylamino-8-aminoisoquinoline Compounds.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Identification and structure-activity relationships of 1-aryl-3-piperidin-4-yl-urea derivatives as CXCR3 receptor antagonists

The synthesis and biological evaluation of a series of 1-aryl-3-piperidin-4-yl-urea derivatives as small-molecule CXCR3 antagonists is described. SAR studies resulted in significant improvement of potency and physicochemical properties and established the key pharmacophore of the series, and led to the identification of 9t, which exhibits an IC50 of 16 nM in the GTPgammaS35 functional assay.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME

Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Nickela-electrocatalyzed C?H Alkoxylation with Secondary Alcohols: Oxidation-Induced Reductive Elimination at Nickel(III)

Nickela-electrooxidative C?H alkoxylations with challenging secondary alcohols were accomplished in a fully dehydrogenative fashion, thereby avoiding stoichiometric chemical oxidants, with H2 as the only stoichiometric byproduct. The nickela-electrocatalyzed oxygenation proved viable with various (hetero)arenes, including naturally occurring secondary alcohols, without racemization. Detailed mechanistic investigation, including DFT calculations and cyclovoltammetric studies of a well-defined C?H activated nickel(III) intermediate, suggest an oxidation-induced reductive elimination at nickel(III).

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem