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Regioisomeric Preference in Ring-Opening Polymerization of 3?,5?-Cyclic Phosphoesters of Functional Thymidine DNA Analogues

Regioregularity is a crucial property in the synthesis of DNA analogues, as natural DNA is synthesized exclusively in the 5? to 3? direction. We have focused our attention on the determination of the regioisomeric distribution of poly(3?,5?-cyclic 3-(3-butenyl) thymidine ethylphosphate)s obtained from the ring-opening polymerization of (R)-3?,5?-cyclic 3-(3-butenyl) thymidine ethylphosphate. The regioisomeric preference was investigated by comparison to synthesized model compounds of 3?,3?-, 3?,5?-, and 5?,5?-linkages, where the model 3?-phosphoester linkages were to the secondary alcohol of 3-hydroxytetrahydrofuran and the model 5?-linkages derived from coupling to the primary alcohol of tetrahydrofurfuryl alcohol. From the 31P resonance frequency assignments of those small molecule model compounds, 31P NMR spectra revealed the major connectivity in the polymer backbone to be 3?,5?-linkages, with ?30% of other isomeric forms. Model reactions employing a series of alcohol initiators imparting various degrees of steric hindrance, to mimic the increased steric hindrance of the propagating alcohol relative to the initiator, were then conducted to afford the corresponding ring-opened unimer adducts and to gain understanding of the regioselectivity during the ring-opening polymerization. 1H-31P heteronuclear multiple-bond correlation spectroscopy showed ethanol and 4-methoxybenzyl alcohol initiation to yield only the P-O5? bond cleavage product, whereas attack by isopropyl alcohol upon (R)-3?,5?-cyclic 3-(3-butenyl) thymidine ethylphosphate afforded both P-O3? and P-O5? bond cleavage products, supporting our hypothesis that the increased steric hindrance of the propagating species dictates the regioselectivity of the P-O bond cleavage. Further model reactions suggested that the P-O5? bond cleavage products can be detected upon the formation of dimers during the ring-opening polymerization. Overall, this work provides a fundamental understanding of the polymerization behavior of six-membered cyclic phosphoesters and broadens the scope of DNA analogues from the ring-opening polymerization of 3?,5?-cyclic phosphoesters.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE

The present invention relates to compounds of general formula (I): wherein A, Y, X, n and B are as defined herein; and their use in the treatment and prevention of metabolic disorders, inflammatory conditions, allergic conditions, fever, pain including allodynia and nociception, eating disorders, cachexia, brain injuries, cancer of the genitals, sleep apnoea, cardiovascular disease, flush effect associated with nicotinic acid and related compounds or for the promotion of wound healing. Certain compounds of general formula (I) are new and the invention also relates to these compounds and to their use in medicine.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The important role of 3-Hydroxytetrahydrofuran

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ALKOXY SUBSTITUTED IMIDAZOQUINOLINES

Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C4H8O2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 453-20-3

NOVEL PROCESS FOR THE MANUFACTURE OF 3-OXO-TETRAHYDROFURAN

This invention relates to a novel method for the preparationof 3-oxotetrahydrofurancomprising oxidating 3-hydroxy-tetrahydrofuran in the presence of a catalytic amount of TEMPO with trichloroisocyanuric acid.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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453-20-3, Name is 3-Hydroxytetrahydrofuran, belongs to tetrahydrofurans compound, is a common compound. Formula: C4H8O2In an article, once mentioned the new application about 453-20-3.

AMINO PYRAZINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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METHOD FOR PRODUCING 3-HYDROXYTETRAHYDROFURAN AND METHOD FOR PRODUCING 1, 3-BUTANE DIOL

An object of the present invention is to provide a method for producing 3-hydroxytetrahydrofuran that can be used as a raw material for 1,3-butane diol, using as a raw material a compound that can be derived from biomass. The present invention relates to a method for producing 3-hydroxytetrahydrofuran including a step of reacting 1,4-anhydroerythritol and hydrogen to produce 3-hydroxytetrahydrofuran. In the production method, the step of reacting 1,4-anhydroerythritol and hydrogen is preferably allowed to proceed in the presence of a catalyst comprising a carrier and at least one oxide selected from the group consisting of an oxide of a Group 6 element and an oxide of a Group 7 element, the oxide being supported on the carrier.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 453-20-3, and how the biochemistry of the body works.Related Products of 453-20-3

Related Products of 453-20-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.453-20-3, Name is 3-Hydroxytetrahydrofuran, molecular formula is C4H8O2. In a Patent£¬once mentioned of 453-20-3

Aromatic polycyclic carboxylic acid derivatives (by machine translation)

The invention belongs to the field of medical technology, in particular to general formula (I) indicated by the aromatic ring carboxylic acid derivatives GPR40 receptor agonist, a pharmaceutically acceptable salt, an ester thereof or a stereoisomer thereof, wherein R1 , R2 , R3 , R4 And R5 Such as defined in the specification; the invention also relates to methods of preparing such compounds, pharmaceutical preparation and pharmaceutical composition, and the compounds and pharmaceutical compositions in the preparation as GPR40 receptor agonists for the prevention and/or for the treatment of diabetes in the application. (by machine translation)

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 453-20-3

Application of 453-20-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.453-20-3, Name is 3-Hydroxytetrahydrofuran, molecular formula is C4H8O2. In a Patent£¬once mentioned of 453-20-3

2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES

The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I) wherein R1 is a group selected from: Formulas (A), (B), (C)

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 3-Hydroxytetrahydrofuran

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 453-20-3

Synthetic Route of 453-20-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.453-20-3, Name is 3-Hydroxytetrahydrofuran, molecular formula is C4H8O2. In a Patent£¬once mentioned of 453-20-3

Heterocyclic derivative of tyrosine kinase inhibitors (by machine translation)

The invention belongs to the field of medical technology, in particular to general formula (I) shown in the heterocyclic derivative of tyrosine kinase inhibitors, pharmaceutically acceptable salts thereof, esters thereof and their stereoisomers, wherein Y, W, Q, m, L, R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 7 ‘, R 8, R 8’ as defined in the specification. The invention also relates to methods of preparing such compounds, pharmaceutical preparations comprising these compounds and pharmaceutical compositions, and the use of these compounds as tyrosine kinase inhibitors for the preparation of medicine for preventing and/or treatment of the mutant EGFR cancer diseases and EGFR T790M diseases caused by mutations in the drug-resistant application of the medicament. (by machine translation)

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extracurricular laboratory:new discovery of 3-Hydroxytetrahydrofuran

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Low-energy positron and electron scattering from tetrahydrofuran and 3-hydroxy-tetrahydrofuran

We present new cross section results from a joint experimental and theoretical investigation into low-energy positron and electron scattering from two targets of biological interest, namely tetrahydrofuran and 3-hydroxy-tetrahydrofuran. We compare and discuss the total, elastic and inelastic cross sections for these species in the light of potential positron and electron-induced damage in biomolecular systems. Published under licence by IOP Publishing Ltd.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem