Category: 4344-84-7

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4344-84-7, name is 5-Oxotetrahydrofuran-2-carboxylic acid, introducing its new discovery. 4344-84-7

A Comprehensive Study on Metal Triflate-Promoted Hydrogenolysis of Lactones to Carboxylic Acids: From Synthetic and Mechanistic Perspectives

Direct hydrogenolysis of lactone to carboxylic acid (i.e., hydrogenolysis of the Calkoxy-O bond with the carbonyl group untouched) is generally difficult, as the current strategies employing Br¡ãnsted acids as the catalyst usually require harsh conditions such as a high temperature and a high H2 pressure. Herein, we report a developed solvent-free catalytic transformation, in which W(OTf)6 is believed to promote the hydrogenolysis process. This strategy could efficiently hydrogenate lactones to carboxylic acids under extra mild conditions (e.g., a reaction temperature of <150 C and 1 atm of H2) and showed a broad substrate scope. In addition, the catalytic protocol can be further applied to the hydrogenolysis of polyhydroxyalkanoate, as a renewable polymer, to the corresponding straight-chain carboxylic acids. An extensive mechanistic study was subsequently performed, and the density functional theory calculations revealed a reaction pattern, including the complete cleavage of the C=O bond with the assistance of the W(OTf)6 catalyst. Moreover, the key intermediate created in the mechanism, as an oxonium with an OTf moiety, was successfully detected by electrospray ionization mass spectra. Through a comparison with the Br¡ãnsted acid-catalyzed system, the study confirmed that the existence of the OTf moiety can significantly lower the barriers associated with the rearrangement and elimination processes. Meanwhile, emphasis was placed on the critical role that the anion plays, as well as the fact that the anion effect is directly related to the chemoselectivity. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.4344-84-7, you can also check out more blogs about4344-84-7

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 4344-84-7, molcular formula is C5H6O4, introducing its new discovery. , 4344-84-7

Zidovudine derivatives having antibacterial activity and its preparation method and application (by machine translation)

The invention discloses a Combivir derivative and its preparation method and application, which belongs to the antibacterial activity of the medicament with the synthesis technology field. The technical scheme of the present invention is to point: zidovudine derivatives having antibacterial activity, structural formula is:, wherein R is C1 – 4 Alkyl or a halogen atom. The invention also discloses the zidovudine derivatives having antibacterial activity of specific synthetic process and its application in preparing antibacterial drug. The invention according to zidovudine containing azido group in the molecule, by reacting it with click with different substituents of the aniline base alkyne apperception compound reaction to get zidovudine derivatives, and selecting the Staphylococcus aureus – gram positive bacteria, gram-negative bacteria and fungi – Escherichia coli – Candida albicans to the synthesized Combivir derivative of the in vitro antibacterial activity determination, the results show that the compounds demonstrate better antibacterial activity. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 4344-84-7, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 4344-84-7

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

4344-84-7, 5-Oxotetrahydrofuran-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4344-84-7

REFERENCE EXAMPLE 8 Production of 1-t-butyl 2-oxoglutarate [Compound (8)] To a solution of 5.0 g of 5-oxo-2-tetrahydrofurancarboxylic acid in 100 ml of dichloromethane was added 0.3 ml of concentrated sulfuric acid, to which was further added an excess volume (ca. 50 ml) of isobutene. The reaction mixture was left standing overnight at room temperature under tight sealing, which was poured into a cooled saturated aqueous solution of sodium hydrogencarbonate. The dichloromethane layer was separated, washed with water, dried (Na2 SO4) and concentrated to give t-butyl 5-oxo-2-tetrahydrofurancarboxylate as a colorless oily substance. IRnumaxNeat cm-1: 1760. NMR (60 MHz, CDCl3)delta: 1.50(9H, s), 2.4(4H, m), 4.8(1H, m).

4344-84-7 5-Oxotetrahydrofuran-2-carboxylic acid 636468, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US4891427; (1990); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem