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Nickel promoted functionalization of CO2 to anhydrides and ketoacids

The reductive functionalization of carbon dioxide into high value organics was accomplished via the coupling with carbon monoxide and ethylene/propylene at a zerovalent nickel species bearing the 2-((di-t-butylphosphino)methyl)pyridine ligand (PN). An initial oxidative coupling between carbon dioxide, olefin, and (PN)Ni(1,5-cyclooctadiene) afforded five-membered nickelacycle lactone species, which were produced with regioselective 1,2-coupling in the case of propylene. The propylene derived nickelacycle lactone was isolated and characterized by X-ray diffraction. Addition of carbon monoxide, or a combination of carbon monoxide and diethyl zinc to the nickelacycle lactone complexes afforded cyclic anhydrides and 1,4-ketoacids, respectively, in moderate to high yields. The primary organometallic product of the transformation was zerovalent (PN)Ni(CO)2. This journal is

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The Wittig Reaction with Glutaric and Succinic Anhydrides

Six-membered cyclic anhydrides, including glutaric and some of its alkylated derivatives, have been shown to yield enol-lactones with ethoxycarbonylmethylenetriphenylphosphorane; the (E) isomer is formed preferentially.The reactions of methyl-substituted succinic anhydrides with the same phosphorane give predominantly the (E) enol-lactone in all examples.The influence of alkyl substituents on the rates of the reactions and the product ratios in both the succinic and glutaric anhydride series is discussed.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The influence of the metal (Al, Cr and Co) and the substituents of the porphyrin in controlling the reactions involved in the copolymerization of propylene oxide and cyclic anhydrides by porphyrin metal(III) complexes

A series of porphyrin metal(III) complexes of general formula LMX (L = tetraphenylporphyrin (TPP), octaethylporphyrin (OEP), tetrakispentafluorophenylporphyrin (TFPP), M = Al, Cr, Co, X = Cl, OH or OEt); has been investigated as catalyst systems for the copolymerization of propylene oxide (PO) and cyclic anhydrides to produce polypropylene carboxylates, with and without a Lewis base cocatalyst: bis(triphenylphosphine)iminium chloride (PPN+Cl-). The highest rate of copolymerization was observed with 1.0 equiv. cocatalyst and the use of phthalic anhydride (PA) monomer allowed the formation of higher molecular weight polyesters. The terpolymerization of PO, cyclic anhydride and CO2 produced poly(ester-b-carbonates). With PPN+Cl- cocatalyst, TPPCrCl catalyst system produced two polymer chains per metal. The polymerization processes were followed by 1H NMR spectroscopy and polymer samples were characterized by GPC, Mass (ESI and MALDI TOF) and NMR (1H, 13C{1H}) spectroscopy. The observed results are compared with earlier studies of salen and related complexes.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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6-Aryl-4,5-dihydro-3(2H)-pyridazinones. A new class of compounds with platelet aggregation inhibiting and hypotensive activities

This paper reports on the synthesis and pharmacological activity of 6-aryl-4,5-dihydro-3(2H)-pyridazinone derivatives. The compounds exhibit an aggregation inhibiting action on human platelets in vitro and on rat platelets under ex vivo conditions, as well as a hypotensive action on rats. The strongest pharmacological effects were found with dihydropyridazinones, which have a 6-[p-[(chloroalkanoyl)amino]phenyl] substituent, together with a methyl group in the 5-position. The antiaggregation activity of compounds of this type is in vitro up to 16000 times and ex vivo up to 370 times greater than that of acetylsalicylic acid; the hypotensive action is up to 40 times as great as that of the comparative substance dihydralazine.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Syntheses, in vitro antibacterial and cytotoxic activities of a series of 3-substituted succinimides

We have synthesized a series of 3-substituted succinimides and their in vitro antibacterial activities have been tested towards Gram-positive and Gram-negative bacteria from the ATCC collection. Some of them possess significant antibacterial activity against Gram-positive organisms (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212) but all are poorly active or inactive against Gram-negative organisms (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). The compounds with the lowest minimal inhibitory concentrations (esters of 3-hydroxy succinimides) are also the most cytotoxic against green monkey Vero cell line (ATCC CCL-81) and could explain that perhaps apoptosis should be implicated in eukaryotic cell cytotoxicity of succinimides.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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HIGHLY REGIOSELECTIVE RING-OPENING OF alpha-SUBSTITUTED CYCLIC ACID ANHYDRIDES CATALYZED BY LIPASE

Lipase Amano P irreversibly catalyzed a ring-opening of alpha-substituted cyclic acid anhydrides 1 preferentially at the less hindered carbonyl group to give monoesters with high regioselectivity.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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N-Quinazolinylpiperidinyl-lactams

N-[1-(4-amino-2-quinazolinyl)-3- or 4-piperidinyl]-lactams, e.g., those of the formula STR1 and salts thereof are antihypertensive agents.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Synthesis of thienospiran derivatives and studies of regioselectivity in Friedel-Crafts acylation reaction

Syntheses of several spiro[benzo[b]thiophen-6(5H),1′-cycloalkan]-4(7H)- ones (Type A) and spiro[benzo[b]thiophen-5,1′-cycloalkan]-4(5H)-ones (Type B) and their 2-alkyl derivatives are described. The regioselectivity in the Friedel-Crafts acylation of thiophenes with anhydride of various unsymmetrically substituted succinic acid having substituent(s) at the same carbon atom in two different solvents namely dichloromethane and nitrobenzene is studied. A plausible explanation of such regioselective acylation of thiophenes has been incorporated.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Characterization of volatile components in four vegetable oils by headspace two-dimensional comprehensive chromatography time-of-flight mass spectrometry

Edible oil adulteration is the biggest source of food fraud all over the world. Since characteristic aroma is an important quality criterion for edible oils, we analyzed volatile organic compounds (VOCs) in four edible vegetable oils (soybean, peanut, rapeseed, and sunflower seed oils) by headspace comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (Headspace-GC×GC-TOFMS) in this study. After qualitative and quantitative analysis of VOCs, we used unsupervised (PCA) and supervised (Random forests) multivariate statistical methods to build a classification model for the four edible oils. The results indicated that the four edible oils had their own characteristic VOCs, which could be used as markers to completely classify these four edible oils into four groups.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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PPAR-GAMMA MODULATORES

The present invention relates to modulators of PPAR-gamma of formula (I), and to processes for the preparation and use of the same. Such PPAR-gamma modulators are useful in the treatment of metabolic diseases and disorders.Lambda”invention concerne des modulateurs de PPAR-gamma et leurs procedes de preparation et d”utilisation. On utilise ces modulateurs de PPAR-gamma pour traiter les maladies et les troubles metaboliques.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem