Category: 4100-80-5

4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, belongs to Tetrahydrofurans compound, is a common compound. name: 3-Methyldihydrofuran-2,5-dioneIn an article, once mentioned the new application about 4100-80-5.

Evaluation of anthropogenic secondary organic aerosol tracersfrom aromatic hydrocarbons

Products of secondary organic aerosol (SOA) from aromatic volatile organic compounds (VOCs) – 2,3-dihydroxy-4-oxopentanoic acid, dicarboxylic acids, nitromonoaromatics, and furandiones – were evaluated for their potential to serve as anthropogenic SOA tracer5with respect to their (1) ambient concentrations and detectability in PM2:5 in Iowa City, IA, USA; (2) gas-particle partitioning behaviour; and (3) source specificity by way of correlations with primary and secondary source tracersand literature review. A widely used tracer for toluene-derived SOA, 2,3-dihydroxy-4-oxopentanoic acid was only detected in the particle phase (Fp D 1) at low but consistently measurable ambient concentrations (averaging 0.3 ngm-3/. Four aromatic dicarboxylic acids were detected at relatively higher concentrations (9.1-34.5 ngm-3/, of which phthalic acid was the most abundant. Phthalic acid had a low particlephase fraction (Fp D0.26) likely due to quantitation interferences from phthalic anhydride, while 4-methylphthalic acid was predominantly in the particle phase (Fp D 0.82). Phthalic acid and 4-methylphthalic acid were both highly correlated with 2,3-dihydroxy-4-oxopentanoic acid (rsD 0.73, p D 0.003; r5D 0.80, p > 0.001, respectively), suggesting that they were derived from aromatic VOCs. Isophthalic and terephthalic acids, however, were detected only in the particle phase (Fp D 1), and correlations suggested association with primary emission sources. Nitromonoaromatics were dominated by particle-phase concentrations of 4-nitrocatechol (1.6 ngm-3/ and 4-methyl-5-nitrocatechol (1.6 ngm-3/ that were associated with biomass burning. Meanwhile, 4-hydroxy-3-nitrobenzyl alcohol was detected in a lower concentration (0.06 ngm-3/ in the particle phase only (Fp D 1) and is known as a product of toluene photooxidation. Furandiones in the atmosphere have only been attributed to the hotooxidation of aromatic hydrocarbons; however the substantial partitioning toward the gas phase (Fp =0.16) and their water sensitivity limit their application as tracers. The outcome of this study is the demonstration that 2,3-dihydroxy-4-oxopentanoic acid, phthalic acid, 4-methylphthalic acid, and 4-hydroxy-3-nitrobenzyl alcohol are good candidates for tracing SOA from aromatic VOCs.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: Tetrahydrofurans, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4100-80-5, name is 3-Methyldihydrofuran-2,5-dione. In an article£¬Which mentioned a new discovery about 4100-80-5

Acylation of lycoctonine: Semi-synthesis of inuline, delsemine analogues and methyllycaconitine

Lycoctonine has been acylated to afford sequentially inuline, delsemine analogues and methyllycaconitine using isatoic anhydride followed by S-(-)-methylsuccinic anhydride. This protocol is a rapid, facile method for the regiospecific introduction of the anthranilate ester moiety found in potent nicotinic acetylcholine receptor antagonists.

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Related Products of 4100-80-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4100-80-5, molcular formula is C5H6O3, introducing its new discovery.

QUANTITATIVE RELATIONS BETWEEN STRUCTURE AND ANTIINFLAMMATORY ACTIVITY OF ARYLOXOALKANOIC ACIDS

The antiinflammatory effect of a series of aryloxoalkanoic acids II and of their biphenyl derivatives III was examined by measuring the inhibition of the development of carageenan- and adjuvant-induced edemas.The quantitative relations between the antiinflammatory effect and physicochemical and structural parameters of the compounds tested were evaluated.The equations obtained by the method of regression analysis showed a significant linear dependence of both inhibitory activities on the lipophilicity of the compounds and a considerable effect of some structural changes as expressed by indicator variables.The antiinflammatory effect is especially enhanced in both tests by the presence of a cyclic substituent at the aromatic ring.The high antiinflammatory effect of biphenylyl derivatives III is paralleled by their prolonged action.The prolongation of the effect is most likely a result of a suitable biotransformation of acid III to an efficient metabolite.The structural requirements which resulted from both the regression analysis and from the hypothesis of biotransformation of acids III were utilized in the synthesis of suitably substituted biphenylyloxoalkanoic acids.By this approach derivatives IIIe-i were obtained some of which showed a high antiinflammatory and also protracted effect. 4-(2′,4′-Difluorobiphenylyl)-4-oxo-2-methylbutanoic acid (VUFB 16066, Flobufen) was chosen for further preclinical development.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4100-80-5 is helpful to your research. Related Products of 4100-80-5

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, belongs to Tetrahydrofurans compound, is a common compound. HPLC of Formula: C5H6O3In an article, once mentioned the new application about 4100-80-5.

CONFORMATION OF SUCCINIC ACID DERIVATIVES BY DOUBLE 13C-LABELLING

Three-bonded carbon/carbon couplings (3Jcc) are used, in conjunction with MM2 calculations, to examine conformational equilibria in several di-13C-labelled succinic acid derivatives.

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Reference of 4100-80-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 4100-80-5, 3-Methyldihydrofuran-2,5-dione, introducing its new discovery.

Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity

In this study, 12 known cycloartane triterpenoids (1?12) with four different skeletons isolated from the roots of Souliea vaginata were screened for the first time for in vitro anti-HIV activity using AZT as a standard. Among the compounds, beesioside I (1) showed the highest potency against HIV-1NL4-3 with an EC50 value of 2.32 muM (CC50 > 40 muM). Preliminary structure-activity relationship (SAR) studies on 1 indicated that simple modification of its aglycone (13) could significantly influence the antiviral activity. Particularly, the introduction of an acyl group at the C-3 position of 13 led to significant improvement in both anti-HIV potency and selectivity index. Among all synthetically modified derivatives, compound 13g was the most potent compound with an EC50 value of 0.025 muM and TI value greater than 800, comparable to those of 3-O-(3?,3?-dimethylsuccinyl)-betulinic acid (DSB, bevirimat). Other analogues exhibited strong to weak inhibition of HIV-1 replication in MT-4 cells. The length, carboxylic terminus, and C-3? dimethyl substitution of the C-3 side chain substantially affected the anti-HIV activity. Finally, compound 13g was an effective agent against HIV with high potential for further investigation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 4100-80-5. In my other articles, you can also check out more blogs about 4100-80-5

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of 3-Methyldihydrofuran-2,5-dione. Introducing a new discovery about 4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione

MoO3-TiO2 synergy in oxidative dehydrogenation of lactic acid to pyruvic acid

An efficient catalytic process for the oxidative dehydrogenation of biomass-derived lactic acid by earth-abundant MoO3/TiO2 mixed oxide catalysts is presented. A series of MoO3/TiO2 materials with varied MoO3 loadings were prepared and their performance in the aerobic and anaerobic conversion of lactic acid was evaluated. A strong synergistic effect between MoO3 and TiO2 components of the mixed oxide catalyst was observed. Optimum catalysts in terms of activity and pyruvic acid selectivity can be obtained by ensuring a high dispersion of MoOx species on the titania surface. Mo-oxide aggregates catalyze undesired side-reactions. XPS measurements indicate that the redox processes involving supported Mo ions are crucial for the catalytic cycle. A mechanism is proposed, in which lactic acid adsorbs onto basic sites of the titania surface and is dehydrogenated over the Mo=O acid-base pair of a vicinal tetrahedral Mo site. The catalytic cycle closes by hydrolysis of surface pyruvate and water desorption accompanied by the reduction of the Mo center, which is finally oxidized by O2 to regenerate the initial active site. Under anaerobic conditions, a less efficient catalytic cycle is established involving a bimolecular hydrogen transfer mechanism, selectively yielding propionic and pyruvic acids as the major products. The optimum catalyst is 2 wt% MoO3/TiO2 predominantly containing tetrahedral Mo species. With this catalyst the oxidative conversion of lactic acid at 200 C proceeds with a selectivity of ca. 80% to pyruvic acid. The pyruvic acid productivity is 0.56 g g-1 h-1.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of 3-Methyldihydrofuran-2,5-dione, you can also check out more blogs about4100-80-5

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 4100-80-5, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, molecular formula is C5H6O3

Synthesis of N-(3-phenylpropyl)-substituted tricyclic ABE ring analogues of the alkaloid methyllycaconitine

The synthesis of several ABE tricyclic analogues 5, 31 and 32 of the alkaloid methyllycaconitine (1) is reported. The analogues contain two key pharmacophores: a tertiary N-(3-phenylpropyl) substituent attached to a 3-azabicyclo-[3.3.1]nonane ring system and a 2-(3-methyl-2,5-dioxopyrrolidin-1- yl)benzoate ester. Double Mannich reaction of the cyclic beta-keto esters 6 and 17 with the bis(aminol) ether 7 using methyltrichlorosilane as an activating agent provided an efficient method for the construction of the 3-azabicyclo[3.3.1]nonanes 8 and 18. Ring-closing metathesis of the derived dienes 11, 19, and 20 afforded the tricyclic ethers 12, 21, and 22, respectively, the C-8 ester of which was reduced to a hydroxymethyl group to form the ABE tricyclic analogues 13, 23, and 24. Conversion of the alcohol 13 to the anthranilate ester 14 using N-(trifluoroacetyl)anthranilic acid followed by fusion with methylsuccinic anhydride afforded the analogue 5 containing the key N-(methylsuccinimido) anthranilate pharmacophore. In the case of the alcohols 23 and 24 the 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoate ester pharmacophore was appended by direct esterification with unsaturated acid 28 followed by hydrogenation to the ABE tricyclic compounds 33 and 34. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C5H6O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, molecular formula is C5H6O3

Synthesis and pharmacological evaluation of 6-arylpyridazinones as potent vasorelaxants

Preclinical Research As part of a research program to identify compounds with potent antihypertensive properties, a new series of dihydropyridazin-3(2H)- one analogs was synthesized and evaluated for vasodilator activity in rat thoracic aortic rings. Most of the newly synthesized compounds displayed good vasorelaxant activity as compared with SK&F-93741 and hydralazine, with the N2-unsubstituted 4-isobutyramidophenylpyridazinone derivative 5 being the most potent vasorelaxant, producing vasorelaxation greater than that of hydralazine and equipotent to SK&F-93741. A significant effect of the 6-phenyl substituents and substitution at N-2 position of pyridazinone nucleus on the vasodilatory activity was observed.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C5H6O3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4100-80-5, in my other articles.

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Tetrahydrofuran – Wikipedia,
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Electric Literature of 4100-80-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, molecular formula is C5H6O3. In a Article£¬once mentioned of 4100-80-5

Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides

The focused library of 21 new N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide, 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)propanamide, and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives as potential new hybrid anticonvulsant agents was synthesized. These hybrid molecules were obtained as close analogs of previously described N-benzyl derivatives and fuse the chemical fragments of clinically relevant antiepileptic drugs such as ethosuximide, levetiracetam, and lacosamide. The initial anticonvulsant screening was performed in mice (ip) using the ‘classical’ maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests, as well as in the six-Hertz (6 Hz) model of pharmacoresistant limbic seizures. Applying the rotarod test, the acute neurological toxicity was determined. The broad spectra of activity across the preclinical seizure models in mice (ip) displayed compounds 4, 5, 11, and 19. The most favorable anticonvulsant properties demonstrated 4 (ED50 MES = 96.9 mg/kg, ED50 scPTZ = 75.4 mg/kg, ED50 6 Hz = 44.3 mg/kg) which showed TD50 = 335.8 mg/kg in the rotarod test that yielded satisfying protective indexes (PI MES = 3.5, PI scPTZ = 4.4, PI 6 Hz = 7.6). Consequently, compound 4 revealed comparable or better safety profile than model antiepileptic drugs (AEDs): ethosuximide, lacosamide, and valproic acid. In the in vitro assays, compound 4 was observed as relatively effective binder to the neuronal voltage-sensitive sodium and diltiazem site of L-type calcium channels.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4100-80-5, name is 3-Methyldihydrofuran-2,5-dione, introducing its new discovery. SDS of cas: 4100-80-5

Reactions of lactones with tropospheric oxidants: A kinetics and products study

Tropospheric lifetimes of two lactones, gamma-valerolactone (GVL) and alpha-methyl gamma-butyrolactone (AMGBL) in terms of their reactions with two important tropospheric oxidants- OH and Cl – are estimated, after determining the respective rate coefficients of their reactions in the gas phase using relative rate method. Values of the rate coefficients of the reactions of GVL (kOH?= (1.95?¡À?0.58) x 10?12; kCl?=?2.26?¡À?0.53?¡Á?10?11 cm3molecule?1s?1) and AMGBL (kOH?=?1.81?¡À?0.43?¡Á?10?12; kCl?=?3.42?¡À?0.63?¡Á?10?11 cm3molecule?1s?1) at 298?K imply that reaction with OH is the dominant reaction in the ambient conditions, and that reaction with Cl atom becomes relevant under marine boundary layer (MBL) conditions, reducing the tropospheric lifetimes to almost half. The tropospheric life times of GVL and AMGBL based on their reaction with OH under ambient conditions are comparable, 71.2 and 76.7?h respectively. However, the products of the reactions are found to be different. In GVL, a promising second generation biofuel component, only ring opening reactions are important, acetic acid and CO2 being the only observed volatile products. In AMGBL, additional ring oxidized products are also formed, of which 3,4-dihydro-3-methyl-2,5-furandione is the most dominant one. The absence of such ring oxidized products in GVL is assigned to the difference in the preferred position of H atom abstraction, based on the computed rate coefficients of individual channels reported in the literature. This suggests that the impact in terms of aerosol generation in the troposphere may also be different for GVL and AMGBL, which differ only in the position of methyl substitution.

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Tetrahydrofuran – Wikipedia,
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