Archives for Chemistry Experiments of 3-Methyldihydrofuran-2,5-dione

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Improved synthesis of pyridazinediones under microwave irradiation

Pyridazinediones have been synthesized with good to excellent yields under microwave irradiation. The results were compared with traditional stirring.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Synthesis of Methylated Benzofluoranthenes and Benzofluoranthenes

A series of monomethyl and dimethyl derivatives of benzofluoranthene (BbF) and benzofluoranthene (BkF) were synthesized in order to investigate the enviromental occurence and structural requirements for carcinogenicity of methylated nonalternant polycyclic aromatic hydrocarbons. 9-Methyl-BbF (5), 12-methyl-BbF (6), and 1-methyl-BbF (7) were prepared from the appropriate oxotetrahydro-BbF’s (17-19). 8-Methyl-BbF (8) was synthesized from 1-methyl-3-oxo-1,2,3,10b-tetrahydrofluoranthene (20) in 11 steps. 3-Methyl-BbF (9) and 1,3-dimethyl-BbF (10) were prepared from 3-methyl-1-oxo-1,2,3,3a-tetrahydrobenzofluoranthene (31), which was synthesized from methyl 11H-benzofluorene-11-carboxylate (28). 7-Methyl-BbF (11) was obtained by condensation of 1-methylfluorene (33) with o-bromobenzaldehyde, followed by treatment with KOH and quinoline. 5,6-Dimethyl-BbF (12) was synthesized by reaction of 2,3-dimethylbutadiene with acephenanthrylene (38) followed by aromatization. 8-Methyl-BkF (13) was synthesized from 8-oxo-8,9,10,11-tetrahydro-BkF. 9-Methyl-BkF (14) was prepared by Friedel-Crafts reaction of 2-methylsuccinic anhydride with fluoranthene, followed by Wolff-Kishner reduction, cyclization, LiAlH4 reduction, dehydration, and aromatization. 2-Methyl-BkF (16) was synthesized by an analogous sequence, beginning with 2-methylfluoranthene and succinic anhydride. 7,12-Dimethyl-BkF (15) was prepared by a two-step reduction of 7,12-dicyano-BkF (51).

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Process for the production of 3-substituted-2,5-dioxo-tetrahydrofuran

Process for the production of 3-substituted-2,5-dioxo-tetrahydrofuran which involves converting diketene or a substituted diketene in the presence of a catalytic quantity of a carbonyl complex or of a mixture of two carbonyl complexes of metals of the VIIIth group with carbon monoxide and hydrogen at an elevated temperature and an elevated pressure.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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POLYMER MODIFIED ASPHALT REACTION PRODUCTS

In a process for producing a cross-linked asphalt/polymer composition (?polymer-modified asphalt? or PMA) that comprises or is produced from asphalt and an ethylene copolymer, an anhydride is used as a promoter. The ethylene copolymer comprises copolymerized units derived from ethylene and an epoxy-containing comonomer. An improvement in asphalt properties is demonstrated without the use of an acid catalyst.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Method for treating anxiety in mammals

This disclosure describes compositions of matter useful as anxiolytic agents and the method of meliorating anxiety in mammals therewith; the active ingredients of said compositions of matter being certain substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines or the pharmacologically acceptable acid-addition salts thereof.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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ISOPRENYL COMPOUNDS AND METHODS THEREOF

Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Discovery of 3-Methyldihydrofuran-2,5-dione

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Electric Literature of 4100-80-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4100-80-5, molcular formula is C5H6O3, introducing its new discovery.

Synthesis of novel unsaturated AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine: With olefinic J = 13.5 Hz, but still cis

We have synthesised unsaturated AE-bicyclic analogues of lycoctonine class norditerpenoid alkaloids by acetylide addition and regiochemically controlled reductions. Reduction of a substituted propargylic alcohol with hydrogen gas (poisoned Pd catalyst) gave an alkene with vicinal J = 13.5 Hz. This was shown to be of Z-geometry by unambiguously preparing the corresponding E-alkene (J = 15.4 Hz).

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Design, synthesis, and biological evaluation of substituted benzoate analogues of the selective nicotinic acetylcholine receptor antagonist, methyllycaconitine

The norditerpenoid alkaloid methyllycaconitine (MLA) acts as a competitive antagonist on the nicotinic acetylcholine receptor (nAChR) with a high preference for the neuronal alpha-bungarotoxin (alphaBgt)-sensitive nAChR over the muscle nAChR in mammals. MLA is thus a useful pharmacological tool. Furthermore, its efficient binding to insect nAChR indicates a high insecticidal potency. Within the complex hexacyclic structure of MLA, we envisaged a potential simple pharmacophore. This led to the design and synthesis of acyclic and monocyclic analogues of MLA. The biological activity of these derivatives at both neuronal nicotinic and muscarinic AChR was evaluated. Some of these structurally simple compounds, despite displaying a modest affinity for the nAChR, showed good specificity. We were able to show the importance of the 2-(methylsuccinimido)benzoate ester moiety and the E-ring of MLA. None of the analogues tested displayed any affinity for [3H]nicotine binding sites in brain membranes, indicating that alpha7-selectivity is already inherent in these simple structures. If higher affinities are to be obtained, however, there is a clear need for more structural information in the design of second generation simple analogues of MLA.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Catalytic carbonylation of beta-lactones to succinic anhydrides

A well-defined,highly active and selective catalyst for the synthesis of succinic anhydrides from CO and beta-lactones is reported. At 200 psi of CO, the catalyst [(N,N?-bis(3,5-di-tert-butylsalicylidene)phenylenediamino)Al(THF)2][Co(CO)4] carbonylates beta-propiolactones to succinic anhydrides in high yield. (R)-beta-Butyrolactone is carbonylated to (S)-methylsuccinic anhydride with clean inversion of stereochemistry, while cis-2,3-dimethyl-beta-propiolactone yields exclusively trans-2,3-dimethylsuccinic anhydride. These data are consistent with a mechanism involving nucleophilic attack by [Co(CO)4]- on the beta carbon of the lactone, followed by CO insertion and anhydride formation. Copyright

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The important role of 3-Methyldihydrofuran-2,5-dione

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6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents

This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem