Category: 17347-61-4

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17347-61-4, Example 15: Preparation of 2,2-dimethyl-4-oxo-4-(((lR,3aS,5aR,5bR,7aR,9S,l laR,l lbR, 13aR,13bR)-5a,5b,8,8,l la-pentamethyl-3a-((S)-2-(l-methyl-4-phenyl-lH-imidazol-2-yl) pyrrolidine- l-carbonyl)-l-(prop-l-en-2-yl)icosahydro-lH-cyclopentaralchrysen-9-yl)oxy) butanoic acid:2,2-Dimethylsuccinic anhydride (385 mg, 3.0 mmol) was added to a stirred solution of ((lR,3aS,5aR,5bR,7aR,9S,l laR,l lbR,13aR,13bR)-9-hydroxy-5a,5b,8,8,l la-pentamethyl- l-(prop-l-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysen-3a-yl)((S)-2-(l-methyl-4-phenyl- lH-imidazol-2-yl)pyrrolidin-l-yl)methanone (Example 1-step 2, 500 mg, 0.75 mmol) and DMAP (183 mg, 1.49 mmol) in pyridine (8 ml) at room temperature and heated at 90¡ãC for about 24 hours. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with dichloromethane, washed with 20percent HCl and brine solution. The residue was dried over Na2S04, filtered, the solvent was evaporated under reduced pressure and purified on silica gel column (100-200 mesh, elution 36-40percent ethyl acetate/hexanes) to afford the title compound (240 mg, Yield: 40percent) as an off white solid. H1 NMR (DMSO-D6, 300 MHz): delta 12.15 (s, 1H), 7.64 (d, J = 7.5 Hz, 2H), 7.42 (s, 1H), 7.27 (t, J = 7.5 Hz, 2H), 7.11 (t, J = 7.5, 1H), 5.11 (m, 1H), 4.50 (s, 1H), 4.43 (s, 1H), 4.35 (m, 1H), 3.85 (m, 1H), 3.68 (s, 3H), 3.65 (m, 1H), 2.75 (m, 1H), 2.10-2.60 (m, 6H), 0.70-2.0 (m, 48H); Mass (ESI): 794.55 [M+H]+; HPLC: 92.60percent.

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; ADULLA, Panduranga Reddy; GAZULA LEVI, David Krupadanam; BAMMIDI, Eswara Rao; KOTHAKAPU, Ranga Reddy; (78 pag.)WO2016/1820; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

General procedure: 3-aminobenzamide (50 mg, 0.37 mmol) and maleic anhydride (43.2 mg, 0.44 mmol) were dissolved in dry THF (1 ml) and stirred at room temperature for 18 hours. The precipitate was filtered off and dried in vacuo to give 2 (71 mg, 83%).

17347-61-4, The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ekblad, Torun; Lindgren, Anders E.G.; Andersson, C. David; Caraballo, Remi; Thorsell, Ann-Gerd; Karlberg, Tobias; Spjut, Sara; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 546 – 551;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

To l’-carboxylic acid tert-butyl ester-6-bromo-spiro[l,3-benzodioxine-2,4′- piperidine] (14.58 g, 37.94 mmol) in ether (300 mL) under argon at -78 0C was added sec- butyllithium (1.4 M; 32.5 mL, 45.5 mmol) dropwise and the reaction was stirred at -78 0C for 30 min. 3,3-Dimethyldihydrofuran-2,5-dione in ether (10 mL) was added and the reaction was stirred for 30 min at -78 0C and quenched with water (-40 mL). The reaction was warmed to rt and concentrated to remove the organic solvents. The aqueous layer was acidified with 5N HCl to pH = 3-4, extracted with dichloromethane (150 mL), and the organic layer was washed with water and brine, dried over sodium sulfate, and concentrated. The product was purified using silica gel column chromatography (2-3% methanol/dichloromethane). The fractions were concentrated, triturated with dichloromethane (~5 mL)/ether (-10 mL)/hexanes (-15-20 mL), and filtered off white solid to obtain 5.52 g (34%); MS m/z: 434 (M + H).

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; CEPHALON, INC.; WO2009/97309; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: Intermediate II A solution of 3,3-dimethyl-dihydrofuran-2,5-dione I (25 g, 195 mmol) in anhydrous EtOH ( 150 mL) was stirred at 50 ¡ãC overnight. After cooling down to room temperature, the solvent was removed under reduced pressure with a rotary evaporator and the residue was triturated with hexane at -50 ¡ãC to afford the intermediate II (25 g, 33 mmol, 67.9 percent) as a white solid. 1 H NMR (400 MHz, CDCI3) 5 ppm 4.13-4.18 (2H, q, J = 7.2 Hz), 2.62 (2H, s),1.28 (6H, s), 1.32-1 .25 (3H, t, J = 7.6 Hz). LC/MS: m/z calculated 174.1 , found 1 3.1 (M-1 )-., 17347-61-4

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE LLC; GAO, Daxin; HAN, Nianhe; JOHNS, Brian; JIN, Zhimin; NING, Fangxian; TANG, Jun; WU, Yongyong; YANG, Heping; WO2013/20245; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

17347-61-4, To an ice-cold stirred solution of 4-[(2-tert-butylphenoxy)methyl]piperidine hydrochloride (0.20 g, 0.71 mmol) and triethylamine (0.10 g, 1.0 mmol) in THF (20.0 mL) was added 3,3-dimethyldihydrofuran-2,5-dione (0.11 g, 0.87 mmol) and the resulting mixture was warmed to room temperature. After 16 h the reaction mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and 1N hydrochloric acid and separated. The organic layer was washed with saturated sodium chloride, dried (MgSO4), filtered and concentrated under reduced pressure to give a white solid. The solid was recrystallized from hexane/ethyl acetate to provide 4-{4-[(2-tert-butylphenoxy)methyl]piperidin-1-yl}-2,2-dimethyl-4-oxobutanoic acid (0.19 g, 72percent) as a white powder. 1H NMR (300 MHz, CDCl3) delta 7.33-7.25 (m, 1H), 7.21-7.14 (m, 1H), 6.95-6.87 (m, 1H), 6.86-6.81 (m, 1H), 4.79-4.70 (m, 3H), 4.05-3.95 (m, 1H), 3.93-3.80 (m, 2H), 3.23-3.10 (m, 1H), 2.77-2.60 (m, 3H), 2.25-1.75 (m, 3H), 1.38 (s, 9H), 1.33 (s, 6H).

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP2202223; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

2,2-Dimethylsuccinic anhydride (2 g, 8×2 mmol) was added to a stirred mixture of dihydrobetulinic aldehyde (1 g, 2 mmol) and A- dimethylaminopyridine (2.2 g, 8×2 mmol) in anhydrous pyridine 15 mL at room EPO temperature. The reaction mixture was stirred for 48 hours at 60 C and cooled down to room temperature. The mixture was diluted with 5percent HCl solution (50 mL), the off-white precipitate was filtered off, washed with water (2x 20 mL) and dried. Washing with hot methanol gave white solids (0.83 g, 67percent total yield).1H NMR (CDCl3): delta 9.63 (s, IH), 4.5 (dd, J1 = 10.1 Hz, J2 = 5.5 Hz, IH), 2.6 (m, 2H), 2.25-0.6 (m, 53H)., 17347-61-4

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; REGENTS OF THE UNIVERSITY OF MINNESOTA; WO2006/105356; (2006); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

A mixture of N-(3-tert-butyl-phenyl)-6-piperazin-1-yl-nicotinamide (20 mg, 0.06 mmol) in CH2Cl2 (5 mL) was treated with 2,2-dimethylsuccinic anhydride (11 mg, 0.07 mmol). After stirring at rt overnight the solvent was evaporated. The residue was dissolved in a very small volume of CH2Cl2. The product was isolated by precipitation after addition of excess of hexanes (25 mg, Yield: 91percent) HRMS m/z calcd for C26H34N4O4 [M+H]+: 467.2653; Found: 467.2652.

17347-61-4, The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bolin, David Robert; Cheung, Adrian Wai-Hing; Hamilton, Matthew Michael; Marcopulos, Nicholas; McDermott, Lee Apostle; Qian, Yimin; US2010/113782; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 6: Synthesis of 4-(lR,3aS,5aR,5bR,7aR,9S, l laR,l lbR,13aR,13bR)-3a-((R)-2-(5-(4- chloro phenyl)- 1 H-imidazo l-2-yl)pyrro lidine- 1 -carbonyl)-5 a,5b, 8 ,8,11 a-pentamethyl- 1 – (prop- 1 -en-2-yl) icosahydro- 1 H-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid: [0225] To a stirred solution of (R)-2-(5-(4-chlorophenyl)-lH-imidazol-2- yl)pyrrolidin-l -yl)(( lR,3aS,5aR,5bR,7aR,9S, 11 aR, 1 IbR, 13aR, 13bR)-9-hydroxy- 5a,5b,8,8,l la-pentamethyl-l-(prop-l-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysen-3a- yl)methanone (step 5, 0.300 g, 0.43 mmol, 1.0 eq) and 2,2-dimethyl succinicanhydride (0.22 g, 1.75 mmol, 4.0 eq) in toluene (7.5 mL) was added DMAP (0.10 g, 0.87 mmol, 2.0 eq). The reaction mixture was heated at 90¡ãC for overnight. TLC indicated starting material was consumed and the desired product was observed. The mixture was concentrated under reduced pressure, cooled to 0¡ãC, acidified to pH= 5 with IN HC1 and extracted with CH2CI2. The combined organic extracts were washed with water, dried over Na2S04, filtered and evaporated under reduced pressure. The crude residue was purified by column chromatography by using 2percent methanol: dichloromethane as an eluent to gave the desired product (0.150 g, 43.0percent) as a white solid. H1 NMR (DMSO-d6, 300 MHz): delta 12.16 (s, 1H), 11.67 (s, 1H), 7.74 (d, 2H), 7.48 (s. 1H), 7.36 (d, 2H), 5.04 (s, 1H), 4.54 (d, 2H), 4.36 (t, 1H), 3.78 (s, 1H), 3.56 (bs, 2H), 2.08 (m 1H), 2.38-1.85 (m, 9H), 1.58-1.32 (m, 15H), 1.16 (m, 7H), 0.93-0.87 (m, 10H) and 0.83-0.78 (m, 12H); Mass: [M]+ 814.53 (100percent); HPLC: 89.00percent., 17347-61-4

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA REDDY, Adulla; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; VL SUBRAHMANYAM, Lanka; DAVID KRUPADANAM, Gazula, Levi; VENKATI, Mukkera; SUDHAKAR, Neela; SRINIVAS REDDY, Kallem; WO2014/105926; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

Synthesis of BA-derivatives 30, 35, 39-40, 45-48. A solution of the appropriate BA analog (1 eq), DMAP (1.5 eq) and the appropriate acid anhydride (5 eq) in anhydrous pyridine (1.5 mL) was stirred at 160 0C for 2 h using microwave (Biotage). The reaction mixture was diluted with EtOAc (15 mL) and washed three times with 20percent HCl solution and distilled water. The organic layer was dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The residue was chromatographed using a silica gel column to yield pure target compounds.

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; DUKE UNIVERSITY; LEE, Kuo-Hsiung; QIAN, Keduo; YU, Donglei; CHEN, Chin-Ho; HUANG, Li; BORI, Ibrahim Danlami; WO2010/132334; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

To a chilled solution (ice/water bath) of bromobenzene (7.71 g, 49.1 mmol) and 3,3-dimethyldihydro-2,5-furandione (5.99 g, 46.7 mmol) in dichloroethane (150 mL) was added aluminum trichworide (13.28 g, 99.58 mmol). The ice bath was removed and the reaction mixture was stirred at rt overnight. The mixture was again chilled in an ice/water bath, and then quenched with 1 M aqueous hydrochloric acid. Water (70 mL) was added and the layers were separated. The aqueous layer was extracted with ethyl acetate (3.x.50 mL). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by flash chromatography (Biotage apparatus, 17:83 ethyl acetate/hexane) to give 4-(4-bromophenyl)-2,2-dimethyl-4-oxobutanoic acid as a white solid (8.34 g, 63percent). LC-MS: ret. time 2.79 min; m/z 284.8 (MH+); 1H NMR (300 MHz, CDCl3) delta 1.36 (s, 6H), 3.27 (s, 2H), 7.60 (d, 2H), 7.81 (d, 2H).

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US2004/224997; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem