Category: 17347-61-4

An article , which mentions 17347-61-4, molecular formula is C6H8O3. The compound – 2,2-Dimethylsuccinicanhydride played an important role in people’s production and life., 17347-61-4

Towards small molecule inhibitors of mono-ADP-ribosyltransferases

Protein ADP-ribosylation is a post-translational modification involved in DNA repair, protein degradation, transcription regulation, and epigenetic events. Intracellular ADP-ribosylation is catalyzed predominantly by ADP-ribosyltransferases with diphtheria toxin homology (ARTDs). The most prominent member of the ARTD family, poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) has been a target for cancer drug development for decades. Current PARP inhibitors are generally non-selective, and inhibit the mono-ADP-ribosyltransferases with low potency. Here we describe the synthesis of acylated amino benzamides and screening against the mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10, and the poly-ADP-ribosyltransferase ARTD1/PARP1. The most potent compound inhibits ARTD10 with sub-micromolar IC50.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.17347-61-4, Name is 2,2-Dimethylsuccinicanhydride, molecular formula is C6H8O3, introducing its new discovery.

Synthesis and in vitro antitumor activities of lupeol dicarboxylic acid monoester derivatives

Ten lupeol dicarboxylic acid monoester derivatives as new potent antitumor agents were synthesized and evaluated for in vitro antitumor activities against A549, LAC, HepG2 and HeLa cell lines. Among them, compounds 1-5 showed excellent antitumor activities against all tested tumor cell lines and compounds 6-10 exhibited high activities against A549, HepG2 and HeLa cells, exceeded lupeol, lupanol and doxorubicin. Compound 2 displayed the highest potent antitumor activities with IC50 values of 5.78 muM against A549 cell, 2.38 muM against LAC cell, 6.14 muM against HepG2 cell and 0.00842 muM against HeLa cell.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, Name is 2,2-Dimethylsuccinicanhydride, belongs to Tetrahydrofurans compound, is a common compound. 17347-61-4In an article, authors is Abell, Andrew D., once mentioned the new application about 17347-61-4.

The Wittig Reaction with Glutaric and Succinic Anhydrides

Six-membered cyclic anhydrides, including glutaric and some of its alkylated derivatives, have been shown to yield enol-lactones with ethoxycarbonylmethylenetriphenylphosphorane; the (E) isomer is formed preferentially.The reactions of methyl-substituted succinic anhydrides with the same phosphorane give predominantly the (E) enol-lactone in all examples.The influence of alkyl substituents on the rates of the reactions and the product ratios in both the succinic and glutaric anhydride series is discussed.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 17347-61-4, Name is 2,2-Dimethylsuccinicanhydride,introducing its new discovery.

Discovery, synthesis, and structure-activity relationship development of a series of N -4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4) with oral efficacy in an antiparkinsonian animal model

There is an increasing amount of literature data showing the positive effects on preclinical antiparkinsonian rodent models with selective positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4). However, most of the data generated utilize compounds that have not been optimized for druglike properties, and as a consequence, they exhibit poor pharmacokinetic properties and thus do not cross the blood-brain barrier. Herein, we report on a series of N-4-(2,5-dioxopyrrolidin-1-yl) phenylpicolinamides with improved PK properties with excellent potency and selectivity as well as improved brain exposure in rodents. Finally, ML182 was shown to be orally active in the haloperidol induced catalepsy model, a well-established antiparkinsonian model.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 17347-61-4, molcular formula is C6H8O3, introducing its new discovery. , 17347-61-4

NOVEL LUPANE DERIVATIVES

The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

Step G: Intermediate 27-1To a solution of the intermediate 26-1 (26 mg, 0.037 mmol) in anhydrous pyridine (2 mL) were added DMAP (22.42 mg, 0.184 mmol) and 3,3-dimethyldihydro-2,5- furandione (47 mg, 0.367 mmol). After it was stirred at 80 ¡ãC overnight, the reaction mixture was diluted with EtOAc (30 mL). The organic phase was washed with aqueous HC1 (2 N, 10 mL), brine (20 mL), dried over sodium sulfate and evaporated to dryness in vacuo to give a residue, which was purified by column chromatography on silica gel (Hex:EtOAc 4: 1) to afford the intermediate 27-1 (15 mg, 48.9 percent) as a white foam. LC/MS: m/z calculated 835.4, found 858.4 (M + Na)+.

17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE LLC; GAO, Daxin; HAN, Nianhe; JIN, Zhimin; NING, Fangxian; TANG, Jun; WU, Yongyong; YANG, Heping; WO2011/100308; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 154-[4-(2-tert-Butylphenyl)piperazin-1-yl]-2,2-dimethyl-4-oxobutanoic acidA mixture of 1-(2-tert-butylphenyl)piperazine dihydrochloride obtained in Reference Example 1 (400 mg), 2,2-dimethylsuccinic anhydride (400 mg), triethylamine (1.39 mL), and tetrahydrofuran (20 mL) was stirred at room temperature for over-night.Water was added to the reaction solution, and the mixture was extracted with ethyl acetate.The ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate.The solvent was evaporated under reduced pressure to provide the title compound (1.03 g, 95percent) as a colorless solid.1H NMR (300 MHz, DMSO-d6) delta 1.17 (s, 3H), 1.19 (s, 3H), 1.41 (s, 9H), 2.54-2.84 (m, 7H), 3.06-3.23 (m, 1H), 3.90-3.95 (m, 1H), 4.38-4.40 (m, 1H), 7.11-7.16 (m, 1H), 7.19-7.24 (m, 1H), 7.30-7.36 (m, 2H), 11.79 (br, 1H)., 17347-61-4

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; Kasai, Shizuo; McGee, JR., Kevin Francis; US2012/71489; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound,it involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy- 5a,5b,8,8,11a-pentamethyl-N-((5-phenyl-1H-imidazol-2-yl)methyl)-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxamide (0.6 g, 0.98 mmol, 1.0 eq) and 2,2-dimethyl succinic anhydride (0.5 g, 3.92 mmol, 4.0 eq) in toluene (12 mL) was added DMAP (0.239 g, 1.96 mmol, 2.0 eq). The reaction mixture was heated at 90 C for overnight. TLC indicated starting material was consumed and the desired product was observed. The mixture was concentrated under reduced pressure, cooled to 0 C, acidified to pH= 6-7 with 1N HCl and extracted with CH2CI2. The combined organic extracts were washed with water, dried over Na2SO4, filtered and evaporated under reduced pressure. The crude residue was purified by silicagel column chromatography by using 60% EtOAc: n-Hexane as an eluent gave the desired product (0.13 g, 18% yield) as brown color solid. 1H MR (300 MHz, DMSO): delta 12.2 (bs, 1H), 11.66 (bs, 1H), 8.13-8.11 (m, 1H), 7.73 (d, J = 6.3 Hz, 2H), 7.32 (s, 1H), 7.3 (t, J = 6.9Hz, 2H), 7.17-7.14 (m, 1H), 4.64 (s, 1H), 4.52 (s, 1H), 4.37-4.22 (m, 4H), 3.05-2.98 (m, 1H), 2.31-2.18 (m, 2H), 1.91-1.61 (m, 6H), 1.6-1.21 (m, 18H), 1.09-0.96 (m, 8H), 0.92 (s, 3H), 0.81-0.63 (m, 12H). ES Mass: [M+l]+ 740.55. HPLC: 86.0%.

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; NEELA, Sudhakar; MOGILI, Narsingam; (87 pag.)WO2017/21922; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

The raw material 12 – carbonyl oleanolic acid (189 mg, 0 . 40 mmol) is dissolved in anhydrous pyridine (3 ml) in, adding 2, 2 – dimethyl succinic anhydride (256 mg, 2 mmol), DMAP (49 mg, 0 . 40 mmol), after dissolving completely, microwave reactor is heated to 160 ¡ãC, reaction 3 h. The end of the reaction, by adding ethyl acetate (50 ml), for 10percent HCl to adjust the pH 4 – 5; organic layer is saturated salt water washing (25 ml ¡Á 3), dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure to remove the solvent, silica gel column chromatography (hexane: ethyl acetate=1:1), to obtain white solid 202 mg, is compound 17, yield 68percent.

17347-61-4, The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chen Zhong; Duan Huaqing; Yang Shilin; Li Guoxiong; (26 pag.)CN109485688; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3,3-DIMETHYL-DIHYDRO-FURAN-2,5-dione (6.4g) was heated at [50OC] in ethanol (150 [ML)] overnight. The solvent was removed in vacuo and the residue triturated with hexane to yield 2, [2-DIMETHYL-SUCCINIC] acid 4-ethyl ester (4.66g) which was used without further purification. t-Butanol (7.5 mL) was added to a mixture of 2,2-Dimethyl-succinic acid 4- ethyl ester (2.74g, 15. [7MMOL)] in dichloromethane (62 mL) containing magnesium sulfate (7.5 g) and [CONC.] sulfuric acid (0.85 mL) and the mixture was stirred at room temperature overnight. Saturated sodium bicarbonate solution was added and the product was extracted into dichloromethane, washed with brine solution, dried and concentrated to yield the diested as a colorloess oil (1.89 g). The ethyl ester was hydrolyzed by trating the crude sample with potassium hydroxide (2.75g) in a mixture of ethanol (50 [ML)] and water (25 mL) at room temperatire for 2h. The reaction was acidified using 1N [HC1] [(AQ)] and extracted into ether, dried and concentrated to yield 2,2-Dimethyl-succinic acid [1-TERT-BUTYL] ester (1.4g). This acid was treated under the conditions of Example 320 (step 1) to yield 3- [[3- (3-CHLORO-PHENYL)- [1,] 2,4] oxadiazol-5-yl] -2,2-dimethyl-propionic acid tert-butyl ester (1.9g). This t-Bu ester was deprotected using formic acid (19 mL) at [50¡ãC] for 20 min. The crude product was concentrated and triturated with a mixture of ether and hexane to yield [3- [3- (3-CHLORO-PHENYL)- [1,2,4] [OXADIAZOL-5-YL]-2,] 2-dimethyl-propionic acid (1.12g). To a solution [OF 3- [3- (3-CHLORO-PHENYL)- [1,2,4] oxadiazol-5-yl] -2,2-dimethyl-propionic acid (561 mg, 2 mmol) and triethylamine [(1.] [1] [ML,] 8 mmol) in THF (9 ml), isobutyl chloroformate (0.31 mL, 2.4 mmol) was added dropwise [AT-78 ¡ãC.] After being stirred for lh, hydrazine hydrate (1 mL, 11 mmol) was added. The reaction mixture was stirred at room temperature for 1 h and concentrated. A small amount of ice was added to quence any excess reagent and precipitate the product, which was collected by filtration to give 482 mg of the title compound., 17347-61-4

17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem