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Dammarane-type leads panaxadiol and protopanaxadiol for drug discovery: Biological activity and structural modification

Based on the definite therapeutic benefits, such as neuroprotective, cardioprotective, anticancer, anti-diabetic and so on, the Panax genus which contains many valuable plants, including ginseng (Panax ginseng C.A. Meyer), notoginseng (Panax notoginseng) and American ginseng (Panax quinquefolius L.), attracts research focus. Actually, the biological and pharmacological effects of the Panax genus are mainly attributed to the abundant ginsenosides. However, the low membrane permeability and the gastrointestinal tract influence seriously limit the absorption and bioavailability of ginsenosides. The acid or base hydrolysates of ginsenosides, 20 (R,S)-panaxadiol and 20 (R,S)-protopanaxadiol showed improved bioavailability and diverse pharmacological activities. Moreover, relative stable skeletons and active hydroxyl group at C-3 position and other reactive sites are suitable for structural modification to improve biological activities. In this review, the pharmacological activities of panaxadiol, protopanaxadiol and their structurally modified derivatives are comprehensively summarized.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Related Products of 17347-61-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.17347-61-4, Name is 2,2-Dimethylsuccinicanhydride, molecular formula is C6H8O3. In a Patent£¬once mentioned of 17347-61-4

EPOXY ELASTOMER COMPOSITIONS

An epoxy terminated prepolymer formed as a reaction product of a cycloaliphatic epoxide resin and an amine terminated polymeric polyol, and a catalyst that promotes the reaction of the cycloaliphatic epoxide resin and the aminated polyol. The epoxy terminated prepolymer and an anhydride hardener react to form an epoxy elastomer composition having a microphase separated morphology of hard particles, formed with the anhydride hardener reacted with the epoxy terminated prepolymer, dispersed in a soft continuous phase formed from polymeric polyol in the epoxy terminated prepolymer.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Trapping of N-Acyliminium Ions with Enamides: An Approach to Medium-Sized Diaza-Heterocycles

Enamides equipped with N-acyliminium ion precursors were obtained through reduction of ynamides tethered to N-imides. Intramolecular TMSOTf-mediated trapping of N-acyliminium ions provided a variety of polyfunctionalized medium-sized diaza-heterocycles of putative pharmacological interest.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Programming the assembly of carboxylic acid-functionalised hybrid polyoxometalates

We report here the straightforward synthesis and characterisation of a series Anderson-type hybrid polyoxometalates in high yield, functionalised with carboxylic acid following the reaction of anhydride precursors with the starting hybrid cluster ([n-N(C4H9)4] 3[MnMo6O18((OCH2) 3CNH2)2]). Seven new structures have been obtained, five of which have acid-terminated ligands. Six of these structures have been isolated with a yield higher than 80% with high purity. This reaction is limited by the bulkiness of the anhydride used; this effect can be employed to selectively synthesise one isomer out of three other possibilities. The acid groups and aromatic platforms attached to the clusters can act as building tools to bridge several length scales and engineer molecular packing within the crystal structure. The presence of acids should also change the hydrophilicity of the clusters, and therefore the way they interact with hydrophilic surfaces. We also show a potential relationship between the acid group interaction in the packing diagram and the cluster’s tendency to interact with a hydrophilic surface. In addition to reporting a derived synthetic path to new acid-terminated Mn-Anderson-type hybrids, we describe here a new way to program self-assembly motifs of these compounds in the crystal structure and at interfaces.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Application of 17347-61-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 17347-61-4, molcular formula is C6H8O3, introducing its new discovery.

NOVEL C-21-KETO LUPANE DERIVATIVES PREPARATION AND USE THEREOF

The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some scientific research about 2,2-Dimethylsuccinicanhydride

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Electric Literature of 17347-61-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.17347-61-4, Name is 2,2-Dimethylsuccinicanhydride, molecular formula is C6H8O3. In a Article£¬once mentioned of 17347-61-4

Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives

3-Alkylamido-3-deoxy-betulinic acids were synthesized and evaluated for anti-HIV activity as part of the structure-activity relationship study of the potent anti-HIV agent 3-O-(3′,3′-dimethyl)-succinyl-betulinic acid (DSB) (2). 3alpha-Diglycorylamide-3-deoxy-betulinic acid demonstrated relatively potent anti-HIV activity (EC50 0.24 muM, TI 728). However, replacing the ester group at C-3 in 2 and its analogues with an amido group yielded inactive or much less potent compounds against HIV replication, indicating that the ester group at C-3 in 2-4 is essential for potent anti-HIV activity.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Peptidomimetic inhibitors of the human cytomegalovirus protease

A compound of formula (I) is disclosed:wherein X, z, W, Y, R1 through R5, m and n are as define herein. These compounds are peptidomimetic inhibitors of human cytomegalovirus (HCMV) protease and are useful for the treatment of human cytomegalovirus infection.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Synthetic Route of 17347-61-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.17347-61-4, Name is 2,2-Dimethylsuccinicanhydride, molecular formula is C6H8O3. In a article£¬once mentioned of 17347-61-4

Cytotoxic and Apoptosis-inducing Activities of Taraxastane-type Triterpenoid Derivatives in Human Cancer Cell Lines

Twenty-eight taraxastane-type triterpenoid derivatives 4???31 were prepared from the naturally occurring triterpenoids faradiol (1) and heliantriol C (3). The cytotoxic activities of these compounds and arnidiol (2) were evaluated in leukemia (HL60), lung (A549), duodenal (AZ521), and breast (SK-BR-3) cancer cell lines. 21-Oxoarnidiol (18) and faradiol 3,16-di-O-l-alaninate (31) exhibited potent cytotoxicity, with 50% inhibitory concentrations of 0.5???2.7?mum. In particular, flow cytometric analysis indicated that compound 31 induced typical apoptotic cell death in HL60 cells. These results suggested that taraxastane-type triterpenoid derivatives might provide useful antitumor agents with apoptosis-inducing activity.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Electric Literature of 17347-61-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.17347-61-4, Name is 2,2-Dimethylsuccinicanhydride, molecular formula is C6H8O3. In a article£¬once mentioned of 17347-61-4

ANTIVIRAL COMPOUNDS AND USE THEREOF

The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Top Picks: new discover of 2,2-Dimethylsuccinicanhydride

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 17347-61-4, help many people in the next few years.Formula: C6H8O3

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C6H8O3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 17347-61-4, name is 2,2-Dimethylsuccinicanhydride. In an article£¬Which mentioned a new discovery about 17347-61-4

1-(Tetrahydrofurylmethyl)azoles

Compounds useful as plant growth regulators and fungicides and having the formula STR1 and stereoisomers thereof, wherein W is –CH= or =N–; Q is optionally substituted aryl, especially optionally substituted phenyl, or optionally substituted aralkyl or alkyl; R1, R2, R3, R4, R5 and R6, which may be the same or different, are H, optionally substituted alkyl, cycloalkyl, aralkyl or phenyl; R7 and R8 are H, alkyl or optionally substituted phenyl; and acid addition salts and metal complexes thereof, and processes and intermediates for their preparation.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem