Properties and Exciting Facts About 3-Methyldihydrofuran-2(3H)-one

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METHOD FOR PRODUCING COMPOUND HAVING ACID-LABILE GROUP

The present invention provides a process for producing a compound having a group represented by general formula (II): (wherein R1, R2, and R3 may be the same or different, and each represent a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted aralkyl, or R1 and R2 may bind to each other to form an alicyclic hydrocarbon ring together with the adjacent carbon atoms, or R2 and R3 may bind to each other to form a alicyclic heterocyclic ring together with the adjacent O-C-C that may have a substituent), which comprises allowing a compound having a hydroxyl group to react with halogenated alkyl ether represented by general formula (I): (wherein R1, R2, and R3 are the same as those defined above, respectively and X represents a halogen atom).

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The Preparation of Synthetic Analogues of Strigol

A range of analogues of the natural germination stimulant, strigol, for parasitic weeds of the genera Striga and Orobanche, has been prepared.Most of the products contain an alpha-formyl-gamma-lactone (or alpha-formyl-gamma-lactam) grouping attached through an enol-ether linkage to the 5-position of a but-2-enolide.Some have shown sufficiently high activities as to warrant large-scale field trials.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Selective hydrogenolysis of 2-furancarboxylic acid to 5-hydroxyvaleric acid derivatives over supported platinum catalysts

The conversion of 2-furancarboxylic acid (FCA), which is produced by oxidation of furfural, to 5-hydroxyvaleric acid (5-HVA) and its ester/lactone derivatives with H2 was investigated. Monometallic Pt catalysts were effective, and other noble metals were not effective due to the formation of ring-hydrogenation products. Supports and solvents had a small effect on the performance; however, Pt/Al2O3 was the best catalyst and short chain alcohols such as methanol were better solvents. The optimum reaction temperature was about 373 K, and at higher temperature the catalyst was drastically deactivated by deposition of organic materials on the catalyst. The highest yield of target products (5-HVA, delta-valerolactone (DVL), and methyl 5-hydroxyvalerate) was 62%, mainly obtained as methyl 5-hydroxyvalerate (55% yield). The byproducts were mainly ring-hydrogenation compounds (tetrahydrofuran-2-carboxylic acid and its ester) and undetected ones (loss of carbon balance). The catalyst was gradually deactivated during reuses even at a reaction temperature of 373 K; however, the catalytic activity was recovered by calcination at 573 K. The reactions of various related substrates were carried out, and it was found that the O-C bond in the O-CC structure (1,2,3-position of the furan ring) is dissociated before CC hydrogenation while the presence and position of the carboxyl group (or methoxy carbonyl group) much affect the reactivity.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Pichia stipitis OYE 2.6 variants with improved catalytic efficiencies from site-saturation mutagenesis libraries

An earlier directed evolution project using alkene reductase OYE 2.6 from Pichia stipitis yielded 13 active site variants with improved properties toward three homologous Baylis-Hillman adducts. Here, we probed the generality of these improvements by testing the wild-type and all 13 variants against a panel of 16 structurally-diverse electron-deficient alkenes. Several substrates were sterically demanding, and as hoped, creating additional active site volume yielded better conversions for these alkenes. The most impressive improvement was found for 2-butylidenecyclohexanone. The wild-type provided less than 20% conversion after 24 h; a triple mutant afforded more than 60% conversion in the same time period. Moreover, even wild-type OYE 2.6 can reduce cyclohexenones with very bulky 4-substituents efficiently.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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A Concise Synthesis of the Key Tetrahydrofuran Moieties of Caruifolin A and EBC-342

A common strategy for the concise synthesis of the key tetrahydrofuran moieties of caruifolin A and EBC-342 is presented. Asymmetric dihydroxylation and intramolecular SN2-cyclization are key strategic reactions for the synthesis of the furan fragments.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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A living foundry for Synthetic Biological Materials: A synthetic biology roadmap to new advanced materials

Society is on the cusp of harnessing recent advances in synthetic biology to discover new bio-based products and routes to their affordable and sustainable manufacture. This is no more evident than in the discovery and manufacture of Synthetic Biological Materials, where synthetic biology has the capacity to usher in a new Materials from Biology era that will revolutionise the discovery and manufacture of innovative synthetic biological materials. These will encompass novel, smart, functionalised and hybrid materials for diverse applications whose discovery and routes to bio-production will be stimulated by the fusion of new technologies positioned across physical, digital and biological spheres. This article, which developed from an international workshop held in Manchester, United Kingdom, in 2017 [1], sets out to identify opportunities in the new materials from biology era. It considers requirements, early understanding and foresight of the challenges faced in delivering a Discovery to Manufacturing Pipeline for synthetic biological materials using synthetic biology approaches. This challenge spans the complete production cycle from intelligent and predictive design, fabrication, evaluation and production of synthetic biological materials to new ways of bringing these products to market. Pathway opportunities are identified that will help foster expertise sharing and infrastructure development to accelerate the delivery of a new generation of synthetic biological materials and the leveraging of existing investments in synthetic biology and advanced materials research to achieve this goal.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Ruthenium hydrogenation catalysts

The invention relates to a novel ruthenium complex having the formula Ru(eta3 -C6 H8 -PCy2)(PCy3)Cl, wherein Cy is cyclohexyl; its use in the preparation of RuHCl(H2)(PCy3)2 and RuH2 (H2)2 (PCy3)2 ; and the use of the complexes as catalysts in hydrogenation, imination and reductive hydrolysis processes.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Nickel-BINAP catalyzed enantioselective alpha-arylation of alpha-substituted gamma-butyrolactones

A Ni(0)-BINAP system is utilized for the highly enantioselective alpha-arylation of alpha-substituted gamma-butyrolactones with aryl chlorides and bromides. alpha-Quaternization is achieved in moderate to excellent yields. Furthermore, the rate accelerating effect caused by the addition of Zn(II) salts is investigated. Copyright

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Application of 1679-47-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1679-47-6, Name is 3-Methyldihydrofuran-2(3H)-one, molecular formula is C5H8O2. In a Article£¬once mentioned of 1679-47-6

ADDITION OF 1-METHOXY-1-BUTEN-3-YNE TO LACTONES: SYNTHESIS OF SUBSTITUTED OF SPIROKETALS

A method for the preparation of a variety of substituted spiroketals from lactones and 1-methoxy-1-buten-3-yne has been developed.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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GC/MS analysis of oil extractives from wood and bark of pinus sylvestris, Abies alba, Picea abies, and Larix decidua

Wood and bark oil extractives components (OECs) of Pinus sylvestris, Abies alba, Picea abies, and Larix decidua grown in the Czech Republic were analyzed using gas chromatography/ mass spectrometry (GC/MS). The analysis showed the presence of monoterpene, sesquiterpene, diterpenoids, and resin acids. The highest percentages of OECs in the wood of P. sylvestris were alpha-fenchyl alcohol (26.04%), D-fenchyl alcohol (12.39%), and L-borneol (8.81%); the OECs in the bark included alpha-methyl-gamma-butyrolactone (31.88%) and isodecyl octyl phthalate (15.85%). The most frequently occurring OEC in A. alba wood were 4-hydroxy-4-methyl-2-pentanone (73.36%), alpha-cedrol (10.08%), and 2,6-dimethyl-1,3,6-heptatriene (7.35%); the most OECs in the bark were di(2-ethylhexyl)phthalate (59.83%), methyl cyclopentane (16.63%), and 13-epimanool (6.31%). P. abies wood OECs included 4-hydroxy-4-methyl-2-pentanone (29.42%), alpha-cedrol (26.98%), Delta3-carene (6.08%), and terpinen-4-ol (5.42%); the most OECs in the bark were di(2-ethylhexyl)phthalate (30.91%), cyclohexane (12.89%), caryophyllene oxide (8.90%), and alpha-pinene (4.59%). OECs of L. decidua wood were alpha-terpineol (26.06%), isoborneol (14.12%), camphene (11.78%), D-fenchyl alcohol (10.39%), and larixol (4.85%); OECs in the bark were larixol (33.29%), phthalic acid mono-2-ethylhexyl ester (16.96%), 13-epimanool (15.40%), and cyclohexane (8.44%).

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem