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Polymers are used in simple consumer items like carpets, furniture, glues, and clothing but are also used in advanced engineering, including materials used in the aerospace industry. Therefore, polymers and consequently their monomers play an important role in our everyday life. Currently, most of the monomers are produced from fossil resources, the supply of which is diminishing. In this paper we review strategies and catalytic processes to obtain currently used and potentially new monomers from renewable bio-based feedstocks and platform chemicals. This Review is divided by type of monomer and includes diacids and esters, diols, hydroxy acids and esters, lactones, carbonates, cyclic ethers, diamines, amino acids and lactams, alkenes, acrylics, and conjugated dienes. Only routes based on the use of homogeneous catalysis, heterogeneous catalysis, or bio-catalysis are described. Fermentative processes are not discussed.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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A mild and efficient alpha-heteroarylation of simple esters and amides was developed via nucleophilic aromatic substitution. The choice of NaHMDS in toluene gave the best results. A tandem alpha-heteroarylation and hydroxylation protocol using air as the oxidant afforded tertiary alcohols in good yields.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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An investigation was made of the effect of 1,4-bis(diphenylphosphino)butane (dppb) on the regioselectivity of the hydroformylation of alpha,beta-unsaturated esters with synthesis gas, catalyzed by rhodium(I) complexes.Excellent regioselectivity was obtained when dppb was added as a ligand for the reaction of methyl acrylate and alpha-methylene-gamma-butyrolactone with synthesis gas.However, it inhibits the reaction when methyl methacrylate is used as the substrate.The asymmetric hydroformylation of alpha-methylene-gamma-butyrolactone using (+)Cl(-) as the catalyst and (R)-BINAP as the chiral ligand (6:1 ratio of (R)-BINAP/Rh) gave an aldehydic lactone, containing a quaternary chiral center, in up to 37percent ee.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformations – aminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamide – afforded the corresponding N-substituted lactams. (Figure Presented).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Monosubstituted gamma-lactols 1a-1c, 3a-3c and 4a-4c, as well as disubstituted gamma-lactol 5 and the gamma-hydroxy-substituted gamma-lactone 6, were transformed into disubstituted tetrahydrofuran derivatives by treatment with allyl- and propargylsilanes in the presence of Lewis acids. The diastereoselectivities were moderate to excellent and are interpreted by application of the Felkin-Anh model to cyclic oxocarbenium ions. The effects of the equilibria between conformers of the intermediates are discussed. The surprisingly high diastereoselectivity of 4-substituted gamma-lactols 3 can be explained on this basis.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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An efficient synthesis of (±)-leporin A (1) has been developed using a tandem Knoevenagel condensation-inverse electron demand intramolecular hetero Diels-Alder reaction to construct the key tricyclic intermediate 3 from pyridone 5 and dienal 6 in one pot in 35% yield. Hydroxylation (71%) of 3 and methylation (77%) of the resulting hydroxypyridone 2 completed the first total synthesis of (±)-leporin A (1).

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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A novel enantioselective Pd-catalyzed intermolecular carboetherification of dihydrofurans is reported. The in situ generation of chiral bis-phosphine mono-oxide ligands is crucial, and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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O-Alk-3-enyl- and O-alk-4-enyl-Se-phenylselenocarbonates undergo regio-specific exo cyclization to the corresponding gamma- and delta-lactones on treatment with tri-n-butylstannane and AIBN.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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This invention relates to substituted pyrrolo[1,2-b]pyridazine compounds of Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug thereof. The compounds interact with CRF1, receptors, including human CRF1, receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety-related disorders such as anxiety, and mood disorders such as major depression.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem