Category: 149809-43-8

149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, belongs to tetrahydrofurans compound, is a common compound. Recommanded Product: 149809-43-8In an article, once mentioned the new application about 149809-43-8.

The present invention relates to a compound of formula III, wherein, R is selected from the group consisting of C1-C4 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted benzyl, preferably isopropyl; and two Ar groups may be the same or different, and are each independently selected from the group consisting of substituted or unsubstituted aryl groups, preferably substituted or unsubstituted phenyl, such as p-methoxyphenyl and the like, wherein the compound is preferably in a solid form.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 149809-43-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In a Patent£¬once mentioned of 149809-43-8

For the preparation of a preparation method of the midbody of posaconazole (by machine translation)

This invention discloses a process for preparing the formula 1 shown in the process for the preparation of posaconazole intermediate compound 1 method. Preparation method of the invention is compound have been reported in the literature for 2 as raw material, first of all three alkyl silicon-based protection of hydroxy to obtain compound 3, then with the triazole sodium salt of 4 reaction, to obtain compound 5, then in toluene sulfonyl chloride and alkali escapes the silicon ether and perform under the action of toluene sulfonyl protection to obtain compound 1. The invention can overcome the disadvantages of the prior art, and does not pass the splitting step, reduced side reaction occurs and impurity appear, improves the reaction selectivity and yield. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 149809-43-8. In my other articles, you can also check out more blogs about 149809-43-8

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 149809-43-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate,introducing its new discovery.

PROCESS FOR THE PREPARATION OF CHIRAL TRIAZOLONES

A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y3-NH2; of formula (Ila) 0=C=N-Y0 and/or of formula (lIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 149809-43-8, and how the biochemistry of the body works.Related Products of 149809-43-8

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of 149809-43-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate,introducing its new discovery.

Synthesis of 3H-SCH 51048 and 14 C-SCH 56592

3H-SCH 51048 and 14C-SCH 56592 have been synthesized. 3H-SCH 51048 was prepared in two steps by acid catalyzed tritium exchange while 14C-SCH 56592 was prepared in three steps from 14C-formamidine acetate in an overall 21% radiochemical yield.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 149809-43-8, and how the biochemistry of the body works.Reference of 149809-43-8

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of 149809-43-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 149809-43-8, molcular formula is C21H21F2N3O4S, introducing its new discovery.

HIGHLY STEREOSELECTIVE ACCESS TO NOVEL 2,2,4-TRISUBSTITUTED TETRAHYDROFURANS BY HALOCYCLIZATION: PRACTICAL CHEMOENZYMATIC SYNTHESIS OF SCH 51048, A BROAD-SPECTRUM ORALLY ACTIVE ANTIFUNGAL AGENT

A convenient synthesis of (-)-(2R)-cis-tosylate 2 is reported via stereoselective 5-exo iodocyclization of the optically active 2,2-disubstituted olefin 9a.Enzymatic desymmetrization of the homoallylic diol 4 with Novo SP435 allowed optimal pro-(S) selectivity to provide the desired (-)-(S)-monoacetate 9a.Under the irreversible reaction conditions, the presence of a bulky aryl substituent on the 2,2-disubstituted olefin seems to determine stereochemical outcome of these halocyclizations.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 149809-43-8 is helpful to your research. Reference of 149809-43-8

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In an article, author is Su, Yang, once mentioned the application of 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S, molecular weight is 449.47, MDL number is MFCD13195567, category is Tetrahydrofurans. Now introduce a scientific discovery about this category, Name: ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate.

Investigation on ternary system tetrahydrofuran/ethanol/water with three azeotropes separation via the combination of reactive and extractive distillation

In this work, a systematic method for conceptual design and multi-objective optimization of an energy efficient and sustainable reactive/extractive distillation (RED) process is proposed to separate a ternary wastewater mixture with multi-azeotrope tetrahydrofuran/ethanol/water. Conceptual design of the proposed scheme is carried out by the analysis of thermodynamic feasibility (e.g., residue curve maps and iso-volatility line). In the proposed process, the component of water in the ternary system is firstly removed by adding the reactant in a reactive distillation column and the remaining binary azeotropic mixture is then separated via ED. During the ED process, the best entrainer dimethyl sulfoxide could be determined via the comparison of iso- and uni-volatility. An improved multi-objective genetic algorithm is employed for optimizing the established process with some key decision variables (e.g., feed locations and distillate rate). The results illustrated that the economic and environmental benefits of the proposed RED process will be greatly improved. (c) 2020 Elsevier Ltd. All rights reserved.

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Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In an article, author is Dar’in, Dmitry,once mentioned of 149809-43-8, Name: ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate.

Spirocyclizations Involving Oxonium Ylides Derived from Cyclic alpha-Diazocarbonyl Compounds: An Entry into 6-Oxa-2-azaspiro[4.5]decane Scaffold

New types of cyclic diazo compounds capable of Rh(II)-catalyzed spirocyclizations with tetrahydrofuran have been discovered. The formation of the spirocyclic framework is thought to proceed via the formation of Rh(II) carbene species followed by interaction with the Lewis basic oxygen atom of tetrahydrofuran to give oxonium ylide species. The latter evolves predominantly via the Stevens type rearrangement leading to an [n + 1] ring expansion of the tetrahydrofuran moiety, which results in the formation of a medicinally relevant 6-oxa-2-azaspiro[4.5]decane scaffold. The spirocyclization process was often observed in competition with mechanistically distinct C-H insertion into a tetrahydrofuran molecule. This competing process gave compounds based on the 3-(tetrahydrofur-2-yl)pyrrolidine scaffold, which are also relevant from the medicinal chemistry standpoint. These findings enrich the available arsenal of metal-catalyzed spirocyclization methods based on the use of cyclic diazo compounds.

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Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 149809-43-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, SMILES is O=S(C1=CC=C(C)C=C1)(OC[C@H]2CO[C@](C3=CC=C(F)C=C3F)(CN4N=CN=C4)C2)=O, belongs to Tetrahydrofurans compound. In a article, author is Rodrigues, Ana Clara B., introduce new discover of the category.

Structure-relation properties of N-substituted phenothiazines in solution and solid state: Photophysical, photostability and aggregation-induced emission studies

Five N-substituted phenothiazines (with different alkyl and aryl groups) were investigated aiming to rationalize the influence of the substitution in the photooxidation processes and in the aggregation induced emission (AIE) properties of these compounds. A comprehensive spectroscopic and photophysical investigation in solution (diluted in solutions of methylcyclohexane, MCH, tetrahydrofuran, THF, and in THF: water mixtures aiming to promote aggregation) and in the solid state (powder and films), with the characterization of all the excited state deactivation routes with the determination of quantum yields (fluorescence, phosphorescence and singlet oxygen sensitization), lifetimes and rate constants, was performed. Room temperature phosphorescence in the solid state was observed for the methyl and bi-phenyl derivatives. Stability upon irradiation of the compounds was further investigated and the biphenyl derivative was found stable in contrast with phenothiazine and the other alkyl (methyl and hexyl) derivatives. Thesewere further rationalized with TD-DFT calculations. These findings present relevant information to the efficient design of photo-stable phenothiazine derivatives in light emitting applications. (c) 2020 Elsevier B.V. All rights reserved.

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Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, SMILES is O=S(C1=CC=C(C)C=C1)(OC[C@H]2CO[C@](C3=CC=C(F)C=C3F)(CN4N=CN=C4)C2)=O, in an article , author is Safar, Peter, once mentioned of 149809-43-8, Application In Synthesis of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate.

Synthesis and sequential diastereoselective incorporation of hydroxyl groups into hexahydrofuro[3,2-f]indolizin-7(2H)-one to give mono-, di- and tetra-hydroxyfuroindolizidines

Dihydrofuro[2,3-f]indolizidinone obtained from biosourced reagents even at multigram-scale was used as an advanced building-block with up to five points of chemical diversification. This resulted in the sequential synthesis of a series of mono-, di- and tetra-hydroxyfuranoindolizidines belonging to a very scarce and elaborate tetrahydrofuran-fused indolizidine family with up to six controlled stereogenic centers. These sequences include, among others, diastereoselective olefin epoxidation, stereoselective epoxide ring opening into tetrahydrofurantrans-diols, their protection as an ester or acetonide, and lactam carbonyl reduction ultimately followed by acetate or acetonide deprotection.

Interested yet? Read on for other articles about 149809-43-8, you can contact me at any time and look forward to more communication. Application In Synthesis of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate.

Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 149809-43-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, SMILES is O=S(C1=CC=C(C)C=C1)(OC[C@H]2CO[C@](C3=CC=C(F)C=C3F)(CN4N=CN=C4)C2)=O, belongs to Tetrahydrofurans compound. In a article, author is Gong, Zhong-Liang, introduce new discover of the category.

Handedness-inverted polymorphic helical assembly and circularly polarized luminescence of chiral platinum complexes

Circularly polarized luminescence (CPL) materials have potential applications in three-dimensional (3D) displays, quantum encryption, and optical sensors. The development of single-component CPL materials with polymorphic assembly and handedness inversion remains a significant challenge. Herein, we present the access of such materials by controlling the underlying assembly pathway of well-designed chiral emitters. A pair of enantiomeric platinum complexes (R)-1 and (S)-1 decorated with a chiral alpha-methylbenzyl isocyanide ligand were prepared. By using the mixed-solvent (THF/n-hexane, THF=tetrahydrofuran) or high-concentration condition, these complexes were found to assemble via a cooperative or isodesmic pathway with significantly enhanced yellow or red emission, respectively. The aggregate samples obtained via these conditions show efficient CPL (dissymmery factor divide g(lum) divide >0.02, emission quantum yield phi>20%). Interestingly, different assembly pathway leads to helical nanoribbons or nanofibers with opposite handedness from the complex with the same molecular chirality. This has been unambiguously and consistently manifested by circular dichroism and CPL spectral analysis and transmission electron, scanning electron, and atomic force microscope studies. This work demonstrates an appealing example of constructing polymorphic helical architectures with highly efficient CPL and inverted handedness thanks to the excellent assembly and emission of platinum complexes.

Synthetic Route of 149809-43-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 149809-43-8.

Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem