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New oak barrels from four French regions were used to mature Silver tequila 100% agave. Changes in minor volatile profile of tequila were evaluated through 32 maturation weeks. The generation and/or disappearance of volatile compounds was followed by using liquid-liquid batch extraction and subsequent GC/MS analysis of obtained samples. Globally, 173 compounds were identified, and 67 were relatively quantified. Analysis of variance exposed 10 individual compounds and the peak of 2-methoxyphenol + (2Z)-3,7-dimethylocta-2,6-dien-1-ol showing significant differences (p ? 0.05) between barrels? origin and 49 compounds and the peak of 2-methoxyphenol + (2Z)-3,7-dimethylocta-2,6-dien-1-ol by maturation time. Compounds such as 2,6-dimethoxyphenol (p ? 0.030), 1-decanol (p ? 0.000), 2-methoxyphenol + (trans)-3,7-dimethyl-2,6-octadien-1-ol (p ? 0.038), 2-methylbutanoic acid (p ? 0.012), 3-methyl-1-butyl acetate (p ? 0.031), furan-2-carbaldehyde (p ? 0.010) and octanoic acid (p ? 0.043), marked significant differences by time and barrel origin. Forward stepwise general discriminant analysis made it possible to classify correctly 81.7% of the samples according to the barrel origin using 8 compounds and 96.7% according to the maturation time with 24 compounds. All the samples were correctly classified as tequilas in maturation transition (G, 2?8 weeks) and Aged tequilas (A, 10?32 weeks), from the changes in the minor volatile profile.

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Chinese rice wine (CRW) is the oldest kind of wine in China and is mainly fermented by wheat Qu and yeast with rice, millet, etc. This gives CRW a unique quality, but the flavor components are complex. Its formation is related to microorganisms, but the link between CRW and microorganisms is poorly understood. Here, we used two kinds of sorghum (JZ22 and JB3, of which JZ22 has a higher tannin content) as the raw materials to brew and determined the structural and functional dynamics of the microbiota by metagenomics and flavor analyses. We detected 106 (JZ22) and 109 (JB3) volatile flavor compounds and 8 organic acids. By correlation analysis, we established 687 (JZ22) and 496 (JB3) correlations between the major flavor compounds and microbes. In JZ22, Blautia, Collinsella, Bifidobacterium, Faecalibacterium and Prevotella had the most correlations with flavor production. In JB3, the top 5 genera were Stenotrophomonas, Bdellovibrio, Solibacillus, Sulfuritalea and Achromobacter. In addition, more esters were detected, and more microorganisms correlated with ester generation in JZ22. This study provides a new idea for the micro ecological diversity of CRW fermented with sorghum. This is of significance for improving the quality and broadening the CRW varieties.

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In this study we assessed the impact of carbon dioxide enrichment (CDE) on flavour quality development of peach fruit, using peach trees grown in a greenhouse with a carbon-dioxide-enriched atmosphere. Fruit sugar, organic acids, volatiles contents and consumer acceptability were investigated, focusing on the period of postharvest ripening. Higher levels of sucrose, lactones, norisoprenoids, and lower levels of malic acid were found in CDE-treated fruit than those in the control fruit grown under normal conditions. We also measured significantly elevated amounts of pyruvic acid, precursors of volatile compounds, linoleic acid and linolenic acid as a result of CDE. Additionally, CDE-treated fruit were relatively well accepted by consumers compared to the control fruit. These results suggested that CDE can markedly improve the flavour quality and consumer acceptance of greenhouse-grown peaches. The possible mechanism could be that CDE increased precursors available for the biosynthesis of flavour compounds through regulation of photosynthesis.

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Tetrahydrofuran – Wikipedia,
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The use of an amidine of formula (I) and/or a conversion product thereof as a catalyst for the crosslinking of a composition based on silane group-containing polymers. The amidine of formula (I) and the conversion products thereof are essentially odourless at room temperature and non-volatile and accelerate the crosslinking of the composition very well without impairing the storage stability of the composition, and are very compatible in the composition. As a result, the compositions do not have a tendency to separate, migrate or evaporate the catalyst.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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In this work, the morphological and chemical properties of Chardonnay and Gewuerztraminer aromatic grapes (northern Spain) have been studied with the aim to assess their response to chamber-drying under controlled conditions and compare it with that of Pedro Ximenez grapes (southern Spain). Morphological characteristics, such as weight, size and roundness, and other of the skin such as thickness, enabled discrimination of the two types of grapes varieties. Changes in browning index, colour, antioxidant activity, aroma compounds determined by GC-MS and flavan-3-ols and flavonols concentrations determined by HPLC-DAD were studied during drying. Based on the results, Chardonnay and Gewuerztraminer grapes contained increased amounts of flavan-3-ol derivatives, which are the greatest contributors to polymerization and condensation reactions. Also, their smaller size resulted in faster drying and leads to sugary musts that were lighter-coloured, less brown and more aromatic than Pedro Ximenez grapes.

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The assessment of the dual impact of heating treatments on food safety and aroma is a major issue for the food sector. The aim of the present study was to demonstrate the relevance of multidimensional GC techniques, olfactometry and mass spectrometry for the parallel determination of process-induced toxicants and odorants in food starting with cooked meat as a food model. PAHs were analyzed by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry after extraction by accelerated solvent extraction (ASE-GC×GC-TOF/MS). Odour-active compounds were determined by dynamic headspace-GC hyphenated with eightbooth olfactometry and mass spectrometry (DH-GC-MS/8O) and DH-heart-cutting multidimensional GC hyphenated with olfactometry and mass spectrometry (DH-GC-GC-MS/O). For PAH determination, the GC×GC conditions consisted of a combination of a primary non-polar BPX-5 column and a secondary polar BPX-50 column, and a modulation period of 5s. In terms of linearity (R2 ranging from 0.985 to 0.997), recovery rate (84-111%) and limit of detection (5-65ng/kg of cooked meat), the ASE-GC×GC-TOF/MS method was found consistent with the multiresidue determination of 16 PAHs including benzo[a]pyrene in cooked meat. For aroma compounds, DH-GC-MS/8O and DH-GC-MS/O revealed 53 major meat odour-active compounds. A customized heart-cutting GC-GC-MS/O enabled the coeluting odour zones with high odour-activity to be resolved and revealed 15 additional odour-active compounds. Finally, these developments of multidimensional approaches were used to investigate the balance between 16 PAHs and 68 odour-active compounds generated with different cooking techniques.

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The offer of fresh-cut peaches and nectarines represents a valid alternative for stone fruit commercialization and matches the increasing market demand of ready-to-eat (RTE) products. In this study we explored the effect of fruit processing and storage on the volatilome of RTE fresh-cut nectarine. Fruit of three cultivars were sliced and packed in an industrial line and stored for 5 d at 5 C. Volatile organic compound (VOC) evolution was assessed daily in both intact and processed fruit by an exhaustive untargeted analysis, performed by proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) and solid phase microextraction- gas chromatography-mass spectrometry (SPME/GC-MS). Fresh-cut processing induced a major variation in nectarine volatilome depending on genetic differences and storage. This volatilome amelioration may be considered as an applicable strategy to enhance peach and nectarine perceived quality. Moreover, results of this study allowed the detection of a set of possible biomarkers enabling the selection of the best nectarine genotypes for processing and the prediction of the product shelf life based on the release of flavours and off-flavours.

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Tetrahydrofuran – Wikipedia,
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Palladium chloride catalyzed reaction < room temperature, one atmosphere > of primary, secondary, and tertiary allylic alcohols with carbon monoxide and oxygen, hydrochloric acid, and cupric chloride in tetrahydrofuran affords five-membered ring lactones.

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The human CYP2A6 enzyme metabolises several xenobiotics including nicotine, the addictive component in tobacco. Reduced activity of CYP2A6, either for genetic reasons or by administering inhibitors of CYP2A6, reduces tobacco smoking. The aim was to design novel inhibitors of CYP2A6 using 3D-QSAR analysis combined with virtual screening. A 3D-QSAR model was utilised to identify the most important features of the inhibitors, and this knowledge was used to design inhibitors for CYP2A6. Chemical database screening yielded several potent inhibitor candidates such as alkylamine derivatives (compound no. 5, IC 50 = 0.1 muM) and 1-benzothiophene-3-carbaldehyde that can be used as lead compounds in the development of drugs for smoking reduction therapy.

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Tetrahydrofuran – Wikipedia,
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Aldonolactones containing from four to eight carbon atoms, and lactones of the related monohydroxy-n-alkanoic acids, were subjected to reaction with 57 percent hydriodic acid at 125 deg C.As in the classical studies of Kiliani, the reduction of D-glycero-D-ido-heptono-1,4-lactone yielded mainly gamma-heptanolactone.Analogously, the corresponding gamma-alkanolactones were obtained as major products from the 1,4-lactones of the D-xylono, D-allono-, and D-erythro-L-talo-octono configuration.Monoiodo-n-alkanoic acids were also formed in admixture with the lactones in all of these reactions.D-Erythrono-1,4-lactone was unique among the aldonolactones in that it led only to an acid, i.e., 3-iodo-n-butanoic acid.The latter was also the product of the non-reductive reaction of hydriodic acid with beta-butyrolactone whereas, by contrast, gamma-butyrolactone afforded 4-iodobutanoic acid.Among compounds in the five to eight carbon series, it was found that under conditions close to equilibrium the ratio of lactone to iodoacid decreased progressively with the length of the carbon chain; e.g., in the 4 h reactions of gamma-valero, gamma-capro, gamma-heptano,- and gamma-octanolactone, the ratios were 2.4, 1.2, 0.2, and 0.1, respectively.An accompanying characteristic of these reactions is a progression in the number of isomeric iodoacids formed.Whereas gamma-valerolactone was accompanied by 4-iodopentanoic acid, there were two isomers (4- and 5-) of iodohexanoic acid, three monoiodo- (including 6-iodo-) heptanoic acids, and four (including 7-iodo-) octanoic acids.In all instances, the isomer substituted at the penultimate carbon was major.An interplay of several individual reactions, including ring-opening displacements, eliminations-additions, and rearrangements, as well as a probable influence of entropy changes on the lactone-acid equilibria, appear to account largely for these observations.

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Tetrahydrofuran – Wikipedia,
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