Category: 1028-33-7

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Acta Pharmaceutica Jugoslavica called Interaction of pentifylline with mitochondria, Author is Leskovac, Vladimir; Pericin, Draginja, which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Application of 1028-33-7.

Pentifylline (I) [1028-33-7] inhibits the oxidative phosphorylation of liver and brain mitochondria in vitro, but not by uncoupling. In addition, I inhibits selectively the uncoupled electron flow through the coenzyme Q: cytochrome c portion of the respiratory chain. Through all other portions of the respiratory chain, the uncoupled electron flow is almost unaffected. I interacts strongly with liver mitochondria which, in vivo, may slow down the consumption of cytosolic substrates through the respiratory chain, especially if their concentrations are low.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Identification of purines on paper chromatograms, the main research direction is CAFFEINE; PURINES.Quality Control of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.

Caffeine (10-20 γ) is detected on paper chromatograms by exposing the spot to Br vapor after locating it under ultraviolet light. The spot is steamed briefly and heated at 110-120°. The rose-pink color which develops is turned reddish purple by exposure to NH3. The Rf value differentiates caffeine from the other compounds giving the reaction: theobromine, theophylline, 1-n-hexyltheobromine, proxyphylline, etophylate, and diprophylline.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1028-33-7, is researched, Molecular C13H20N4O2, about Autoradiographic study of the distribution of 1-hexyl-3,7-dimethylxanthine-14C in mice, the main research direction is HEXYLXANTHINES METAB; XANTHINES METAB; DIMETHYLXANTHINES METAB; METAB DIMETHYLXANTHINES.Application of 1028-33-7.

Pregnant white mice were given 2 mg. of 1-hexyl-3,7-dimethylxanthine-14C (SK7-14C) dissolved in Me2SO in the tail vein, and sacrificed 5 and 20 min., 1, 4, 24, 48, and 96 hrs. after injection. Shortly after injection, the radioactivity accumulated in the brain but left it rather rapidly. Different parts of the eye showed a rather specific uptake of radioactivity. The lens of the fetus contained a higher level of radioactivity than that of the mother 3 days after injection. The walls of the large vessels had an affinity for SK7 or its metabolites, and it appears that SK7 passed the blood-brain barrier rather easily but penetrated the placental barrier rather poorly. The bone marrow concentrated the drug or its metabolites for a rather long time. The major excretion routes of the labeled substance (or substances) were the bile and urine.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of Investigative Dermatology called Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: Evidence for mediation by nuclear factor 1 down-regulation, Author is Duncan, Matthew R.; Hasan, Anthony; Berman, Brian, which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Electric Literature of C13H20N4O2.

Pentoxifylline (PTX) is a methylxanthine that exhibits multiple biol. activities, including the inhibition of collagen synthesis by dermal fibroblasts. Because some PTX activities have recently been linked to transcription factor-mediated regulation of gene transcription, we have investigated if PTX acts to inhibit collagen synthesis at a transcriptional locus by measuring procollagen mRNA levels and by assaying for the presence of an activator of procollagen gene promoters, nuclear factor (NF)-1. The effects of another methylxanthine, pentifylline (PTF), shown herein to be a ten-fold more potent inhibitor of collagen synthesis than PTX, and interferon-α, -β, and -γ were studied in parallel. Anal. of extracellular protein and RNA from 48-h-treated fibroblasts showed that PTX, PTF, and interferons decreased α1(I), α2(I), and α1(III) procollagens by reducing the steady-state levels of the corresponding procollagen mRNA transcripts. Reduction of procollagen mRNA levels appeared to be dependent on new protein synthesis, as it was prevented by treatment with cycloheximide. Assay for the presence of nuclear NF-1 by gel mobility shift anal. showed that extracts from interferon, PTX, and PTF-treated fibroblasts lacked proteins recognizing the consensus DNA binding sequence for NF-1. Taken together, these observations suggest interferons and methylxanthines may inhibit fibroblast collagen synthesis by a common mechanism requiring new protein synthesis that suppresses procollagen gene transcription through down-regulation of NF-1.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Name: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Determination of pentifylline in sustained release tablets. Author is Abu-Shady, Hamed A.; Hassib, Sonia T.; Youssef, Nadia F..

Pentifylline was determined by 2 sensitive methods viz: a titrimetric method in which pentifylline was treated with N-bromosuccinimide in aqueous sulfuric acid medium and a spectrophotometric method for the determination of pentifylline in the presence of nicotinic acid, recording absorbance of the mixture in methanol at 273 and 263 nm. The methods were applied with success for the evaluation of pentifylline in tablets. An attempt to determine other purine derivatives by N-bromosuccinimide is included.

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Tetrahydrofuran – Wikipedia,
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Formula: C13H20N4O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Pharmacology of 1-hexyl-3,7-dimethyixanthine.

Intravenous injection of 1-hexyl-3,7-dimethylxanthlne (I) (dissolved in 70% propylene glycol) temporarily decreased blood pressure by 30-40, 50-60, and 70 mm. in doses of 1, 3, and 5 mg./kg. body weight, resp., in cats, rabbits, and dogs. Propylene glycol also showed hypotensive action but to a lesser extent. After the injection, urine volume and urinary excretion of Na+ and Cl- significantly increased, but the renal blood flow remained unchanged. Cardiac movement was slightly augmented by I after a transient depression. Intracarotid injection of I in doses of 0.05 to 0.3 mg./kg. body weight markedly increased the blood flow in the internal carotid artery without any change in systemic blood pressure.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bruns, Robert F. researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Recommanded Product: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.They published the article 《Adenosine antagonism by purines, pteridines, and benzopteridines in human fibroblasts》 about this compound( cas:1028-33-7 ) in Biochemical Pharmacology. Keywords: adenosine antagonist structure activity. We’ll tell you more about this compound (cas:1028-33-7).

Testing of >100 purine bases and structurally related heterocycles as adenosine (I) [58-61-7] antagonists in VA13 fibroblasts (determined by cAMP increase) yielded 3 families of I antagonists: xanthines, benzo[g]pteridines, and 9-substituted adenines. For the xanthines, the optimal group at the 1-position was Bu (5-fold improvement vs. Me), at the 7-position was 2-chloroethyl (5-fold improvement vs. H), and at the 8-position was p-bromophenyl (100-fold improvement vs. H). The receptors apparently had butyl- and phenyl-sized pockets at the 1- and 8-positions, resp., since compounds with larger groups had greatly reduced activity.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioscience Reports called Inhibition of sodium, potassium-dependent adenosine triphosphatase by adenosine in intact pigeon erythrocytes, Author is Leskovac, Vladimir, which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Category: tetrahydrofurans.

In intact pigeon erythrocytes adenosine (I) [58-61-7] was a potent inhibitor of Na,K-dependent ATPase  [9000-83-3]. In purified cell-membrane preparations, adenosine was only a weak competitive inhibitor of Na,K-ATPase, with respect to ATP indicating that adenosine may not be a direct inhibitor of the Na pump in intact red cells per se. Adenosine may exert its inhibitor effect via endogenous cell factors.

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Tetrahydrofuran – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Effect of methylxanthines on the concentration of gamma-aminobutyric acid in brain of normal and anoxic rats.Category: tetrahydrofurans.

In normal rats, caffeine (I) [58-08-2] (25 mg/kg, orally) increased cerebral GABA  [56-12-2] concentration (41.3%) whereas pentifylline (II) [1028-33-7] (25 mg/kg, orally) diminished the concentration of GABA by 23.1%, the effects of similar concentrations of theophylline  [58-55-9] and theobromine  [83-67-0] were not significant. In anoxic rats, I and II caused a significant decrease in GABA concentration whereas theophylline increased GABA levels. Thus structurally similar methylxanthines have different effects on GABA concentrations in the brain.

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Elben, U.; Schroeer, R. published the article 《Calcium complexes of xanthine derivatives: a new aspect of the mode of action of hemorheologically active drugs》. Keywords: calcium xanthine complex preparation hemorheol.They researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Application of 1028-33-7. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1028-33-7) here.

Five Ca complexes of xanthine derivatives were prepared by reacting the xanthine derivative with Ca(SCN)2. The effects of the Ca complexes on red blood cell deformity were determined and related to the hemorheol. properties of the drugs.

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Tetrahydrofuran – Wikipedia,
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